Characterization of a novel BmαTX47 toxin modulating sodium channels: the crucial role of expression vectors in toxin pharmacological activity

scientific article published on 26 February 2014

Characterization of a novel BmαTX47 toxin modulating sodium channels: the crucial role of expression vectors in toxin pharmacological activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/TOXINS6030816
P932PMC publication ID3968363
P698PubMed publication ID24577584
P5875ResearchGate publication ID260430788

P2093author name stringTian Li
Wenxin Li
Yawen He
Songping Liang
Yingliang Wu
Lingna Xu
Honglian Liu
P2860cites workStructural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.Q50656863
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Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh alphaITQ73457797
Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3Q77067706
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Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenalQ27488936
X-ray structure and mutagenesis of the scorpion depressant toxin LqhIT2 reveals key determinants crucial for activity and anti-insect selectivityQ27643290
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Structural and Functional Diversity of Acidic Scorpion Potassium Channel ToxinsQ27678594
Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1Q27684283
NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeusQ27766732
Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune diseaseQ28280077
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variantsQ28504505
Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii KarschQ33254164
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ImKTx1, a new Kv1.3 channel blocker with a unique primary structureQ33817224
SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venomQ34075733
Voltage-gated ion channels and gating modifier toxins.Q34161355
Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin familyQ34166046
Voltage-gated sodium channels at 60: structure, function and pathophysiologyQ34265707
Makatoxin I, a novel toxin isolated from the venom of the scorpion Buthus martensi Karsch, exhibits nitrergic actionsQ34420065
Voltage-gated sodium channel modulation by scorpion alpha-toxinsQ34579624
Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channelsQ35266412
Covalent labeling of protein components of the sodium channel with a photoactivable derivative of scorpion toxinQ36353987
Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.Q36436547
Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxinsQ37344014
Molecular basis of the high insecticidal potency of scorpion alpha-toxinsQ38341470
Molecular basis of charge movement in voltage-gated sodium channelsQ41254973
Interaction of scorpion alpha-toxins with cardiac sodium channels: binding properties and enhancement of slow inactivationQ41949009
Recombinant expression, purification, and characterization of scorpion toxin BmαTX14.Q43823781
Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-ButhidaeQ43839768
Cloning and expression of Buthus martensii Karsch scorpion toxin gene (BmK IT3) in Escherichia coliQ43971957
Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesisQ44181931
Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3.Q44772923
Positions under positive selection--key for selectivity and potency of scorpion alpha-toxinsQ45351268
Two recombinant α-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channelsQ45414902
A scorpion alpha-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons.Q48094049
The unique pharmacology of the scorpion alpha-like toxin Lqh3 is associated with its flexible C-tail.Q48245058
Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.Q48830408
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P921main subjectpharmacologyQ128406
P304page(s)816-829
P577publication date2014-02-26
P1433published inToxinsQ15724569
P1476titleCharacterization of a novel BmαTX47 toxin modulating sodium channels: the crucial role of expression vectors in toxin pharmacological activity
P478volume6

Reverse relations

Q89170434Mouse β-Defensin 3, A Defensin Inhibitor of Both Its Endogenous and Exogenous Potassium Channelscites workP2860

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