Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression

scientific article published on 12 March 2015

Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M114.617092
P8608Fatcat IDrelease_mfzzfru4jfef3fdfdz43w4wcym
P932PMC publication ID4424341
P698PubMed publication ID25767117

P50authorFrancis Chee Kuan TanQ47339778
Gavin S. DaweQ56065856
P2093author name stringChao Liu
Zhi-Cheng Xiao
P2860cites workSynapse Formation and Function Is Modulated by the Amyloid Precursor ProteinQ22241520
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's diseaseQ24298553
AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of RanvierQ24311821
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer modelQ24603560
Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardationQ43168798
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).Q43516562
Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.Q43556227
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.Q44299710
Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not PolyubiquitylationQ44420471
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.Q46084355
Sodium channel activity modulates multiple functions in microgliaQ46179678
Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neuronsQ46466583
Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.Q46535530
Impaired firing and cell-specific compensation in neurons lacking nav1.6 sodium channels.Q47850400
c-Jun phosphorylation in Alzheimer diseaseQ48190468
Formation and maturation of synapses in primary cultures of rat cerebral cortical cells: an electron microscopic studyQ48340777
Dissociated cortical networks show spontaneously correlated activity patterns during in vitro developmentQ48531694
Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant MiceQ48601594
Persistent Sodium Currents through Brain Sodium Channels Induced by G Protein βγ SubunitsQ48643992
Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.Q48683657
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's diseaseQ48920532
Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates.Q48939471
In Vitro Phosphorylation of the Cytoplasmic Domain of the Amyloid Precursor Protein by Glycogen Synthase Kinase-3βQ56591577
Polarized distribution of ion channels within microdomains of the axon initial segmentQ79366632
Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapsesQ24653551
Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunitsQ27865299
De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEPQ28111582
Nomenclature of voltage-gated sodium channelsQ28141860
Signal transduction by the JNK group of MAP kinasesQ28142592
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memoryQ28202553
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system functionQ28289375
Modulation of rat cardiac sodium channel by the stimulatory G protein alpha subunitQ28579766
Interaction of voltage-gated sodium channel Nav1.6 (SCN8A) with microtubule-associated protein Map1bQ28587249
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
Direct observation of individual endogenous protein complexes in situ by proximity ligationQ29616032
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formationQ29616564
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradationQ29622825
The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular traffickingQ30487520
Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal networkQ30498362
Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).Q33888893
Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.Q33913155
Prostaglandin E2 promotes Na1.8 trafficking via its intracellular RRR motif through the protein kinase A pathwayQ34089500
Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disabilityQ34382820
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3betaQ34393147
Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.Q35709838
Subunit dependence of Na channel slow inactivation and open channel block in cerebellar neuronsQ35774461
Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functionsQ35993999
Amyloid precursor protein at node of Ranvier modulates nodal formationQ36124650
JNK signalling: a possible target to prevent neurodegeneration.Q36855703
Role of the terminal domains in sodium channel localization.Q37448824
Cytosolic Na+ controls and epithelial Na+ channel via the Go guanine nucleotide-binding regulatory proteinQ37464157
Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neuronsQ37617388
Sodium channels and microglial functionQ37943907
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)Q38321052
Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface deliveryQ39790331
Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brainQ40719915
The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transductionQ42468094
APP processing is regulated by cytoplasmic phosphorylationQ42917696
The effects of amyloid precursor protein on postsynaptic composition and activity.Q43009196
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)12048-12057
P577publication date2015-03-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleAmyloid precursor protein enhances Nav1.6 sodium channel cell surface expression
P478volume290

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cites work (P2860)
Q47296024APP upregulation contributes to retinal ganglion cell degeneration via JNK3.
Q37529350Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway
Q90183474Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model
Q89971236An alternative mechanism of early nodal clustering and myelination onset in GABAergic neurons of the central nervous system
Q36665599Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1-42.
Q83225902Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls
Q37460683Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis
Q38403275Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.
Q39292465The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms
Q30835774The kinetochore-dependent and -independent formation of the CDC20-MAD2 complex and its functions in HeLa cells

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