Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

scientific article

Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1012059887
P356DOI10.1186/1744-8069-8-69
P932PMC publication ID3495684
P698PubMed publication ID22978421
P5875ResearchGate publication ID230857905

P50authorChristian AlzheimerQ93388090
P2093author name stringMirjam Eberhardt
Angelika Lampert
Tobias Huth
Richard W Carr
Ruth Sittl
Barbara Namer
Lisa K Kutsche
Alexandra B Klinger
Andrea S Link
E Theresa Schuy
Tali Hoffmann
P2860cites workPerceptual changes accompanying controlled preferential blocking of A and C fibre responses in intact human skin nervesQ48686878
Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.Q48747956
The sea anemone toxins BgII and BgIII prolong the inactivation time course of the tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons.Q49012140
Secondary hyperalgesia to punctate mechanical stimuli. Central sensitization to A-fibre nociceptor inputQ51430960
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalizationQ51796609
Loss of Na+ channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis.Q52514118
Modification of sodium channels in myelinated nerve by Anemonia sulcata toxin IIQ52738380
Decreased rate of sodium conductance inactivation in the node of Ranvier induced by a polypeptide toxin from sea anemoneQ52838902
β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ currentQ53420852
Anemonia sulcata toxins modify activation and inactivation of Na+ currents in a crayfish neuroneQ68935533
Rate of action of Anemonia sulcata toxin II on sodium channels in myelinated nerve fibresQ72540378
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neuronesQ81508652
Nav1.6 channels generate resurgent sodium currents in spinal sensory neuronsQ81615419
Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currentsQ82656688
Excitability parameters and sensitivity to anemone toxin ATX-II in rat small diameter primary sensory neurones discriminated by Griffonia simplicifolia isolectin IB4Q84872000
An SCN9A channelopathy causes congenital inability to experience painQ28278844
Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neuronsQ28592952
Which nerve fibers mediate the axon reflex flare in human skin?Q30847030
Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.Q33290606
Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop.Q34323654
Single-cell analysis of sodium channel expression in dorsal root ganglion neuronsQ34422391
Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons.Q34526433
Phenotype and function of somatic primary afferent nociceptive neurones with C-, Adelta- or Aalpha/beta-fibresQ34539920
Functional properties and differential neuromodulation of Na(v)1.6 channelsQ34791973
Actions of sea anemone type 1 neurotoxins on voltage-gated sodium channel isoforms.Q34977765
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerveQ35064387
Cross-Species Conservation of Open-Channel Block by Na Channel β4 Peptides Reveals Structural Features Required for Resurgent Na CurrentQ35227380
Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamideQ35275248
A role for nociceptive, myelinated nerve fibers in itch sensationQ35557581
International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels.Q35600872
Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na V 1.6-resurgent and persistent currentQ35921901
Differential Expression of Sodium Channel β Subunits in Dorsal Root Ganglion Sensory NeuronsQ35922414
The molecular machinery of resurgent sodium current revealedQ36017122
Time-dependent block and resurgent tail currents induced by mouse beta4(154-167) peptide in cardiac Na+ channelsQ36295611
Separate peripheral pathways for pruritus in manQ36956980
Fibre function and perception during cutaneous nerve blockQ37038289
Sodium channelopathies and painQ37681340
Sodium channels in normal and pathological painQ37724336
Anemone toxin discriminates between ionic channels for receptor potential and for action potential production in a sensory neuronQ39298263
Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin.Q39385828
Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channelsQ39881948
Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3.Q40287589
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currentsQ42946073
Resurgent Syphilis in the United States: Urgent Need to Address an Evolving EpidemicQ44273187
Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium currentQ45233496
TRPV1-mediated itch in seasonal allergic rhinitis.Q46120680
Sodium currents in subthalamic nucleus neurons from Nav1.6-null miceQ47843312
Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant MiceQ48601594
Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.Q48683657
P304page(s)69
P577publication date2012-09-15
P1433published inMolecular PainQ15766244
P1476titleSea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons
P478volume8

Reverse relations

cites work (P2860)
Q34585723Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission.
Q52148310Corticotropin-releasing factor increases Purkinje neuron excitability by modulating sodium, potassium, and Ih currents.
Q24605644Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
Q38725114FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons
Q47145444Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea
Q37122003Interactions among DIV voltage-sensor movement, fast inactivation, and resurgent Na current induced by the NaVβ4 open-channel blocking peptide
Q35205500Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain
Q36091952Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons
Q35625713Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations
Q48343647Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology
Q38839506Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors
Q46974854Prolonged, reversible neurologic symptoms after carpet sea anemone envenomation in a pet store worker
Q35673535Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker
Q42371768Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.
Q45302772Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.
Q41505443Sodium channel slow inactivation interferes with open channel block
Q48337085Sodium channels and pain: from toxins to therapies
Q37080784Upregulation of the sodium channel NaVβ4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation
Q86093643[Physiology of pain]