Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

scientific article published on September 18, 2010

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMCL.2010.08.121
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0960894X10012576?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0960894X10012576?httpAccept=text/xml
P698PubMed publication ID20855211

P2093author name stringLei Shi
Dong Liu
Matthew S. Johnson
Prisca Honore
Brett Antonio
Rosemarie Roeloffs
Irene Drizin
Chengmin Zhong
XuFeng Zhang
Robert J. Gregg
Char-Chang Shieh
Shailen Joshi
Stephen Werness
James B. Thomas
Michael J. Krambis
Robert N. Atkinson
Connie R. Faltynek
Gricelda Simler
Mark A. Matulenko
Michael F. Jarvis
Marc J. C. Scanio
Michael E. Kort
Kennan C. Marsh
Joseph P. Mikusa
Brian E. Marron
Matthew A. Secrest
Ahmed H. Hakeem
Mark L. Chapman
Douglas S. Krafte
P2860cites workFrom ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channelsQ28143653
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
The role of voltage-gated sodium channels in neuropathic painQ29543085
Palladium-catalyzed cross-coupling reactions in total synthesisQ30993316
Sodium channels, excitability of primary sensory neurons, and the molecular basis of painQ33716324
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the ratQ34239178
Pyridinylpiperazines, a new class of selective .alpha.2-adrenoceptor antagonistsQ34247765
Voltage-gated sodium channels and hyperalgesiaQ34292572
Voltage-gated sodium channel blockers; target validation and therapeutic potentialQ34434328
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.Q34625901
Voltage-gated sodium channel blockers for the treatment of chronic painQ34980986
New targets for neuropathic pain therapeuticsQ36219689
Sodium channel blockersQ36815891
Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatmentQ37371254
Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitorsQ42275101
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory painQ46821942
A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic ratsQ46843439
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectniacinamideQ192423
P304page(s)6812-6815
P577publication date2010-09-18
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleSubtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives
Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives
P478volume20