Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis

scientific article published on 7 September 2010

Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00359-010-0582-9
P698PubMed publication ID20820785

P50authorDavid K. JonesQ56440773
Christopher A AhernQ57070092
P2093author name stringMaen F Sarhan
Peter C Ruben
Chong Hyun Lee
P2860cites workKcsA crystal structure as framework for a molecular model of the Na(+) channel poreQ73977454
A defect in skeletal muscle sodium channel deactivation exacerbates hyperexcitability in human paramyotonia congenitaQ74315934
Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channelsQ81360756
Mechanisms of Adaptation in a Predator-Prey Arms Race: TTX-Resistant Sodium ChannelsQ22065829
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequencesQ24336098
Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channelQ24563388
Sequence and genomic structure of the human adult skeletal muscle sodium channel alpha subunit gene on 17qQ28208755
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interactionQ28243909
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivationQ28363700
A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neuronsQ28377530
Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene familyQ30436012
Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleQ30447518
Binding properties of (3)H-PbTx-3 and (3)H-saxitoxin to brain membranes and to skeletal muscle membranes of puffer fish Fugu pardalis and the primary structure of a voltage-gated Na(+) channel alpha-subunit (fMNa1) from skeletal muscle of F. pardaliQ30830873
Structure of the sodium channel pore revealed by serial cysteine mutagenesis.Q33618326
Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation.Q33852460
Molecular motions within the pore of voltage-dependent sodium channelsQ33907113
Defective fast inactivation recovery and deactivation account for sodium channel myotonia in the I1160V mutantQ33907568
Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modificationQ33915656
Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysisQ33915721
Voltage-gated sodium channels as therapeutic targetsQ33925684
Interaction between fast and slow inactivation in Skm1 sodium channelsQ34041249
On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channelQ34041257
Steady-state availability of sodium channels. Interactions between activation and slow inactivationQ34088636
Holding potential affects the apparent voltage-sensitivity of sodium channel activation in crayfish giant axonsQ34126640
A mutation in the pore of the sodium channel alters gatingQ34129377
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.Q34169482
Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channelsQ34173224
Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibuleQ34180126
The cooperative voltage sensor motion that gates a potassium channelQ34482244
Na channel inactivation from open and closed statesQ35215140
The permeability of the sodium channel to metal cations in myelinated nerveQ36387879
Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurementsQ36412534
Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the poreQ36416088
A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependenceQ36436280
Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.Q36436547
Role of domain 4 in sodium channel slow inactivationQ36442905
Immobilizing the moving parts of voltage-gated ion channelsQ36444725
How membrane proteins sense voltageQ37114573
The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channelQ37280509
Genetic basis of tetrodotoxin resistance in pufferfishesQ38318555
Two critical residues in p-loop regions of puffer fish Na+ channels on TTX sensitivityQ40037690
Restoration of inactivation and block of open sodium channels by an inactivation gate peptideQ41469205
Functional expression and properties of the human skeletal muscle sodium channelQ41470649
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivationQ41608443
The permeability of the sodium channel to organic cations in myelinated nerveQ41920397
The selectivity filter of the voltage-gated sodium channel is involved in channel activationQ43624026
17 Cut-open oocyte voltage-clamp techniqueQ46504085
SELECTION ON LOCOMOTOR PERFORMANCE CAPACITY IN A NATURAL POPULATION OF GARTER SNAKES.Q46717622
A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive propertiesQ48479782
A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block.Q48628517
Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysisQ48942641
Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.Q49019522
A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivationQ50646634
Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II.Q50796508
TTX Resistivity of Na+Channel in Newt Retinal NeuronQ51533333
A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.Q51744647
COSTS OF EXPLOITING POISONOUS PREY: EVOLUTIONARY TRADE-OFFS IN A PREDATOR-PREY ARMS RACE.Q54101292
P433issue1
P921main subjectcommon garter snakeQ911786
P304page(s)33-43
P577publication date2010-09-07
P1433published inJournal of Comparative PhysiologyQ1709835
P1476titleBiophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis
P478volume197

Reverse relations

cites work (P2860)
Q37735702Behavioral and chemical ecology of marine organisms with respect to tetrodotoxin
Q30424913Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes
Q35897348Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs.
Q30252741Convergent adaptation to dangerous prey proceeds through the same first-step mutation in the garter snake Thamnophis sirtalis
Q57138021Large-effect mutations generate trade-off between predatory and locomotor ability during arms race coevolution with deadly prey
Q30409940Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the garter snake Thamnophis sirtalis
Q24633753The chemical and evolutionary ecology of tetrodotoxin (TTX) toxicity in terrestrial vertebrates
Q34034876The molecular mystique of tetrodotoxin

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