Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3)

scientific article

Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3) is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/ENEURO.0053-14.2015
P932PMC publication ID4596092
P698PubMed publication ID26464979

P2093author name stringAlfonso Abizaid
Martin Wellman
P2860cites workMembrane protein oligomeric structure and transport functionQ59084286
Metabotropic glutamate receptor 5 is a disulfide-linked dimerQ71763241
Heterodimerization of a functional GABAB receptor is mediated by parallel coiled-coil alpha-helicesQ73101258
Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the ratQ73196663
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouseQ74244402
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body massQ74268345
GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimerQ74596023
Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout miceQ80350255
Heterodimerization is required for the formation of a functional GABA(B) receptorQ22008591
Ghrelin is a growth-hormone-releasing acylated peptide from stomachQ22010951
Dopamine and reward: The anhedonia hypothesis 30 years onQ22252806
Loss of constitutive activity of the growth hormone secretagogue receptor in familial short statureQ24306403
A receptor in pituitary and hypothalamus that functions in growth hormone releaseQ24308321
Dopamine receptors: from structure to functionQ24336139
Ghrelin octanoylation mediated by an orphan lipid transferaseQ24336259
Mice lacking ghrelin receptors resist the development of diet-induced obesityQ24536127
Brain circuits regulating energy homeostasisQ24569806
Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanismQ24613339
Ghrelin increases intake of rewarding food in rodentsQ24614699
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stressQ24650789
Pharmacological targeting of the serotonergic system for the treatment of obesityQ24658013
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetiteQ24669708
Genome-wide atlas of gene expression in the adult mouse brainQ26253934
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonistQ28156211
Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticityQ28185479
Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration StudiesQ28210337
5-HT 2C receptor activation decreases appetite and body weight in obese subjectsQ28253985
Common structural basis for constitutive activity of the ghrelin receptor familyQ28283575
Effects of second generation antipsychotics on leptin and ghrelinQ46519463
Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor geneQ46622195
Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemiaQ46807918
A negative feedback system between brain serotonin systems and plasma active ghrelin levels in miceQ46907127
Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomesQ46977972
Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleusQ47854765
Different Developmental Patterns of Melanocortin MC3 and MC4 Receptor mRNA: Predominance of Mc4 in Fetal Rat Nervous SystemQ48038995
5-HT(2C) receptor activation inhibits appetitive and consummatory components of feeding and increases brain c-fos immunoreactivity in mice.Q48140056
The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response taskQ48185891
D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampusQ48223824
Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390.Q48361029
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasisQ48382703
Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal HypothalamusQ48387738
D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat.Q48514054
Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimersQ48590457
Role of Dopamine D1and D2Receptors in the Nucleus Accumbens in Mediating RewardQ48617036
Leptin attenuates acute food deprivation-induced relapse to heroin seeking.Q48691260
Effects of dopamine antagonists on neuronal activity related to a delayed response task in monkey prefrontal cortexQ48956882
Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary.Q49154825
Hyperphagia in pre-fed rats following oral delta9-THC.Q50152394
The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humansQ50336243
Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelinQ51527227
The role of food deprivation in the maintenance and reinstatement of cocaine-seeking behavior in ratsQ51819657
Modulation of memory fields by dopamine D1 receptors in prefrontal cortexQ52051956
Stress and relapse to drug seeking in rats: studies on the generality of the effectQ52166382
Dopamine D1 receptors in the nucleus accumbens: involvement in the reinforcing effect of tegmental stimulationQ52251656
Reduced locomotor responses to cocaine in ghrelin-deficient miceQ45290502
Effects of repeated restraint stress on gastric motility in ratsQ46100147
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.Q46495742
Role of melanocortinergic neurons in feeding and the agouti obesity syndromeQ28300979
Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis studyQ28377153
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormoneQ28504894
Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiationQ28589151
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmissionQ30493133
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid systemQ33323392
Shedding light on the intricate puzzle of ghrelin's effects on appetite regulationQ33346919
Heterodimerization of hypothalamic G-protein-coupled receptors involved in weight regulation.Q33522369
A trafficking checkpoint controls GABA(B) receptor heterodimerizationQ33913403
Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preferenceQ34013454
D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses.Q34063708
Ghrelin: an orexigenic and somatotrophic signal from the stomachQ34085744
The role of the central ghrelin system in reward from food and chemical drugsQ34167084
Dopaminergic control of synaptic plasticity in the dorsal striatumQ34206258
Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigationQ34250821
Serotonin and drug reward: focus on 5-HT2C receptorsQ34277384
Distribution of D2 dopamine receptor mRNA in rat brainQ34309246
SR141716A, a potent and selective antagonist of the brain cannabinoid receptorQ34332716
Dopamine receptor signalingQ34364279
Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neuronsQ34372318
Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice.Q34378314
Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera.Q34395395
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Q34485514
Role of heteromer formation in GABAB receptor functionQ34485603
Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostatQ34507189
Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissueQ34513077
Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamusQ34528756
Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone.Q34643862
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissuesQ34743649
5-HT2C receptor agonists: pharmacological characteristics and therapeutic potentialQ34750267
Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumptionQ34970821
Role of brain dopamine in food reward and reinforcementQ35140226
Oligomerization of G protein-coupled receptors: past, present, and futureQ35546811
The impact of stress on addictionQ35592706
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptorsQ35604455
Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 AgonismQ35719941
Expression of ghrelin receptor mRNA in the rat and the mouse brainQ35915057
The 'magic' of L-dopa: why is it the gold standard Parkinson's disease therapy?Q36152366
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic systemQ36557845
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.Q36747895
G-protein-coupled receptors: an updateQ36788551
Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functionsQ37098373
Ghrelin and ghrelin receptor modulation of psychostimulant action.Q37196538
Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors.Q37326316
Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluidQ37362568
Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.Q37371469
Ghrelin and dopamine: new insights on the peripheral regulation of appetite.Q37517893
Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity.Q37788058
5-HT2C Agonists as Therapeutics for the Treatment of SchizophreniaQ38048646
Subtypes of dopamine receptors involved in the mechanism of reinforcementQ38259064
"First do no harm." A systematic review of the prevalence and management of antipsychotic adverse effectsQ38291338
Antagonism of ghrelin receptor reduces food intake and body weight gain in miceQ38353682
Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activationQ38495363
Reward or reinforcement: what's the difference?Q38715705
Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptorsQ38869715
Ghrelin's Orexigenic Effect Is Modulated via a Serotonin 2C Receptor InteractionQ38905070
Ghrelin mediates stress-induced food-reward behavior in miceQ39364936
Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signalingQ39518263
Constitutive activity of neural melanocortin receptorsQ39637960
Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent mannerQ40011175
Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and beta-arrestinsQ40127887
The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptorsQ40220162
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.Q40984747
A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.Q41186190
High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discsQ41226865
Effect of nigrostriatal dopamine depletion on the post-training, memory-improving action of amphetamineQ41389351
Stress, vulnerability and adult alcohol relapse.Q41649968
Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in miceQ41896578
Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolismQ42151441
Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilizationQ42596581
Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice.Q42991900
Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structureQ44072283
Dimerization of the delta opioid receptor: implication for a role in receptor internalizationQ44347088
Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted miceQ44456158
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
P577publication date2015-04-24
P1433published ineNeuroQ27726083
P1476titleGrowth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3)
P478volume2