| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1992PNAS...89..554G |
| P356 | DOI | 10.1073/PNAS.89.2.554 |
| P953 | full work available at URL | http://www.pnas.org/content/89/2/554.full.pdf |
| https://europepmc.org/articles/PMC48277 | ||
| https://europepmc.org/articles/PMC48277?pdf=render | ||
| https://pnas.org/doi/pdf/10.1073/pnas.89.2.554 | ||
| P3181 | OpenCitations bibliographic resource ID | 4330489 |
| P932 | PMC publication ID | 48277 |
| P698 | PubMed publication ID | 1309946 |
| P5875 | ResearchGate publication ID | 21845653 |
| P2093 | author name string | A. L. George | |
| R. G. Kallen | |||
| R. L. Barchi | |||
| M. Chahine | |||
| R. Horn | |||
| L. Q. Chen | |||
| M. E. Gellens | |||
| P2860 | cites work | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease | Q26778460 |
| Localization of a human brain sodium channel gene (SCN2A) to chromosome 2 | Q28257786 | ||
| Assignment of a human skeletal muscle sodium channel α-subunit gene (SCN4A) to 17q23.1–25.3 | Q28282366 | ||
| Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform | Q34314458 | ||
| Conus geographus toxins that discriminate between neuronal and muscle sodium channels. | Q34376153 | ||
| Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels | Q34390940 | ||
| Voltage-dependent calcium block of normal and tetramethrin-modified single sodium channels | Q34536274 | ||
| A rat brain Na+ channel alpha subunit with novel gating properties | Q36385916 | ||
| Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels | Q36433797 | ||
| Pursuing the structure and function of voltage-gated channels | Q36581941 | ||
| Expression of cardiac Na channels with appropriate physiological and pharmacological properties in Xenopus oocytes | Q37508644 | ||
| Molecular diversity of voltage-sensitive Na channels | Q38269274 | ||
| Lidocaine block of cardiac sodium channels | Q41556598 | ||
| Functional properties of rat brain sodium channels expressed in a somatic cell line | Q41743770 | ||
| Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle | Q41745813 | ||
| Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating | Q41934196 | ||
| Primary structure and functional expression of a mammalian skeletal muscle sodium channel | Q42189395 | ||
| Human cardiac sodium channels expressed in Xenopus oocytes | Q44575315 | ||
| Tetrodotoxin-sensitive voltage-dependent Na currents recorded from Xenopus oocytes injected with mammalian cardiac muscle RNA. | Q46053879 | ||
| High-STX-affinity vs. low-STX-affinity Na+ channel subtypes in nerve, heart, and skeletal muscle | Q48423187 | ||
| SkM2, a Na+ channel cDNA clone from denervated skeletal muscle, encodes a tetrodotoxin-insensitive Na+ channel | Q50799937 | ||
| A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II. | Q51744647 | ||
| Functional differences between two classes of sodium channels in developing rat skeletal muscle. | Q51806180 | ||
| Sodium channels in cultured cardiac cells | Q51853148 | ||
| Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres. | Q51874590 | ||
| Studies on Tetrodotoxin Resistant Action Potentials in Denervated Skeletal Muscle | Q52736584 | ||
| Localization of sodium channel subtypes in adult rat skeletal muscle using channel-specific monoclonal antibodies | Q69002874 | ||
| Voltage clamp and internal perfusion of single rat heart muscle cells | Q71046629 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | sodium | Q658 |
| cardiology | Q10379 | ||
| voltage | Q25428 | ||
| P304 | page(s) | 554-8 | |
| P577 | publication date | 1992-01-15 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel | |
| P478 | volume | 89 |
| Q34171258 | 1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK. |
| Q57816587 | A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na1.5 Gating Pores |
| Q89020335 | A SNaPshot assay for detection of 45 mutations in the SCN5A gene in the Chinese Han Population |
| Q38307575 | A carboxy-terminal alpha-helical segment in the rat skeletal muscle voltage-dependent Na+ channel is responsible for its interaction with the amino-terminus |
| Q33162301 | A case of Long QT syndrome type 3 aggravated by beta-blockers and alleviated by mexiletine: the role of epinephrine provocation test |
| Q31119456 | A common human SCN5A polymorphism modifies expression of an arrhythmia causing mutation |
| Q35054513 | A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel |
| Q39790737 | A double tyrosine motif in the cardiac sodium channel domain III-IV linker couples calcium-dependent calmodulin binding to inactivation gating |
| Q34808264 | A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome |
| Q28276372 | A mutation in telethonin alters Nav1.5 function |
| Q34544772 | A novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada syndrome |
| Q42549337 | A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. |
| Q34172404 | A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state |
| Q34295483 | A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype |
| Q28363700 | A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation |
| Q24294801 | A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels |
| Q89936495 | Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy |
| Q27329882 | Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice |
| Q90646888 | Action potentials in Xenopus oocytes triggered by blue light |
| Q33892566 | Alternative splicing of the cardiac sodium channel creates multiple variants of mutant T1620K channels |
| Q28577039 | An antisense oligonucleotide against H1 inhibits the classical sodium current but not ICa(TTX) in rat ventricular cells |
| Q38039083 | An introduction to murine models of atrial fibrillation |
| Q35553358 | Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis |
| Q35922458 | Atrial Anti-Arrhythmic Effects of Heptanol in Langendorff-Perfused Mouse Hearts |
| Q33740934 | Basal late sodium current is a significant contributor to the duration of action potential of guinea pig ventricular myocytes |
| Q34170654 | Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6 |
| Q37936683 | Biology of cardiac sodium channel Nav1.5 expression |
| Q39732040 | Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis |
| Q46676588 | Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis |
| Q38207583 | Biophysics, pathophysiology, and pharmacology of ion channel gating pores |
| Q42118233 | Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine |
| Q47720327 | Cardiac Arrhythmias Related to Sodium Channel Dysfunction. |
| Q35127761 | Cardiac Sodium Channel Diseases |
| Q38393181 | Cardiac disease modeling using induced pluripotent stem cell-derived human cardiomyocytes |
| Q36932045 | Cardiac sodium channel mutations: why so many phenotypes? |
| Q36605921 | Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm |
| Q38837706 | Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative. |
| Q42153730 | Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice |
| Q24322255 | Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction |
| Q28082428 | Channelopathies of skeletal muscle excitability |
| Q47926593 | Chaos game representation of proteins |
| Q30784795 | Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels |
| Q43115368 | Characterization of N-terminally mutated cardiac Na(+) channels associated with long QT syndrome 3 and Brugada syndrome |
| Q37359567 | Characterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome. |
| Q44133762 | Characterization of a voltage-dependent Na(+) current in human esophageal smooth muscle |
| Q48127863 | Characterization of endogenous sodium channel gene expressed in Chinese hamster ovary cells |
| Q36689783 | Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome |
| Q48510781 | Characterization of scorpion alpha-like toxin group using two new toxins from the scorpion Leiurus quinquestriatus hebraeus |
| Q51628270 | Characterization of the sodium currents in isolated human cardiocytes. |
| Q28363715 | Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels |
| Q50790307 | Chimeric study of sodium channels from rat skeletal and cardiac muscle |
| Q37723799 | Cilostazol ameliorates atrial ionic remodeling in long-term rapid atrial pacing dogs |
| Q36655920 | Clinical aspects and physiopathology of Brugada syndrome: review of current concepts |
| Q40752935 | Comparison of aconitine-modified human heart (hH1) and rat skeletal (mu1) muscle Na+ channels: an important role for external Na+ ions |
| Q34016936 | Comparison of heterologously expressed human cardiac and skeletal muscle sodium channels |
| Q40976833 | Comparison of slow inactivation in human heart and rat skeletal muscle Na+ channel chimaeras |
| Q26769921 | Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions |
| Q28206505 | Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A) |
| Q96952526 | Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms |
| Q38119213 | Determinants of myocardial conduction velocity: implications for arrhythmogenesis |
| Q35798904 | Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia |
| Q33907181 | Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity |
| Q34019030 | Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels |
| Q34017596 | Distinct local anesthetic affinities in Na+ channel subtypes |
| Q34171895 | Effects of channel cytoplasmic regions on the activation mechanisms of cardiac versus skeletal muscle Na(+) channels |
| Q33801118 | Effects of tetrodotoxin on the mammalian cardiovascular system |
| Q50716149 | Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom. |
| Q52020738 | Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. |
| Q30519490 | Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies. |
| Q33896741 | Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial |
| Q40710544 | Enhancement of closed-state inactivation in long QT syndrome sodium channel mutation DeltaKPQ. |
| Q52822505 | Evolutionary History of Voltage-Gated Sodium Channels. |
| Q41119626 | Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro. |
| Q35512577 | Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5. |
| Q36977102 | Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel |
| Q34168386 | Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site |
| Q37231007 | F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models |
| Q40311694 | Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block |
| Q27642791 | Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana |
| Q41470649 | Functional expression and properties of the human skeletal muscle sodium channel |
| Q36008853 | Functional expression of "cardiac-type" Nav1.5 sodium channel in canine intracardiac ganglia. |
| Q28584225 | Functional protein expression of multiple sodium channel alpha- and beta-subunit isoforms in neonatal cardiomyocytes |
| Q38264681 | Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present |
| Q38506245 | Gating pore current is a novel biophysical defect of Nav1.5 mutations associated with unusual cardiac arrhythmias and dilation |
| Q35014373 | Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy |
| Q36345800 | Genetic Analysis of SCN5A in Korean Patients Associated with Atrioventricular Conduction Block |
| Q36485019 | Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome |
| Q37680349 | Genetic analysis of cardiac SCN5A Gene in Iranian patients with hereditary cardiac arrhythmias. |
| Q45037578 | Genetic analysis of the cardiac sodium channel gene SCN5A in Koreans with Brugada syndrome. |
| Q38125767 | Genetic biomarkers in Brugada syndrome. |
| Q41746723 | Genetics, molecular mechanisms and management of long QT syndrome |
| Q37707209 | Genomic biomarkers of SUDEP in brain and heart |
| Q43977820 | Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current |
| Q35169656 | Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel |
| Q47724309 | Human saphenous vein endothelial cells express a tetrodotoxin-resistant, voltage-gated sodium current |
| Q42946073 | Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents |
| Q72107364 | Hyperkalemic periodic paralysis with cardiac dysrhythmia: A novel sodium channel mutation? |
| Q24306114 | Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5 |
| Q22011020 | Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A |
| Q28580858 | Identification of two nervous system-specific members of the erg potassium channel gene family |
| Q37644340 | Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. |
| Q33789839 | Impact of recent molecular studies on evaluation of ventricular arrhythmias |
| Q48830408 | Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited. |
| Q40129475 | Inactivation of single cardiac Na+ channels in three different gating modes |
| Q41970628 | Induction of high STAT1 expression in transgenic mice with LQTS and heart failure |
| Q33905815 | Inherited disorders of voltage-gated sodium channels |
| Q33145216 | Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis |
| Q41949009 | Interaction of scorpion alpha-toxins with cardiac sodium channels: binding properties and enhancement of slow inactivation |
| Q26829681 | Ion Channels in the Heart |
| Q28087459 | Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death |
| Q60076592 | Ion channels lose the rhythm |
| Q41737227 | Ion flux dependent and independent functions of ion channels in the vertebrate heart: lessons learned from zebrafish |
| Q36330249 | K+-conducting ion channel of the chloroplast inner envelope: functional reconstitution into liposomes |
| Q52624657 | KV4.3 Expression Modulates NaV1.5 Sodium Current. |
| Q94560886 | Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents |
| Q34789375 | Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel |
| Q42128374 | Localization of Nav1.5 sodium channel protein in the mouse brain |
| Q29544671 | Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome |
| Q35053991 | Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo. |
| Q41445181 | Mechanisms of noncovalent β subunit regulation of NaV channel gating |
| Q57037497 | Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na1.5 clarify the molecular basis of Brugada syndrome |
| Q39448475 | Mechanosensitive Piezo Channels in the Gastrointestinal Tract |
| Q42680525 | Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel |
| Q42111305 | Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity |
| Q44524501 | Methanethiosulfonate-modification alters local anesthetic block in rNav1.4 cysteine-substituted mutants S1276C and L1280C. |
| Q42680102 | Modulation of Nav1.5 channel function by an alternatively spliced sequence in the DII/DIII linker region. |
| Q35167168 | Modulation of cardiac Na+ channels expressed in a mammalian cell line and in ventricular myocytes by protein kinase C |
| Q41175857 | Modulation of human muscle sodium channels by intracellular fatty acids is dependent on the channel isoform |
| Q24313401 | Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B |
| Q48965228 | Modulation of the human cardiac sodium channel alpha-subunit by cAMP-dependent protein kinase and the responsible sequence domain. |
| Q38116835 | Modulation of voltage-gated ion channels by sialylation |
| Q38997049 | Molecular Pathophysiology of Congenital Long QT Syndrome |
| Q36412378 | Molecular action of lidocaine on the voltage sensors of sodium channels |
| Q34175373 | Molecular and cellular mechanisms of cardiac arrhythmias |
| Q43427939 | Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels |
| Q44241895 | Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels |
| Q33146297 | Molecular biology and the prolonged QT syndromes |
| Q34175659 | Molecular biology of sodium channels and their role in cardiac arrhythmias |
| Q36248216 | Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells |
| Q42670581 | Molecular cloning of a putative tetrodotoxin-resistant sodium channel from dog nodose ganglion neurons |
| Q24336511 | Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family |
| Q48860557 | Molecular determinants of beta 1 subunit-induced gating modulation in voltage-dependent Na+ channels. |
| Q39443518 | Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines. |
| Q34469735 | Molecular genetic basis of sudden cardiac death |
| Q40814961 | Molecular identification of a TTX-sensitive Ca(2+) current |
| Q36844541 | Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition |
| Q33173678 | Molecular mechanism for an inherited cardiac arrhythmia |
| Q28504505 | Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants |
| Q33828302 | Multiple Nav1.5 isoforms are functionally expressed in the brain and present distinct expression patterns compared with cardiac Nav1.5. |
| Q33601521 | Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome |
| Q43110938 | Mutations in the Voltage Sensors of Domains I and II of Nav1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents. |
| Q48953016 | Myotonic dystrophy kinase modulates skeletal muscle but not cardiac voltage-gated sodium channels |
| Q51374758 | Na(+) current contribution to the diastolic depolarization in newborn rabbit SA node cells. |
| Q27005721 | Na+ channel function, regulation, structure, trafficking and sequestration |
| Q41512118 | Na+ channels in cardiac and neuronal cells derived from a mouse embryonal carcinoma cell line |
| Q47267398 | NaV Channels: Assaying Biosynthesis, Trafficking, Function |
| Q37304434 | Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat. |
| Q33220170 | OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels |
| Q56568085 | Optically Controlled Oscillators in an Engineered Bioelectric Tissue |
| Q42262143 | Oxidation of multiple methionine residues impairs rapid sodium channel inactivation |
| Q40288640 | Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine |
| Q40062212 | Peroxynitrite formation mediates LPC-induced augmentation of cardiac late sodium currents |
| Q37706952 | Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics |
| Q36339192 | Pharmacogenetics and cardiac ion channels |
| Q92535613 | Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model |
| Q37365724 | Pharmacological targeting of long QT mutant sodium channels |
| Q34482842 | Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs |
| Q26772794 | Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison |
| Q28379344 | Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin |
| Q53964824 | Polymorphism H558R in the human cardiac sodium channel SCN5A gene is associated with atrial fibrillation. |
| Q36591586 | Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p |
| Q90632675 | Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation |
| Q33812750 | Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers |
| Q28210170 | Primary structure of the adult human skeletal muscle voltage‐dependent sodium channel |
| Q24337133 | Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain |
| Q42091393 | Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic |
| Q48518879 | Properties of wild-type and fluorescent protein-tagged mouse tetrodotoxin-resistant sodium channel (Na V 1.8) heterologously expressed in rat sympathetic neurons |
| Q21129289 | Propranolol blocks cardiac and neuronal voltage-gated sodium channels |
| Q36620769 | Proton sensors in the pore domain of the cardiac voltage-gated sodium channel |
| Q36472602 | Quantification of gastrointestinal sodium channelopathy |
| Q50721381 | Quaternary ammonium block of mutant Na+ channels lacking inactivation: features of a transition-intermediate mechanism. |
| Q36494631 | RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure. |
| Q42230425 | Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action |
| Q38196174 | Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology |
| Q71900148 | Recombinant interleukin-2 acts like a class I antiarrhythmic drug on human cardiac sodium channels |
| Q38035054 | Redox control of cardiac excitability |
| Q57805857 | Regulation and physiological function of Nav1.5 and KCNQ1 channels |
| Q40069459 | Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6. |
| Q57398487 | Replication of Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies |
| Q28359616 | Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels |
| Q84961023 | Role of "non-cardiac" voltage-gated sodium channels in cardiac cells |
| Q38158224 | Role of ion channels in coronary microcirculation: a review of the literature |
| Q36166676 | Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2 |
| Q36822944 | Role of sodium channels in propagation in heart muscle: how subtle genetic alterations result in major arrhythmic disorders |
| Q30858816 | SCN5A is expressed in human jejunal circular smooth muscle cells |
| Q41968270 | SCN5A splicing variants and the possibility of predicting heart failure-associated arrhythmia. |
| Q34827081 | SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study. |
| Q50296980 | SCNAs:SNCBs transport Na+ from extracellular region to cytosol |
| Q42562889 | Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes |
| Q48163837 | Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain. |
| Q40186297 | Serine-401 as a batrachotoxin- and local anesthetic-sensing residue in the human cardiac Na+ channel |
| Q34756665 | Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels |
| Q24684695 | Single-channel properties of human NaV1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsy |
| Q28587543 | Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a |
| Q49908047 | Sodium Channelopathies of Skeletal Muscle. |
| Q37041660 | Sodium channel diversity in the vestibular ganglion: NaV1.5, NaV1.8, and tetrodotoxin-sensitive currents |
| Q48070915 | Sodium channel functioning based on an octagonal structure model |
| Q30305989 | Sodium channel isoform-specific effects of halothane: protein kinase C co-expression and slow inactivation gating |
| Q33163356 | Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation |
| Q27643216 | Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels |
| Q34179823 | State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit |
| Q42861172 | Statistical limits to the identification of ion channel domains by sequence similarity |
| Q34171270 | Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels |
| Q28279905 | Structure and function of splice variants of the cardiac voltage-gated sodium channel Na(v)1.5 |
| Q24314768 | Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells |
| Q33618326 | Structure of the sodium channel pore revealed by serial cysteine mutagenesis. |
| Q40750888 | Structure, function and expression of voltage-dependent sodium channels |
| Q42454898 | Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels |
| Q33951922 | Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels |
| Q41627139 | Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease-Causing Mutation |
| Q30870281 | Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction |
| Q41139993 | TTX-sensitive and -resistant Na+ currents, and mRNA for the TTX-resistant rH1 channel, are expressed in B104 neuroblastoma cells |
| Q37713991 | Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review). |
| Q40504259 | Tandem promoters and developmentally regulated 5'- and 3'-mRNA untranslated regions of the mouse Scn5a cardiac sodium channel |
| Q51532240 | Tetrodotoxin-blockable calcium currents in rat ventricular myocytes; a third type of cardiac cell sodium current. |
| Q40754070 | The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive? |
| Q33869265 | The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4. |
| Q48595392 | The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel |
| Q38585131 | The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology. |
| Q49123469 | The cardiac sodium channel mRNA is expressed in the developing and adult rat and human brain |
| Q28252115 | The genetic basis of Brugada syndrome: a mutation update |
| Q28262724 | The genetic basis of long QT and short QT syndromes: a mutation update |
| Q37011109 | The genetic component of Brugada syndrome |
| Q44714535 | The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity |
| Q36436600 | The human heart and rat brain IIA Na+ channels interact with different molecular regions of the beta1 subunit |
| Q38611594 | The late sodium current in heart failure: pathophysiology and clinical relevance |
| Q33970623 | The long QT syndromes: genetic basis and clinical implications |
| Q77475359 | The molecular basis of long QT syndrome and prospects for therapy |
| Q34178080 | The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels |
| Q36731634 | The promiscuous nature of the cardiac sodium current |
| Q28081627 | The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders |
| Q34161908 | The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. |
| Q37303962 | The sodium channel Nav1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Nav1.5 channel. |
| Q24647082 | The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart |
| Q37730498 | The tetrodotoxin binding site is within the outer vestibule of the sodium channel |
| Q52689608 | The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations. |
| Q40647479 | Tricyclic antidepressants as long-acting local anesthetics |
| Q37540104 | Unfolded protein response regulates cardiac sodium current in systolic human heart failure |
| Q24598512 | Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis |
| Q55279100 | Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology. |
| Q34116066 | Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion |
| Q35667228 | Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects |
| Q38381248 | Voltage-gated sodium channels in the mammalian heart |
| Q42621770 | Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels |
| Q48860850 | cAMP-dependent phosphorylation of two sites in the alpha subunit of the cardiac sodium channel |
| Q37148058 | hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities |
Search more.