Functional properties and differential neuromodulation of Na(v)1.6 channels

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Functional properties and differential neuromodulation of Na(v)1.6 channels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MCN.2008.05.009
P932PMC publication ID3433175
P698PubMed publication ID18599309
P5875ResearchGate publication ID5252701

P2093author name stringYuan Chen
Todd Scheuer
William A Catterall
Frank H Yu
Daniel Beacham
Elizabeth M Sharp
P2860cites workIdentification of the sites of selective phosphorylation and dephosphorylation of the rat brain Na+ channel alpha subunit by cAMP-dependent protein kinase and phosphoprotein phosphatasesQ72661684
Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neuronsQ80141640
The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancyQ81325064
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neuronesQ81508652
Nav1.6 channels generate resurgent sodium currents in spinal sensory neuronsQ81615419
Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2Q24317249
A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunctionQ24626279
Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapsesQ24653551
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifsQ24671990
Single-channel properties of human NaV1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsyQ24684695
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channelsQ28143653
Neuromodulation of Na+ channels: an unexpected form of cellular plasticityQ28199083
Molecular basis of an inherited epilepsyQ28207595
Comparative distribution of voltage-gated sodium channel proteins in human brainQ28211443
From genes to pain: Na v 1.7 and human pain disordersQ28254063
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’Q28314940
Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channelQ28369249
Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancyQ28513583
Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15 and PKA by a modified leucine zipper motifQ28579237
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancyQ28585126
Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient miceQ28592196
Cloning, distribution and functional analysis of the type III sodium channel from human brainQ31720612
Dendritic coincidence detection of EPSPs and action potentialsQ31793896
Activation of protein kinase C differentially modulates neuronal Na+, Ca2+, and gamma-aminobutyrate type A channelsQ33642070
Regulation of back-propagating action potentials in hippocampal neuronsQ33680866
Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.Q33945987
Properties of slow, cumulative sodium channel inactivation in rat hippocampal CA1 pyramidal neurons.Q34169826
Molecular and cellular mechanisms of cardiac arrhythmiasQ34175373
Inherited sodium channelopathies: novel therapeutic and proarrhythmic molecular mechanismsQ34416490
Identification of epilepsy genes in human and mouseQ34432267
Localization of voltage-gated ion channels in mammalian brainQ35672531
The primary periodic paralyses: diagnosis, pathogenesis and treatmentQ36272858
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neuronsQ36678533
Channelopathies in idiopathic epilepsyQ36774738
Dopamine receptor subtypes colocalize in rat striatonigral neuronsQ37270387
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channelQ37665790
Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanismsQ40178283
Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C.Q40323299
Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brainQ40719915
Voltage-dependent neuromodulation of Na+ channels by D1-like dopamine receptors in rat hippocampal neuronsQ40946719
Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brainQ41084445
Persistent sodium current in mammalian central neuronsQ41117708
Modulation of Ca2+ channels by G-protein beta gamma subunitsQ41214714
Panning transfected cells for electrophysiological studiesQ41519573
Selective phosphorylation of the alpha subunit of the sodium channel by cAMP-dependent protein kinaseQ41553272
Functional modulation of brain sodium channels by cAMP-dependent phosphorylationQ41622922
Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A.Q42441851
Cyclic-AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neuronsQ42488228
Muscarinic modulation of sodium current by activation of protein kinase C in rat hippocampal neuronsQ42517592
Functional analysis of the mouse Scn8a sodium channel.Q42540512
D1/D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons.Q43551102
Phosphorylation of the alpha subunit of rat brain sodium channels by cAMP-dependent protein kinase at a new site containing Ser686 and Ser687.Q43645915
Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortexQ43766587
Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism.Q44102369
Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15.Q44163841
Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticityQ44568731
D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons.Q45153496
Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon.Q45221829
Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium currentQ45233496
Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neuronsQ45713980
Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes.Q45941245
Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null miceQ46181156
Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells.Q46764066
Sodium currents in subthalamic nucleus neurons from Nav1.6-null miceQ47843312
Impaired firing and cell-specific compensation in neurons lacking nav1.6 sodium channels.Q47850400
Dopaminergic modulation of voltage-gated Na+ current in rat hippocampal neurons requires anchoring of cAMP-dependent protein kinase.Q48128866
Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brainQ48140249
Identification of an intracellular domain of the sodium channel having multiple cAMP-dependent phosphorylation sites.Q48170104
Voltage-activated sodium channels amplify inhibition in neocortical pyramidal neuronsQ48242436
Nav1.1 channels with mutations of severe myoclonic epilepsy in infancy display attenuated currents.Q48264922
Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a (NaV1.6) in cerebellar purkinje neurons and granule cellsQ48545805
Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant miceQ48601594
Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel alpha subunit.Q48628389
Phosphorylation of the alpha subunit of the sodium channel by protein kinase C.Q48631410
Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neuronsQ48633456
Slow recovery from inactivation of Na+ channels underlies the activity-dependent attenuation of dendritic action potentials in hippocampal CA1 pyramidal neuronsQ48633473
Functional modulation of brain sodium channels by protein kinase C phosphorylationQ48640678
Cyclic AMP-dependent phosphorylation of the alpha subunit of the sodium channel in synaptic nerve ending particlesQ48645924
Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.Q48683657
Late Sodium Channel Openings Underlying Epileptiform Activity Are Preferentially Diminished by the Anticonvulsant PhenytoinQ48693041
State-dependent regulation of neuronal excitability by dopamineQ48735021
Activation of protein kinase C alters voltage dependence of a Na+ channelQ48823087
Slow inactivation of the sodium conductance in squid giant axons. Pronase resistanceQ54579818
A phosphorylation site in the Na+ channel required for modulation by protein kinase CQ68262675
Differential subcellular localization of the RI and RII Na+ channel subtypes in central neuronsQ69366003
Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinaseQ70473890
P433issue4
P304page(s)607-615
P577publication date2008-05-20
P1433published inMolecular and Cellular NeuroscienceQ6895985
P1476titleFunctional properties and differential neuromodulation of Na(v)1.6 channels
P478volume38

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cites work (P2860)
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