Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency

scientific article

Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CB300674X
P932PMC publication ID4201638
P698PubMed publication ID23557677

P50authorBaldomero OliveraQ4850450
Raymond NortonQ57414127
Kallol GuptaQ82652309
Doju YoshikamiQ125252656
P2093author name stringZhihe Kuang
Grzegorz Bulaj
Jozsef Gulyas
Jean E Rivier
Min-Min Zhang
Padmanabhan Balaram
Joanna Gajewiak
P2860cites workThe Protein Data BankQ24515306
Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinQ24609009
Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channelsQ27638974
Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIAQ27642020
Design of Bioactive Peptides from Naturally Occurring  -Conotoxin StructuresQ27670677
Distinct Disulfide Isomers of μ-Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium ChannelsQ27675187
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptorsQ27676650
Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide unitsQ28255121
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
BioMagResBankQ29614807
Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatusQ33379312
Disulfide Bond Assignments by Mass Spectrometry of Native Natural Peptides: Cysteine Pairing in Disulfide Bonded ConotoxinsQ33693128
Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channelsQ33885974
Conus venoms: a rich source of novel ion channel-targeted peptidesQ33975042
μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channelsQ34007370
Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletionQ34128194
Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA.Q34362601
Conus geographus toxins that discriminate between neuronal and muscle sodium channels.Q34376153
The roles of sodium channels in nociception: Implications for mechanisms of painQ34674268
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerveQ35064387
Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIAQ35587036
Sodium channel toxins--receptor targeting and therapeutic potentialQ35972174
Conotoxins down underQ36585325
Conus venoms - a rich source of peptide-based therapeuticsQ37264911
Sodium channels in normal and pathological painQ37724336
Mu-conotoxins as leads in the development of new analgesicsQ37739202
The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxinsQ37780453
Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIICQ41839011
PADLOC: A Powerful Tool to Assign Disulfide Bond Connectivities in Peptides and Proteins by NMR SpectroscopyQ44004024
Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channelsQ44241895
Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neuronsQ44251069
Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA.Q45080779
μ-Conotoxin PIIIA, a New Peptide for Discriminating among Tetrodotoxin-Sensitive Na Channel SubtypesQ48009606
Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channelsQ48349414
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.Q48784731
Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA.Q48901886
Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activityQ50687380
Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channelsQ51226387
Three-dimensional structure in solution of the calcium channel blocker omega-conotoxinQ72579546
Rapid mass spectrometric determination of disulfide connectivity in peptides and proteinsQ86298614
P433issue6
P304page(s)1344-1351
P577publication date2013-04-16
P1433published inACS Chemical BiologyQ165583
P1476titleMammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency
P478volume8

Reverse relations

cites work (P2860)
Q38204930Animal toxins influence voltage-gated sodium channel function.
Q26774171Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition
Q39234026Enhancing the therapeutic potential of peptide toxins
Q34161190Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3.
Q58582851NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency
Q27021886Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity
Q34792648Systematic study of binding of μ-conotoxins to the sodium channel NaV1.4.
Q37453655The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4.
Q45384168µ-Conotoxins Modulating Sodium Currents in Pain Perception and Transmission: A Therapeutic Potential

Search more.