An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier

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An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.5434-11.2012
P932PMC publication ID3413458
P698PubMed publication ID22623668

P50authorKae-Jiun ChangQ55168117
Xiaoyang ChengQ59161420
Matthew N. RasbandQ38642164
P2093author name stringStephen G Waxman
Sulayman D Dib-Hajj
Tammy Szu-Yu Ho
Andreas Gasser
P2860cites workDifferential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of RanvierQ43601410
A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neuronsQ44719523
A targeting motif involved in sodium channel clustering at the axonal initial segmentQ48269160
Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conductionQ48460269
Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axonsQ24300238
Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytesQ24319636
Early events in node of Ranvier formation during myelination and remyelination in the PNSQ24323237
AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firingQ24682474
Neurofascin assembles a specialized extracellular matrix at the axon initial segmentQ24682746
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segmentsQ24685343
Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domainQ24685559
Structural requirements for interaction of sodium channel beta 1 subunits with ankyrinQ28216947
Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamilyQ28250012
Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’Q28314940
The Kv2.1 K+ channel targets to the axon initial segment of hippocampal and cortical neurons in culture and in situQ28577741
Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanismsQ28582251
Localization and targeting of voltage-dependent ion channels in mammalian central neurons.Q30492681
Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channelsQ33876731
Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.Q33945987
Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesionQ34013147
Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α SubunitsQ34193048
Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.Q34433609
Schwann cell spectrins modulate peripheral nerve myelinationQ34977826
Polarized domains of myelinated axons.Q35558428
Axonal sodium-channel bands shape the response to electric stimulation in retinal ganglion cellsQ36106264
Endocytotic elimination and domain-selective tethering constitute a potential mechanism of protein segregation at the axonal initial segment.Q36322188
Intrinsic and extrinsic determinants of ion channel localization in neuronsQ36513239
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neuronsQ36678533
AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity.Q36972640
Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G.Q37010706
The functional organization and assembly of the axon initial segment.Q37272829
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitabilityQ38751797
Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion moleculesQ40507834
Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neuronsQ42169958
Presynaptic activity regulates Na(+) channel distribution at the axon initial segmentQ43027148
P4510describes a project that usesImageJQ1659584
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)7232-7243
P577publication date2012-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleAn ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier
P478volume32

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cites work (P2860)
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