Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels

scientific article published in December 2002

Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-291X(02)02706-7
P698PubMed publication ID12459175

P50authorJan TytgatQ13735914
Lourival Possani PostayQ16593662
Ignacio López-GonzálezQ42700636
Ricardo FelixQ59594330
Timoteo Olamendi-PortugalQ115787610
Jurg van der WaltQ123124449
Karin DyasonQ123124468
P2093author name stringAlberto Darszon
Chris Ulens
Blanca Inés García
P2860cites workScorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscleQ24562334
NMR solution structure of butantoxinQ27625026
Scorpion toxins specific for Na+-channelsQ28144635
Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channelsQ28363715
Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom.Q30810564
Genes and peptides from the scorpion Centruroides sculpturatus Ewing, that recognize Na(+)-channelsQ31015919
A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamiliesQ33878580
Peptides and genes coding for scorpion toxins that affect ion-channels.Q34086633
The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperatorQ34422753
Electrostatic distance geometry in a K+ channel vestibuleQ35792758
Activation of mouse sperm T-type Ca2+ channels by adhesion to the egg zona pellucidaQ36686734
Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels.Q40653150
Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibuleQ40657689
Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurusQ41841592
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.Q42604432
Two similar peptides from the venom of the scorpion Pandinus imperator, one highly effective blocker and the other inactive on K+ channelsQ48434499
Inhibition of T-type voltage-gated calcium channels by a new scorpion toxinQ48921080
Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.Q49057197
Functional Anatomy of Scorpion Toxins Affecting Sodium ChannelsQ56687942
Scorpion toxins that block T-type Ca2+ channels in spermatogenic cells inhibit the sperm acrosome reactionQ60708378
Dual regulation of the T-type Ca2+ current by serum albumin and β-estradiol in mammalian spermatogenic cellsQ60708401
T-type Ca2+ channels and alpha1E expression in spermatogenic cells, and their possible relevance to the sperm acrosome reactionQ71215338
Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptorsQ73235365
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)562-568
P577publication date2002-12-01
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleTwo new scorpion toxins that target voltage-gated Ca2+ and Na+ channels
P478volume299

Reverse relations

cites work (P2860)
Q46243051A Deeper Examination of Thorellius atrox Scorpion Venom Components with Omic Techonologies
Q34270288A Subfamily of Acidic α-K+ Toxins
Q41836715Actions of kurtoxin on tetrodotoxin-sensitive voltage-gated Na+ currents, NaV1.6, in murine vas deferens myocytes
Q57041975CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells
Q36083460Calcium channels and Ca2+ fluctuations in sperm physiology
Q34052215Calcium channels in the development, maturation, and function of spermatozoa
Q34283547Diversity of folds in animal toxins acting on ion channels.
Q34805577Mass fingerprinting of the venom and transcriptome of venom gland of scorpion Centruroides tecomanus
Q36012070Molecular mechanism of scorpion neurotoxins acting on sodium channels: insight into their diverse selectivity
Q36252140Molecular regulation of voltage-gated Ca2+ channels
Q47383499NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity.
Q37415013Neuroprotective effects of blockers for T-type calcium channels.
Q52654024Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus.
Q34291786Profiling the resting venom gland of the scorpion Tityus stigmurus through a transcriptomic survey.
Q60708378Scorpion toxins that block T-type Ca2+ channels in spermatogenic cells inhibit the sperm acrosome reaction
Q38193329T-type Ca2+ channels in spermatogenic cells and sperm
Q36437519Targeting N-type and T-type calcium channels for the treatment of pain
Q26781422The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential
Q36804457Towards the discovery of novel T-type calcium channel blockers.

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