Atomic mutagenesis in ion channels with engineered stoichiometry

scientific article published on 6 October 2016

Atomic mutagenesis in ion channels with engineered stoichiometry is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.18976
P932PMC publication ID5092047
P698PubMed publication ID27710770

P50authorBenoît RouxQ4890170
Christopher A AhernQ57070092
Jing LiQ60192880
P2093author name stringJason D Galpin
Daniel T Infield
John D Lueck
Adam L Mackey
P2860cites workStructural basis for the coupling between activation and inactivation gates in K(+) channelsQ24630519
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Update of the CHARMM all-atom additive force field for lipids: validation on six lipid typesQ29616710
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Molecular driving forces determining potassium channel slow inactivationQ30444688
Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopyQ30472195
Initial steps of inactivation at the K+ channel selectivity filterQ33674104
An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal bindingQ34115140
Protein ligation: an enabling technology for the biophysical analysis of proteinsQ34529929
RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sitesQ35445840
A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium ChannelsQ35860617
Atomic basis for therapeutic activation of neuronal potassium channelsQ36033788
Intramembrane charge movements and excitation- contraction coupling expressed by two-domain fragments of the Ca2+ channel.Q36243264
Protein trans-splicing by a split intein encoded in a split DnaE gene of Synechocystis sp. PCC6803Q36253922
Probing the cavity of the slow inactivated conformation of shaker potassium channelsQ36299751
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Intermediate state trapping of a voltage sensorQ36446395
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Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral anglesQ36546184
Protein splicing in cis and in transQ36561753
C-type inactivation of voltage-gated K+ channels: pore constriction or dilation?Q36568471
Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicingQ37192045
Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated stateQ37204017
Recovery from slow inactivation in K+ channels is controlled by water moleculesQ37237569
Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channelsQ37365843
Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channelsQ37530408
Inteins: Nature's Gift to Protein ChemistsQ37630472
Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domainsQ37729614
Modulation of C-type inactivation by K+ at the potassium channel selectivity filterQ40118529
Frequency-dependent inactivation of mammalian A-type K+ channel KV1.4 regulated by Ca2+/calmodulin-dependent protein kinase.Q41110383
Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.Q41290065
A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channelsQ41644878
A versatile platform for single- and multiple-unnatural amino acid mutagenesis in Escherichia coliQ42836961
Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channelsQ43427939
Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region.Q45930888
An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression.Q46001070
Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channelsQ46048873
Energetics of ion conduction through the K+ channel.Q48620522
A facile system for genetic incorporation of two different noncanonical amino acids into one protein in Escherichia coli.Q50558836
The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations.Q52210321
Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells.Q54419427
Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systemsQ56750591
Structural parts involved in activation and inactivation of the sodium channelQ59072056
Mechanism of frequency-dependent broadening of molluscan neurone soma spikesQ66927724
Optimized plasmid systems for the incorporation of multiple different unnatural amino acids by evolved orthogonal ribosomesQ88008733
P407language of work or nameEnglishQ1860
P921main subjectstoichiometryQ213185
P577publication date2016-10-06
P1433published ineLifeQ2000008
P1476titleAtomic mutagenesis in ion channels with engineered stoichiometry
P478volume5

Reverse relations

cites work (P2860)
Q94569494Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing
Q55112235Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte.
Q92832010Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Q60912728Shifts in the selectivity filter dynamics cause modal gating in K channels
Q56529660Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs

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