Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel

scientific article

Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0896-6273(01)00487-1
P698PubMed publication ID11719205

P2093author name stringG Yellen
D del Camino
P2860cites workThe Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Potassium channel receptor site for the inactivation gate and quaternary amine inhibitorsQ27632398
Biophysical and molecular mechanisms of Shaker potassium channel inactivationQ29617879
Silver as a probe of pore-forming residues in a potassium channelQ30193514
Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopyQ30472195
The moving parts of voltage-gated ion channelsQ33671684
The barium site in a potassium channel by x-ray crystallographyQ33891602
Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gatingQ33916837
Potassium blocks barium permeation through a calcium-activated potassium channelQ34170721
The internal quaternary ammonium receptor site of Shaker potassium channelsQ34362419
Multi-ion occupancy alters gating in high-conductance, Ca(2+)-activated K+ channelsQ36410821
Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating.Q36411850
Time course of TEA(+)-induced anomalous rectification in squid giant axonsQ36427295
N-type inactivation and the S4-S5 region of the Shaker K+ channelQ36435725
Anomalous effect of permeant ion concentration on peak open probability of cardiac Na+ channelsQ36435845
Intermediate conductances during deactivation of heteromultimeric Shaker potassium channelsQ36436105
Selectivity changes during activation of mutant Shaker potassium channelsQ36445050
Voltage gating of ion channelsQ40391780
The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridgeQ41003350
Ion effects on gating of the Ca(2+)-activated K+ channel correlate with occupancy of the poreQ41108691
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant AxonsQ41761074
Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channelsQ42653386
The inner quaternary ammonium ion receptor in potassium channels of the node of RanvierQ42958073
Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversityQ46403606
Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.Q52448076
Immobilisation of gating charge by a substance that simulates inactivation.Q52705734
Ionic pores, gates, and gating currents.Q52724151
K+ channels close more slowly in the presence of external K+ and Rb+Q59079933
Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonatesQ72520684
Voltage clamp experiments on internally perfused giant axonsQ72695318
Blocker protection in the pore of a voltage-gated K+ channel and its structural implicationsQ73412357
Gated access to the pore of a voltage-dependent K+ channelQ73564876
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectvoltageQ25428
P304page(s)649-656
P577publication date2001-11-01
P1433published inNeuronQ3338676
P1476titleTight steric closure at the intracellular activation gate of a voltage-gated K(+) channel
P478volume32

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cites work (P2860)
Q39995529A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.
Q34188472A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation
Q37730860A slick, slack pathway through the pore
Q36295688Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate
Q42621571Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence
Q42035760Allosteric coupling of the inner activation gate to the outer pore of a potassium channel
Q44575118Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate
Q40086058An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker.
Q36610027An external sodium ion binding site controls allosteric gating in TRPV1 channels
Q44243367Aqueous access channels in subunit a of rotary ATP synthase
Q37474795BK channel opening involves side-chain reorientation of multiple deep-pore residues
Q42192885Base of pore loop is important for rectification, activation, permeation, and block of Kir3.1/Kir3.4.
Q38044898Being flexible: the voltage-controllable activation gate of kv channels.
Q35549225Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications
Q35044650Channel gating of NMDA receptors
Q42009472Characterization of five RNA editing sites in Shab potassium channels
Q35145307Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating
Q37040647Closed state-coupled C-type inactivation in BK channels
Q42047997Closed-channel block of BK potassium channels by bbTBA requires partial activation.
Q34185246Concerted gating mechanism underlying KATP channel inhibition by ATP.
Q42078363Conformational changes of pore helix coupled to gating of TRPV5 by protons
Q42775177Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
Q36436648Constitutive activation of the Shaker Kv channel
Q34925195Coupled movements in voltage-gated ion channels
Q36070158Coupling between the voltage-sensing and pore domains in a voltage-gated potassium channel.
Q36436552Coupling between voltage sensors and activation gate in voltage-gated K+ channels
Q42183400Coupling of S4 helix translocation and S6 gating analyzed by molecular-dynamics simulations of mutated Kv channels
Q36412572Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels
Q36121859Coupling of voltage-sensors to the channel pore: a comparative view
Q36295859Cross talk between activation and slow inactivation gates of Shaker potassium channels
Q36558180Cysteine mutagenesis and computer modeling of the S6 region of an intermediate conductance IKCa channel
Q35123192Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.
Q37999317Cytoplasmic domains and voltage-dependent potassium channel gating.
Q48830418Defining the Conductance of the Closed State in a Voltage-Gated K+ Channel
Q36295873Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction
Q30484864Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity.
Q44557623Different gating mechanisms in glutamate receptor and K+ channels.
Q33755245Differential effect of L-cysteine in isolated whole-bladder preparations from neonatal and adult rats
Q35240329Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel
Q27675968Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel
Q34180133Effect of S6 tail mutations on charge movement in Shaker potassium channels
Q40293341Effects of Kv1.2 intracellular regions on activation of Kv2.1 channels.
Q34632406Elucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels
Q90711493Epilepsy-associated mutations in the voltage sensor of KCNQ3 affect voltage dependence of channel opening
Q36296111Evidence for a deep pore activation gate in small conductance Ca2+-activated K+ channels
Q44527174Evidence for intersubunit interactions between S4 and S5 transmembrane segments of the Shaker potassium channel
Q37646643Evolutionarily conserved intracellular gate of voltage-dependent sodium channels.
Q36436477Extracellular sodium interacts with the HERG channel at an outer pore site
Q36493546Functional architecture of the inner pore of a voltage-gated Ca2+ channel
Q36299689Gating and inward rectifying properties of the MthK K+ channel with and without the gating ring
Q36491086Gating at the selectivity filter in cyclic nucleotide-gated channels
Q40659405Gating dependence of inner pore access in inward rectifier K(+) channels
Q35569293Gating mechanism of KATP channels: function fits form
Q92859901Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis
Q44588580Gating of shaker-type channels requires the flexibility of S6 caused by prolines
Q37069023Gating the pore of P2X receptor channels
Q28290774Glutamate receptor ion channels: structure, regulation, and function
Q42961365How S4 segments move charge. Let me count the ways
Q24644565Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues
Q28817852Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers
Q24644498Influence of permeant ions on voltage sensor function in the Kv2.1 potassium channel
Q34309921Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+.
Q36140665Initial steps in the opening of a Shaker potassium channel
Q33983069Inositol trisphosphate receptor Ca2+ release channels.
Q90746743Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels
Q44671454Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels
Q27674791Interactions of Cations with the Cytoplasmic Pores of Inward Rectifier K+ Channels in the Closed State
Q34315701Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
Q36493535Investigating the putative glycine hinge in Shaker potassium channel.
Q34311621Ion channel associated diseases: overview of molecular mechanisms
Q38247898Ion channel engineering: perspectives and strategies
Q30539929K channel gating by an affinity-switching selectivity filter
Q36493498K channel subconductance levels result from heteromeric pore conformations
Q43240829Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
Q36438058Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization
Q28654247K⁺ channel gating: C-type inactivation is enhanced by calcium or lanthanum outside
Q59084719Life's transistors
Q36436660Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the pore
Q27681473Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.
Q37023303Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel.
Q42603548Localization of PIP2 activation gate in inward rectifier K+ channels
Q40713986Localization of the activation gate for small conductance Ca2+-activated K+ channels.
Q36493538Localization of the activation gate of a voltage-gated Ca2+ channel
Q48823550Mechanisms of the inhibition of Shaker potassium channels by protons
Q35584086Merging functional studies with structures of inward-rectifier K+ channels
Q37039299Modification of K+ channel-drug interactions by ancillary subunits.
Q42686706Modulation of MthK potassium channel activity at the intracellular entrance to the pore.
Q36445000Molecular Coupling between Voltage Sensor and Pore Opening in the Arabidopsis Inward Rectifier K+ Channel KAT1
Q34800154Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels
Q30482832Molecular dynamics simulation of Kv channel voltage sensor helix in a lipid membrane with applied electric field
Q36353448Molecular mechanism for depolarization-induced modulation of Kv channel closure
Q36436615Movements near the gate of a hyperpolarization-activated cation channel
Q33922826Multi-scale electrophysiology modeling: from atom to organ
Q61797851New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question
Q51129304Nitric oxide activates TRP channels by cysteine S-nitrosylation.
Q40157311On the mechanism of TBA block of the TRPV1 channel.
Q47427190Opening the gate in potassium channels
Q36568507Opening the shaker K+ channel with hanatoxin
Q36380573Patch fluorometry: shedding new light on ion channels
Q36446389Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels
Q36539721Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel
Q42152315Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel
Q37385262Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome
Q34313783Pore-opening mechanism in trimeric P2X receptor channels
Q34368444Position and motions of the S4 helix during opening of the Shaker potassium channel
Q34446397Potassium channel mechanics
Q35589981Potassium channels
Q38151974Potassium channels: structures, diseases, and modulators
Q34985100Potassium channels: structures, models, simulations.
Q24600608Principles of conduction and hydrophobic gating in K+ channels
Q39704220Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation
Q36299751Probing the cavity of the slow inactivated conformation of shaker potassium channels
Q33634079Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.
Q34196066Redox-sensitive extracellular gates formed by auxiliary β subunits of calcium-activated potassium channels
Q43233633Regulatory role of the extreme C-terminal end of the S6 inner helix in C-terminal-truncated Kv1.2 channel activation
Q36295815Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.
Q34546935Role of conserved glycines in pH gating of Kir1.1 (ROMK)
Q42634179Role of the S6 C-terminus in KCNQ1 channel gating
Q42152089STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
Q40115311Saturation and microsecond gating of current indicate depletion-induced instability of the MaxiK selectivity filter
Q36445276Scanning the intracellular S6 activation gate in the shaker K+ channel
Q36412653Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels
Q35789217Selectivity filter gating in large-conductance Ca(2+)-activated K+ channels
Q56529660Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs
Q36837526Spatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway
Q40092801Stability of the Shab K+ channel conductance in 0 K+ solutions: the role of the membrane potential
Q36445416Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal.
Q36295841State-dependent block of BK channels by synthesized shaker ball peptides
Q35629078Status of the intracellular gate in the activated-not-open state of shaker K+ channels
Q27318375Structural Refinement of Proteins by Restrained Molecular Dynamics Simulations with Non-interacting Molecular Fragments
Q100395410Structural basis for pH gating of the two-pore domain K+ channel TASK2
Q35503245Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7).
Q45949168Structural determinants of gating in the TRPV1 channel.
Q42861247Structural determinants of the closed KCa3.1 channel pore in relation to channel gating: results from a substituted cysteine accessibility analysis
Q42595144Structural determinants of the regulation of the voltage-gated potassium channel Kv2.1 by the modulatory α-subunit Kv9.3.
Q36493622Structure and anticipatory movements of the S6 gate in Kv channels
Q38039087TRP channels: sensors and transducers of gasotransmitter signals.
Q38222944TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters).
Q36558208Tail end of the s6 segment: role in permeation in shaker potassium channels
Q42686974The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment
Q94464114The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating
Q33362306The Kv channel blocker 4-aminopyridine enhances Ag+ uptake: a scanning electrochemical microscopy study of single living cells
Q41558471The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure
Q57463886The S6 gate in regulatory Kv6 subunits restricts heteromeric K channel stoichiometry
Q44606572The Selectivity Filter May Act as the Agonist-activated Gate in the G Protein-activated Kir3.1/Kir3.4 K+ Channel
Q61135723The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
Q34277792The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.
Q26771787The hitchhiker's guide to the voltage-gated sodium channel galaxy
Q83226302The ion selectivity filter is not an activation gate in TRPV1-3 channels
Q34227906The ligand-sensitive gate of a potassium channel lies close to the selectivity filter
Q42677283The open pore conformation of potassium channels
Q34181912The pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels
Q34925261The search is on for the voltage sensor-to-gate coupling
Q35217946The viral potassium channel Kcv: structural and functional features.
Q22337264The voltage-gated potassium channels and their relatives
Q47449784Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.
Q35954286Towards a structural view of gating in potassium channels
Q28188178Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily
Q35808791Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel
Q42348251Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hK(v)1.3 channels
Q38824309Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating
Q36445268Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel
Q33537959Voltage-dependent gating in a "voltage sensor-less" ion channel
Q38010173Voltage-dependent gating of HERG potassium channels
Q35161667Voltage-gated K channels
Q48386968Voltage-gated K+ channel from mammalian brain: 3D structure at 18A of the complete (alpha)4(beta)4 complex
Q42736179Where's the gate? Gating in the deep pore of the BK(Ca) channel
Q36946670hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

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