integrin-mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

integrin-mediated signaling pathway is …
instance of (P31):
biological processQ2996394

sublass of (P279):
cell surface receptor signaling pathwayQ14820580

External links are
P2888exact matchhttp://purl.obolibrary.org/obo/GO_0007229
P686Gene Ontology IDGO:0007229
P2892UMLS CUIC1155451

Reverse relations

regulates (molecular biology) (P128)
Q21116586negative regulation of integrin-mediated signaling pathway
Q21109661positive regulation of integrin-mediated signaling pathway
Q21109682regulation of integrin-mediated signaling pathway

biological process (P682)
Q21982978A disintegrin and metallopeptidase domain 15 (metargidin)
Q29529518A disintegrin and metallopeptidase domain 34
Q29530774A disintegrin and metallopeptidase domain 4
Q29531769A disintegrin and metallopeptidase domain 6A
Q29525634A disintegrin and metalloprotease domain 4
Q587961ABL proto-oncogene 1, non-receptor tyrosine kinase
Q29793643ADAM (disintegrin plus metalloprotease) family CELE_C04A11.4
Q21113783ADAM metallopeptidase domain 10
Q21113788ADAM metallopeptidase domain 11
Q29527258ADAM metallopeptidase domain 11
Q21113814ADAM metallopeptidase domain 15
Q28556400ADAM metallopeptidase domain 15
Q29825276ADAM metallopeptidase domain 17a
Q29829921ADAM metallopeptidase domain 28
Q29518757ADAM metallopeptidase domain 32
Q21113741ADAM metallopeptidase domain 9
Q29830344ADAM metallopeptidase domain 9
Q21170793ADAM metallopeptidase with thrombospondin type 1 motif 1
Q4651006ADAM metallopeptidase with thrombospondin type 1 motif 13
Q29520443ADAM metallopeptidase with thrombospondin type 1 motif, 1
Q29527280ADAM metallopeptidase with thrombospondin type 1 motif, 15
Q29521067ADAM metallopeptidase with thrombospondin type 1 motif, 19
Q29524432ADAM metallopeptidase with thrombospondin type 1 motif, 9
Q29518084ADAM metallopeptidase with thrombospondin type 1, motif 3
Q23605343Alpha/beta hydrolase domain-containing protein Smed_3525
Q21604110Alpha3-beta1 integrin-binding protein BB_B07
Q21097376Angiopoietin like 3
Q14910072Apolipoprotein A-I
Q1316030Apolipoprotein A1
Q28560424Apolipoprotein A1
Q21115283BCAR1 scaffold protein, Cas family member
Q28561060BCAR1 scaffold protein, Cas family member
Q62278548Blood coagulation inhibitor Disintegrin
Q62297251Blood coagulation inhibitor Disintegrin
Q21984738Breast cancer anti-estrogen resistance 1
Q14874000C-abl oncogene 1, non-receptor tyrosine kinase
Q29807650CALMyrin (Calcium and Integrin Binding protein) homolog CELE_F30A10.1
Q21204405CCM2 scaffold protein
Q21108354CD47 molecule
Q21151603CEACAM1 protein
Q21111800Cadherin 17
Q21497168Cadherin 17
Q28558346Cadherin 17
Q29809358Calcium and integrin binding family member 2 Dmel_CG9236
Q28558592Cd47 molecule
Q1198053Cell division cycle 42
Q15311709Cell division cycle 42
Q14907754Cellular communication network factor 2
Q28557384Cellular communication network factor 2
Q5145885Collagen type III alpha 1 chain
Q28556992Collagen type III alpha 1 chain
Q55203292Collagen type III alpha 1 chain
Q21106791Collagen type XVI alpha 1 chain
Q14906850Collagen, type III, alpha 1
Q21111152Cullin 3
Q21981309Cullin 3
Q28563338Cullin 3
Q21204197DAB adaptor protein 2
Q21105158Dedicator of cytokinesis 1
Q62293711EgrG_000056100.1
Q62278113EgrG_000871000.1
Q62287597EgrG_001122100.1
Q5385169Erbb2 interacting protein
Q62310421FERM central domain
Q29526129FERM domain containing kindlin 1
Q55200819FERM domain containing kindlin 1
Q29519096FERM domain containing kindlin 3
Q29833438FERM domain containing kindlin 3b
Q21097222FGR proto-oncogene, Src family tyrosine kinase
Q21498087FGR proto-oncogene, Src family tyrosine kinase
Q28557549FGR proto-oncogene, Src family tyrosine kinase
Q21983259FYN binding protein
Q21108611FYN binding protein 1
Q29516830FYN binding protein 1
Q21105527FYN binding protein 2
Q28563491FYN binding protein 2
Q28560678Fc epsilon receptor Ig
Q21101408Fc fragment of IgE receptor Ig
Q21495674Fc receptor, IgE, high affinity I, gamma polypeptide
Q29809866Fermitin 1 Dmel_CG14991
Q29810606Fermitin 2 Dmel_CG7729
Q21139718Fermitin family homolog 3
Q21131506Fermitin family member 1
Q21981359Fermitin family member 1
Q21130906Fermitin family member 2
Q21981360Fermitin family member 2
Q21135182Fermitin family member 3
Q21989283Fermitin family member 3
Q21118136Fibulin 1
Q21112469Fucosyltransferase 8
Q21979957Fucosyltransferase 8
Q21498519GRB2-associated-binding protein 2
Q21113798HCK proto-oncogene, Src family tyrosine kinase
Q21101451ISG15 ubiquitin like modifier
Q21986058ISG15 ubiquitin-like modifier
Q29524401ISG15 ubiquitin-like modifier
Q29815078Icarus Dmel_CG9031
Q29812115Inflated Dmel_CG9623
Q14912127Integrin alpha 1
Q14912138Integrin alpha 2
Q21498663Integrin alpha 2b
Q14912141Integrin alpha 3
Q14912102Integrin alpha 4
Q21491044Integrin alpha 5 (fibronectin receptor alpha)
Q21498660Integrin alpha 6
Q21498649Integrin alpha 8
Q21498651Integrin alpha 9
Q15321203Integrin alpha E, epithelial-associated
Q21983362Integrin alpha L
Q21983365Integrin alpha V
Q14904990Integrin alpha X
Q29802785Integrin alpha ina-1 CELE_F54G8.3
Q29801107Integrin alpha pat-2 CELE_F54F2.1
Q21498653Integrin alpha-11
Q21141625Integrin alpha-3
Q21144027Integrin alpha-7
Q21498657Integrin alpha-7
Q21983361Integrin alpha-M
Q107603385Integrin alpha1-beta1 complex
Q107515896Integrin alpha1-beta1 complex
Q107603396Integrin alpha10-beta1 complex
Q107516006Integrin alpha10-beta1 complex
Q107603397Integrin alpha11-beta1 complex
Q107516010Integrin alpha11-beta1 complex
Q107603386Integrin alpha2-beta1 complex
Q107515987Integrin alpha2-beta1 complex
Q107603388Integrin alpha3-beta1 complex
Q107515894Integrin alpha3-beta1 complex
Q127383959Integrin alpha3-beta3 complex
Q107515990Integrin alpha4-beta1 complex
Q107603372Integrin alpha4-beta7 complex
Q107516023Integrin alpha4-beta7 complex
Q107603357Integrin alpha5-beta1 complex
Q107515885Integrin alpha5-beta1 complex
Q107603390Integrin alpha6-beta1 complex
Q107515994Integrin alpha6-beta1 complex
Q107516020Integrin alpha6-beta4 complex
Q107603393Integrin alpha7-beta1 complex
Q107515997Integrin alpha7-beta1 complex
Q107603394Integrin alpha8-beta1 complex
Q107516001Integrin alpha8-beta1 complex
Q107603395Integrin alpha9-beta1 complex
Q107516004Integrin alpha9-beta1 complex
Q107516038Integrin alphaD-beta2 complex
Q107603398Integrin alphaD-beta2 complex
Q107603399Integrin alphaE-beta7 complex
Q107516026Integrin alphaE-beta7 complex
Q107603387Integrin alphaIIb-beta3 complex
Q107515898Integrin alphaIIb-beta3 complex
Q107603400Integrin alphaL-beta2 complex
Q107516030Integrin alphaL-beta2 complex
Q107603402Integrin alphaM-beta2 complex
Q107516033Integrin alphaM-beta2 complex
Q29816793Integrin alphaPS4 subunit Dmel_CG16827
Q29810737Integrin alphaPS5 subunit Dmel_CG5372
Q107603412Integrin alphaX-beta2 complex
Q107516036Integrin alphaX-beta2 complex
Q107603403Integrin alphav-beta1 complex
Q107516013Integrin alphav-beta1 complex
Q107603362Integrin alphav-beta3 complex
Q107604255Integrin alphav-beta3 complex
Q107515889Integrin alphav-beta3 complex
Q107603406Integrin alphav-beta5 complex
Q107515892Integrin alphav-beta5 complex
Q107603407Integrin alphav-beta6 complex
Q107516016Integrin alphav-beta6 complex
Q107603408Integrin alphav-beta8 complex
Q107516018Integrin alphav-beta8 complex
Q21144190Integrin beta
Q14912087Integrin beta 1 (fibronectin receptor beta)
Q21985068Integrin beta 1 binding protein 1
Q14912069Integrin beta 2
Q21437600Integrin beta 2-like
Q14913644Integrin beta 3
Q29828302Integrin beta 3a
Q21983359Integrin beta 4
Q21983360Integrin beta 5
Q21983371Integrin beta 6
Q21985070Integrin beta 7
Q29532066Integrin beta 8
Q29808612Integrin beta pat-3 CELE_ZK1058.2
Q21145034Integrin beta-4
Q29816759Integrin betanu subunit Dmel_CG1762
Q11913806Integrin linked kinase
Q21495079Integrin linked kinase
Q28560428Integrin subunit alpha 1
Q55203086Integrin subunit alpha 1
Q21119178Integrin subunit alpha 10
Q29525920Integrin subunit alpha 10
Q21119184Integrin subunit alpha 11
Q29516947Integrin subunit alpha 2
Q55199731Integrin subunit alpha 2b
Q29518045Integrin subunit alpha 4
Q21107787Integrin subunit alpha 7
Q28562331Integrin subunit alpha 7
Q21107782Integrin subunit alpha 8
Q29526804Integrin subunit alpha 8
Q21107790Integrin subunit alpha 9
Q21107784Integrin subunit alpha D
Q28562966Integrin subunit alpha D
Q55199778Integrin subunit alpha D
Q4201959Integrin subunit alpha E
Q3648604Integrin subunit alpha L
Q29515951Integrin subunit alpha M
Q4201963Integrin subunit alpha X
Q29523914Integrin subunit alpha X
Q28563069Integrin subunit beta 1
Q21114501Integrin subunit beta 1 binding protein 1
Q29519863Integrin subunit beta 1 binding protein 1
Q29518813Integrin subunit beta 1 binding protein 2
Q29527085Integrin subunit beta 2
Q4201964Integrin subunit beta 3
Q29526036Integrin subunit beta 3
Q21105257Integrin subunit beta 4
Q28561299Integrin subunit beta 4
Q21097233Integrin subunit beta 5
Q21202191Integrin subunit beta 6
Q28563145Integrin subunit beta 6
Q21114531Integrin subunit beta 7
Q29517594Integrin subunit beta 7
Q21121471Integrin subunit beta 8
Q21121467Integrin subunit beta like 1
Q28561718Integrin subunit beta like 1
Q29832970Integrin, alpha 11a
Q43372192Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2
Q29821264Integrin, alpha 3a
Q21137040Integrin, alpha 5 (Fibronectin receptor, alpha polypeptide), isoform CRA_b
Q56251943Integrin, alpha 6b
Q21983366Integrin, alpha D
Q29825638Integrin, alpha M (complement component 3 receptor 3 subunit), tandem duplicate 1
Q29831212Integrin, beta 1b.2
Q29822069Integrin, beta 2
Q56251929Integrin, beta 4
Q43373453Integrin, beta 5
Q21984332Integrin, beta-like 1
Q29830534Integrin, beta-like 1
Q29517042Integrin-binding sialoprotein
Q23526221Integrin-like repeat-containing lysozyme CA_P0151
Q28560433Integrin-linked kinase
Q29808066Integrin-linked protein kinase homolog pat-4 CELE_C29F9.7
Q21107905Laminin subunit alpha 3
Q21104621Laminin subunit alpha 5
Q29526023Laminin subunit alpha 5
Q21496569Laminin, alpha 3
Q21985626Laminin, alpha 5
Q6554368Linker for activation of T cells
Q21495767Linker for activation of T cells
Q28557569Linker for activation of T cells
Q21142368Megakaryocyte and platelet inhibitory receptor G6b
Q28560143Megakaryocyte and platelet inhibitory receptor G6b
Q30332095Megakaryocyte and platelet inhibitory receptor G6b
Q4681402Mucosal vascular addressin cell adhesion molecule 1
Q21987678Mucosal vascular addressin cell adhesion molecule 1
Q28562256Mucosal vascular addressin cell adhesion molecule 1
Q29816459Multiple edematous wings Dmel_CG1771
Q21113133Myosin heavy chain 9
Q29812680Myospheroid Dmel_CG1560
Q21133641NME/NM23 nucleoside diphosphate kinase 2
Q22676635NME/NM23 nucleoside diphosphate kinase 2
Q28557298NME/NM23 nucleoside diphosphate kinase 2
Q23475109Na-Ca exchanger/integrin-beta4 Caur_1388
Q21100383Neural precursor cell expressed, developmentally down-regulated 9
Q21114530Neuropilin 1
Q21985312Neuropilin 1
Q28556594Neuropilin 1
Q21988938PML-RAR alpha-regulated adaptor molecule 1
Q21104864PML-RARA regulated adaptor molecule 1
Q21984735PTK2 protein tyrosine kinase 2
Q21985329PTK2 protein tyrosine kinase 2 beta
Q14906595Paxillin
Q21987398Pleckstrin
Q22679878Pleckstrin
Q28561283Pleckstrin
Q28560285Pleiotrophin
Q21116913Protein kinase D1
Q28562670Protein tyrosine kinase 2
Q28559587Protein tyrosine kinase 2 beta
Q7120997Protein tyrosine phosphatase non-receptor type 11
Q14905498Protein tyrosine phosphatase, non-receptor type 11
Q28557971Protein tyrosine phosphatase, non-receptor type 11
Q29798409Protein unc-112 CELE_C47E8.7
Q14912013Proteolipid protein (myelin) 1
Q205986Proteolipid protein 1
Q28562997Proteolipid protein 1
Q15331521Ras homolog family member A
Q21135018Regulator of chromosome condensation 2
Q21987471Regulator of chromosome condensation 2
Q21986406Rho GTPase activating protein 35
Q21984733Rous sarcoma oncogene
Q21109354SRC proto-oncogene, non-receptor tyrosine kinase
Q28558649SRC proto-oncogene, non-receptor tyrosine kinase
Q29819339Scab Dmel_CG8095
Q21991147Sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Q21109000Semaphorin 7A (John Milton Hagen blood group)
Q29526093Semaphorin 7A (John Milton Hagen blood group)
Q29827889Si:ch211-188c16.1
Q61569307Smp_139830.1
Q28559599Spleen associated tyrosine kinase
Q14907340Spleen tyrosine kinase
Q21119231TXK tyrosine kinase
Q21992520TXK tyrosine kinase
Q29524043TXK tyrosine kinase
Q21992241TYRO protein tyrosine kinase binding protein
Q21110152Talin 1
Q21983363Talin 1
Q29520914Talin 1
Q21107532Tec protein tyrosine kinase
Q21990677Tec protein tyrosine kinase
Q21126683Tetraspanin 32
Q21980267Tetraspanin 32
Q29526493Tetraspanin 32
Q5009851Thy-1 cell surface antigen
Q28559057Thy-1 cell surface antigen
Q55202689Thy-1 cell surface antigen
Q14906181Thymus cell antigen 1, theta
Q21123076Transmembrane immune signaling adaptor TYROBP
Q28558922Transmembrane immune signaling adaptor Tyrobp
Q29516740Tubulin, gamma complex associated protein 2
Q29806998Uncharacterized integrin beta-like protein C05D9.3 CELE_C05D9.3
Q21989690Vav 1 oncogene
Q21989701Vav 3 oncogene
Q21111121Vav guanine nucleotide exchange factor 1
Q21107548Vav guanine nucleotide exchange factor 3
Q21174458Zinc finger protein 304
Q8075984Zyxin
Q21989758Zyxin
Q29521318Zyxin
Q55200767Zyxin
Q62281028a disintegrin and metalloproteinase with
Q62304549a disintegrin and metalloproteinase with
Q61597565adamTS protein 3
Q5014566cellular communication network factor 2
Q61624848disintegrin and metalloproteinase
Q62281463disintegrin and metalloproteinase
Q62305397disintegrin and metalloproteinase
Q21173306dystonin
Q61631226fermitin family 1
Q61500676hypothetical protein
Q62285959integrin alpha 3
Q62311403integrin alpha 3
Q61533884integrin alpha 5
Q61605755integrin alpha 7
Q61605767integrin alpha 7
Q62296449integrin alpha FG GAP repeat containing protein
Q61547164integrin alpha ps
Q61589724integrin alpha ps
Q62276269integrin alpha ps
Q62292555integrin alpha ps
Q62293173integrin alpha ps
Q62298196integrin alpha ps
Q62313186integrin alpha ps
Q107603389integrin alpha4-beta1 complex
Q107603391integrin alpha6-beta4 complex
Q61488884integrin beta 2
Q62288817integrin beta 2
Q62323068integrin beta 2
Q62286039integrin linked kinase associated
Q62311529integrin linked kinase associated
Q62279242integrin linked protein kinase
Q62301034integrin linked protein kinase
Q4201946integrin subunit alpha 1
Q4201948integrin subunit alpha 2
Q21107760integrin subunit alpha 2b
Q4201950integrin subunit alpha 3
Q4201951integrin subunit alpha 4
Q21110097integrin subunit alpha 5
Q21107772integrin subunit alpha 6
Q3799301integrin subunit alpha M
Q21107757integrin subunit alpha V
Q4201966integrin subunit beta 1
Q2458503integrin subunit beta 2
Q2744706protein tyrosine kinase 2
Q21101275protein tyrosine kinase 2 beta
Q7660502spleen associated tyrosine kinase
Q61631231teneurin
Q61641806unc 112 protein
Q62325729unc 112 protein

main subject (P921)
Q24321588A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers
Q22007972Activation of Rac1 by a Crk SH3-binding protein, DOCK180
Q24337468Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein
Q24292174Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility
Q24329209Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase
Q24312758Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene
Q22254174Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells
Q24336777Rh-related antigen CD47 is the signal-transducer integrin-associated protein

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