Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV

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Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.246876
P932PMC publication ID3149324
P698PubMed publication ID21659528

P50authorTheodore R CumminsQ90928923
P2093author name stringSongping Liang
Yucheng Xiao
James O Jackson
P2860cites workFunction and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwenaQ27639643
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channelsQ28143653
From genes to pain: Na v 1.7 and human pain disordersQ28254063
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
An SCN9A channelopathy causes congenital inability to experience painQ28278844
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Targeting voltage sensors in sodium channels with spider toxins.Q33759435
A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venomQ34331989
The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and InactivationQ34359543
Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunitQ34384573
Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.Q34479240
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disordersQ34585790
The roles of sodium channels in nociception: Implications for mechanisms of painQ34674268
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.Q35001630
Voltage-gated sodium channel toxins: poisons, probes, and future promiseQ35141466
Mechanisms of sodium channel inactivationQ35172793
Sodium-mediated axonal degeneration in inflammatory demyelinating disease.Q36127890
Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channelsQ36205258
Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domainsQ36435921
Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxinQ36436376
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configurationQ36914467
Deconstructing voltage sensor function and pharmacology in sodium channelsQ36983062
Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxinsQ37344014
ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.Q38288024
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channelsQ40131479
Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.Q40397576
The human skeletal muscle Na channel mutation R669H associated with hypokalemic periodic paralysis enhances slow inactivation.Q40907023
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivationQ41608443
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.Q42047248
Closing in on the resting state of the Shaker K(+) channel.Q42633636
Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channelsQ44822076
Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channelsQ46870452
The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neuronsQ48604057
Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels.Q50641403
Comparative pharmacology and cloning of two novel arachnid sodium channels: Exploring the adaptive insensitivity of scorpion to its toxinsQ79997064
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectvoltageQ25428
P304page(s)27301-27310
P577publication date2011-06-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleCommon molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV
P478volume286

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cites work (P2860)
Q27684660A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a
Q38040330Advances in targeting voltage-gated sodium channels with small molecules
Q27678595Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)
Q38204930Animal toxins influence voltage-gated sodium channel function.
Q36110521Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB.
Q34973773Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics
Q47732599Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies.
Q28587362Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currents
Q26864410From foe to friend: using animal toxins to investigate ion channel function
Q34024636Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins
Q33744738Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri
Q90089706Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.
Q37291159Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels.
Q28831151Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami
Q34795674Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel
Q49375959Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain
Q35538490Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach
Q52325902Spider toxin inhibits gating pore currents underlying periodic paralysis.
Q92839087Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Q37012447Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana
Q34801598Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae
Q36310578The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
Q33681373The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.
Q33784251Toxin diversity revealed by a transcriptomic study of Ornithoctonus huwena
Q63396036Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy

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