Merging functional studies with structures of inward-rectifier K+ channels

scientific article published on December 1, 2003

Merging functional studies with structures of inward-rectifier K+ channels is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1002151738
P356DOI10.1038/NRN1244
P953full work available at URLhttp://www.nature.com/articles/nrn1244
http://www.nature.com/articles/nrn1244.pdf
https://hal.archives-ouvertes.fr/hal-03440312/file/p12-Bichet-2003-NRN-Review.pdf
P698PubMed publication ID14618155
P5875ResearchGate publication ID9008802

P50authorDelphine BichetQ55690139
P2093author name stringLily Yeh Jan
Friederike A. Haass
P2860cites workPharmacological ReviewsQ2085079
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
X-ray structure of a voltage-dependent K+ channelQ22337257
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolutionQ22337277
Alterations in conserved Kir channel-PIP2 interactions underlie channelopathiesQ24300436
Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channelQ24537354
A family of putative Kir potassium channels in prokaryotesQ24798078
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Structure of the KcsA channel intracellular gate in the open stateQ27635036
Gating of inwardly rectifying K+ channels localized to a single negatively charged residueQ49089320
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channelQ49089411
Specification of pore properties by the carboxyl terminus of inwardly rectifying K+ channelsQ49105116
Association and stoichiometry of K(ATP) channel subunitsQ73413932
Involvement of histidine residues in proton sensing of ROMK1 channelQ73538392
Gated access to the pore of a voltage-dependent K+ channelQ73564876
Residues beyond the selectivity filter of the K+ channel kir2.1 regulate permeation and block by external Rb+ and Cs+Q74007784
Localization of PIP2 activation gate in inward rectifier K+ channelsQ42603548
Structure and dynamics of the pore of inwardly rectifying K(ATP) channels.Q42616698
The K+ channel signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivityQ42642296
Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channelsQ42653386
The open pore conformation of potassium channelsQ42677283
The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segmentQ42686974
Mechanism of rectification in inward-rectifier K+ channelsQ42978407
Distinct histidine residues control the acid-induced activation and inhibition of the cloned K(ATP) channelQ43714150
Gating properties of inward-rectifier potassium channels: effects of permeant ionsQ43785725
Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channelsQ43981543
Regulation of the inward rectifying properties of G-protein-activated inwardly rectifying K+ (GIRK) channels by Gbeta gamma subunitsQ44196779
Compromised ATP binding as a mechanism of phosphoinositide modulation of ATP-sensitive K+ channelsQ44234594
Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosisQ44261811
Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminusQ44270128
Inward Rectification by Polyamines in Mouse Kir2.1 Channels: Synergy between Blocking ComponentsQ44436440
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivityQ44452050
Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channelQ44592821
Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+.Q46223902
Determination of the subunit stoichiometry of an inwardly rectifying potassium channelQ46248253
Tetrameric subunit structure of the native brain inwardly rectifying potassium channel Kir 2.2.Q46888987
Identification of a potassium channel site that interacts with G protein betagamma subunits to mediate agonist-induced signalingQ47970470
Modulation of rat atrial G protein-coupled K+ channel function by phospholipidsQ48221723
Molecular mechanism for sodium-dependent activation of G protein-gated K+ channelsQ48564702
Energetics of ion conduction through the K+ channelQ48620522
Conformational Rearrangements Associated with the Gating of the G Protein-Coupled Potassium Channel Revealed by FRET MicroscopyQ48829711
Gating of inward rectifier K+ channels by proton-mediated interactions of N- and C-terminal domainsQ48886814
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactionsQ48906142
The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.Q48906684
K+ binding sites and interactions between permeating K+ ions at the external pore mouth of an inward rectifier K+ channel (Kir2.1).Q48915932
Architecture of a K+ channel inner pore revealed by stoichiometric covalent modificationQ48921102
Energetic optimization of ion conduction rate by the K+ selectivity filterQ27635927
The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanismQ27638959
Crystal structure and mechanism of a calcium-gated potassium channelQ27639064
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolutionQ27640256
Crystal structure of the potassium channel KirBac1.1 in the closed stateQ27641201
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and GbetagammaQ27641311
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZQ27732927
VMD: visual molecular dynamicsQ27860554
A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiationQ28115658
Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channelQ28203784
Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteinsQ28210562
Potassium channel structuresQ28218200
Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channelsQ28235279
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptorQ28237709
Identification of domains conferring G protein regulation on inward rectifier potassium channelsQ28270459
Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activationQ28274792
The mechanism of inward rectification of potassium channels: "long-pore plugging" by cytoplasmic polyaminesQ28280584
Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channelsQ28346279
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channelQ28360309
Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating siteQ28361626
Structural rearrangements underlying K+-channel activation gatingQ30304111
Synergistic activation of G protein-gated inwardly rectifying potassium channels by the betagamma subunits of G proteins and Na(+) and Mg(2+) ionsQ30442683
Transmembrane structure of an inwardly rectifying potassium channelQ30658648
Ion permeation mechanism of the potassium channelQ30864083
Yeast screen for constitutively active mutant G protein-activated potassium channelsQ30986153
Coupling Gbetagamma-dependent activation to channel opening via pore elements in inwardly rectifying potassium channelsQ30986158
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.Q31924379
Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.Q32063793
Cloning and expression in yeast of a plant potassium ion transport systemQ33214391
Inward rectification in KATP channels: a pH switch in the pore.Q33852328
Molecular determinants of KATP channel inhibition by ATP.Q33888944
Nucleotides and phospholipids compete for binding to the C terminus of KATP channelsQ34014094
Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channelQ34093658
KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunitQ36815192
Coupled ion movement underlies rectification in an inward-rectifier K+ channelQ36852275
Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiaeQ37599088
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.Q38306779
pH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C terminiQ38330465
Identification of residues contributing to the ATP binding site of Kir6.2.Q39777428
Molecular dynamics of the KcsA K(+) channel in a bilayer membraneQ40164648
K(+) versus Na(+) ions in a K channel selectivity filter: a simulation studyQ40211009
Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutantsQ40233471
Gating dependence of inner pore access in inward rectifier K(+) channelsQ40659405
Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channelQ40767033
ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunitQ40976849
Nonselective and G betagamma-insensitive weaver K+ channelsQ41190453
Dynamic rearrangement of the outer mouth of a K+ channel during gatingQ41212365
Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activationQ42065529
Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channelQ42279128
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectificationQ42282616
Distinct sites on G protein beta gamma subunits regulate different effector functionsQ42523857
PIP2 and PIP as determinants for ATP inhibition of KATP channelsQ42538515
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GbetagammaQ42544747
Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cellsQ42556484
Molecular determinants for sodium-dependent activation of G protein-gated K+ channelsQ42595329
Ion conduction pore is conserved among potassium channelsQ34099241
Mutations in the K+ channel signature sequenceQ34115135
The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understandingQ34172980
Contribution of the selectivity filter to inactivation in potassium channelsQ34179836
The pore helix is involved in stabilizing the open state of inwardly rectifying K+ channelsQ34181912
Answers and questions from the KvAP structuresQ34219348
The ligand-sensitive gate of a potassium channel lies close to the selectivity filterQ34227906
Cyclic nucleotide-gated channels: shedding light on the opening of a channel poreQ34354389
Functional expression of a vertebrate inwardly rectifying K+ channel in yeastQ34451669
A novel inward rectifier K+ channel with unique pore propertiesQ34471139
Membrane phospholipid control of nucleotide sensitivity of KATP channelsQ34478704
Gating of inward rectifier K(+) channels by proton-mediated interactions of intracellular protein domainsQ34498127
Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ionsQ34616024
Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0.Q34840556
Ion channels: structural bioinformatics and modellingQ34915255
Gating of GIRK channels: details of an intricate, membrane-delimited signaling complexQ35171930
Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphatesQ35806004
Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunitQ35948542
Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channelQ35999251
Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1.Q36412119
Ion conduction through C-type inactivated Shaker channels.Q36435957
Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.Q36436065
Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyaminesQ36436070
Permeation and gating of an inwardly rectifying potassium channel. Evidence for a variable energy wellQ36436110
Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channelsQ36436285
Molecular coupling of S4 to a K(+) channel's slow inactivation gateQ36436295
Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.Q36436571
Permeation properties of inward-rectifier potassium channels and their molecular determinantsQ36444965
Selectivity changes during activation of mutant Shaker potassium channelsQ36445050
Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channelsQ36445212
Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channelQ36445268
Spermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore blockQ36558213
pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndromeQ36787083
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)957-967
P577publication date2003-12-01
P1433published inNature Reviews NeuroscienceQ2108225
P1476titleMerging functional studies with structures of inward-rectifier K(+) channels
Merging functional studies with structures of inward-rectifier K+ channels
P478volume4

Reverse relations

cites work (P2860)
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