Aly/REF export factor

mammalian protein found in Homo sapiens

Aly/REF export factor is …
instance of (P31):
proteinQ8054

External links are
P705Ensembl protein IDENSP00000421592
P638PDB structure ID3ULH
P637RefSeq protein IDNP_005773
P352UniProt protein IDQ86V81

P682biological processRNA splicingQ237218
transportQ1435575
viral processQ14865169
osteoblast differentiationQ14876609
mRNA processingQ14877417
mRNA transportQ14882333
replication fork processingQ14883729
mRNA splicing, via spliceosomeQ15311667
mRNA export from nucleusQ15334263
RNA export from nucleusQ15334281
mRNA 3'-end processingQ21100337
termination of RNA polymerase II transcriptionQ21100338
positive regulation of DNA-templated transcription, elongationQ21102333
viral mRNA export from host cell nucleusQ21102335
regulation of DNA recombinationQ21102369
P681cell componentnucleusQ40260
cytoplasmQ79899
cytosolQ220599
extracellular exosomeQ903634
membraneQ14349455
nucleoplasmQ14817956
nuclear speckQ14819271
spliceosomal complexQ14888942
transcription export complexQ15334258
catalytic step 2 spliceosomeQ21100474
exon-exon junction complexQ21104920
P702encoded byALYREFQ18035105
P703found in taxonHomo sapiensQ15978631
P527has part(s)RNA recognition motif domainQ24768845
Chromatin target of PRMT1 protein, C-terminalQ24788501
P680molecular functionprotein bindingQ167149
RNA bindingQ14330639
nucleic acid bindingQ14864825
P361part ofRNA-binding domain superfamilyQ41797127
Nucleotide-binding alpha-beta plait domain superfamilyQ54450559
RNA recognition motif domain, protein familyQ83138470
Chromatin target of PRMT1 protein, C-terminal domain, protein familyQ83166718

Reverse relations

has part(s) (P527)
Q50258653ALYREF, FYTTD1, LUZP4 [nucleoplasm]
Q50295522Docking of Mature Histone mRNA complex:TAP at the NPC
Q50295519Docking of Mature Replication Dependent Histone mRNA with the NPC
Q50295526Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
Q50267421EJC [cytosol]
Q50258646EJC [nucleoplasm]
Q50295494Formation of the Spliceosomal E complex
Q55184148Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex [cytosol]
Q50267432Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex [nucleoplasm]
Q50267440Mature intronless derived mRNA:TAP:Aly/Ref complex [cytosol]
Q50267426Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [cytosol]
Q50267425Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [nucleoplasm]
Q50267439Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex [nucleoplasm]
Q50295813Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC
Q50295521Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex
Q50295525Release of the SLBP independent Histone mRNA from the NPC
Q50267329Spliceosomal A Complex [nucleoplasm]
Q50267354Spliceosomal Active C Complex [nucleoplasm]
Q50267348Spliceosomal B Complex [nucleoplasm]
Q50267315Spliceosomal E Complex [nucleoplasm]
Q50267351Spliceosomal Intermediate C Complex [nucleoplasm]
Q50267360Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm]
Q113155696TREX transcription-export complex, DX39A variant
Q113155809TREX transcription-export complex, DX39B variant
Q50267366pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm]

main subject (P921)
Q465502265-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader
Q24297150Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core
Q24299046Genome instability and transcription elongation impairment in human cells depleted of THO/TREX
Q24338302Human mRNA export machinery recruited to the 5' end of mRNA
Q24300178Linking transcriptional elongation and messenger RNA export to metastatic breast cancers
Q24318387Luzp4 defines a new mRNA export pathway in cancer cells
Q24310689Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication
Q24306879Recruitment of the human TREX complex to mRNA during splicing

Q18035105ALYREFencodesP688

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