A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.

scientific article published on 04 February 2014

A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PNAS..111.2758G
P356DOI10.1073/PNAS.1324189111
P932PMC publication ID3932919
P698PubMed publication ID24497506
P5875ResearchGate publication ID260108421

P50authorBaldomero OliveraQ4850450
Beatrix UeberheideQ56435647
Aleksandra WalewskaQ80270146
Layla AzamQ125252474
Doju YoshikamiQ125252656
Shrinivasan RaghuramanQ125252658
P2093author name stringYi Liu
Brad R Green
Grzegorz Bulaj
Natali A Minassian
Min-Min Zhang
Marshall Bern
Alan D Wickenden
Joanna Gajewiak
Pradip K Bandyopadhyay
Julita Imperial
H Mimi Zhou
Mack Flinspach
Rebecca H Hagan
P2860cites workInhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.Q42640701
Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channelsQ44241895
Multiple 6-bromotryptophan residues in a sleep-inducing peptideQ45067298
A novel post-translational modification involving bromination of tryptophan. Identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venomQ46083732
A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block.Q48628517
Catalytic oxidation of sulfhydryl groups by o-phenanthroline copper complex.Q53859237
Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinQ24609009
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International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neuronsQ28592952
Gating properties of Na(v)1.7 and Na(v)1.8 peripheral nerve sodium channels.Q30730215
Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channelsQ33885974
Molecular motions within the pore of voltage-dependent sodium channelsQ33907113
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.Q33925844
Conus venoms: a rich source of novel ion channel-targeted peptidesQ33975042
Extrapore Residues of the S5-S6 Loop of Domain 2 of the Voltage-Gated Skeletal Muscle Sodium Channel (rSkM1) Contribute to the μ-Conotoxin GIIIA Binding SiteQ34168386
Neurotoxins and Their Binding Areas on Voltage-Gated Sodium ChannelsQ34232755
Acetylcholine receptor channel structure probed in cysteine-substitution mutants.Q34250941
Voltage-gated sodium channels at 60: structure, function and pathophysiologyQ34265707
Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom ductQ34319949
The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and InactivationQ34359543
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerveQ35064387
NaVβ Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier μO-Conotoxin MrVIBQ35122879
Na+ Channel ? Subunits: Overachievers of the Ion Channel FamilyQ35235909
Regulatory role of voltage-gated Na+ channel β subunits in sensory neuronsQ35564862
Differential Expression of Sodium Channel β Subunits in Dorsal Root Ganglion Sensory NeuronsQ35922414
Use-dependent block of the voltage-gated Na+ channel by tetrodotoxin and saxitoxin: Effect of pore mutations that change ionic selectivityQ36277894
Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunitsQ36385951
Co‐expression of NaVβ subunits alters the kinetics of inhibition of voltage‐gated sodium channels by pore‐blocking μ‐conotoxinsQ36709224
Conotoxins of the O-superfamily affecting voltage-gated sodium channels.Q36770013
Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxinsQ36783993
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configurationQ36914467
β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cellsQ37132478
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7.Q37238345
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivationQ37301303
muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2.Q39951303
P433issue7
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)2758-2763
P577publication date2014-02-04
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.
P478volume111

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cites work (P2860)
Q36624604Binary architecture of the Nav1.2-β2 signaling complex
Q64983927Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms.
Q34780602Conotoxin gene superfamilies
Q26774171Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition
Q28587362Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currents
Q50922680Generation of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus
Q28648269Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus
Q35684927Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.
Q36727498Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.
Q27021886Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity
Q26771787The hitchhiker's guide to the voltage-gated sodium channel galaxy
Q38525254Therapeutic conotoxins: a US patent literature survey
Q47961506Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery
Q63396036Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy
Q47776524Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease
Q45384168µ-Conotoxins Modulating Sodium Currents in Pain Perception and Transmission: A Therapeutic Potential
Q35560136Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.

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