Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node

scientific article

Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2009.07.028
P932PMC publication ID2813407
P698PubMed publication ID19665465
P5875ResearchGate publication ID26727345

P2093author name stringRichard B Robinson
Colleen E Clancy
Ronit V Oren
Lev Protas
P2860cites workInternational Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heartQ28588673
The sinoatrial node, a heterogeneous pacemaker structureQ34023812
Resurgence of sodium channel researchQ34142210
Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunitsQ34148666
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heartQ34361080
An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial nodeQ34871426
Pacemaker channels.Q35807704
The promiscuous nature of the cardiac sodium currentQ36731634
Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 familiesQ40658302
Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.Q40788199
Cardiac pacemaking in the sinoatrial nodeQ40850880
Single-channel properties of the sinoatrial node Na+ current in the newborn rabbit.Q42652724
Is sodium current present in human sinoatrial node cells?Q43169649
Properties of the hyperpolarization-activated current (I(f)) in isolated mouse sino-atrial cellsQ43737605
Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cellQ44183047
The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial nodeQ44524951
Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemakingQ44978747
Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventriclesQ45203235
Effects of vagal stimulation and applied acetylcholine on pacemaker potentials in the guinea-pig heartQ46873205
Correlation between electrical activity and the size of rabbit sino-atrial node cellsQ47322505
Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heartQ47985654
Na(+) current contribution to the diastolic depolarization in newborn rabbit SA node cellsQ51374758
Regional differences in the role of the Ca2+ and Na+ currents in pacemaker activity in the sinoatrial nodeQ51541181
The newborn rabbit sino-atrial node expresses a neuronal type I-like Na+ channelQ51549315
Characterization of a TTX-sensitive Na+ current in pacemaker cells isolated from rabbit sinoatrial nodeQ51569657
A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cellsQ51574206
Two electrophysiologically distinct types of cultured pacemaker cells from rabbit sinoatrial nodeQ51813860
L-type but not T-type calcium current changes during postnatal development in rabbit sinoatrial nodeQ52130751
Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cellsQ52196629
Functional and morphological organization of the guinea-pig sinoatrial node compared with the rabbit sinoatrial nodeQ53899864
Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial nodeQ57980198
Resting K conductances in pacemaker and non-pacemaker heart cells of the rabbitQ72390574
Properties and modulation of If in newborn versus adult cardiac SA nodeQ73191433
Differential Expression of Gap Junction Proteins in the Canine Sinus NodeQ74405494
Distribution of atrial and nodal cells within the rabbit sinoatrial node: models of sinoatrial transitionQ74567072
Direct perfusion of the sinus node: an experimental model for pharmacologic and electrophysiologic studies of the heartQ78935613
P433issue1
P304page(s)172-180
P577publication date2009-08-07
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleAge-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node
P478volume48

Reverse relations

cites work (P2860)
Q35250714A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling
Q38860361Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 4 causes deterioration of canine sinoatrial node function
Q41934074CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases
Q90593828Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia
Q33784566Determinants of Heterogeneity, Excitation and Conduction in the Sinoatrial Node: A Model Study
Q33801118Effects of tetrodotoxin on the mammalian cardiovascular system
Q90460900Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development
Q92932133Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
Q48309276In-utero exposure to nicotine alters the development of the rabbit cardiac conduction system and provides a potential mechanism for sudden infant death syndrome.
Q33982881Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.
Q35864806Selective Sinoatrial Node Optical Mapping and the Mechanism of Sinus Rate Acceleration
Q35913417The "funny" current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells
Q46403905The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice

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