Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease

scholarly article by Amanda Fortes Francisco et al published October 2018 in Antimicrobial Agents and Chemotherapy

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00832-18
P932PMC publication ID6153806
P698PubMed publication ID30082291

P50authorMartin C TaylorQ42172320
P2093author name stringMichael D Lewis
John M Kelly
Amanda Fortes Francisco
Shiromani Jayawardhana
P2860cites workRed-emitting luciferases for bioluminescence reporter and imaging applications.Q39800473
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.Q42215365
T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chainQ42653469
Benznidazole prevents endothelial damage in an experimental model of Chagas disease.Q44480610
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trialQ47708871
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infectionQ48342608
What to expect and when: benznidazole toxicity in chronic Chagas' disease treatmentQ48530669
Trypanosoma cruzi infection induces a massive extrafollicular and follicular splenic B-cell response which is a high source of non-parasite-specific antibodies.Q50559773
Trypanosoma cruzi: differentiation after interaction of epimastigotes and Triatoma infestans intestinal homogenate.Q52457794
Chagas’ DiseaseQ57985265
Chagas diseaseQ58842312
Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathyQ58844325
New, improved treatments for Chagas disease: from the R&D pipeline to the patientsQ21092295
Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infectionQ24194546
A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imagingQ27011506
CD8+ T cells in Trypanosoma cruzi infectionQ28081766
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas DiseaseQ28548342
Transient regenerative potential of the neonatal mouse heartQ29620371
Hydroxymethylnitrofurazone is active in a murine model of Chagas' diseaseQ34108634
Chagas disease cardiomyopathy: immunopathology and geneticsQ34125557
Parasite persistence in the aetiology of Chagas diseaseQ34240113
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infectionQ34310471
Chagas' heart disease: clinical-pathological correlationQ35011251
Prevalence of Chagas disease in Latin-American migrants living in Europe: a systematic review and meta-analysisQ35095569
Trypanosoma cruzi and Chagas' Disease in the United StatesQ35361594
Impact of benznidazole on infection course in mice experimentally infected with Trypanosoma cruzi I, II, and IVQ35692509
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomesQ36516224
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathyQ37272449
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stageQ37342932
Trypanocidal drugs: mechanisms, resistance and new targetsQ37623081
Chagas disease and strokeQ37732618
Review: surveillance of Chagas diseaseQ38021060
Diagnosis and management of Chagas disease and cardiomyopathyQ38030830
Autoimmune pathogenesis of Chagas heart disease: looking back, looking aheadQ38412987
Immunity and immune modulation in Trypanosoma cruzi infectionQ38599837
Current and Future Chemotherapy for Chagas DiseaseQ38610293
Putting Infection Dynamics at the Heart of Chagas DiseaseQ38950397
Biological factors that impinge on Chagas disease drug developmentQ39010376
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single populationQ39242262
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS TrialQ39269371
Randomized Trial of Benznidazole for Chronic Chagas' CardiomyopathyQ39269382
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectpathologyQ7208
pharmacologyQ128406
infectious diseaseQ18123741
benznidazoleQ425300
Chagas diseaseQ649558
P577publication date2018-10-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleAssessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease
P478volume62

Reverse relations

Q92765270Low-Level Parasite Persistence Drives Vasculitis and Myositis in Skeletal Muscle of Mice Chronically Infected with Trypanosoma cruzicites workP2860

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