Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants

scientific article published on April 2003

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-3495(03)75040-1
P932PMC publication ID1302801
P698PubMed publication ID12668443

P2093author name stringMark S P Sansom
Frances M Ashcroft
Peter Proks
Charlotte E Capener
P2860cites workThe Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolutionQ22337277
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A family of putative Kir potassium channels in prokaryotesQ24798078
Structure of a glycerol-conducting channel and the basis for its selectivityQ27627520
Energetic optimization of ion conduction rate by the K+ selectivity filterQ27635927
Structural basis of water-specific transport through the AQP1 water channelQ27637193
Control of the selectivity of the aquaporin water channel family by global orientational tuningQ27638881
Crystal structure and mechanism of a calcium-gated potassium channelQ27639064
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Raster3D: photorealistic molecular graphicsQ27860557
Comparative protein modelling by satisfaction of spatial restraintsQ27860866
Stereochemical quality of protein structure coordinatesQ27860874
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channelQ28360309
HOLE: a program for the analysis of the pore dimensions of ion channel structural modelsQ29619250
Transmembrane structure of an inwardly rectifying potassium channelQ30658648
Ion permeation mechanism of the potassium channelQ30864083
The preference of tryptophan for membrane interfaces.Q31997161
Inwardly rectifying potassium channels.Q33712453
Molecular determinants of KATP channel inhibition by ATP.Q33888944
The pore dimensions of gramicidin A.Q34020191
How proteins adapt to a membrane-water interfaceQ34023262
Potassium channel structure: domain by domainQ34029190
Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channelQ34093658
Ion conduction pore is conserved among potassium channelsQ34099241
Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF.Q34105092
Potassium channels: structures, models, simulations.Q34985100
Flexibility of the Kir6.2 inward rectifier K(+) channel poreQ35061235
The functions of tryptophan residues in membrane proteinsQ35415759
Permeation properties of inward-rectifier potassium channels and their molecular determinantsQ36444965
Climatic impact of tropical lowland deforestation on nearby montane cloud forestsQ39163848
Electrostatics and the ion selectivity of ligand-gated channelsQ40127813
An alamethicin channel in a lipid bilayer: molecular dynamics simulationsQ40140076
Simulations of ion permeation through a potassium channel: molecular dynamics of KcsA in a phospholipid bilayerQ40157344
Molecular dynamics of the KcsA K(+) channel in a bilayer membraneQ40164648
K(+) versus Na(+) ions in a K channel selectivity filter: a simulation studyQ40211009
Adhesion forces of lipids in a phospholipid membrane studied by molecular dynamics simulationsQ40225194
Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperatureQ41775672
The open pore conformation of potassium channelsQ42677283
Energetics of ion conduction through the K+ channelQ48620522
Water and potassium dynamics inside the KcsA K(+) channelQ48625241
Architecture of a K+ channel inner pore revealed by stoichiometric covalent modificationQ48921102
Rubidium and sodium permeability of the ATP-sensitive K+ channel in single rat pancreatic beta-cells.Q52544591
Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systemsQ56750591
Molecular dynamics with coupling to an external bathQ57569060
Electrostatics and diffusion of molecules in solution: simulations with the University of Houston Brownian dynamics programQ61773837
Residues beyond the selectivity filter of the K+ channel kir2.1 regulate permeation and block by external Rb+ and Cs+Q74007784
P433issue4
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)2345-2356
P577publication date2003-04-01
P1433published inBiophysical JournalQ2032955
P1476titleFilter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants
P478volume84

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cites work (P2860)
Q44627977A prokaryotic glutamate receptor: homology modelling and molecular dynamics simulations of GluR0.
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Q40287714Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.
Q40949543Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
Q35716412Identification of the Conformational transition pathway in PIP2 Opening Kir Channels
Q39845752Intrinsic Free Energy of the Conformational Transition of the KcsA Signature Peptide from Conducting to Nonconducting State
Q34469912Ion conduction through the hERG potassium channel
Q79249047Ion permeation of pores in model membranes: selectivity, fluctuations and the role of surface charge
Q35121309K+ conduction in the selectivity filter of potassium channels is monitored by the charge distribution along their sequence
Q44629033KcsA closed and open: modelling and simulation studies
Q35590744Membrane protein simulations: ion channels and bacterial outer membrane proteins
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Q37331670Proton inhibition of unitary currents of vanilloid receptors
Q36436751Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect
Q40115311Saturation and microsecond gating of current indicate depletion-induced instability of the MaxiK selectivity filter
Q55651384Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K+ channel.
Q44606572The Selectivity Filter May Act as the Agonist-activated Gate in the G Protein-activated Kir3.1/Kir3.4 K+ Channel
Q36981780The selectivity of K+ ion channels: testing the hypotheses
Q39996636Tl+-induced micros gating of current indicates instability of the MaxiK selectivity filter as caused by ion/pore interaction
Q37986452Transferring knowledge towards understanding the pore stabilizing variations in K(+) channels: pore stability in K(+) channels

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