ABL proto-oncogene 1, non-receptor tyrosine kinase

mammalian protein found in Homo sapiens

Wikidata entity: Q587961

Wikimedia Commons category is Tyrosine-protein kinase ABL1



P682 biological process ... Q184726 (phagocytosis) phagocytosis
P682 biological process ... Q210538 (DNA repair) DNA repair
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q288322 (autophagy) autophagy
P682 biological process ... Q14599315 (response to oxidative stress) response to oxidative stress
P682 biological process ... Q14633883 (regulation of transcription, DNA-templated) regulation of transcription, DNA-templated
P682 biological process ... Q14633930 (positive regulation of substrate adhesion-dependent cell spreading) positive regulation of substrate adhesion-dependent cell spreading
P682 biological process ... Q14818018 (cellular response to DNA damage stimulus) cellular response to DNA damage stimulus
P682 biological process ... Q14818063 (positive regulation of apoptotic process) positive regulation of apoptotic process
P682 biological process ... Q14818068 (positive regulation of transcription by RNA polymerase II) positive regulation of transcription by RNA polymerase II
P682 biological process ... Q14818120 (regulation of cell population proliferation) regulation of cell population proliferation
P682 biological process ... Q14818129 (regulation of cell cycle) regulation of cell cycle
P682 biological process ... Q14819470 (substrate adhesion-dependent cell spreading) substrate adhesion-dependent cell spreading
P682 biological process ... Q14819846 (positive regulation of protein phosphorylation) positive regulation of protein phosphorylation
P682 biological process ... Q187640 (cell adhesion) cell adhesion
P682 biological process ... Q189814 (endocytosis) endocytosis
P682 biological process ... Q14820654 (positive regulation of cytosolic calcium ion concentration) positive regulation of cytosolic calcium ion concentration
P682 biological process ... Q14821004 (positive regulation of release of sequestered calcium ion into cytosol) positive regulation of release of sequestered calcium ion into cytosol
P682 biological process ... Q14821388 (positive regulation of ERK1 and ERK2 cascade) positive regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14859610 (positive regulation of endothelial cell migration) positive regulation of endothelial cell migration
P682 biological process ... Q14859964 (thymus development) thymus development
P682 biological process ... Q14859977 (Bergmann glial cell differentiation) Bergmann glial cell differentiation
P682 biological process ... Q14860450 (intrinsic apoptotic signaling pathway in response to DNA damage) intrinsic apoptotic signaling pathway in response to DNA damage
P682 biological process ... Q14860512 (endothelial cell migration) endothelial cell migration
P682 biological process ... Q14862215 (regulation of cell motility) regulation of cell motility
P682 biological process ... Q14862244 (cellular response to oxidative stress) cellular response to oxidative stress
P682 biological process ... Q14863045 (platelet-derived growth factor receptor signaling pathway) platelet-derived growth factor receptor signaling pathway
P682 biological process ... Q14863111 (cellular response to lipopolysaccharide) cellular response to lipopolysaccharide
P682 biological process ... Q14863114 (positive regulation of actin cytoskeleton reorganization) positive regulation of actin cytoskeleton reorganization
P682 biological process ... Q14863410 (B cell proliferation) B cell proliferation
P682 biological process ... Q14863419 (negative regulation of mitotic cell cycle) negative regulation of mitotic cell cycle
P682 biological process ... Q14763008 (mitotic cell cycle) mitotic cell cycle
P682 biological process ... Q14763019 (positive regulation of mitotic cell cycle) positive regulation of mitotic cell cycle
P682 biological process ... Q21095682 (negative regulation of I-kappaB kinase/NF-kappaB signaling) negative regulation of I-kappaB kinase/NF-kappaB signaling
P682 biological process ... Q21096406 (microspike assembly) microspike assembly
P682 biological process ... Q21104794 (regulation of extracellular matrix organization) regulation of extracellular matrix organization
P682 biological process ... Q21104795 (positive regulation of Wnt signaling pathway, planar cell polarity pathway) positive regulation of Wnt signaling pathway, planar cell polarity pathway
P682 biological process ... Q21106688 (regulation of cellular senescence) regulation of cellular senescence
P682 biological process ... Q21106739 (cellular response to dopamine) cellular response to dopamine
P682 biological process ... Q21107055 (negative regulation of long-term synaptic potentiation) negative regulation of long-term synaptic potentiation
P682 biological process ... Q21108612 (platelet-derived growth factor receptor-beta signaling pathway) platelet-derived growth factor receptor-beta signaling pathway
P682 biological process ... Q21109181 (transitional one stage B cell differentiation) transitional one stage B cell differentiation
P682 biological process ... Q21109182 (negative regulation of phospholipase C activity) negative regulation of phospholipase C activity
P682 biological process ... Q21112798 (neuroepithelial cell differentiation) neuroepithelial cell differentiation
P682 biological process ... Q21113390 (DNA conformation change) DNA conformation change
P682 biological process ... Q21468479 (positive regulation of microtubule binding) positive regulation of microtubule binding
P682 biological process ... Q21468480 (positive regulation of actin filament binding) positive regulation of actin filament binding
P682 biological process ... Q22245268 (activation of protein kinase C activity) activation of protein kinase C activity
P682 biological process ... Q22269591 (collateral sprouting) collateral sprouting
P682 biological process ... Q22306628 (neuropilin signaling pathway) neuropilin signaling pathway
P682 biological process ... Q14863422 (spleen development) spleen development
P682 biological process ... Q14863427 (B cell receptor signaling pathway) B cell receptor signaling pathway
P682 biological process ... Q14863711 (negative regulation of ERK1 and ERK2 cascade) negative regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14863968 (Fc-gamma receptor signaling pathway involved in phagocytosis) Fc-gamma receptor signaling pathway involved in phagocytosis
P682 biological process ... Q14863970 (T cell receptor signaling pathway) T cell receptor signaling pathway
P682 biological process ... Q14864035 (positive regulation of I-kappaB kinase/NF-kappaB signaling) positive regulation of I-kappaB kinase/NF-kappaB signaling
P682 biological process ... Q14864247 (regulation of autophagy) regulation of autophagy
P682 biological process ... Q14864488 (positive regulation of muscle cell differentiation) positive regulation of muscle cell differentiation
P682 biological process ... Q14864683 (epidermal growth factor receptor signaling pathway) epidermal growth factor receptor signaling pathway
P682 biological process ... Q14864791 (regulation of T cell differentiation) regulation of T cell differentiation
P682 biological process ... Q14864952 (positive regulation of stress fiber assembly) positive regulation of stress fiber assembly
P682 biological process ... Q14865235 (cellular response to hydrogen peroxide) cellular response to hydrogen peroxide
P682 biological process ... Q14865300 (regulation of microtubule polymerization) regulation of microtubule polymerization
P682 biological process ... Q14865865 (neuromuscular process controlling balance) neuromuscular process controlling balance
P682 biological process ... Q14872793 (DNA damage induced protein phosphorylation) DNA damage induced protein phosphorylation
P682 biological process ... Q14873943 (integrin-mediated signaling pathway) integrin-mediated signaling pathway
P682 biological process ... Q14873995 (negative regulation of protein serine/threonine kinase activity) negative regulation of protein serine/threonine kinase activity
P682 biological process ... Q14873996 (regulation of actin cytoskeleton reorganization) regulation of actin cytoskeleton reorganization
P682 biological process ... Q14873997 (regulation of response to DNA damage stimulus) regulation of response to DNA damage stimulus
P682 biological process ... Q14874551 (negative regulation of BMP signaling pathway) negative regulation of BMP signaling pathway
P682 biological process ... Q14876082 (regulation of actin cytoskeleton organization) regulation of actin cytoskeleton organization
P682 biological process ... Q14885826 (neural tube closure) neural tube closure
P682 biological process ... Q14889747 (negative regulation of cell-cell adhesion) negative regulation of cell-cell adhesion
P682 biological process ... Q14890370 (regulation of axon extension) regulation of axon extension
P682 biological process ... Q14890380 (regulation of Cdc42 protein signal transduction) regulation of Cdc42 protein signal transduction
P682 biological process ... Q14897720 (neuron differentiation) neuron differentiation
P682 biological process ... Q14901963 (mitochondrial depolarization) mitochondrial depolarization
P682 biological process ... Q14903134 (positive regulation of osteoblast proliferation) positive regulation of osteoblast proliferation
P682 biological process ... Q14903970 (positive regulation of focal adhesion assembly) positive regulation of focal adhesion assembly
P682 biological process ... Q14904372 (negative regulation of ubiquitin-protein transferase activity) negative regulation of ubiquitin-protein transferase activity
P682 biological process ... Q14904989 (activated T cell proliferation) activated T cell proliferation
P682 biological process ... Q14905605 (positive regulation of cell migration involved in sprouting angiogenesis) positive regulation of cell migration involved in sprouting angiogenesis
P682 biological process ... Q14905689 (regulation of hematopoietic stem cell differentiation) regulation of hematopoietic stem cell differentiation
P682 biological process ... Q14906419 (negative regulation of cellular senescence) negative regulation of cellular senescence
P682 biological process ... Q14907708 (positive regulation of neuron death) positive regulation of neuron death
P682 biological process ... Q14908219 (alpha-beta T cell differentiation) alpha-beta T cell differentiation
P682 biological process ... Q14912137 (establishment of protein localization) establishment of protein localization
P682 biological process ... Q14912175 (negative regulation of endothelial cell apoptotic process) negative regulation of endothelial cell apoptotic process
P682 biological process ... Q14913087 (cerebellum morphogenesis) cerebellum morphogenesis
P682 biological process ... Q14914088 (B cell proliferation involved in immune response) B cell proliferation involved in immune response
P682 biological process ... Q14916316 (B-1 B cell homeostasis) B-1 B cell homeostasis
P682 biological process ... Q15311698 (actin filament branching) actin filament branching
P682 biological process ... Q15328828 (peptidyl-tyrosine autophosphorylation) peptidyl-tyrosine autophosphorylation
P682 biological process ... Q428253 (innate immune response) innate immune response
P682 biological process ... Q2984243 (DNA mismatch repair) DNA mismatch repair
P682 biological process ... Q3630494 (protein autophosphorylation) protein autophosphorylation
P682 biological process ... Q4374357 (post-embryonic development) post-embryonic development
P682 biological process ... Q24594331 (regulation of modification of synaptic structure) regulation of modification of synaptic structure
P682 biological process ... Q27302036 (positive regulation of blood vessel branching) positive regulation of blood vessel branching
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q14873990 (actin cytoskeleton organization) actin cytoskeleton organization
P682 biological process ... Q14873991 (regulation of endocytosis) regulation of endocytosis
P682 biological process ... Q14873992 (regulation of cell adhesion) regulation of cell adhesion
P682 biological process ... Q14873993 (signal transduction in response to DNA damage) signal transduction in response to DNA damage
P682 biological process ... Q14873994 (positive regulation of oxidoreductase activity) positive regulation of oxidoreductase activity
P682 biological process ... Q14330986 (peptidyl-tyrosine phosphorylation) peptidyl-tyrosine phosphorylation
P682 biological process ... Q14331037 (positive regulation of peptidyl-tyrosine phosphorylation) positive regulation of peptidyl-tyrosine phosphorylation
P682 biological process ... Q14599311 (apoptotic process) apoptotic process
P682 biological process ... Q210861 (cell differentiation) cell differentiation
P681 cell component ... Q39572 (mitochondrion) mitochondrion
P681 cell component ... Q30869 (nucleolus) nucleolus
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q154626 (cytoskeleton) cytoskeleton
P681 cell component ... Q14645696 (soma) soma
P681 cell component ... Q14817965 (nuclear body) nuclear body
P681 cell component ... Q14860845 (actin cytoskeleton) actin cytoskeleton
P681 cell component ... Q14817956 (nucleoplasm) nucleoplasm
P681 cell component ... Q22325163 (protein-containing complex) protein-containing complex
P681 cell component ... Q22327475 (postsynapse) postsynapse
P681 cell component ... Q14864857 (cell leading edge) cell leading edge
P681 cell component ... Q14905148 (extrinsic component of cytoplasmic side of plasma membrane) extrinsic component of cytoplasmic side of plasma membrane
P681 cell component ... Q465608 (nuclear membrane) nuclear membrane
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q12821248 (dendrite) dendrite
P681 cell component ... Q14330632 (perinuclear region of cytoplasm) perinuclear region of cytoplasm
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q220599 (cytosol) cytosol
P373 Commons category String Tyrosine-protein kinase ABL1 ???
P591 EC enzyme number String 2.7.10.2 ???
P702 encoded by ... Q14873998 (ABL1) ABL1
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P692 Gene Atlas image CommonsMedia http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20ABL1%20202123%20s%20at%20fs.png ???
P527 has part(s) ... Q24719835 (tyrosine-protein kinase, catalytic domain) tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24738472 (tyrosine-protein kinase, active site) tyrosine-protein kinase, active site
P527 has part(s) ... Q24740842 (serine-threonine/tyrosine-protein kinase, catalytic domain) serine-threonine/tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24768234 (protein kinase domain) protein kinase domain
P527 has part(s) ... Q24768561 (F-actin binding) F-actin binding
P527 has part(s) ... Q24769051 (protein kinase, ATP binding site) protein kinase, ATP binding site
P527 has part(s) ... Q24771787 (SH3 domain) SH3 domain
P527 has part(s) ... Q24780316 (SH2 domain) SH2 domain
P527 has part(s) ... Q41796988 (Tyrosine-protein kinase ABL, SH2 domain) Tyrosine-protein kinase ABL, SH2 domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14633858 (DNA binding) DNA binding
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14818106 (protein C-terminus binding) protein C-terminus binding
P680 molecular function ... Q14819233 (signaling receptor binding) signaling receptor binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860293 (syntaxin binding) syntaxin binding
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14860440 (transcription coactivator activity) transcription coactivator activity
P680 molecular function ... Q14860806 (actin filament binding) actin filament binding
P680 molecular function ... Q14860850 (magnesium ion binding) magnesium ion binding
P680 molecular function ... Q14860854 (protein domain specific binding) protein domain specific binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14863338 (protein tyrosine kinase activity) protein tyrosine kinase activity
P680 molecular function ... Q14863344 (SH2 domain binding) SH2 domain binding
P680 molecular function ... Q21122061 (neuropilin binding) neuropilin binding
P680 molecular function ... Q21125944 (supercoiled DNA binding) supercoiled DNA binding
P680 molecular function ... Q22314931 (sequence-specific double-stranded DNA binding) sequence-specific double-stranded DNA binding
P680 molecular function ... Q14865298 (SH3 domain binding) SH3 domain binding
P680 molecular function ... Q14873983 (actin monomer binding) actin monomer binding
P680 molecular function ... Q14873984 (nicotinate-nucleotide adenylyltransferase activity) nicotinate-nucleotide adenylyltransferase activity
P680 molecular function ... Q14873985 (non-membrane spanning protein tyrosine kinase activity) non-membrane spanning protein tyrosine kinase activity
P680 molecular function ... Q14873986 (manganese ion binding) manganese ion binding
P680 molecular function ... Q14873987 (mitogen-activated protein kinase binding) mitogen-activated protein kinase binding
P680 molecular function ... Q14883718 (bubble DNA binding) bubble DNA binding
P680 molecular function ... Q14890003 (protein kinase C binding) protein kinase C binding
P680 molecular function ... Q14897681 (ephrin receptor binding) ephrin receptor binding
P680 molecular function ... Q14905186 (phosphotyrosine residue binding) phosphotyrosine residue binding
P680 molecular function ... Q14911670 (four-way junction DNA binding) four-way junction DNA binding
P680 molecular function ... Q13667380 (metal ion binding) metal ion binding
P680 molecular function ... Q14873988 (proline-rich region binding) proline-rich region binding
P138 named after ... Q4666726 (Abelson murine leukemia virus) Abelson murine leukemia virus
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q24744796 (Tyrosine-protein kinase ABL1/transforming protein Abl) Tyrosine-protein kinase ABL1/transforming protein Abl
P361 part of ... Q41797170 (SH3-like domain superfamily) SH3-like domain superfamily
P361 part of ... Q41797956 (SH2 domain superfamily) SH2 domain superfamily
P361 part of ... Q83130430 (Tyrosine-protein kinase, catalytic domain, protein family) Tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83137014 (Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family) Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83138186 (Protein kinase domain, protein family) Protein kinase domain, protein family
P361 part of ... Q83138426 (F-actin binding domain, protein family) F-actin binding domain, protein family
P361 part of ... Q83140574 (SH3 domain, protein family) SH3 domain, protein family
P361 part of ... Q83164644 (SH2 domain, protein family) SH2 domain, protein family
P361 part of ... Q83170840 (Tyrosine-protein kinase ABL, SH2 domain, protein family) Tyrosine-protein kinase ABL, SH2 domain, protein family
P361 part of ... Q95352684 (Tyrosine-protein kinase, active site, protein family) Tyrosine-protein kinase, active site, protein family
P361 part of ... Q95354221 (Protein kinase, ATP binding site, protein family) Protein kinase, ATP binding site, protein family
P129 physically interacts with ... Q177094 (imatinib) imatinib
P129 physically interacts with ... Q198728 (ponatinib) ponatinib
P129 physically interacts with ... Q412327 (nilotinib) nilotinib
P129 physically interacts with ... Q419940 (dasatinib) dasatinib
P129 physically interacts with ... Q21098957 (saracatinib) saracatinib
P129 physically interacts with ... Q799775 (bafetinib) bafetinib
P129 physically interacts with ... Q894611 (bosutinib) bosutinib
P129 physically interacts with ... Q27088522 (rebastinib) rebastinib
P129 physically interacts with ... Q27088612 (umbralisib) umbralisib
P129 physically interacts with ... Q27114666 (imatinib mesylate) imatinib mesylate

External Ids
P1417Encyclopædia Britannica Online IDtopic/BCR-abl
P705Ensembl protein IDENSP00000323315
P705Ensembl protein IDENSP00000361423
P705Ensembl protein IDENSP00000376971
P646Freebase ID/m/07b808
P486MeSH descriptor IDD016313
P6366Microsoft Academic ID (discontinued)125418893
P6366Microsoft Academic ID (discontinued)2910835860
P10283OpenAlex IDC125418893
P638PDB structure ID5HU9
P638PDB structure ID2G2F
P638PDB structure ID1OPL
P638PDB structure ID2HZ0
P638PDB structure ID2E2B
P638PDB structure ID2HZI
P638PDB structure ID2FO0
P638PDB structure ID3PYY
P638PDB structure ID4WA9
P638PDB structure ID3UE4
P638PDB structure ID2G1T
P638PDB structure ID3QRI
P638PDB structure ID2HYY
P638PDB structure ID2HZ4
P638PDB structure ID2V7A
P638PDB structure ID4TWP
P638PDB structure ID3QRK
P638PDB structure ID2HIW
P638PDB structure ID4XEY
P638PDB structure ID2GQG
P638PDB structure ID2G2H
P638PDB structure ID4YC8
P638PDB structure ID3CS9
P638PDB structure ID3QRJ
P638PDB structure ID4JJB
P638PDB structure ID5DC0
P638PDB structure ID5DC4
P638PDB structure ID5DC9
P638PDB structure ID4JJD
P638PDB structure ID1JU5
P638PDB structure ID4J9D
P638PDB structure ID4J9F
P638PDB structure ID4J9G
P638PDB structure ID4JJC
P638PDB structure ID4J9C
P638PDB structure ID1AB2
P638PDB structure ID1AWO
P638PDB structure ID1BBZ
P638PDB structure ID1ZZP
P638PDB structure ID2ABL
P638PDB structure ID2G2I
P638PDB structure ID2O88
P638PDB structure ID3EG0
P638PDB structure ID3EG1
P638PDB structure ID3EG2
P638PDB structure ID3EG3
P638PDB structure ID3EGU
P638PDB structure ID3K2M
P638PDB structure ID3T04
P638PDB structure ID3UYO
P638PDB structure ID4J9B
P638PDB structure ID4J9E
P638PDB structure ID4J9H
P638PDB structure ID4J9I
P637RefSeq protein IDNP_005148
P637RefSeq protein IDNP_009297
P352UniProt protein IDP00519

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