Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis

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Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.125211
P8608Fatcat IDrelease_qtpocoupvfgdvlq3wh67hjomia
P3181OpenCitations bibliographic resource ID2657943
P932PMC publication ID2881780
P698PubMed publication ID20385552

P50authorJan TytgatQ13735914
Alexander VassilevskiQ57089906
P2093author name stringBert Billen
Sarah Debaveye
Eugene Grishin
Anton Nikolsky
P2860cites workPrimary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channelQ24563388
Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainanaQ27642791
Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channelsQ27643216
Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitorsQ27646846
Three-dimensional structure analysis of mu-agatoxins: further evidence for common motifs among neurotoxins with diverse ion channel specificitiesQ27732634
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channelsQ28143653
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Peptide toxins that selectively target insect Na(V) and Ca(V) channelsQ37292215
Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypesQ37433422
Molecular diversity of spider venom.Q37704430
Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugsQ40110329
The insect voltage-gated sodium channel as target of insecticidesQ40824111
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.Q42047248
Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivationQ42676461
Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel functionQ47072615
Expression of functional sodium channels from cloned cDNA.Q48312078
Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IVQ48949713
Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versutaQ50769066
Purification and characterization of Hainantoxin-V, a tetrodotoxin-sensitive sodium channel inhibitor from the venom of the spider Selenocosmia hainanaQ51298694
Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channelsQ51821558
The universal algorithm of maturation for secretory and excretory protein precursors.Q51925906
Two classes of channel-specific toxins from funnel web spider venomQ69590239
Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacologyQ28379056
A novel strategy for the identification of toxinlike structures in spider venom.Q30350110
Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).Q30917272
Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugsQ33271332
Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoformsQ33349649
Purification and characterization of biologically active peptides from spider venomsQ33518680
Comparison of polypeptide compositions from individual Agelena orientalis spider venomsQ33553158
Polypeptide neurotoxins from spider venomsQ33734585
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.Q33925844
Pharmacology and biochemistry of spider venoms.Q34102067
Paralytic and insecticidal toxins from the funnel web spider, Hololena curtaQ34116096
Sodium channels and gating currentsQ34252607
Diversity of folds in animal toxins acting on ion channels.Q34283547
Curtatoxins. Neurotoxic insecticidal polypeptides isolated from the funnel-web spider Hololena curta.Q34300335
Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis apertaQ34311297
A new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain.Q34349090
Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunitQ34384573
A spider toxin that induces a typical effect of scorpion alpha-toxins but competes with beta-toxins on binding to insect sodium channelsQ34389719
Solution structure of two insect-specific spider toxins and their pharmacological interaction with the insect voltage-gated Na+ channelQ34396834
Molecular interaction of delta-conotoxins with voltage-gated sodium channels.Q34430245
Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.Q34479240
Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxinsQ34529515
Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis apertaQ34561468
Insect-selective spider toxins targeting voltage-gated sodium channelsQ34601862
Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channelsQ34708118
An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)].Q35739171
Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel.Q35739174
Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity.Q35792529
Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.Q35792848
Insect sodium channels and insecticide resistanceQ36700565
Peptides of arachnid venoms with insecticidal activity targeting sodium channelsQ36705617
On the opening of voltage-gated ion channels.Q36856732
Conotoxin modulation of voltage-gated sodium channelsQ36976932
Animal peptides targeting voltage-activated sodium channels.Q37264921
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectinsectQ1390
cell biologyQ7141
Agelena orientalisQ2159620
P1104number of pages10
P304page(s)18545-18554
P577publication date2010-04-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleUnique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis
P478volume285

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cites work (P2860)
Q90692344Aspartic Acid Isomerization Characterized by High Definition Mass Spectrometry Significantly Alters the Bioactivity of a Novel Toxin from Poecilotheria
Q35066469Comprehensive analysis of the venom gland transcriptome of the spider Dolomedes fimbriatus
Q46794384Convenient nomenclature of cysteine-rich polypeptide toxins from sea anemones
Q33963196Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.
Q34232755Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels
Q36312190Peptidomic and transcriptomic profiling of four distinct spider venoms
Q28652860Quo vadis venomics? A roadmap to neglected venomous invertebrates
Q37397378Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.
Q37012447Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird Spider Ornithoctonus hainana
Q34801598Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae
Q28660876The first venomous crustacean revealed by transcriptomics and functional morphology: remipede venom glands express a unique toxin cocktail dominated by enzymes and a neurotoxin
Q38092679The insecticidal potential of venom peptides
Q50086110Toxins That Affect Voltage-Gated Sodium Channels

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