| scholarly article | Q13442814 |
| P50 | author | Alan Goldin | Q42884134 |
| Stephen G Waxman | Q91085251 | ||
| P2093 | author name string | William A Catterall | |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | sodium | Q658 |
| voltage | Q25428 | ||
| pharmacology | Q128406 | ||
| P304 | page(s) | 397-409 | |
| P577 | publication date | 2005-12-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Pharmacological Reviews | Q2085079 |
| P1476 | title | International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels | |
| P478 | volume | 57 |
| Q91981432 | A Missense Variant in SCN8A in Alpine Dachsbracke Dogs Affected by Spinocerebellar Ataxia |
| Q90315097 | A biophysically detailed computational model of urinary bladder small DRG neuron soma |
| Q84579017 | A distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts |
| Q37599922 | A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. |
| Q37359854 | A functional null mutation of SCN1B in a patient with Dravet syndrome |
| Q33533542 | A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data |
| Q89544532 | A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel |
| Q46696659 | A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating |
| Q86045082 | A new Nav1.7 mutation in an erythromelalgia patient |
| Q44081086 | A novel anticonvulsant modulates voltage-gated sodium channel inactivation and prevents kindling-induced seizures. |
| Q36011829 | A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain |
| Q48651379 | A slowly inactivating sodium current (INa2) in the plateau range in canine cardiac Purkinje single cells |
| Q48682947 | A thermoprotective role of the sodium channel β1 subunit is lost with the β1 (C121W) mutation |
| Q30480532 | A threshold equation for action potential initiation |
| Q33647219 | ATDB 2.0: A database integrated toxin-ion channel interaction data |
| Q39471005 | Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA. |
| Q36394989 | Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumour cells |
| Q43215610 | Actions of a hydrogen sulfide donor (NaHS) on transient sodium, persistent sodium, and voltage-gated calcium currents in neurons of the subfornical organ |
| Q41836715 | Actions of kurtoxin on tetrodotoxin-sensitive voltage-gated Na+ currents, NaV1.6, in murine vas deferens myocytes |
| Q41893711 | Actions of veratridine on tetrodotoxin-sensitive voltage-gated Na currents, Na1.6, in murine vas deferens myocytes |
| Q47885953 | Activation of the prelimbic medial prefrontal cortex induces anxiety-like behaviors via N-Methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in mice |
| Q30849610 | Activity and connectivity changes of central projection areas revealed by functional magnetic resonance imaging in NaV1.8-deficient mice upon cold signaling. |
| Q42752726 | Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons. |
| Q36628794 | Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells |
| Q89860164 | Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7. |
| Q28387164 | Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons |
| Q38040330 | Advances in Targeting Voltage‐Gated Sodium Channels with Small Molecules |
| Q37949254 | Advances in the Mode of Action of Pyrethroids |
| Q35236367 | Age- and sex-related characteristics of tonic GABA currents in the rat substantia nigra pars reticulata |
| Q33618577 | Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node |
| Q47797338 | Age-dependent expression of Nav1.9 channels in medial prefrontal cortex pyramidal neurons in rats. |
| Q53082766 | Allosteric modulation as a unifying mechanism for receptor function and regulation |
| Q48218329 | Altered synaptic transmission at olfactory and vomeronasal nerve terminals in mice lacking N-type calcium channel Cav2.2. |
| Q33892566 | Alternative Splicing of the Cardiac Sodium Channel Creates Multiple Variants of Mutant T1620K Channels |
| Q33796526 | Alternative splicing of Na(V)1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T. |
| Q35583086 | Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression |
| Q90183474 | Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model |
| Q91670966 | An Integrated Model of Minor Intron Emergence and Conservation |
| Q28278844 | An SCN9A channelopathy causes congenital inability to experience pain |
| Q47971059 | An increase in voltage-gated sodium channel current elicits microglial activation followed inflammatory responses in vitro and in vivo after spinal cord injury |
| Q27316868 | Anaesthetic tricaine acts preferentially on neural voltage-gated sodium channels and fails to block directly evoked muscle contraction |
| Q39587472 | Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. |
| Q47232892 | Ancient Origin of Four-Domain Voltage-gated Na+ Channels Predates the Divergence of Animals and Fungi |
| Q26777284 | Angiotensin II-superoxide-NFκB signaling and aortic baroreceptor dysfunction in chronic heart failure |
| Q36246739 | Animal toxins can alter the function of Nav1.8 and Nav1.9. |
| Q38204930 | Animal toxins influence voltage-gated sodium channel function. |
| Q48349727 | Antidepressants inhibit Nav1.3, Nav1.7, and Nav1.8 neuronal voltage-gated sodium channels more potently than Nav1.2 and Nav1.6 channels expressed in Xenopus oocytes. |
| Q47408714 | Antinociceptive Effects of Botulinum Toxin Type A on Trigeminal Neuropathic Pain |
| Q39076979 | Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression |
| Q54373490 | Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells |
| Q92379234 | Assessment of Spontaneous Neuronal Activity In Vitro Using Multi-Well Multi-Electrode Arrays: Implications for Assay Development |
| Q35788409 | Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata |
| Q41445901 | Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy. |
| Q37564322 | Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress |
| Q48312558 | Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5. |
| Q39017694 | Axonal Excitability in Amyotrophic Lateral Sclerosis : Axonal Excitability in ALS. |
| Q36657811 | Axonal conduction and injury in multiple sclerosis: the role of sodium channels |
| Q58734460 | Axonal sodium channel NaV1.2 drives granule cell dendritic GABA release and rapid odor discrimination |
| Q34778955 | Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart |
| Q43075742 | Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics. |
| Q52322522 | Beyond Sensation: Exploring the Molecular and Genetic Basis for Pain: An Interview with Stephen Waxman, MD, PhD. |
| Q35166946 | Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon |
| Q33581458 | Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells |
| Q35743263 | Binding Modes of μ-Conotoxin to the Bacterial Sodium Channel (NaVAb) |
| Q39652333 | Binding of diarrheic shellfish poisoning toxins to okadaic acid binding proteins purified from the sponge Halichondria okadai |
| Q60708089 | Biochemical and Functional Interplay Between Ion Channels and the Components of the Dystrophin-Associated Glycoprotein Complex |
| Q37936683 | Biology of cardiac sodium channel Nav1.5 expression |
| Q35995096 | Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex |
| Q37145025 | Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4 |
| Q46676588 | Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis |
| Q36110521 | Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. |
| Q30710079 | Blockage of the upregulation of voltage-gated sodium channel nav1.3 improves outcomes after experimental traumatic brain injury |
| Q36032974 | Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation |
| Q90639874 | Ca2+-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity |
| Q37280087 | Calreticulin negatively regulates the surface expression of Cav1.3 L-type calcium channel. |
| Q38272073 | Can the 'neuron theory' be complemented by a universal mechanism for generic neuronal differentiation |
| Q37520074 | Cardiac Sodium-Calcium Exchange and Efficient Excitation-Contraction Coupling: Implications for Heart Disease |
| Q47773798 | Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation |
| Q54441071 | Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy. |
| Q38475669 | Cav1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells. |
| Q37086520 | Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. |
| Q36659685 | Cell-autonomous axon growth of young motoneurons is triggered by a voltage-gated sodium channel |
| Q37474494 | Cerebellum-related characteristics of Scn8a-mutant mice |
| Q90225343 | Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7. |
| Q36771264 | Channel, neuronal and clinical function in sodium channelopathies: from genotype to phenotype |
| Q44053683 | Channel-noise-induced stochastic facilitation in an auditory brainstem neuron model. |
| Q39905077 | Characteristics for enhanced response of serotonin-evoked ion dynamics in differentiated NG108-15 cells |
| Q36707638 | Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening |
| Q37670013 | Characterization of a novel BmαTX47 toxin modulating sodium channels: the crucial role of expression vectors in toxin pharmacological activity |
| Q28828991 | Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides |
| Q46907212 | Characterization of the slowly inactivating sodium current INa2 in canine cardiac single Purkinje cells. |
| Q44398411 | Characterization of three “Birtoxin-like” toxins from the Androctonus amoreuxi scorpion venom |
| Q92989953 | Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1 |
| Q35212961 | Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lac |
| Q37705156 | Cholesterol and ion channels |
| Q91121458 | Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease |
| Q39873954 | Cloning and molecular characterization of a putative voltage-gated sodium channel gene in the crayfish. |
| Q45845930 | Cnidarian Toxins Acting on Voltage-Gated Ion Channels |
| Q54979414 | Co-expression of β Subunits with the Voltage-Gated Sodium Channel NaV1.7: the Importance of Subunit Association and Phosphorylation and Their Effects on Channel Pharmacology and Biophysics. |
| Q35144846 | Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+ Channel Voltage Sensors in Domains II and IV |
| Q37158502 | Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications |
| Q46838522 | Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges |
| Q26774171 | Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition |
| Q36432810 | Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? |
| Q36096681 | Conotoxins that confer therapeutic possibilities |
| Q39071018 | Consequences of acute Nav1.1 exposure to deltamethrin |
| Q48648767 | Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP-stimulated microglia |
| Q38991080 | Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves |
| Q30465622 | Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase |
| Q27003318 | Conus Venom Peptide Pharmacology |
| Q24609009 | Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin |
| Q36709224 | Co‐expression of NaVβ subunits alters the kinetics of inhibition of voltage‐gated sodium channels by pore‐blocking μ‐conotoxins |
| Q27655335 | Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels |
| Q24310927 | Crystallographic insights into sodium-channel modulation by the β4 subunit |
| Q38727831 | Current and Future Issues in the Development of Spinal Agents for the Management of Pain |
| Q35106142 | De novo assembly of a transcriptome for Calanus finmarchicus (Crustacea, Copepoda)--the dominant zooplankter of the North Atlantic Ocean |
| Q28118989 | De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy |
| Q42604265 | De novo synthesis of modified saxitoxins for sodium ion channel study |
| Q92092776 | Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential |
| Q36170194 | Dependence of the Excitability of Pituitary Cells on Cyclic Nucleotides |
| Q41228961 | Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation. |
| Q47693282 | Design of sodium channel ligands with defined selectivity - a case study in scorpion alpha-toxins. |
| Q55010535 | Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations. |
| Q34429921 | Development and function of the voltage-gated sodium current in immature mammalian cochlear inner hair cells. |
| Q36941125 | Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. |
| Q37385343 | Development of newer calcium channel antagonists: therapeutic potential of efonidipine in preventing electrical remodelling during atrial fibrillation |
| Q48261346 | Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells. |
| Q91813722 | Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane |
| Q48194900 | Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav 1.1 to Nav 1.7). |
| Q35792529 | Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity. |
| Q46306808 | Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes |
| Q41634934 | Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. |
| Q52715170 | Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts. |
| Q52718223 | Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cells |
| Q99567798 | Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia |
| Q48250984 | Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures. |
| Q46427631 | Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles |
| Q40089012 | Distribution of the voltage-gated sodium channel Na(v)1.7 in the rat: expression in the autonomic and endocrine systems. |
| Q90438743 | Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling |
| Q42939077 | Docking studies of phthalimide pharmacophore as a sodium channel blocker |
| Q90673950 | Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability |
| Q30372768 | Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. |
| Q54328278 | Dorsal root ganglia isolated from Nf1+/− mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels |
| Q34600288 | Dorsal root tetrodotoxin-resistant sodium channels do not contribute to the augmented exercise pressor reflex in rats with chronic femoral artery occlusion |
| Q48315134 | DrTx(1–42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs |
| Q38212437 | Dravet syndrome--from epileptic encephalopathy to channelopathy |
| Q37279209 | Dynamical characterization of inactivation path in voltage-gated Na(+) ion channel by non-equilibrium response spectroscopy |
| Q48069157 | Eduard Friedrich Wilhelm Pflüger and the Nobel Prize |
| Q36953269 | Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons |
| Q47914830 | Effect of verapamil and lidocaine on TRPM and NaV1.9 gene expressions in renal ischemia-reperfusion |
| Q48404454 | Effects in neocortical neurons of mutations of the Na(v)1.2 Na+ channel causing benign familial neonatal-infantile seizures. |
| Q49910948 | Effects of 4,9-anhydrotetrodotoxin on voltage-gated Na+ channels of mouse vas deferens myocytes and recombinant NaV1.6 channels |
| Q38684842 | Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels |
| Q64941808 | Effects of Lidocaine and Articaine on Neuronal Survival and Recovery. |
| Q37460882 | Effects of Na+ Current and Mechanogated Channels in Myofibroblasts on Myocyte Excitability and Repolarization |
| Q48256807 | Effects of sevoflurane on voltage-gated sodium channel Na(v)1.8, Na(v)1.7, and Na(v)1.4 expressed in Xenopus oocytes |
| Q33801118 | Effects of tetrodotoxin on the mammalian cardiovascular system |
| Q33929785 | Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes |
| Q24634301 | Electrogenic tuning of the axon initial segment |
| Q37769877 | Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease |
| Q36665599 | Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1-42. |
| Q38978484 | Emerging Targets for the Management of Osteoarthritis Pain |
| Q35840261 | Endogenously determined restriction of food intake overcomes excitation–contraction uncoupling in JP45KO mice with aging |
| Q37352705 | Engineering prokaryotic channels for control of mammalian tissue excitability |
| Q89892373 | Enhancement by TNF-α of TTX-resistant NaV current in muscle sensory neurons after femoral artery occlusion |
| Q40150359 | Enhancement of sodium current in NG108-15 cells during neural differentiation is mainly due to an increase in NaV1.7 expression |
| Q43666461 | Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. |
| Q50569040 | Epileptic activity is a surrogate for an underlying etiology and stopping the activity has a limited impact on developmental outcome |
| Q42249654 | Erythromelalgia mutation Q875E Stabilizes the activated state of sodium channel Nav1.7. |
| Q39081692 | Estimating the modulatory effects of nanoparticles on neuronal circuits using computational upscaling |
| Q33965177 | Estradiol attenuates multiple tetrodotoxin-sensitive sodium currents in isolated gonadotropin-releasing hormone neurons |
| Q37604152 | Estragole blocks neuronal excitability by direct inhibition of Na+ channels |
| Q59813540 | Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations |
| Q59192560 | Evaluation of toxicity equivalent factors of paralytic shellfish poisoning toxins in seven human sodium channels types by an automated high throughput electrophysiology system |
| Q52822505 | Evolutionary History of Voltage-Gated Sodium Channels |
| Q33300128 | Excitability constraints on voltage-gated sodium channels |
| Q30646640 | Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings |
| Q38754189 | Exploring the latest avenues for antiepileptic drug discovery and development |
| Q30363787 | Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics. |
| Q34562987 | Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway. |
| Q41901986 | Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn |
| Q36490817 | Expression of Voltage-Gated Sodium Channel Nav1.3 Is Associated with Severity of Traumatic Brain Injury in Adult Rats |
| Q42857299 | Expression of skeletal muscle Na(V)1.4 Na channel isoform in canine cardiac Purkinje myocytes. |
| Q47935042 | Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy |
| Q46133792 | Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction |
| Q37183321 | FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner. |
| Q28973611 | FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders |
| Q28575580 | Fibrillation potentials of denervated rat skeletal muscle are associated with expression of cardiac-type voltage-gated sodium channel isoform Nav1.5 |
| Q38032349 | Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias |
| Q42280999 | First detection of N1575Y mutation in pyrethroid resistant Anopheles gambiae in Southern Côte d'Ivoire |
| Q30542058 | Fluorescent saxitoxins for live cell imaging of single voltage-gated sodium ion channels beyond the optical diffraction limit |
| Q64080440 | Fritillariae Thunbergii Bulbus: Traditional Uses, Phytochemistry, Pharmacodynamics, Pharmacokinetics and Toxicity |
| Q91734245 | From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei |
| Q36126209 | Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. |
| Q26774664 | Functional implications of axon initial segment cytoskeletal disruption in stroke |
| Q39166783 | Functional modulation of voltage-dependent sodium channel expression by wild type and mutated C121W-β1 subunit. |
| Q34791973 | Functional properties and differential neuromodulation of Na(v)1.6 channels |
| Q90590562 | GPCR regulation of secretion |
| Q45771999 | Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy |
| Q51938135 | Gene duplications and evolution of vertebrate voltage-gated sodium channels |
| Q35201269 | Gene expression profile during functional maturation of a central mammalian synapse. |
| Q37428828 | Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice |
| Q38026870 | Genetic aspects of sodium channelopathy in small fiber neuropathy |
| Q37382551 | Genetics and molecular pathophysiology of Na(v)1.7-related pain syndromes |
| Q38243946 | Genotype phenotype associations across the voltage-gated sodium channel family |
| Q48588227 | Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes |
| Q28542818 | Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain |
| Q43235399 | Global gene expression analysis of rodent motor neurons following spinal cord injury associates molecular mechanisms with development of postinjury spasticity |
| Q90750515 | GpTx-1 and [Ala5 , Phe6 , Leu26 , Arg28 ]GpTx-1, two peptide NaV 1.7 inhibitors: analgesic and tolerance properties at the spinal level |
| Q43249870 | Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels |
| Q35609134 | Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons |
| Q35585817 | Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype |
| Q36987685 | Identification of Amino Acid Residues in Fibroblast Growth Factor 14 (FGF14) Required for Structure-Function Interactions with Voltage-gated Sodium Channel Nav1.6. |
| Q35072592 | Identification of Navβ1 residues involved in the modulation of the sodium channel Nav1.4. |
| Q99607301 | Identification of a SCN4A mutation in a large Chinese family with atypical normokalemic periodic paralysis using whole-exome sequencing |
| Q38668773 | Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons. |
| Q37960086 | Immunopharmacology: utilizing antibodies as ion channel modulators |
| Q33900820 | Impact of fast sodium channel inactivation on spike threshold dynamics and synaptic integration |
| Q40489715 | Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. |
| Q40275732 | Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. |
| Q37483401 | In vivo transfection of manganese superoxide dismutase gene or nuclear factor κB shRNA in nodose ganglia improves aortic baroreceptor function in heart failure rats |
| Q36674682 | Infrequent SCN9A mutations in congenital insensitivity to pain and erythromelalgia. |
| Q83841683 | Inhibition by morphine and its analogs of action potentials in adult rat dorsal root ganglion neurons |
| Q35275248 | Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide |
| Q36147308 | Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2. |
| Q45825169 | Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes |
| Q28587249 | Interaction of voltage-gated sodium channel Nav1.6 (SCN8A) with microtubule-associated protein Map1b |
| Q35642815 | Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7. |
| Q28535380 | Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity |
| Q37855929 | Ion Channel Blockers for the Treatment of Neuropathic Pain |
| Q26765808 | Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases |
| Q47269323 | Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies |
| Q57176937 | Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles |
| Q33780658 | Ion Channels of Pituitary Gonadotrophs and Their Roles in Signaling and Secretion |
| Q39959875 | Ion channel diversity, channel expression and function in the choroid plexuses |
| Q36003349 | Ion channels and signaling in the pituitary gland |
| Q54979515 | Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons. |
| Q33777055 | Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer? |
| Q37855927 | Isoform-Selective Voltage-Gated Na + Channel Modulators as Next-Generation Analgesics |
| Q37785310 | Isoform-specific and pan-channel partners regulate trafficking and plasma membrane stability; and alter sodium channel gating properties |
| Q30449041 | K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy |
| Q28581622 | KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8 |
| Q28509315 | LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain |
| Q94560886 | Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents |
| Q36980119 | Lidocaine: neurobiological targets and effects on the auditory system |
| Q30492681 | Localization and targeting of voltage-dependent ion channels in mammalian central neurons. |
| Q89820423 | Localized Axolemma Deformations Suggest Mechanoporation as Axonal Injury Trigger |
| Q30540365 | Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. |
| Q39062814 | Low pHo boosts burst firing and catecholamine release by blocking TASK-1 and BK channels while preserving Cav1 channels in mouse chromaffin cells |
| Q46884127 | Lysophosphatidic acid-LPA1 receptor-Rho-Rho kinase-induced up-regulation of Nav1.7 sodium channel mRNA and protein in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion |
| Q47124126 | Lysosomal Calcium in Neurodegeneration |
| Q27677218 | Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency |
| Q37798911 | Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels |
| Q36281738 | Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling |
| Q28550738 | Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues |
| Q35133771 | Mechanism of μ-conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4. |
| Q47230575 | Mechanisms of Drug Binding to Voltage-Gated Sodium Channels |
| Q26777940 | Mechanisms of sodium channel clustering and its influence on axonal impulse conduction |
| Q47955089 | Mechanisms underlying odorant-induced and spontaneous calcium signals in olfactory receptor neurons of spiny lobsters, Panulirus argus |
| Q48163788 | Membrane properties and electrogenesis in the distal axons of small dorsal root ganglion neurons in vitro |
| Q57490199 | Microglia in Alzheimer's Disease: A Role for Ion Channels |
| Q37096949 | Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants |
| Q38613252 | Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade. |
| Q38180649 | Models of calcium permeation through T-type channels |
| Q30430009 | Modular organization of α-toxins from scorpion venom mirrors domain structure of their targets, sodium channels. |
| Q38902592 | Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells |
| Q44921188 | Modulation of T-type Ca2+ channels by Lavender and Rosemary extracts. |
| Q37126278 | Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs |
| Q40031615 | Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells |
| Q34999159 | Modulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats |
| Q39567009 | Modulation of the FGF14:FGF14 homodimer interaction through short peptide fragments. |
| Q30460758 | Modulation of voltage-gated K+ channels by the sodium channel β1 subunit |
| Q48728455 | Modulation of voltage-gated sodium channels hyperpolarizes the voltage threshold for activation in spinal motoneurones |
| Q81421178 | Modulatory proteins can rescue a trafficking defective epileptogenic Nav1.1 Na+ channel mutant |
| Q93102861 | Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels |
| Q35602384 | Molecular and functional differences in voltage-activated sodium currents between GABA projection neurons and dopamine neurons in the substantia nigra |
| Q43427939 | Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels |
| Q33290470 | Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates |
| Q34621064 | Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide |
| Q39443518 | Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines. |
| Q84511911 | Molecular genetics of long QT syndrome |
| Q40163109 | Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation |
| Q36995199 | Molecular mechanisms of migraine? |
| Q35556000 | Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances |
| Q33963196 | Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. |
| Q24683346 | Molecular targets for antiepileptic drug development |
| Q36678533 | Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons |
| Q33770959 | Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain |
| Q37112043 | Mutant bacterial sodium channels as models for local anesthetic block of eukaryotic proteins |
| Q41636842 | Mutation E87Q of the β1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel |
| Q36487377 | Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade |
| Q34166489 | Mutational analysis of the analgesic peptide DrTx(1-42) revealing a functional role of the amino-terminal turn |
| Q34585790 | Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders |
| Q39012035 | Myotonic Dystrophy Type 2: An Update on Clinical Aspects, Genetic and Pathomolecular Mechanism |
| Q37072034 | Na(+) channel blockers for the treatment of pain: context is everything, almost |
| Q34585853 | Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons. |
| Q48090925 | Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system |
| Q27005721 | Na+ channel function, regulation, structure, trafficking and sequestration |
| Q37960093 | Na+ channelopathies and epilepsy: recent advances and new perspectives. |
| Q43052828 | Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression |
| Q42908846 | Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels. |
| Q38114737 | Na/Ca exchange and contraction of the heart. |
| Q34006486 | NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons |
| Q50788841 | NaV1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas |
| Q46301976 | NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders. |
| Q88919088 | NaV1.9 channels in muscle afferent neurons and axons |
| Q38560993 | NaV1.9: a sodium channel linked to human pain |
| Q35122879 | NaVβ Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier μO-Conotoxin MrVIB |
| Q28235994 | Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents |
| Q35003780 | Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons |
| Q82656688 | Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents |
| Q64105954 | Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain |
| Q39603773 | Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli. |
| Q48564518 | Nerve growth factor and ATP excite different neck muscle nociceptors in anaesthetized mice |
| Q38042001 | Neurological perspectives on voltage-gated sodium channels. |
| Q46560325 | Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels |
| Q39593951 | Neuropathic Nav1.3-Mediated Sensitization to P2X Activation is Regulated by Protein Kinase C |
| Q34232755 | Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels |
| Q38114817 | New and Developing Drugs for the Treatment of Neuropathic Pain in Diabetes |
| Q38098766 | New insights on arthropod toxins that potentiate erectile function |
| Q90193598 | Noncanonical Ion Channel Behaviour in Pain |
| Q37721674 | Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity. |
| Q37453604 | Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. |
| Q57646598 | Novel and de novo mutations in pediatric refractory epilepsy |
| Q42071580 | Novel derivatives of phthalimide with potent anticonvulsant activity in PTZ and MES seizure models. |
| Q92847004 | Nuclear Factor-kappaB Gates Nav1.7 Channels in DRG Neurons via Protein-Protein Interaction |
| Q26827489 | Obstructing Toxin Pathways by Targeted Pore Blockage |
| Q41701432 | Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation |
| Q35900668 | Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia |
| Q30381626 | Optimal Neutralization of Centruroides noxius Venom Is Understood through a Structural Complex between Two Antibody Fragments and the Cn2 Toxin. |
| Q35523730 | Optimization of propafenone analogues as antimalarial leads |
| Q42293071 | Organization and Plasticity of Sodium Channel Expression in the Mouse Olfactory and Vomeronasal Epithelia |
| Q30473859 | Ototrauma induces sodium channel plasticity in auditory afferent neurons |
| Q48258918 | Overexpression of NaV 1.6 channels is associated with the invasion capacity of human cervical cancer |
| Q39435580 | Overexpression of the VSSC‐associated CAM, beta‐2, enhances LNCaP cell metastasis associated behavior |
| Q34262020 | PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice. |
| Q37943756 | Pain Disorders and Erythromelalgia Caused by Voltage-Gated Sodium Channel Mutations |
| Q37944353 | Pain, analgesia and genetics |
| Q48343647 | Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology |
| Q38253772 | Painful neuropathies: the emerging role of sodium channelopathies |
| Q35647808 | Palmitoylation influences the function and pharmacology of sodium channels. |
| Q30409940 | Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the garter snake Thamnophis sirtalis |
| Q39965463 | Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation |
| Q38839506 | Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors |
| Q29396058 | Persistent Sodium Current and Its Role in Epilepsy |
| Q38025139 | Pharmacogenetics of pain and analgesia |
| Q92186364 | Pharmacological Profiling of Purified Human Stem Cell-Derived and Primary Mouse Motor Neurons |
| Q30835612 | Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a |
| Q36783993 | Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins |
| Q47718329 | Physical basis of specificity and delayed binding of a subtype selective sodium channel inhibitor |
| Q36905057 | Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action |
| Q36249467 | Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes |
| Q50086104 | Posttranslational Modification of Sodium Channels |
| Q48962346 | Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain |
| Q55262770 | Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats. |
| Q35432154 | Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development |
| Q26784432 | Primary erythromelalgia: a review |
| Q36782181 | Probing kinetic drug binding mechanism in voltage-gated sodium ion channel: open state versus inactive state blockers |
| Q27683885 | Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism |
| Q54430750 | Properties of cholinergic and non-cholinergic submucosal neurons along the mouse colon |
| Q37585424 | Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine |
| Q35238062 | Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons. |
| Q48518879 | Properties of wild-type and fluorescent protein-tagged mouse tetrodotoxin-resistant sodium channel (Na V 1.8) heterologously expressed in rat sympathetic neurons |
| Q33379312 | Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus |
| Q60919534 | Puerarin Relieves Paclitaxel-Induced Neuropathic Pain: The Role of Na1.8 β1 Subunit of Sensory Neurons |
| Q43152313 | Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons. |
| Q36918520 | Pumilio-2 Regulates Translation of Nav1.6 to Mediate Homeostasis of Membrane Excitability |
| Q57479263 | Purification and Characterization of JZTx-14, a Potent Antagonist of Mammalian and Prokaryotic Voltage-Gated Sodium Channels |
| Q36096504 | Quantal and nonquantal transmission in calyx-bearing fibers of the turtle posterior crista |
| Q39326229 | Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp |
| Q37946885 | Recent Developments Regarding Voltage-Gated Sodium Channel Blockers for the Treatment of Inherited and Acquired Neuropathic Pain Syndromes |
| Q64226623 | Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development? |
| Q34075908 | Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures |
| Q43823781 | Recombinant expression, purification, and characterization of scorpion toxin BmαTX14 |
| Q42996663 | Recovery of viscerosensory innervation from the dorsal root ganglia of the adult rat following capsaicin-induced injury. |
| Q47757391 | Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells. |
| Q34192179 | Reduced expression and activation of voltage‐gated sodium channels contributes to blunted baroreflex sensitivity in heart failure rats |
| Q34118114 | Region-specific changes in gene expression in rat brain after chronic treatment with levetiracetam or phenytoin |
| Q38111276 | Regulation of Ion Channels by Membrane Lipids |
| Q42318001 | Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains. |
| Q37995940 | Regulation of gene expression during early neuronal differentiation: evidence for patterns conserved across neuron populations and vertebrate classes |
| Q39896695 | Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A. |
| Q38184989 | Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation |
| Q35564862 | Regulatory role of voltage-gated Na+ channel β subunits in sensory neurons |
| Q37460683 | Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis |
| Q48130212 | Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1.6 voltage-gated sodium channels |
| Q36923476 | Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels |
| Q48726185 | Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis. |
| Q34284951 | Role of Na(v)1.9 in activity-dependent axon growth in motoneurons |
| Q92259842 | Role of the voltage sensor module in Nav domain IV on fast inactivation in sodium channelopathies: The implication of closed-state inactivation |
| Q36302123 | SCN4A pore mutation pathogenetically contributes to autosomal dominant essential tremor and may increase susceptibility to epilepsy |
| Q39027820 | SCN8A mutations in Chinese children with early onset epilepsy and intellectual disability |
| Q28066916 | Safety profile of lamotrigine in overdose |
| Q38207566 | Saxitoxin. |
| Q37286952 | Scn2a sodium channel mutation results in hyperexcitability in the hippocampus in vitro |
| Q49375959 | Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain |
| Q28084324 | Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects |
| Q48221607 | Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons |
| Q39960558 | Self-limited hyperexcitability: functional effect of a familial hemiplegic migraine mutation of the Nav1.1 (SCN1A) Na+ channel |
| Q36009629 | Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo |
| Q34637485 | Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures |
| Q46730862 | Sensory renal innervation: a kidney-specific firing activity due to a unique expression pattern of voltage-gated sodium channels? |
| Q35538490 | Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach |
| Q89022924 | Shared and unique aspects of ligand- and voltage-gated ion-channel gating |
| Q37424935 | Shellfish toxins targeting voltage-gated sodium channels |
| Q34310798 | Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels. |
| Q46743852 | Similar properties of transient, persistent, and resurgent Na currents in GABAergic and non-GABAergic vestibular nucleus neurons |
| Q41168552 | Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters |
| Q38815917 | Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves |
| Q47651394 | Sodium Channel β2 Subunits Prevent Action Potential Propagation Failures at Axonal Branch Points. |
| Q45346612 | Sodium channel Na(V)1.5 expression is enhanced in cultured adult rat skeletal muscle fibers |
| Q37318012 | Sodium channel Nav1.7 expression is upregulated in the dorsal root ganglia in a rat model of paclitaxel-induced peripheral neuropathy |
| Q46179678 | Sodium channel activity modulates multiple functions in microglia |
| Q37605350 | Sodium channel blockers for the treatment of neuropathic pain |
| Q30400941 | Sodium channel genes and their differential genotypes at the L-to-F kdr locus in the mosquito Culex quinquefasciatus |
| Q38568991 | Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis |
| Q28082122 | Sodium channel β subunits: emerging targets in channelopathies |
| Q42976628 | Sodium channel β2 subunit promotes filopodia-like processes and expansion of the dendritic tree in developing rat hippocampal neurons |
| Q37681340 | Sodium channelopathies and pain |
| Q48337085 | Sodium channels and pain: from toxins to therapies |
| Q38035905 | Sodium channels and the neurobiology of epilepsy |
| Q44467394 | Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury |
| Q38751614 | Sodium channels in astroglia and microglia |
| Q47959907 | Sodium channels in pain disorders: pathophysiology and prospects for treatment |
| Q37992862 | Sodium channels, the electrogenisome and the electrogenistat: lessons and questions from the clinic |
| Q37238345 | Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. |
| Q102211172 | Sperm ion channels and transporters in male fertility and infertility |
| Q92839087 | Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities |
| Q38269167 | Spider venomics: implications for drug discovery. |
| Q38227133 | Split-luciferase complementary assay: applications, recent developments, and future perspectives |
| Q36753783 | Spontaneous and CRH-Induced Excitability and Calcium Signaling in Mice Corticotrophs Involves Sodium, Calcium, and Cation-Conducting Channels |
| Q34002540 | State-Dependent Modification of Voltage-Gated Sodium Channels by Pyrethroids |
| Q48274837 | State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. |
| Q101038915 | Status of peripheral sodium channel blockers for non-addictive pain treatment |
| Q28082803 | Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels |
| Q92989648 | Structural and Functional Analyses of Cone Snail Toxins |
| Q47771569 | Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective |
| Q64272514 | Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel |
| Q59065909 | Structural basis for gating pore current in periodic paralysis |
| Q27703155 | Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist |
| Q24644825 | Structural determinants of drugs acting on the Nav1.8 channel |
| Q37790486 | Structural trends among second-generation voltage-gated sodium channel blockers |
| Q28279905 | Structure and function of splice variants of the cardiac voltage-gated sodium channel Na(v)1.5 |
| Q33729032 | Structure-based assessment of disease-related mutations in human voltage-gated sodium channels |
| Q42882797 | Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives |
| Q37618893 | Subtype-selective targeting of voltage-gated sodium channels |
| Q53176588 | Subtype‐dependent postnatal development of taste receptor cells in mouse fungiform taste buds |
| Q47619990 | Suppression of neuronal excitability by the secretion of the lamprey (Lampetra japonica) provides a mechanism for its evolutionary stability. |
| Q37322293 | Supramolecular assemblies and localized regulation of voltage-gated ion channels. |
| Q38739374 | Surface dynamics of voltage-gated ion channels |
| Q30629019 | Synergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin |
| Q33885974 | Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels |
| Q39150711 | Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain |
| Q39103125 | Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels |
| Q48230397 | Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5 |
| Q52683949 | TRPs et al.: a molecular toolkit for thermosensory adaptations |
| Q36914467 | Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration |
| Q33662341 | Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels |
| Q52849075 | Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides |
| Q33759435 | Targeting voltage sensors in sodium channels with spider toxins. |
| Q34260913 | Tetrodotoxin (TTX) as a therapeutic agent for pain. |
| Q48257118 | Tetrodotoxin-, dihydropyridine-, and riluzole-resistant persistent inward current: novel sodium channels in rodent spinal neurons |
| Q36532591 | Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons |
| Q37305279 | Tetrodotoxin: a brief history |
| Q40754070 | The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive? |
| Q36139482 | The Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Nav1.7 Channel and the Molecular Pathogenesis of Inherited Erythromelalgia |
| Q30486735 | The Concise Guide to PHARMACOLOGY 2013/14: ion channels |
| Q46918332 | The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability |
| Q34999276 | The M-superfamily of conotoxins: a review |
| Q38066723 | The Na(V)1.7 sodium channel: from molecule to man. |
| Q58764681 | The Na1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons |
| Q39756006 | The Nav1.2 channel is regulated by GSK3. |
| Q34483183 | The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill. |
| Q26750661 | The afferent signaling complex: Regulation of type I spiral ganglion neuron responses in the auditory periphery |
| Q30487520 | The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking |
| Q46610550 | The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells. |
| Q37805995 | The discovery and development of analgesics: new mechanisms, new modalities |
| Q36514764 | The distribution and targeting of neuronal voltage-gated ion channels |
| Q36954025 | The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytes |
| Q92932176 | The emerging role of minor intron splicing in neurological disorders |
| Q26771787 | The hitchhiker's guide to the voltage-gated sodium channel galaxy |
| Q82548101 | The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations |
| Q38092679 | The insecticidal potential of venom peptides |
| Q38611594 | The late sodium current in heart failure: pathophysiology and clinical relevance |
| Q40981371 | The modulation of two motor behaviors by persistent sodium currents in Xenopus laevis tadpoles |
| Q37755990 | The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating |
| Q39199255 | The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-α-mediated increase in nociceptors excitability |
| Q36347732 | The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry |
| Q36310578 | The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant. |
| Q38606237 | The voltage-gated sodium channel NaV 1.9 in visceral pain |
| Q35006187 | The voltage-gated sodium channel nav1.8 is expressed in human sperm |
| Q26998280 | Theoretical and simulation studies on voltage-gated sodium channels |
| Q38026605 | Therapeutic Potential of Conopeptides |
| Q35680656 | Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula |
| Q36213560 | Three-dimensional modelling of the voltage-gated sodium ion channel from Anopheles gambiae reveals spatial clustering of evolutionarily conserved acidic residues at the extracellular sites |
| Q42545286 | Thyroid hormone (T3)-induced up-regulation of voltage-activated sodium current in cultured postnatal hippocampal neurons requires secretion of soluble factors from glial cells |
| Q50086110 | Toxins That Affect Voltage-Gated Sodium Channels |
| Q47136596 | Transcriptomic correlates of neuron electrophysiological diversity |
| Q84255216 | Transfection of rat or mouse neurons by biolistics or electroporation |
| Q38239812 | Translational pain research: Lessons from genetics and genomics |
| Q35878205 | Tumor necrosis factor-α enhances voltage-gated Na⁺ currents in primary culture of mouse cortical neurons |
| Q34074334 | Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK. |
| Q24598512 | Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis |
| Q34775754 | Unique mixed phenotype and unexpected functional effect revealed by novel compound heterozygosity mutations involving SCN5A. |
| Q57027353 | Upregulation of Nav1.6 expression in the rostral ventrolateral medulla of stress-induced hypertensive rats |
| Q39882746 | Upregulation of voltage-gated Na+ channels by long-term activation of the ghrelin-growth hormone secretagogue receptor in clonal GC somatotropes |
| Q39458691 | Utility of frozen cell lines in medium throughput electrophysiology screening of hERG and NaV1.5 blockade |
| Q34575055 | Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line |
| Q28565378 | Vasa recta voltage-gated Na+ channel Nav1.3 is regulated by calmodulin |
| Q92150641 | Venoms of Iranian Scorpions (Arachnida, Scorpiones) and Their Potential for Drug Discovery |
| Q39001054 | Verapamil Parameter- and Dose-Dependently Impairs Memory Consolidation in Open Field Habituation Task in Rats |
| Q39010857 | Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways |
| Q38851171 | Voltage-Gated Na+ Channels: Not Just for Conduction |
| Q55279100 | Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology. |
| Q39278584 | Voltage-dependent Sodium Channels and Calcium-activated Potassium Channels in Human Odontoblasts In Vitro |
| Q83874660 | Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat |
| Q35538368 | Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy |
| Q30580969 | Voltage-gated sodium channel Nav 1.5 contributes to astrogliosis in an in vitro model of glial injury via reverse Na+ /Ca2+ exchange |
| Q34456972 | Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells |
| Q33556980 | Voltage-gated sodium channel expression in mouse DRG after SNI leads to re-evaluation of projections of injured fibers |
| Q28655574 | Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin |
| Q39754415 | Voltage-gated sodium channel isoform-specific effects of pompilidotoxins. |
| Q34579624 | Voltage-gated sodium channel modulation by scorpion alpha-toxins |
| Q47776524 | Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease |
| Q33849089 | Voltage-gated sodium channels are required for heart development in zebrafish |
| Q37714086 | Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. |
| Q46438087 | Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs |
| Q33417943 | Voltage-gated sodium channels in taste bud cells |
| Q48273674 | Voltage-gated sodium channels: (NaV )igating the field to determine their contribution to visceral nociception. |
| Q38026557 | Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies. |
| Q36636613 | Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4 |
| Q90560458 | Yield of peripheral sodium channels gene screening in pure small fibre neuropathy |
| Q42369938 | Zinc as a Neuromodulator in the Central Nervous System with a Focus on the Olfactory Bulb |
| Q28265721 | Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators |
| Q33824948 | [EXPRESS] Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy; cause and effect? |
| Q87585683 | [Update on the pharmacology and effects of local anesthetics] |
| Q36953656 | n-Alcohols inhibit voltage-gated Na+ channels expressed in Xenopus oocytes |
| Q52320511 | β1 subunit stabilises sodium channel Nav1.7 against mechanical stress. |
| Q35064387 | μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve |
| Q34007370 | μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels |
Search more.