scholarly article | Q13442814 |
P50 | author | Theodore R Cummins | Q90928923 |
P2093 | author name string | Songping Liang | |
Yucheng Xiao | |||
James O. Jackson | |||
P2860 | cites work | Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena | Q27639643 |
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From genes to pain: Na v 1.7 and human pain disorders | Q28254063 | ||
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel | Q28260421 | ||
An SCN9A channelopathy causes congenital inability to experience pain | Q28278844 | ||
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels | Q28289125 | ||
Targeting voltage sensors in sodium channels with spider toxins. | Q33759435 | ||
A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom | Q34331989 | ||
The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation | Q34359543 | ||
Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit | Q34384573 | ||
Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II. | Q34479240 | ||
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders | Q34585790 | ||
The roles of sodium channels in nociception: Implications for mechanisms of pain | Q34674268 | ||
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. | Q35001630 | ||
Voltage-gated sodium channel toxins: poisons, probes, and future promise | Q35141466 | ||
Mechanisms of sodium channel inactivation | Q35172793 | ||
Sodium-mediated axonal degeneration in inflammatory demyelinating disease. | Q36127890 | ||
Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca 2+ and K + channels | Q36205258 | ||
Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains | Q36435921 | ||
Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxin | Q36436376 | ||
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration | Q36914467 | ||
Deconstructing voltage sensor function and pharmacology in sodium channels | Q36983062 | ||
Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins | Q37344014 | ||
ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. | Q38288024 | ||
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels | Q40131479 | ||
Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels. | Q40397576 | ||
The human skeletal muscle Na channel mutation R669H associated with hypokalemic periodic paralysis enhances slow inactivation. | Q40907023 | ||
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation | Q41608443 | ||
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel. | Q42047248 | ||
Closing in on the resting state of the Shaker K(+) channel. | Q42633636 | ||
Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels | Q44822076 | ||
Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels | Q46870452 | ||
The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons | Q48604057 | ||
Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels | Q50641403 | ||
Comparative pharmacology and cloning of two novel arachnid sodium channels: Exploring the adaptive insensitivity of scorpion to its toxins | Q79997064 | ||
P433 | issue | 31 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | voltage | Q25428 |
P304 | page(s) | 27301-27310 | |
P577 | publication date | 2011-06-09 | |
P1433 | published in | Journal of Biological Chemistry | Q867727 |
P1476 | title | Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV | |
Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+ Channel Voltage Sensors in Domains II and IV | |||
P478 | volume | 286 |
Q27684660 | A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a |
Q38040330 | Advances in Targeting Voltage‐Gated Sodium Channels with Small Molecules |
Q27678595 | Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a) |
Q38204930 | Animal toxins influence voltage-gated sodium channel function. |
Q36110521 | Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. |
Q34973773 | Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics |
Q47732599 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. |
Q28587362 | Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currents |
Q26864410 | From foe to friend: using animal toxins to investigate ion channel function |
Q34024636 | Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins |
Q33744738 | Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri |
Q90089706 | Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. |
Q37291159 | Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels. |
Q28831151 | Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami |
Q34795674 | Native Pyroglutamation of Huwentoxin-IV: A Post-Translational Modification that Increases the Trapping Ability to the Sodium Channel |
Q49375959 | Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain |
Q35538490 | Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach |
Q52325902 | Spider toxin inhibits gating pore currents underlying periodic paralysis |
Q92839087 | Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities |
Q37012447 | Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird Spider Ornithoctonus hainana |
Q34801598 | Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae |
Q34751721 | Synthesis and biological characterization of synthetic analogs of Huwentoxin-IV (Mu-theraphotoxin-Hh2a), a neuronal tetrodotoxin-sensitive sodium channel inhibitor |
Q36310578 | The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant. |
Q33681373 | The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. |
Q33784251 | Toxin diversity revealed by a transcriptomic study of Ornithoctonus huwena |
Q63396036 | Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy |
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