Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice

scientific article published on 15 November 2017

Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/EN.2017-00540
P932PMC publication ID5761608
P698PubMed publication ID29155981

P50authorSriparna GhosalQ59297480
Diego Perez-TilveQ81153600
Jessie ScheimannQ89159078
P2093author name stringEric P Smith
James P Herman
Parinaz Mahbod
Jenny Tong
Maureen E Fitzgerald
Benjamin A Packard
Rachel L Morano
P2860cites workGhrelin is a growth-hormone-releasing acylated peptide from stomachQ22010951
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Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasisQ85856335
Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious ratsQ28578910
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preferenceQ28589080
A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNAQ29615197
Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor.Q30274005
Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.Q30439742
Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted miceQ33644530
Techniques: Recombinogenic engineering--new options for cloning and manipulating DNA.Q34245450
Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress.Q34269843
Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissueQ34513077
Ghrelin increases anxiety-like behavior and memory retention in ratsQ34529618
HPA axis dampening by limited sucrose intake: reward frequency vs. caloric consumptionQ34669278
Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob backgroundQ34695658
Reducing Mouse Anxiety during Handling: Effect of Experience with Handling TunnelsQ34805357
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptorsQ35604455
Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 AgonismQ35719941
Expression of ghrelin receptor mRNA in the rat and the mouse brainQ35915057
Mouse handling limits the impact of stress on metabolic endpointsQ35988461
Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylationQ36329584
The use of the elevated plus maze as an assay of anxiety-related behavior in rodentsQ36759180
Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.Q36825221
The role of the forebrain glucocorticoid receptor in acute and chronic stressQ36976396
Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptorsQ37403334
GOAT links dietary lipids with the endocrine control of energy balanceQ37463007
Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.Q37558852
Ghrelin and glucose homeostasisQ37852176
Ghrelin's Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders.Q38298320
Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cellsQ38500660
Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signalingQ39518263
Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamusQ41969194
Developmental treatment with the dopamine D2/3 agonist quinpirole selectively impairs spatial learning in the Morris water maze.Q42600663
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.Q42918384
Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structureQ44072283
Effects of repeated restraint stress on gastric motility in ratsQ46100147
Des-Acyl Ghrelin and Ghrelin O-Acyltransferase Regulate Hypothalamic-Pituitary-Adrenal Axis Activation and Anxiety in Response to Acute StressQ47404021
Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelinQ48106033
Taming anxiety in laboratory miceQ48184424
Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouseQ48402593
Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimersQ48590457
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)388-399
P577publication date2017-11-15
P1433published inEndocrinologyQ3054009
P1476titleDesacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice
P478volume159