PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice.

scientific article

PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI61934
P932PMC publication ID3315445
P698PubMed publication ID22426212

P50authorRobert O MessingQ57235643
Sulayman D Dib-HajjQ85290384
Stephen G WaxmanQ91085251
P2093author name stringDan Wang
Thomas McMahon
Dai-Fei Wu
Ying-Jian Liang
Jahan Dadgar
Viktor N Kharazia
Dave Chandra
P2860cites workSexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathyQ44479854
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Ethanol withdrawal induces hyperalgesia mediated by PKCepsilonQ46413787
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat.Q46510069
Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neuronsQ46691815
Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neuronsQ47664856
Functional modulation of brain sodium channels by protein kinase C phosphorylationQ48640678
Functional effects of protein kinase C activation on the human cardiac Na+ channelQ48793689
Novel cell lines display properties of nociceptive sensory neurons.Q53505102
Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury.Q54645641
Reduced Nerve Injury-Induced Neuropathic Pain in Kinin B1 Receptor Knock-Out MiceQ56963543
Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful HeatQ58792194
Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinaseQ70473890
Diacylglycerol-induced activation of protein kinase C attenuates Na+ currents by enhancing inactivation from the closed stateQ72634868
A method for global analysis of complex proteomes using sample prefractionation by solution isoelectrofocusing prior to two-dimensional electrophoresisQ74240323
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocationQ28146064
Neuromodulation of Na+ channels: an unexpected form of cellular plasticityQ28199083
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neuronsQ28377530
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunitsQ28504846
Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesiaQ28569084
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neuronsQ28570486
ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1Q28584265
Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brainQ33770959
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathwaysQ33871067
A semisynthetic epitope for kinase substrates.Q34100971
Voltage-gated sodium channels and hyperalgesiaQ34292572
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperaturesQ34637485
Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neuronsQ35037133
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).Q36350876
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neuronsQ36678533
Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C.Q37116100
PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neuronsQ37274046
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.Q37372705
Activation of the TRPV4 ion channel is enhanced by phosphorylation.Q37459860
Sodium channels in normal and pathological painQ37724336
Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase CQ39593951
Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channelQ39756856
Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channelsQ40226703
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and miceQ40263672
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800.Q40299929
Functional role of the C-terminus of voltage-gated sodium channel Na(v)1.8.Q40526727
Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23.Q40587740
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residuesQ40746070
Voltage-dependent neuromodulation of Na+ channels by D1-like dopamine receptors in rat hippocampal neuronsQ40946719
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant miceQ41719698
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.Q41740218
cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS.Q42469507
Vincristine hyperalgesia in the rat: a model of painful vincristine neuropathy in humansQ42554374
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channelsQ43766310
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.Q43818810
A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators.Q43998221
Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15.Q44163841
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)1306-1315
P577publication date2012-03-19
P1433published inJournal of Clinical InvestigationQ3186904
P1476titlePKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice
P478volume122

Reverse relations

cites work (P2860)
Q95645355Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis
Q37601736CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure
Q37675582Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain.
Q37637997Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice
Q37336340Electrophysiological correlates of hyperalgesic priming in vitro and in vivo
Q54116541Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway.
Q35002775Generation and characterization of ATP analog-specific protein kinase Cδ.
Q34957602Increased BDNF protein expression after ischemic or PKC epsilon preconditioning promotes electrophysiologic changes that lead to neuroprotection
Q34455470Inhibition of tetrodotoxin-resistant sodium current in dorsal root ganglia neurons mediated by D1/D5 dopamine receptors
Q40842430PKC-NF-κB are involved in CCL2-induced Nav1.8 expression and channel function in dorsal root ganglion neurons
Q36249467Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes
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Q37093923Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs
Q57184982Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury
Q35001326Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat
Q38789318Role of reactive oxygen species and TRP channels in the cough reflex
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Q33584619Sensory nerve terminal mitochondrial dysfunction induces hyperexcitability in airway nociceptors via protein kinase C
Q33600859Targeting ASIC3 for Relieving Mice Fibromyalgia Pain: Roles of Electroacupuncture, Opioid, and Adenosine
Q33888667Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins.

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