Potential of Integrin Inhibitors for Treating Ovarian Cancer: A Literature Review

scientific article

Potential of Integrin Inhibitors for Treating Ovarian Cancer: A Literature Review is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/CANCERS9070083
P932PMC publication ID5532619
P698PubMed publication ID28698469

P50authorTadashi KimuraQ87225863
P2093author name stringMasaki Kobayashi
Kenjiro Sawada
P2860cites workThe tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome.Q53639283
Ovarian cancerQ54105461
Embryonic mesodermal defects in alpha 5 integrin-deficient miceQ71609560
Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitroQ77874135
Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agentQ79198459
Ovarian cancerQ84605146
Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trialQ87460208
Modes of resistance to anti-angiogenic therapyQ24608005
Comprehensive molecular portraits of human breast tumoursQ24630844
Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancerQ24650026
Integrins: bidirectional, allosteric signaling machinesQ27860700
Integrins in cancer: biological implications and therapeutic opportunitiesQ29614536
RGD and other recognition sequences for integrinsQ29616331
Inhibition of α4β1 integrin increases ovarian cancer response to carboplatinQ30408322
Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasisQ30430565
Recurrent epithelial ovarian cancer: pharmacotherapy and novel therapeuticsQ30444706
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasisQ30447841
The promise of antiangiogenic therapy for ovarian cancerQ30449461
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trialQ33417361
Recent advances in genetic modification of adenovirus vectors for cancer treatmentQ33738828
Maximal cytoreductive effort in epithelial ovarian cancer surgeryQ33955721
A phase 3 trial of bevacizumab in ovarian cancerQ34030022
Ovarian cancer development and metastasisQ34086819
Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment deliveryQ34198775
Role of vascular endothelial growth factor in regulation of physiological angiogenesisQ34249816
A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)Q34269566
Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.Q34311697
Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors.Q34689304
A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanomaQ35212620
A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancerQ35591666
Beta 1-integrins regulate the formation and adhesion of ovarian carcinoma multicellular spheroidsQ35747173
Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skinQ35764323
The regulation of integrin function by divalent cationsQ35998499
Clinical significance of the integrin α6β4 in human malignancies.Q36010634
Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative studyQ36087887
The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectinQ36224126
Elevated levels of Lewis y and integrin α5β1 correlate with chemotherapeutic drug resistance in epithelial ovarian carcinomaQ36538265
Inhibition of integrin β1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathwayQ36592509
VCAM1 expression correlated with tumorigenesis and poor prognosis in high grade serous ovarian cancerQ36789013
Expression of Lewis y antigen and integrin αv, β3 in ovarian cancer and their relationship with chemotherapeutic drug resistanceQ36976151
Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic targetQ37151287
{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.Q37413723
Volociximab in cancerQ37970775
RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosisQ38042484
Integrins and haptoglobin: Molecules overexpressed in ovarian cancer.Q38820962
Cancer Statistics, 2017.Q39038674
Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins.Q39109469
A brief review of the management of platinum-resistant-platinum-refractory ovarian cancerQ39263789
Purified autoantibodies against glucose-regulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cellsQ39527590
Integrin-targeted paclitaxel nanoliposomes for tumor therapyQ39678154
Phase I evaluation of a fully human anti-alphav integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors.Q40453891
Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survivalQ41671359
The specifical inhibition of the expression of integrin alpha5/beta1 probably enhances the treatment effects and improves the prognosis of epithelial ovarian cancerQ42177122
A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - dacarbazine in patients with stage IV metastatic melanomaQ42647126
Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxelQ43287891
AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patientsQ44533910
Incorporation of bevacizumab in the primary treatment of ovarian cancerQ44579933
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P921main subjectovarian cancerQ172341
P577publication date2017-07-08
P1433published inCancersQ27722963
P1476titlePotential of Integrin Inhibitors for Treating Ovarian Cancer: A Literature Review
P478volume9

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cites work (P2860)
Q90523384Fluorescent Nanoparticles for the Guided Surgery of Ovarian Peritoneal Carcinomatosis
Q52651546High expression of integrin αvβ3 enables uptake of targeted fluorescent probes into ovarian cancer cells and tumors.
Q64992482Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents.
Q64080771Nanocomposites as biomolecules delivery agents in nanomedicine
Q91935771PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3
Q64252943Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis
Q48291586The Two Faces of Adjuvant Glucocorticoid Treatment in Ovarian Cancer
Q90107111The role of collagen in cancer: from bench to bedside
Q64062159Therapeutic Targeting of Collective Invasion in Ovarian Cancer
Q90633066Transcriptome Profiling Reveals Matrisome Alteration as a Key Feature of Ovarian Cancer Progression
Q47290265rLj-RGD3 Suppresses the Growth of HeyA8 Cells in Nude Mice

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