Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?

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Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1590/1414-431X20176011
P932PMC publication ID5463531
P698PubMed publication ID28591378

P50authorPaulo Sérgio Lacerda BeirãoQ66976610
Jader Santos CruzQ43740138
P2093author name stringA L P Rodrigues
P Rhana
R R Trivelato
P2860cites workExon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8AQ22008052
Hallmarks of Cancer: The Next GenerationQ22252312
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervalsQ24294528
Therapeutic Value of Voltage-Gated Sodium Channel Inhibitors in Breast, Colorectal, and Prostate Cancer: A Systematic ReviewQ26772803
Clinical and molecular complexity of breast cancer metastasesQ26796326
Voltage-gated sodium channels and cancer: is excitability their primary role?Q26797387
New and emerging factors in tumorigenesis: an overviewQ26801253
The endolysosomal system in cell death and survivalQ27006829
Voltage-gated ion channels in cancer cell proliferationQ27010511
Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contactQ28141221
NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial spaceQ61642117
Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applicationsQ81077744
Voltage-Gated Na+ Channels: Not Just for ConductionQ38851171
Functional expression of the voltage-gated Na⁺-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cellsQ39103592
NaV1.5 Na⁺ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodiaQ39117508
Na(V)1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H(+) efflux in caveolaeQ39618185
Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A.Q39896695
Alternative splicing of Nav1.5: an electrophysiological comparison of 'neonatal' and 'adult' isoforms and critical involvement of a lysine residue.Q39994623
Single cell adhesion measuring apparatus (SCAMA): application to cancer cell lines of different metastatic potential and voltage-gated Na+ channel expressionQ40078794
Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidificationQ40124031
Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell lineQ40200194
Activity-dependent regulation of voltage-gated Na+ channel expression in Mat-LyLu rat prostate cancer cell lineQ40303566
Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.Q40390262
Expression of Na+-dependent citrate transport in a strongly metastatic human prostate cancer PC-3M cell line: regulation by voltage-gated Na+ channel activity.Q40478743
Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAsQ40507940
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasionQ40565703
Voltage-gated Na+ channels confer invasive properties on human prostate cancer cellsQ40607095
Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell lineQ40625814
Contribution of functional voltage‐gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: I. lateral motilityQ40653900
Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro.Q41119626
Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsyQ43283100
Glial cells have heart: rH1 Na+ channel mRNA and protein in spinal cord astrocytesQ47951687
Mutually exclusive exon splicing of type III brain sodium channel alpha subunit RNA generates developmentally regulated isoforms in rat brain.Q48102197
Overexpression of NaV 1.6 channels is associated with the invasion capacity of human cervical cancerQ48258918
Directional movement of rat prostate cancer cells in direct-current electric field: involvement of voltagegated Na+ channel activityQ49029407
Contactin associates with Na+ channels and increases their functional expressionQ28188411
Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root gangliaQ28276370
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivoQ28510216
pH Homeostasis of cellular organellesQ34112147
Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasionQ34116066
The complex ultrastructure of the endolysosomal system.Q34248085
Voltage-gated sodium channels at 60: structure, function and pathophysiologyQ34265707
Angiogenic functions of voltage-gated Na+ Channels in human endothelial cells: modulation of vascular endothelial growth factor (VEGF) signalingQ34947687
Ranolazine inhibits NaV1.5-mediated breast cancer cell invasiveness and lung colonizationQ34970151
Particular sensitivity to calcium channel blockers of the fast inward voltage-dependent sodium current involved in the invasive properties of a metastastic breast cancer cell lineQ35046156
The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.Q35061372
Cancer as a channelopathy: ion channels and pumps in tumor development and progressionQ35184108
Na+ Channel ? Subunits: Overachievers of the Ion Channel FamilyQ35235909
Small RNA: can RNA interference be exploited for therapy?Q35571567
Organellar channels and transportersQ35691118
Evolutionary convergence of alternative splicing in ion channelsQ35752648
Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.Q36107167
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.Q36263013
Neuronal characteristics of small-cell lung cancerQ36304228
Clinical relevance of ion channels for diagnosis and therapy of cancerQ36345960
Voltage-gated sodium channels and metastatic disease.Q36430239
Voltage-gated sodium channels: new targets in cancer therapy?Q36638735
RNA interference: implications for cancer treatmentQ36738853
Emerging roles of alkali cation/proton exchangers in organellar homeostasisQ36889613
Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells.Q37136807
A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.Q37183730
Chemical modification of siRNAs for in vivo use.Q37331765
Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancerQ37616288
Sensors and regulators of intracellular pH.Q37649497
Beneficial effects of omega-3 long-chain fatty acids in breast cancer and cardiovascular diseases: voltage-gated sodium channels as a common feature?Q37694800
Endosome maturation, transport and functionsQ38202717
Dual roles of voltage-gated sodium channels in development and cancerQ38502153
Lysosomal cysteine peptidases - Molecules signaling tumor cell death and survivalQ38563201
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic responseQ38644547
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectvoltage-gated sodium channel complexQ14905705
breast neoplasmQ23929670
neoplastic gene expression regulationQ66660300
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)e6011
P577publication date2017-06-05
P13046publication type of scholarly workreview articleQ7318358
P1433published inBrazilian Journal of Medical and Biological ResearchQ2025772
P1476titleIs there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?
P478volume50

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Q64916539Somatic Mutations Profile of a Young Patient With Metastatic Urothelial Carcinoma Reveals Mutations in Genes Involved in Ion Channels.cites workP2860

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