The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

scientific article published on 24 April 2017

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNCEL.2017.00115
P932PMC publication ID5403416
P698PubMed publication ID28484374

P50authorJeffrey Lopez-RojasQ64539236
P2093author name stringMichael R Kreutz
Maël Duménieu
Marie Oulé
P2860cites workExcitable domains of myelinated nerves: axon initial segments and nodes of Ranvier.Q50710685
Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy.Q51625741
Excitable dendrites and spines: earlier theoretical insights elucidate recent direct observations.Q51647034
A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.Q51779695
Voltage-gated ion channels in dendrites of hippocampal pyramidal neurons.Q51982127
Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation.Q52007593
The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK.Q52023256
Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve.Q52134357
A novel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons.Q52170023
Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier.Q52551533
Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons.Q53746443
Frequency-dependent regulation of rat hippocampal somato-dendritic excitability by the K+ channel subunit Kv2.1Q57318205
Kv4.2 Phosphorylation by Cyclic AMP-dependent Protein KinaseQ58192845
Differential subcellular localization of the RI and RII Na+ channel subtypes in central neuronsQ69366003
Clustered voltage-gated Na+ channels in Aplysia axonsQ71446860
Immunolocalization of sodium channel isoform NaCh6 in the nervous systemQ73616885
Polarized distribution of ion channels within microdomains of the axon initial segmentQ79366632
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neuronesQ81508652
Effect of clustered ion channels along an unmyelinated axonQ84599351
Modulation of A-type potassium channels by a family of calcium sensorsQ22253194
Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gatingQ24291088
DPP10 modulates Kv4-mediated A-type potassium channelsQ24292726
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1Q24321543
Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domainQ24531839
Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapsesQ24653551
Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-RQ24657606
Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibersQ24675297
Neurofascin assembles a specialized extracellular matrix at the axon initial segmentQ24682746
Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domainQ24685559
Neurotransmitter release: the last millisecond in the life of a synaptic vesicleQ26269845
Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron PolarityQ26738910
Potassium Channels and Human Epileptic Phenotypes: An Updated OverviewQ26750434
Mechanisms of sodium channel clustering and its influence on axonal impulse conductionQ26777940
Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neuronsQ26783929
Trafficking mechanisms underlying neuronal voltage-gated ion channel localization at the axon initial segmentQ26829715
Tenascin-C: Form versus functionQ27023815
Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticityQ27318598
Induction of stable ER-plasma-membrane junctions by Kv2.1 potassium channels.Q27340834
Homophilic Adhesion Mechanism of Neurofascin, a Member of the L1 Family of Neural Cell Adhesion MoleculesQ27665583
Structural and Functional Plasticity at the Axon Initial SegmentQ28074870
Sodium channel β subunits: emerging targets in channelopathiesQ28082122
Identification of the Kv2.1 K+ channel as a major component of the delayed rectifier K+ current in rat hippocampal neuronsQ28137617
Subunit composition determines Kv1 potassium channel surface expressionQ28140885
Diversity and dynamics of dendritic signalingQ28142303
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channelsQ28143653
Molecular physiology and modulation of somatodendritic A-type potassium channelsQ35958045
Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neuronsQ36076161
Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel.Q36132382
Plasticity of dendritic functionQ36142848
An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of RanvierQ36146107
Subunit-dependent axonal trafficking of distinct alpha heteromeric potassium channel complexesQ36153384
Unique somato-dendritic distribution pattern of Kv4.2 channels on hippocampal CA1 pyramidal cellsQ36193381
Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channelQ36257767
Endocytotic elimination and domain-selective tethering constitute a potential mechanism of protein segregation at the axonal initial segment.Q36322188
AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related PhenotypesQ36377899
The distribution and targeting of neuronal voltage-gated ion channelsQ36514764
Functional maps within a single neuron.Q36533223
Phosphorylation of K+ channels at single residues regulates memory formationQ36690939
Sodium channels and multiple sclerosis: roles in symptom production, damage and therapy.Q36771880
Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 actionQ36905057
CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitabilityQ36913792
Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neuronsQ36956963
AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity.Q36972640
Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G.Q37010706
Regulation of Kv2.1 K(+) conductance by cell surface channel densityQ37012313
Potassium channels: newly found players in synaptic plasticityQ37138885
Plasticity of intrinsic neuronal properties in CNS disordersQ37143124
Protein kinase a mediates activity-dependent Kv4.2 channel traffickingQ37149483
Kv4.2 is a locus for PKC and ERK/MAPK cross-talkQ37212567
NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retinaQ37220040
The functional organization and assembly of the axon initial segment.Q37272829
Voltage-gated potassium channel as a facilitator of exocytosis.Q37374896
Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated Ih channelsQ37416357
Immunological identification and characterization of a delayed rectifier K+ channel polypeptide in rat brainQ37634866
Microtubules in neurons as information carriers.Q37692740
NaV1.1 channels and epilepsyQ37701079
Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders.Q37714086
Organisation of potassium channels on the neuronal surfaceQ37719019
PSD-95 and SAP97 exhibit distinct mechanisms for regulating K(+) channel surface expression and clusteringQ35512429
Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expressionQ35583086
Short- and long-term plasticity at the axon initial segmentQ35597545
Localization of voltage-gated ion channels in mammalian brainQ35672531
Alterations of A-type potassium channels in hippocampal neurons after traumatic brain injuryQ35831901
A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channelsQ28182481
Contactin associates with Na+ channels and increases their functional expressionQ28188411
A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channelsQ28191498
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brainQ28281102
Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brainQ28504896
ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axonsQ28505131
Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct bindingQ28505343
DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neuronsQ28505997
A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of RanvierQ28507204
AMIGO is an auxiliary subunit of the Kv2.1 potassium channelQ28510051
SAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: regulation by CaMKIIQ28564981
Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cellsQ28566731
The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channelsQ28568564
The role of Kif5B in axonal localization of Kv1 K(+) channelsQ28572501
Kv2.1 cell surface clusters are insertion platforms for ion channel delivery to the plasma membraneQ28575863
Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targetingQ28577143
The Kv2.1 K+ channel targets to the axon initial segment of hippocampal and cortical neurons in culture and in situQ28577741
Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neuronesQ28579059
End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segmentQ28580184
KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8Q28581622
Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neuronsQ28581923
Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutationQ28587835
A role for Kif17 in transport of Kv4.2Q28590946
The anchoring protein SAP97 influences the trafficking and localisation of multiple membrane channelsQ30009893
Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexityQ30393321
Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuitQ30398136
Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing.Q30402999
Kv4.2 knockout mice have hippocampal-dependent learning and memory deficitsQ30455051
Localization and targeting of voltage-dependent ion channels in mammalian central neurons.Q30492681
Myosin-dependent targeting of transmembrane proteins to neuronal dendritesQ30496554
Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels.Q30534454
Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubsQ30543827
Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.Q30574903
Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus.Q46310717
Is action potential threshold lowest in the axon?Q46330889
Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neuronsQ46568281
The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.Q46613601
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in ratsQ46629853
Expression and biophysical properties of Kv1 channels in supragranular neocortical pyramidal neuronesQ46864586
Evolutionary analysis of voltage-gated potassium channels by Bayes method.Q46961964
Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brainQ48140249
A targeting motif involved in sodium channel clustering at the axonal initial segmentQ48269160
Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neuronsQ48327070
Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons.Q48361408
Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conductionQ48460269
CK2 accumulation at the axon initial segment depends on sodium channel Nav1.Q48612471
K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neuronsQ48681398
Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neuronesQ48903952
Genetic modifiers of the Kv beta2-null phenotype in miceQ49034815
Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segmentsQ49092166
Axon initial segment dysfunction in epilepsyQ37726585
Ancillary subunits associated with voltage-dependent K+ channelsQ37731213
Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and diseaseQ37769877
Plasticity of voltage-gated ion channels in pyramidal cell dendritesQ37778461
Differential subcellular distribution of ion channels and the diversity of neuronal function.Q37950205
The axon initial segment in nervous system disease and injuryQ37958904
Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies.Q38026557
Fusion pores, SNAREs, and exocytosis.Q38047266
The node of Ranvier in CNS pathologyQ38218918
A new look at sodium channel β subunitsQ38310610
Subcellular patterning: axonal domains with specialized structure and function.Q38364754
Activity-dependent regulation of excitable axonal domainsQ38606580
Dendritic integration: 60 years of progressQ38647300
Voltage-Gated Na+ Channels: Not Just for ConductionQ38851171
Formation and disruption of functional domains in myelinated CNS axonsQ38975389
Identification of an axonal determinant in the C-terminus of the sodium channel Na(v)1.2.Q39646033
A cytoskeletal-based perimeter fence selectively corrals a sub-population of cell surface Kv2.1 channelsQ40112420
Kv2.1 potassium channels are retained within dynamic cell surface microdomains that are defined by a perimeter fence.Q40229369
Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion moleculesQ40507834
Location-dependent synaptic plasticity rules by dendritic spine cooperativityQ40615185
Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brainQ40719915
Kv beta subunit oxidoreductase activity and Kv1 potassium channel trafficking.Q40762585
Surface expression of Kv1 channels is governed by a C-terminal motifQ40886754
Potassium channel alpha and beta subunits assemble in the endoplasmic reticulumQ41132343
Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic NanoclustersQ41168552
Beta subunits promote K+ channel surface expression through effects early in biosynthesisQ41212377
Homophilic and heterophilic binding activities of Nr-CAM, a nervous system cell adhesion moleculeQ41599432
Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.Q41833439
Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike FiringQ41870709
A unique ion channel clustering domain on the axon initial segment of mammalian neurons.Q41875532
Anti-DPPX encephalitis: pathogenic effects of antibodies on gut and brain neurons.Q42096185
Localization of Nav1.5 sodium channel protein in the mouse brainQ42128374
Dynamic localization and clustering of dendritic Kv2.1 voltage-dependent potassium channels in developing hippocampal neurons.Q42513909
Cell-type-dependent molecular composition of the axon initial segmentQ42566165
Who let the spikes out?Q42719200
Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells.Q42853922
Saltatory conduction in unmyelinated axons: clustering of Na(+) channels on lipid rafts enables micro-saltatory conduction in C-fibersQ42942478
Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticusQ43132307
A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation.Q44085170
Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation.Q44116181
An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targetingQ44319797
Interplay between activation of GIRK current and deactivation of Ih modifies temporal integration of excitatory input in CA1 pyramidal cellsQ44336712
Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.Q44376585
Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents.Q44835132
Regulation of ion channel localization and phosphorylation by neuronal activityQ44934809
Compartmentalized dendritic plasticity and input feature storage in neuronsQ44937127
Acquired dendritic channelopathy in temporal lobe epilepsyQ44992557
Compromised axon initial segment integrity in EAE is preceded by microglial reactivity and contactQ45032169
Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation.Q45919318
Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia.Q46200728
Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebratesQ33290470
Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model.Q33586813
Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neuronsQ33675776
Organization and maintenance of molecular domains in myelinated axonsQ33726825
Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.Q33945987
Distinct potassium channels on pain-sensing neuronsQ33949400
Identification of a trafficking determinant localized to the Kv1 potassium channel poreQ33950345
Localization-dependent activity of the Kv2.1 delayed-rectifier K+ channel.Q33982170
A guardian angel: the involvement of dipeptidyl peptidase IV in psychoneuroendocrine function, nutrition and immune defenceQ33985912
Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neuronsQ34032735
Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.Q34035130
Molecular identity of dendritic voltage-gated sodium channelsQ34115269
Dynamic regulation of the Kv2.1 voltage-gated potassium channel during brain ischemia through neuroglial interactionQ34180633
Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α SubunitsQ34193048
Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrierQ34218857
Molecular identity of axonal sodium channels in human cortical pyramidal cellsQ34229570
Voltage-gated sodium channels at 60: structure, function and pathophysiologyQ34265707
The SNARE complex in neuronal and sensory cellsQ34267880
Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in ratsQ34281720
LTP is accompanied by an enhanced local excitability of pyramidal neuron dendritesQ34290758
Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegenerationQ34390785
Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channelsQ34420795
Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability.Q34425718
Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cellsQ34479857
AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel traffickingQ34559462
Pyramidal neurons: dendritic structure and synaptic integrationQ34588296
The roles of sodium channels in nociception: Implications for mechanisms of painQ34674268
The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).Q34703974
Dendritic Na(+) spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neuronsQ34729485
Functional properties and differential neuromodulation of Na(v)1.6 channelsQ34791973
Sharpness of spike initiation in neurons explained by compartmentalizationQ35067160
Differential cycling rates of Kv4.2 channels in proximal and distal dendrites of hippocampal CA1 pyramidal neurons.Q35098820
Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during developmentQ35432154
P304page(s)115
P577publication date2017-04-24
P1433published inFrontiers in Cellular NeuroscienceQ2131509
P1476titleThe Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms
P478volume11

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