Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain.

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Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1101719543
P356DOI10.1007/S00424-018-2135-Y
P932PMC publication ID6013512
P698PubMed publication ID29572566

P50authorFrancisco BarrosQ47261972
Pedro DomínguezQ57274769
P2093author name stringPilar de la Peña
P2860cites workVoltage-Controlled Enzymes: The New JanusBifronsQ21129281
The voltage-gated potassium channels and their relativesQ22337264
Inwardly rectifying potassium channels: their structure, function, and physiological rolesQ24296441
HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel FamilyQ24317712
A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsQ24655800
hERG channel function: beyond long QTQ27008078
The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel DeactivationQ27666661
The S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation GatingQ27677437
Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanismQ27727293
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
K₂p channels in plants and animals.Q38264988
The family of K2P channels: salient structural and functional propertiesQ38296300
Voltage-gated proton (H(v)1) channels, a singular voltage sensing domain.Q38571185
Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?Q38857131
Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channelsQ39182563
Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.Q39372227
Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating.Q40166581
Gating charge movement precedes ionic current activation in hERG channelsQ40402474
Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow DeactivationQ41045858
A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and poreQ41598401
Sequence of gating charge movement and pore gating in HERG activation and deactivation pathwaysQ41820997
The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibriumQ42603318
Molecular basis of slow activation of the human ether-a-go-go related gene potassium channelQ42628734
A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytesQ42660864
Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.Q42683368
Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions.Q43205719
Rapidly and slowly activating components of delayed rectifier K(+) current in guinea-pig sino-atrial node pacemaker cells.Q46715229
Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domainsQ47261912
Modulation of human erg K+ channel gating by activation of a G protein-coupled receptor and protein kinase C.Q47678976
Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels.Q48630181
Molecular dissection of the contribution of negatively and positively charged residues in S2, S3, and S4 to the final membrane topology of the voltage sensor in the K+ channel, KAT1.Q48836558
Influence of amino-terminal structures on kinetic transitions between several closed and open states in human erg K+ channels.Q48859485
Pathways of HERG inactivationQ48913019
Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytesQ48925493
The topogenic function of S4 promotes membrane insertion of the voltage-sensor domain in the KvAP channel.Q51148441
Transmembrane biogenesis of Kv1.3.Q73395015
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic HomeostasisQ29032115
Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gatingQ30474096
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore openingQ33595798
Integration of Shaker-type K+ channel, KAT1, into the endoplasmic reticulum membrane: synergistic insertion of voltage-sensing segments, S3-S4, and independent insertion of pore-forming segments, S5-P-S6Q33896527
HERG1 channelopathiesQ33915930
Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes.Q34017931
Ion conduction pore is conserved among potassium channelsQ34099241
Phylogeny of ion channels: clues to structure and functionQ34241477
Voltage-gated proton channelsQ34353309
Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1.Q34434968
hERG potassium channels and cardiac arrhythmiaQ34504394
Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG.Q34555630
Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channelQ34998277
Merging functional studies with structures of inward-rectifier K+ channelsQ35584086
Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain.Q35854813
Gating currents associated with intramembrane charge displacement in HERG potassium channelsQ35918682
Coupling of voltage-sensors to the channel pore: a comparative viewQ36121859
Tetrameric assembly of KvLm K+ channels with defined numbers of voltage sensorsQ36342608
Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channelsQ36436152
Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channelsQ36442897
The voltage-sensing domain of a phosphatase gates the pore of a potassium channelQ36636625
Fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamicsQ36742189
Sensing voltage across lipid membranesQ37069037
How membrane proteins sense voltageQ37114573
S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channelQ37338024
Evolution of the human ion channel set.Q37370161
Conduits of life's spark: a perspective on ion channel research since the birth of neuronQ37401733
Architecture and gating of Hv1 proton channelsQ37633286
Cytoplasmic domains and voltage-dependent potassium channel gating.Q37999317
Voltage-dependent gating of HERG potassium channelsQ38010173
Mechanism of electromechanical coupling in voltage-gated potassium channelsQ38044382
hERG K(+) channels: structure, function, and clinical significanceQ38044402
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues.Q38101202
The roles of K(+) channels in cancerQ38171243
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P304page(s)1069-1085
P577publication date2018-03-23
P1433published inPfluegers ArchivQ1091689
P1476titleFunctional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain
P478volume470

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cites work (P2860)
Q61797851New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question
Q57811395Relative positioning of Kv11.1 (hERG) K channel cytoplasmic domain-located fluorescent tags toward the plasma membrane
Q94464114The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating