Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents.

scientific article published on 4 July 2018

Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1098/RSOS.180176
P932PMC publication ID6083693
P698PubMed publication ID30109074

P50authorJinxin CheQ90951619
P2093author name stringFeng Huang
Zhilong Wang
Xin Xie
Yongzhou Hu
Xiaowu Dong
Youhong Hu
Haichao Sheng
P2860cites workCXCR2: a target for pancreatic cancer treatment?Q27021588
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Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells.Q30353532
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CXCR2 receptor antagonists: a medicinal chemistry perspectiveQ35232382
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CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal AdenocarcinomaQ36041701
Discovery of Novel Succinate Dehydrogenase Inhibitors by the Integration of in Silico Library Design and Pharmacophore Mapping.Q36327898
Recent advances in MMP inhibitor designQ36471137
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Why does cancer therapy lack effective anti-metastasis drugs?Q38051530
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Potential of Integrin Inhibitors for Treating Ovarian Cancer: A Literature ReviewQ39429469
Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer.Q39480718
Inhibition of multiple vascular endothelial growth factor receptors (VEGFR) blocks lymph node metastases but inhibition of VEGFR-2 is sufficient to sensitize tumor cells to platinum-based chemotherapeuticsQ40006197
Synthesis and structure-activity relationships of 3,4-diaminocyclobut-3-ene-1,2-dione CXCR2 antagonistsQ40280551
Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis.Q42181728
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.Q44747127
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonistsQ46898022
Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design.Q51747458
Constructing and Validating 3D-pharmacophore Models to a Set of MMP-9 Inhibitors for Designing Novel Anti-melanoma Agents.Q52856612
2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: discovery of novel and potent CXCR2 antagonists.Q53247930
Pharmacophore identification, docking and "in silico" screening for novel CDK1 inhibitors.Q54509182
N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptorsQ80171436
C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonistsQ80218015
3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonistsQ80380661
Pharmacophore-Map-Pick: A Method to Generate Pharmacophore Models for All Human GPCRsQ88061067
P433issue7
P304page(s)180176
P577publication date2018-07-04
P1433published inRoyal Society Open ScienceQ18712516
P1476titleLigand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents
P478volume5

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cites work (P2860)
Q99630072Development of simultaneous interaction prediction approach (SiPA) for the expansion of interaction network of traditional Chinese medicine
Q92651431Digital gene expression analyses of mammary glands from meat ewes naturally infected with clinical mastitis
Q91713632Pharmacophore-Based Virtual Screening Toward the Discovery of Novel Anti-echinococcal Compounds
Q90430431Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations
Q58606442The role of CXCR2 in acute inflammatory responses and its antagonists as anti-inflammatory therapeutics

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