From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei

scientific article published on 09 April 2019

From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BPH.14628
P932PMC publication ID6468265
P698PubMed publication ID30784059

P50authorDenis ServentQ46913748
Evelyne BenoitQ87759389
P2093author name stringMichael Kurz
Gerhard Hessler
Michel De Waard
Laurent Bialy
Laetitia Lucarain
Jean-Marie Chambard
Brigitte Schombert
Michel Partiseti
Tânia C Gonçalves
Rémy Béroud
Andrees Bohme
Stéphanie Combemale
Lucie Jaquillard
Rachid Boukaiba
Sophie Fouconnier
Stéphane Hourcade
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The Na1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia NeuronsQ58764681
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A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channelsQ84882964
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Involvement of Voltage-Gated Calcium Channels in Inflammation and Inflammatory PainQ90698388
Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapsesQ24653551
Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwenaQ27639643
Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)Q27678595
Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriensQ27700858
Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7Q27702229
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to painQ28542818
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical painQ28594552
Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainanaQ30807017
Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitorQ33390819
Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design TrialQ33710457
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The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and InactivationQ34359543
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Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic painQ36646432
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neuronsQ36678533
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configurationQ36914467
Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird Spider Ornithoctonus hainanaQ37012447
Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of PainQ37065681
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Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.Q38006317
The Na(V)1.7 sodium channel: from molecule to man.Q38066723
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Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical IndicationsQ38451134
Niclosamide Inhibits Oxaliplatin Neurotoxicity while Improving Colorectal Cancer Therapeutic ResponseQ38726030
NaV1.7 as a pain target - From gene to pharmacology.Q39029029
P433issue9
P304page(s)1298-1314
P577publication date2019-04-09
P1433published inBritish Journal of PharmacologyQ919631
P1476titleFrom identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei
P478volume176

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cites work (P2860)
Q92826608Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates
Q64054939Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

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