HCK proto-oncogene, Src family tyrosine kinase

mammalian protein found in Homo sapiens

Wikidata entity: Q21113798



P682 biological process ... Q187640 (cell adhesion) cell adhesion
P682 biological process ... Q184726 (phagocytosis) phagocytosis
P682 biological process ... Q210861 (cell differentiation) cell differentiation
P682 biological process ... Q3630494 (protein autophosphorylation) protein autophosphorylation
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q14330986 (peptidyl-tyrosine phosphorylation) peptidyl-tyrosine phosphorylation
P682 biological process ... Q14599533 (negative regulation of apoptotic process) negative regulation of apoptotic process
P682 biological process ... Q14633891 (positive regulation of cell population proliferation) positive regulation of cell population proliferation
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q323426 (exocytosis) exocytosis
P682 biological process ... Q14819462 (regulation of cell shape) regulation of cell shape
P682 biological process ... Q14819849 (inflammatory response) inflammatory response
P682 biological process ... Q14820066 (regulation of DNA-binding transcription factor activity) regulation of DNA-binding transcription factor activity
P682 biological process ... Q14860518 (regulation of inflammatory response) regulation of inflammatory response
P682 biological process ... Q428253 (innate immune response) innate immune response
P682 biological process ... Q14863107 (cytokine-mediated signaling pathway) cytokine-mediated signaling pathway
P682 biological process ... Q14863108 (positive regulation of actin filament polymerization) positive regulation of actin filament polymerization
P682 biological process ... Q14863114 (positive regulation of actin cytoskeleton reorganization) positive regulation of actin cytoskeleton reorganization
P682 biological process ... Q14863362 (transmembrane receptor protein tyrosine kinase signaling pathway) transmembrane receptor protein tyrosine kinase signaling pathway
P682 biological process ... Q14863968 (Fc-gamma receptor signaling pathway involved in phagocytosis) Fc-gamma receptor signaling pathway involved in phagocytosis
P682 biological process ... Q14865169 (viral process) viral process
P682 biological process ... Q14865330 (interferon-gamma-mediated signaling pathway) interferon-gamma-mediated signaling pathway
P682 biological process ... Q14865402 (mitigation of host defenses by virus) mitigation of host defenses by virus
P682 biological process ... Q14873943 (integrin-mediated signaling pathway) integrin-mediated signaling pathway
P682 biological process ... Q14885627 (lipopolysaccharide-mediated signaling pathway) lipopolysaccharide-mediated signaling pathway
P682 biological process ... Q14885836 (mesoderm development) mesoderm development
P682 biological process ... Q14907333 (regulation of phagocytosis) regulation of phagocytosis
P682 biological process ... Q14914100 (innate immune response-activating signal transduction) innate immune response-activating signal transduction
P682 biological process ... Q14916317 (immune system process) immune system process
P682 biological process ... Q15328828 (peptidyl-tyrosine autophosphorylation) peptidyl-tyrosine autophosphorylation
P682 biological process ... Q21095288 (regulation of podosome assembly) regulation of podosome assembly
P682 biological process ... Q21112440 (leukocyte migration involved in immune response) leukocyte migration involved in immune response
P682 biological process ... Q21113796 (leukocyte degranulation) leukocyte degranulation
P682 biological process ... Q21113797 (respiratory burst after phagocytosis) respiratory burst after phagocytosis
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q154626 (cytoskeleton) cytoskeleton
P681 cell component ... Q189073 (cell junction) cell junction
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q83181 (Golgi apparatus) Golgi apparatus
P681 cell component ... Q83330 (lysosome) lysosome
P681 cell component ... Q904514 (focal adhesion) focal adhesion
P681 cell component ... Q1051872 (caveola) caveola
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14353100 (cell projection) cell projection
P681 cell component ... Q14817956 (nucleoplasm) nucleoplasm
P681 cell component ... Q14840128 (cytoplasmic vesicle) cytoplasmic vesicle
P681 cell component ... Q14860091 (transport vesicle) transport vesicle
P681 cell component ... Q329638 (actin filament) actin filament
P681 cell component ... Q14905148 (extrinsic component of cytoplasmic side of plasma membrane) extrinsic component of cytoplasmic side of plasma membrane
P702 encoded by ... Q18026836 (HCK) HCK
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24719835 (tyrosine-protein kinase, catalytic domain) tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24738472 (tyrosine-protein kinase, active site) tyrosine-protein kinase, active site
P527 has part(s) ... Q24740842 (serine-threonine/tyrosine-protein kinase, catalytic domain) serine-threonine/tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24768234 (protein kinase domain) protein kinase domain
P527 has part(s) ... Q24769051 (protein kinase, ATP binding site) protein kinase, ATP binding site
P527 has part(s) ... Q24771787 (SH3 domain) SH3 domain
P527 has part(s) ... Q24780316 (SH2 domain) SH2 domain
P527 has part(s) ... Q41797002 (Tyrosine-protein kinase HCK, SH2 domain) Tyrosine-protein kinase HCK, SH2 domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14819233 (signaling receptor binding) signaling receptor binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14863338 (protein tyrosine kinase activity) protein tyrosine kinase activity
P680 molecular function ... Q14873985 (non-membrane spanning protein tyrosine kinase activity) non-membrane spanning protein tyrosine kinase activity
P680 molecular function ... Q14905186 (phosphotyrosine residue binding) phosphotyrosine residue binding
P361 part of ... Q83164644 (SH2 domain, protein family) SH2 domain, protein family
P361 part of ... Q83170715 (Tyrosine-protein kinase HCK, SH2 domain, protein family) Tyrosine-protein kinase HCK, SH2 domain, protein family
P361 part of ... Q95352684 (Tyrosine-protein kinase, active site, protein family) Tyrosine-protein kinase, active site, protein family
P361 part of ... Q95354221 (Protein kinase, ATP binding site, protein family) Protein kinase, ATP binding site, protein family
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q41797170 (SH3-like domain superfamily) SH3-like domain superfamily
P361 part of ... Q41797956 (SH2 domain superfamily) SH2 domain superfamily
P361 part of ... Q50261758 (Src family kinases (SFKs) [cytosol]) Src family kinases (SFKs) [cytosol]
P361 part of ... Q83130430 (Tyrosine-protein kinase, catalytic domain, protein family) Tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83137014 (Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family) Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83138186 (Protein kinase domain, protein family) Protein kinase domain, protein family
P361 part of ... Q83140574 (SH3 domain, protein family) SH3 domain, protein family

External Ids
P705Ensembl protein IDENSP00000486627
P705Ensembl protein IDENSP00000441169
P705Ensembl protein IDENSP00000365012
P705Ensembl protein IDENSP00000365022
P705Ensembl protein IDENSP00000427757
P705Ensembl protein IDENSP00000262651
P705Ensembl protein IDENSP00000444986
P705Ensembl protein IDENSP00000429848
P705Ensembl protein IDENSP00000491964
P705Ensembl protein IDENSP00000420457
P486MeSH descriptor IDD051572
P672MeSH tree codeD08.811.913.696.620.682.725.800.590
P672MeSH tree codeD12.776.476.568.800.590
P672MeSH tree codeD12.776.624.664.700.181
P638PDB structure ID3VS7
P638PDB structure ID2C0O
P638PDB structure ID3VS5
P638PDB structure ID2C0I
P638PDB structure ID3VRZ
P638PDB structure ID3VRY
P638PDB structure ID3VS0
P638PDB structure ID2HCK
P638PDB structure ID3VS2
P638PDB structure ID2C0T
P638PDB structure ID2HK5
P638PDB structure ID3VS3
P638PDB structure ID3VS4
P638PDB structure ID4LUE
P638PDB structure ID3VS1
P638PDB structure ID1QCF
P638PDB structure ID3VS6
P638PDB structure ID4LUD
P638PDB structure ID4HCK
P638PDB structure ID3HCK
P638PDB structure ID1AD5
P638PDB structure ID1BU1
P638PDB structure ID2OI3
P638PDB structure ID2OJ2
P638PDB structure ID3NHN
P638PDB structure ID3RBB
P638PDB structure ID3REA
P638PDB structure ID3REB
P638PDB structure ID4ORZ
P638PDB structure ID4U5W
P638PDB structure ID5HCK
P637RefSeq protein IDNP_001165600
P637RefSeq protein IDNP_001165601
P637RefSeq protein IDNP_001165602
P637RefSeq protein IDNP_001165603
P637RefSeq protein IDNP_001165604
P637RefSeq protein IDNP_002101
P2892UMLS CUIC0286943
P352UniProt protein IDP08631

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