Mutations in the K+ channel signature sequence

scientific article

Mutations in the K+ channel signature sequence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-3495(94)80887-2
P932PMC publication ID1275813
P698PubMed publication ID8038378

P2093author name stringZ Lu
R MacKinnon
L Heginbotham
T Abramson
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
The effect of sodium ions on the electrical activity of the giant axon of the squidQ22337078
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANESQ22337178
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Potassium channels in myelinated nerve. Selective permeability to small cationsQ24649988
Negative Conductance Caused by Entry of Sodium and Cesium Ions into the Potassium Channels of Squid AxonsQ24655934
Crystal structure of human rhinovirus serotype 1A (HRV1A)Q27697277
Refined structure of baboon alpha-lactalbumin at 1.7 A resolution. Comparison with C-type lysozymeQ27728169
Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sitesQ27731968
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860608
A mechanism for ion selectivity in potassium channels: computational studies of cation-pi interactionsQ28262739
Cloning and expression of an inwardly rectifying ATP-regulated potassium channelQ28297778
Primary structure and functional expression of a mouse inward rectifier potassium channelQ28297815
mSlo , a Complex Mouse Gene Encoding "Maxi" Calcium-Activated Potassium ChannelsQ28298176
Sequence of a probable potassium channel component encoded at Shaker locus of DrosophilaQ28305707
Biophysical and molecular mechanisms of Shaker potassium channel inactivationQ29617879
Novel voltage clamp to record small, fast currents from ion channels expressed in Xenopus oocytesQ30982526
Cloning and expression in yeast of a plant potassium ion transport systemQ33214391
The internal quaternary ammonium receptor site of Shaker potassium channelsQ34362419
Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channelQ34396702
Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural featuresQ34420127
A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloningQ34542084
Shaker encodes a family of putative potassium channel proteins in the nervous system of DrosophilaQ35980609
Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systemsQ36063294
Extracellular K+ specifically modulates a rat brain K+ channelQ36903743
mShal, a subfamily of A-type K+ channel cloned from mammalian brainQ37513834
Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiaeQ37599088
Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammoniumQ38330119
Inactivation of the sodium channel. I. Sodium current experimentsQ41897655
The S4-S5 loop contributes to the ion-selective pore of potassium channelsQ42617317
Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitorQ43473554
Alteration of ionic selectivity of a K+ channel by mutation of the H5 regionQ44911109
Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitorQ45412468
Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channelsQ46048873
Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA.Q46129103
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channelQ46398883
Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversityQ46403606
Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the poreQ46528714
A family of putative potassium channel genes in DrosophilaQ47071432
A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo LocusQ48215777
A distinct potassium channel polypeptide encoded by the Drosophila eag locusQ48222242
K+ current diversity is produced by an extended gene family conserved in Drosophila and mouseQ48267286
Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAsQ48280580
Exchange of conduction pathways between two related K+ channelsQ48793795
Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMPQ49132957
A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K + ChannelsQ49161635
Differences between the deep pores of K+ channels determined by an interacting pair of nonpolar amino acids.Q50794153
Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.Q50800057
The aromatic binding site for tetraethylammonium ion on potassium channelsQ52443507
Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.Q52448076
Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channelsQ68568921
P433issue4
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)1061-1067
P577publication date1994-04-01
P1433published inBiophysical JournalQ2032955
P1476titleMutations in the K+ channel signature sequence
P478volume66

Reverse relations

cites work (P2860)
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Q41032353Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
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Q35076166Muscle KATPChannels: Recent Insights to Energy Sensing and Myoprotection
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Q42641592Mutations in the pore region modify epithelial sodium channel gating by shear stress
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Q35089876Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.
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Q24670197Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function
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Q21129330Optogenetic techniques for the study of native potassium channels
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Q33515020P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels
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Q37794032Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia.
Q48045058Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias
Q36435912Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions
Q47273881Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.
Q36444949Permeation of large tetra-alkylammonium cations through mutant and wild-type voltage-gated sodium channels as revealed by relief of block at high voltage
Q36444965Permeation properties of inward-rectifier potassium channels and their molecular determinants
Q36446427Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.
Q36349233Photochemical tools for remote control of ion channels in excitable cells
Q34299770Phycodnavirus potassium ion channel proteins question the virus molecular piracy hypothesis
Q28821199Physical basis of apparent pore dilation of ATP-activated P2X receptor channels
Q40222794Physical origin of selectivity in ionic channels of biological membranes
Q48825259Plants do it differently. A new basis for potassium/sodium selectivity in the pore of an ion channel
Q42405926Poly[potassium-μ-2-[2-(carboxymethyl)phenyl]acetato].
Q34039970Polyamines as gating molecules of inward-rectifier K+ channels
Q40689276Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels.
Q36779531Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating
Q73713249Pore mutations affecting tetrameric assembly and functioning of the potassium channel KcsA from Streptomyces lividans
Q53955318Pore mutations alter closing and opening kinetics in Shaker K+ channels.
Q41189128Pore size matters for potassium channel conductance
Q36412407Pore structure influences gating properties of the T-type Ca2+ channel alpha1G
Q40214882Pore topology of the hyperpolarization-activated cyclic nucleotide-gated channel from sea urchin sperm
Q41077516Pore-forming segments in voltage-gated chloride channels
Q92832010Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Q34446397Potassium channel mechanics
Q92129305Potassium channel selectivity filter dynamics revealed by single-molecule FRET
Q41533301Potassium channelopathies
Q35589981Potassium channels
Q34117953Potassium channels: from scorpion venoms to high-resolution structure
Q38151974Potassium channels: structures, diseases, and modulators
Q34985100Potassium channels: structures, models, simulations.
Q46200817Potassium excretion through ROMK potassium channel expressed in gill mitochondrion-rich cells of Mozambique tilapia
Q28205333Potassium leak channels and the KCNK family of two-P-domain subunits
Q36427215Potassium-dependent changes in the conformation of the Kv2.1 potassium channel pore
Q42388582Preferential binding of K+ ions in the selectivity filter at equilibrium explains high selectivity of K+ channels.
Q47969407Premonitions of ion channel gating
Q32063793Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.
Q36493494Probing the geometry of the inner vestibule of BK channels with sugars
Q47618754Prokaryotes offer hope for potassium channel structural studies
Q24314905Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
Q27674335Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation
Q36436101Protein rearrangements underlying slow inactivation of the Shaker K+ channel
Q30176222Protein-water-ion interactions in a model of the pore domain of a potassium channel: a simulation study.
Q48231145Quantum decoherence time scales for ionic superposition states in ion channels
Q36653928RETRACTED: Voltage sensor ring in a native structure of a membrane-embedded potassium channel
Q34276666Recent progress on the structure and function of the TrkH/KtrB ion channel
Q73133104Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel
Q41149815Regions responsible for the assembly of inwardly rectifying potassium channels
Q36436751Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect
Q36436741Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.
Q42369746Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells
Q34173641Replacement of glycine 232 by aspartic acid in the KdpA subunit broadens the ion specificity of the K(+)-translocating KdpFABC complex
Q39727450Residues contributing to the Na(+)-binding pocket of the SLC24 Na(+)/Ca(2+)-K(+) Exchanger NCKX2.
Q48908122Residues in a jellyfish shaker-like channel involved in modulation by external potassium
Q41999464Secondary structure analysis of the putative membrane-associated domains of the inward rectifier K+ channel ROMK1.
Q28476317Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block
Q36445050Selectivity changes during activation of mutant Shaker potassium channels
Q44066926Separable gating mechanisms in a Mammalian pacemaker channel.
Q33837597Separation of heteromeric potassium channel Kcv towards probing subunit composition-regulated ion permeation and gating
Q34181050Sequence-Function Analysis of the K+-Selective Family of Ion Channels Using a Comprehensive Alignment and the KcsA Channel Structure
Q48886250Side chain orientation in the selectivity filter of a voltage-gated Ca2+ channel.
Q56879928Site-Specific Evolutionary Rate Inference: Taking Phylogenetic Uncertainty into Account
Q40734306Site-directed glycosylation tagging of functional Kir2.1 reveals that the putative pore-forming segment is extracellular
Q28609289Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes
Q34350663Slow inactivation in voltage gated potassium channels is insensitive to the binding of pore occluding peptide toxins.
Q24678202Small conductance Ca2+-activated K+ channels and calmodulin
Q37681148Small potassium ion channel proteins encoded by chlorella viruses
Q37317653Sodium and potassium competition in potassium-selective and non-selective channels.
Q37727054Sodium channel selectivity and conduction: prokaryotes have devised their own molecular strategy.
Q41809769Sodium permeability of a cloned small-conductance calcium-activated potassium channel.
Q73849517Solution structure of micelle-bound H5 peptide (427-452): a primary structure corresponding to the pore forming region of the voltage dependent potassium channel
Q27655598Solution structure of the Mesorhizobium loti K1 channel cyclic nucleotide-binding domain in complex with cAMP
Q52546897Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.
Q37713628Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia
Q90632366Spectrum of KV 2.1 Dysfunction in KCNB1-Associated Neurodevelopmental Disorders
Q40092801Stability of the Shab K+ channel conductance in 0 K+ solutions: the role of the membrane potential
Q35999251Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel
Q48900428Stable cation coordination at a single outer pore residue defines permeation properties in Kir channels.
Q30328260Steered molecular dynamics investigations of protein function.
Q37315224Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
Q36897702Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel
Q27640256Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution
Q40392903Structural basis of ion channel permeation and selectivity
Q50717057Structural compatibility between the putative voltage sensor of voltage-gated K+ channels and the prokaryotic KcsA channel.
Q30407608Structural correlates of selectivity and inactivation in potassium channels
Q30471867Structural dynamics of the Streptomyces lividans K+ channel (SKC1): secondary structure characterization from FTIR spectroscopy
Q34171001Structural models of the KtrB, TrkH, and Trk1,2 symporters based on the structure of the KcsA K(+) channel
Q36412306Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis
Q34865545Structural studies of ion selectivity in tetrameric cation channels
Q92460141Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion-bound configuration
Q24314854TASK, a human background K+ channel to sense external pH variations near physiological pH
Q28374393TASK-3, a new member of the tandem pore K(+) channel family
Q24338758TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function
Q28571535TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family
Q30587013TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour
Q24306072TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia
Q24323355TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure
Q36558208Tail end of the s6 segment: role in permeation in shaker potassium channels
Q33677681TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes.
Q30496547The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos.
Q42642296The K+ channel signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivity
Q37234238The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating
Q33891602The barium site in a potassium channel by x-ray crystallography
Q28262167The conduction pore of a cardiac potassium channel
Q33964025The conserved potassium channel filter can have distinct ion binding profiles: structural analysis of rubidium, cesium, and barium binding in NaK2K
Q33213684The influence of aromatic residues in hydraphile spacer units: assay by ion selective electrode methods and in bacteria
Q36420126The interaction of Na+ and K+ in voltage-gated potassium channels. Evidence for cation binding sites of different affinity
Q24320034The inward rectification mechanism of the HERG cardiac potassium channel
Q41412979The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture.
Q27627230The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel
Q42157232The pore helix dipole has a minor role in inward rectifier channel function
Q30176466The pore-lining region of shaker voltage-gated potassium channels: comparison of beta-barrel and alpha-helix bundle models
Q34638080The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels
Q47786530The selectivity filter of a potassium channel, murine kir2.1, investigated using scanning cysteine mutagenesis
Q36802307The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: contributions of the pore domains.
Q46765963The signature sequence of voltage-gated potassium channels projects into the external vestibule
Q28579343The structure and function of glutamate receptor ion channels
Q36025437The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution
Q35217946The viral potassium channel Kcv: structural and functional features.
Q48093958The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels
Q37315506The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells
Q48718154They said it couldn't be done...
Q48820160Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels
Q36098638Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms
Q30658648Transmembrane structure of an inwardly rectifying potassium channel
Q24597879Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites
Q36436227Tuning the voltage dependence of tetraethylammonium block with permeant ions in an inward-rectifier K+ channel
Q28474961Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels
Q34991751Two-pore domain K+ channels-molecular sensors
Q35641306Ultrafast inactivation causes inward rectification in a voltage-gated K(+) channel from Caenorhabditis elegans
Q36411763Unidirectional K+ fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes
Q41639645Viruses infecting marine picoplancton encode functional potassium ion channels
Q35595356Visualizing KcsA conformational changes upon ion binding by infrared spectroscopy and atomistic modeling
Q41081700Voltage gating by molecular subunits of Na+ and K+ ion channels: higher-dimensional cubic kinetics, rate constants, and temperature
Q38824309Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating
Q41737177Voltage-gated ion channels and electrical excitability
Q33665556Voltage-gated potassium channels: from hyperexcitability to excitement
Q36420553Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels
Q35834790alpha-helical structural elements within the voltage-sensing domains of a K(+) channel
Q47682481cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation.
Q24309507hSK4, a member of a novel subfamily of calcium-activated potassium channels
Q44610934sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.