Synergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin

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Synergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1014759607
P356DOI10.1038/SREP09241
P932PMC publication ID4363837
P698PubMed publication ID25784299
P5875ResearchGate publication ID273785239

P2093author name stringBo Chen
Zhonghua Liu
Ying Huang
Xi Zhou
Cheng Tang
Songping Liang
Zhaohua Xiao
Changxin Zhang
Yunxiao Zhang
Zhaotun Hu
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Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurementsQ36412534
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The role of sodium channels in neuropathic painQ36661957
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configurationQ36914467
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Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird Spider Ornithoctonus hainanaQ37012447
The cardiac persistent sodium current: an appealing therapeutic target?Q37028768
Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.Q37055488
Persistent Na-channels: origin and function. A reviewQ37225805
Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysisQ39732040
Kinetic Diversity of Single-Channel Burst Openings Underlying Persistent Na+ Current in Entorhinal Cortex NeuronsQ40260249
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Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.Q40788199
Ranolazine selectively blocks persistent current evoked by epilepsy‐associated NaV1.1 mutationsQ41121995
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivationQ41608443
The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regionsQ41854535
Fine gating properties of channels responsible for persistent sodium current generation in entorhinal cortex neuronsQ41939072
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.Q42047248
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currentsQ42946073
Contribution of persistent sodium currents to spike-frequency adaptation in rat hypoglossal motoneuronsQ45050755
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in ratsQ46629853
High conductance sustained single-channel activity responsible for the low-threshold persistent Na(+) current in entorhinal cortex neuronsQ48129045
Sodium currents in neurons from the rostroventrolateral medulla of the rat.Q48304035
An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticusQ48316462
Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex.Q48341696
Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitroQ48586529
A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxinsQ48639787
Substance P potentiates ATP-activated currents in rat primary sensory neuronsQ48862931
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)9241
P577publication date2015-03-18
P1433published inScientific ReportsQ2261792
P1476titleSynergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin
P478volume5

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cites work (P2860)
Q52568373A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line
Q56232635Mutations in SCN3A cause early infantile epileptic encephalopathy
Q91905263Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8.
Q57479263Purification and Characterization of JZTx-14, a Potent Antagonist of Mammalian and Prokaryotic Voltage-Gated Sodium Channels

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