New, improved treatments for Chagas disease: from the R&D pipeline to the patients

scientific article

New, improved treatments for Chagas disease: from the R&D pipeline to the patients is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PNTD.0000484
P8608Fatcat IDrelease_35chnzqbv5hyho6me74oiljduu
P3181OpenCitations bibliographic resource ID1777725
P932PMC publication ID2702098
P698PubMed publication ID19582163
P5875ResearchGate publication ID26651936

P50authorMichael O. HarhayQ37378915
P2093author name stringAnn-Marie Sevcsik
Bernard Pecoul
Fabiana Alves
Graciela Diap
Isabela Ribeiro
Robert Don
Shing Chang
P2860cites workNeglected disease research and development: how much are we really spending?Q21034357
Measuring the burden of neglected tropical diseases: the global burden of disease frameworkQ21144557
The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseQ22065799
Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection)Q24245957
Safety of the blood supply in Latin AmericaQ24557539
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infectionQ24684717
New drugs for neglected diseases: from pipeline to patientsQ24802169
A breakthrough in R&D; for neglected diseases: new ways to get the drugs we needQ24810470
Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase functionQ27650762
The challenges of Chagas Disease-- grim outlook or glimmer of hopeQ33312506
The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and eliminationQ33372349
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hostsQ33978515
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.Q34391586
Clinical and epidemiological aspects of Chagas diseaseQ34521379
Chemotherapy of Chagas diseaseQ34541660
Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection.Q34546953
Chagas disease in Andean countries.Q34692304
Evaluation and treatment of chagas disease in the United States: a systematic reviewQ34713358
The impact of Chagas disease control in Latin America: a reviewQ34828463
Epidemiology of Chagas disease in non-endemic countries: the role of international migration.Q52684308
[Evaluation of the Chagas Disease Control Program and presence of Panstrongylus megistus in central-western Minas Gerais State, Brazil].Q52696993
Nova tripanozomiaze humana: estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homemQ55878589
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' diseaseQ58842622
[Comparative controlled study on the use of benznidazole, nifurtimox and placebo, in the chronic form of Chagas' disease, in a field area with interrupted transmission. I. Preliminary evaluation]Q58843201
Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infectionQ58843267
[Natural history of Chagas disease]Q58843613
Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trialQ58845294
Congenital Transmission of Chagas Disease in Latin American Immigrants in SwitzerlandQ59321893
???Q58842512
Specific chemotherapy of Chagas disease: controversies and advancesQ35569069
Virtual drug discovery and development for neglected diseases through public-private partnershipsQ35605447
An update on Chagas disease (human American trypanosomiasis).Q36709698
An insight on targets and patented drugs for chemotherapy of Chagas disease.Q37067251
Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections.Q37118721
Congenital transmission of Chagas disease in Latin American immigrants in SwitzerlandQ37164717
Rational modification of a candidate cancer drug for use against Chagas diseaseQ37274008
Chagas' disease as a foodborne illnessQ37436314
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthaseQ39502716
Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusional Chagas disease. Historical aspects, present situation, and perspectivesQ40171092
Emerging acute Chagas disease in Amazonian Brazil: case reports with serious cardiac involvementQ40509059
Cardiac involvement is a constant finding in acute Chagas' disease: a clinical, parasitological and histopathological studyQ40649314
The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas diseaseQ40652703
Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivativesQ40715553
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivativesQ42112211
Neglected diseases and poverty in "The Other America": the greatest health disparity in the United States?Q42868433
Chagasic cardiomyopathy in immigrants from Latin America to SpainQ43143328
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas diseaseQ44266812
Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strainsQ44266815
Use of polymerase chain reaction (PCR) and hybridization assays to detect Trypanosoma cruzi in chronic chagasic patients treated with itraconazole or allopurinolQ44828624
Geographic distribution of Triatoma dimidiata and transmission dynamics of Trypanosoma cruzi in the Yucatan peninsula of Mexico.Q45073305
Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT).Q46514298
The Trypanosoma cruzi proteome.Q46601686
ASAQ, a breakthrough in the fight against malariaQ47840298
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
Chagas diseaseQ649558
infectious diseaseQ18123741
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)e484
P577publication date2009-07-07
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleNew, improved treatments for Chagas disease: from the R&D pipeline to the patients
P478volume3

Reverse relations

cites work (P2860)
Q59082746A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites
Q44504229A new series of heteroleptic oxidovanadium(IV) compounds with phenanthroline-derived co-ligands: selective Trypanosoma cruzi growth inhibitors
Q64063181A prophylactic α-Gal-based glycovaccine effectively protects against murine acute Chagas disease
Q58842343Access to Chagas disease treatment in non-endemic countries: the case of Spain
Q35836581Access to care for Chagas disease in the United States: a health systems analysis
Q36702159Advances in Chagas disease drug development: 2009-2010
Q41093486Aromatic amine N-oxide organometallic compounds: searching for prospective agents against infectious diseases
Q58701155Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease
Q35023674Barriers to treatment access for Chagas disease in Mexico
Q28654673Bigger data, collaborative tools and the future of predictive drug discovery
Q52836242Bugging out over Chagas: Bioluminescent protozoans and old drugs might help unravel kissing-bug disease.
Q37717875Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps.
Q41920978Chagas Disease Infection among Migrants at the Mexico/Guatemala Border
Q34315066Chagas disease and the london declaration on neglected tropical diseases
Q36933398Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease
Q37023164Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease.
Q44083547Computational models for neglected diseases: gaps and opportunities
Q37778830Congenital transmission of Chagas disease: a clinical approach
Q47872103Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach
Q28555229Development of Diagnostics for Chagas Disease: Where Should We Put Our Limited Resources?
Q61809672Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach
Q36170517Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries
Q37124216Evaluation of nifurtimox treatment of chronic Chagas disease by means of several parasitological methods
Q28656268Evaluation of spatially targeted strategies to control non-domiciliated Triatoma dimidiata vector of Chagas disease
Q52334618Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
Q35130398Follow-up of an asymptomatic Chagas disease population of children after treatment with nifurtimox (Lampit) in a sylvatic endemic transmission area of Colombia
Q60031608High Throughput and Computational Repurposing for Neglected Diseases
Q36278397Improving access to Chagas disease diagnosis and etiologic treatment in remote rural communities of the Argentine Chaco through strengthened primary health care and broad social participation
Q26786761Kinases as druggable targets in trypanosomatid protozoan parasites
Q28545842Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery
Q40288847Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl-t-Butylnitrone Derivative
Q28548478Neglect of a Neglected Disease in Italy: The Challenge of Access-to-Care for Chagas Disease in Bergamo Area
Q35822254New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.
Q33955428Parasitic loads in tissues of mice infected with Trypanosoma cruzi and treated with AmBisome
Q56511193Pioneering Use of the Cloud for Development of Collaborative Drug Discovery (CDD) Database
Q46735046Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones
Q92347304Purification of Glycosylphosphatidylinositol-Anchored Mucins from Trypanosoma cruzi Trypomastigotes and Synthesis of α-Gal-Containing Neoglycoproteins: Application as Biomarkers for Reliable Diagnosis and Early Assessment of Chemotherapeutic Outcome
Q92440258Rapid immunochromatographic tests for the diagnosis of chronic Chagas disease in at-risk populations: A systematic review and meta-analysis
Q38256874Recent clinical trials for the etiological treatment of chronic chagas disease: advances, challenges and perspectives
Q37544765Reversible cysteine protease inhibitors show promise for a Chagas disease cure
Q35738489Secondary kill effect of deltamethrin on Triatoma infestans
Q40281916Spatiotemporal analysis of reported cases of acute Chagas disease in the State of Pernambuco, Brazil, from 2002 to 2013.
Q28540817Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi
Q33584473Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges
Q42592597The BENEFIT Trial: Where Do We Go from Here?
Q58571928The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
Q33627688The centennial of the discovery of Chagas disease: facing the current challenges
Q38032507The emerging role of amiodarone and dronedarone in Chagas disease
Q33479112The unfinished public health agenda of chagas disease in the era of globalization
Q37879203Therapy of vector-borne protozoan infections in nonendemic settings
Q37744965Trypanosomiasis, cardiomyopathy and the risk of ischemic stroke
Q37998091Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease
Q92124476Use of rapid diagnostic tests (RDTs) for conclusive diagnosis of chronic Chagas disease - field implementation in the Bolivian Chaco region
Q90743739Vanadium compounds in medicine
Q96137447WHF IASC Roadmap on Chagas Disease
Q50936607[Notes on rapid diagnostic tests for chronic Chagas disease].

Search more.