Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels

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Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0704361
P932PMC publication ID1573052
P698PubMed publication ID11704639
P5875ResearchGate publication ID11649544

P50authorCésar BatistaQ44172191
P2093author name stringL D Possani
J Alvarez
C Goudet
T Ferrer
J Tytgat
A Aneiros
A Artiles
L Galàn
P2860cites workImproved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channelQ24563388
Refined structure in solution of the sea anemone neurotoxin ShIQ27730435
Characteristics of Ca2+ channel blockade by oxodipine and elgodipine in rat cardiomyocytesQ77465190
Nomenclature of voltage-gated sodium channelsQ28141860
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channelsQ28143653
Scorpion toxins specific for Na+-channelsQ28144635
Structure and function of the cardiac sodium channelsQ33758984
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.Q33925844
Structure, function and pharmacology of voltage-gated sodium channelsQ34118877
Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin-B.Q34199078
Cardiotonic polypeptides from Anthopleura xanthogrammica (Brandt) and A. elegantissima (Brandt)Q34246159
Structure and function of voltage-gated ion channelsQ34296742
A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activityQ34334967
Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunitQ34384573
Functional architectures of animal toxins: a clue to drug design?Q34477553
Structure and structure-function relationships of sea anemone proteins that interact with the sodium channelQ34550953
Mechanical and electrophysiological effects of sea anemone (Anemonia sulcata) toxins on rat innervated and denervated skeletal muscleQ36128692
The use of Xenopus oocytes for the study of ion channels.Q38184933
Amino-Acid Sequence of a Coelenterate Toxin: Toxin II from Anemonia sulcataQ39112706
A polypeptide (AP-A) from sea anemone (Anthopleura xanthogrammica) with potent positive inotropic actionQ39118414
Electromechanical studies of an Anemonia sulcata toxin in mammalian cardiac muscleQ39132880
Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin AQ39135450
Amino-Acid Sequence of Toxin I from Anemonia sulcataQ39212772
Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel alpha-subunits expressed in tsA201 cellsQ41190309
Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus and Actinodendron plumosumQ41468516
Emerging tandem-mass-spectrometry techniques for the rapid identification of proteinsQ41627287
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.Q42604432
Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivationQ42676461
Polypeptide toxins as tools to study voltage-sensitive Na+ channelsQ48423220
Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.Q49019522
Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.Q50769066
Properties of maintained sodium current induced by a toxin from Androctonus scorpion in frog node of Ranvier.Q51795477
The interaction of polypeptide neurotoxins with tetrodotoxin-resistant Na+ channels in mammalian cardiac cells. Correlation with inotropic and arrhythmic effects.Q51814606
Modification of sodium channels in myelinated nerve by Anemonia sulcata toxin IIQ52738380
Changes in electrical and mechanical activities of rabbit papillary muscle during hypoxic perfusion.Q54537766
Functional Anatomy of Scorpion Toxins Affecting Sodium ChannelsQ56687942
Isolation and characterisation of five neurotoxic and cardiotoxic polypeptides from the sea anemone Anthopleura elegantissimaQ57807836
Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthusQ69371464
The potent excitatory effect of a novel polypeptide, anthopleurin-B, isolated from a sea anemone (Anthopleura xanthogrammica) on the frog spinal cordQ72612026
Positively charged amino acid residues located similarly in sea anemone and scorpion toxinsQ72680294
Differences in the binding sites of two site-3 sodium channel toxinsQ73718150
Effects of a toxin from the mucus of the Caribbean sea anemone (Bunodosoma granulifera) on the ionic currents of single ventricular mammalian cardiomyocytesQ74240945
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectBunodosoma granuliferaQ2464744
P304page(s)1195-1206
P577publication date2001-11-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleCharacterization of two Bunodosoma granulifera toxins active on cardiac sodium channels
P478volume134

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cites work (P2860)
Q34323654Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop.
Q27644801CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties 1
Q33402623Exploiting the nephrotoxic effects of venom from the sea anemone, Phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat
Q56993044NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS
Q35792848Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.
Q36267779Sodium channel inactivation: molecular determinants and modulation
Q34161908The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins.
Q48844320Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels

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