| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2011NatCo...2..351P |
| P6179 | Dimensions Publication ID | 1019762340 |
| P356 | DOI | 10.1038/NCOMMS1351 |
| P698 | PubMed publication ID | 21673672 |
| P50 | author | Adam Frankel | Q43280576 |
| Stephan A. Pless | Q37371029 | ||
| P2093 | author name string | Christopher A Ahern | |
| Jason D Galpin | |||
| P2860 | cites work | ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation | Q22306351 |
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| Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation | Q40485452 | ||
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| Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels | Q40889702 | ||
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| Molecular determinants of state-dependent block of Na+ channels by local anesthetics | Q42284240 | ||
| Comparatibe actions of mexiletine on sodium channels in nerve, skeletal and cardiac muscle | Q42451800 | ||
| The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping. | Q42633455 | ||
| Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics | Q42683794 | ||
| Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit. | Q43508073 | ||
| Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. | Q44072116 | ||
| Altered gating and local anesthetic block mediated by residues in the I-S6 and II-S6 transmembrane segments of voltage-dependent Na+ channels | Q44550653 | ||
| Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart | Q46082698 | ||
| The antianginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria | Q46897241 | ||
| Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels | Q46925632 | ||
| Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue. | Q46943735 | ||
| Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre | Q48632366 | ||
| A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel | Q51481961 | ||
| Aminoalkyl structural requirements for interaction of lidocaine with the class I antiarrhythmic drug receptor on rat cardiac myocytes. | Q51713049 | ||
| Ca-sensitive slow inactivation and lidocaine-induced block of sodium channels in rat cardiac cells | Q51717823 | ||
| Structure-activity relationship of lidocaine homologs producing tonic and frequency-dependent impulse blockade in nerve | Q51809056 | ||
| Quantifying antiarrhythmic drug blocking during action potentials in guinea-pig papillary muscle | Q52700803 | ||
| Nomenclature of voltage-gated sodium channels | Q28141860 | ||
| The Cationminus signpi Interaction | Q28202146 | ||
| Inherited sodium channelopathies: a continuum of channel dysfunction | Q28238528 | ||
| Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp | Q28271872 | ||
| Class 1 antiarrhythmic drugs--characteristic electrocardiographic differences when assessed by atrial and ventricular pacing | Q28272594 | ||
| International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels | Q28289125 | ||
| Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial | Q28300531 | ||
| Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels | Q28379121 | ||
| A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response | Q28471659 | ||
| Cation-pi interactions in structural biology | Q29617384 | ||
| Aromatic-aromatic interaction: a mechanism of protein structure stabilization | Q29620587 | ||
| Clinical spectrum of SCN1A mutations. | Q30377548 | ||
| Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs | Q30449316 | ||
| Use-dependent inhibition of Na+ currents by benzocaine homologs | Q34016917 | ||
| Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation | Q34020143 | ||
| Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels | Q34156425 | ||
| Classifying antiarrhythmic actions: by facts or speculation | Q34292204 | ||
| Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties | Q34339876 | ||
| Interactions of local anesthetics with voltage-gated Na+ channels | Q34382262 | ||
| The pH-dependent rate of action of local anesthetics on the node of Ranvier | Q34559874 | ||
| Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction | Q34684384 | ||
| A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists | Q34715543 | ||
| Cys-loop neuroreceptors: structure to the rescue? | Q34775042 | ||
| A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. | Q36295915 | ||
| Probing the cavity of the slow inactivated conformation of shaker potassium channels | Q36299751 | ||
| Molecular action of lidocaine on the voltage sensors of sodium channels | Q36412378 | ||
| Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues | Q36412399 | ||
| Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. | Q37023303 | ||
| A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue | Q37112929 | ||
| Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide | Q37284698 | ||
| Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity | Q37326589 | ||
| New developments in atrial antiarrhythmic drug therapy | Q37697498 | ||
| Sodium channels in normal and pathological pain | Q37724336 | ||
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 351 | |
| P577 | publication date | 2011-06-14 | |
| P1433 | published in | Nature Communications | Q573880 |
| P1476 | title | Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels | |
| P478 | volume | 2 |
| Q40383649 | A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel. |
| Q37729614 | Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains |
| Q28081786 | Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology |
| Q36033788 | Atomic basis for therapeutic activation of neuronal potassium channels |
| Q42375557 | Atomic mutagenesis in ion channels with engineered stoichiometry |
| Q27330612 | Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel |
| Q37708117 | Block of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway |
| Q39113773 | Cellular encoding of Cy dyes for single-molecule imaging. |
| Q35266383 | Contributions of conserved residues at the gating interface of glycine receptors. |
| Q90286504 | Fenestrations control resting-state block of a voltage-gated sodium channel |
| Q37644340 | Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. |
| Q30364289 | In vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic tool |
| Q38588687 | Incorporation of Non-Canonical Amino Acids |
| Q38733384 | Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity. |
| Q45825169 | Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes |
| Q36446395 | Intermediate state trapping of a voltage sensor |
| Q34537076 | Ion channelopathies in functional GI disorders |
| Q112573615 | Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore |
| Q94560886 | Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents |
| Q28540363 | Locating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channel |
| Q42056519 | Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants |
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| Q42111305 | Membrane permeable local anesthetics modulate NaV1.5 mechanosensitivity |
| Q38613252 | Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade. |
| Q41126715 | Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine. |
| Q39550425 | Molecular and functional determinants of local anesthetic inhibition of NaChBac. |
| Q46369628 | Nanomechanics of cation-π interactions in aqueous solution. |
| Q55112235 | Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte. |
| Q92535613 | Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model |
| Q47718329 | Physical basis of specificity and delayed binding of a subtype selective sodium channel inhibitor |
| Q48267422 | Probing the molecular basis of hERG drug block with unnatural amino acids |
| Q52691609 | Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels. |
| Q42768918 | Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants |
| Q36339469 | Rate-dependent activation failure in isolated cardiac cells and tissue due to Na+ channel block |
| Q34946825 | Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5. |
| Q48510160 | Site-Directed Unnatural Amino Acid Mutagenesis to Investigate Potassium Channel Pharmacology in Xenopus laevis Oocytes |
| Q48274837 | State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. |
| Q28082803 | Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels |
| Q64272514 | Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel |
| Q26771787 | The hitchhiker's guide to the voltage-gated sodium channel galaxy |
| Q38316122 | βTrCP interacts with the ubiquitin-dependent endocytosis motif of the GH receptor in an unconventional manner |
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