Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD

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Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...877364S
P356DOI10.1371/JOURNAL.PONE.0077364
P3181OpenCitations bibliographic resource ID4909007
P932PMC publication ID3797037
P698PubMed publication ID24143224
P5875ResearchGate publication ID258061503

P50authorJoanna TimminsQ57089695
P2093author name stringSean McSweeney
Meike Stelter
Samira Acajjaoui
P2860cites workUnraveling DNA helicases. Motif, structure, mechanism and functionQ22065679
Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanismQ27617870
UvrD helicase unwinds DNA one base pair at a time by a two-part power strokeQ27640956
Rotations of the 2B Sub-domain of E. coli UvrD Helicase/Translocase Coupled to Nucleotide and DNA BindingQ27670550
Crystal structure of a DExx box DNA helicaseQ27733946
Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADPQ27742867
XDSQ27860472
Coot: model-building tools for molecular graphicsQ27860505
Automated search-model discovery and preparation for structure solution by molecular replacement.Q51043258
Bacillus stearothermophilus PcrA monomer is a single-stranded DNA translocase but not a processive helicase in vitro.Q54437963
Large-scale purification and characterization of the Escherichia coli rep gene product.Q54728715
Superfamily I helicases as modular components of DNA-processing machines.Q55054097
Helicases: amino acid sequence comparisons and structure-function relationshipsQ56657141
Hyper-recombination in uvrD mutants of Escherichia coli K-12Q60205978
Directional Loading and Stimulation of PcrA Helicase by the Replication Initiator Protein RepDQ60363419
DNA helicase II of Escherichia coli. Characterization of the single-stranded DNA-dependent NTPase and helicase activitiesQ70166254
Escherichia coli rep helicase unwinds DNA by an active mechanismQ70466136
A DNA-dependent ATPase from T4-infected Escherichia coli. Purification and properties of a 63,000-dalton enzyme and its conversion to a 22,000-dalton formQ72608042
UvrD-dependent replication of rolling-circle plasmids in Escherichia coliQ73348549
Water-mediated ionic interactions in protein structuresQ84305565
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Phasercrystallographic softwareQ27860930
Efficient anisotropic refinement of macromolecular structures using FFTQ27861028
A major role of the RecFOR pathway in DNA double-strand-break repair through ESDSA in Deinococcus radioduransQ28485661
Structure and mechanism of helicases and nucleic acid translocasesQ29620151
Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwindingQ30485195
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific mannerQ30863349
Biotin-streptavidin-labeled oligonucleotides as probes of helicase mechanismsQ31952775
Mechanistic and biological aspects of helicase action on damaged DNA.Q33614603
Molecular analyses of DNA helicases involved in the replicational stress responseQ33976698
Double Strand Break Unwinding and Resection by the Mycobacterial Helicase-Nuclease AdnAB in the Presence of Single Strand DNA-binding Protein (SSB)Q34251039
Prokaryotic and eukaryotic DNA helicases. Essential molecular motor proteins for cellular machineryQ34318859
The 2B domain of the Escherichia coli Rep protein is not required for DNA helicase activityQ34415176
The UvrD helicase and its modulation by the mismatch repair protein MutL.Q35100583
Structure-specific DNA binding and bipolar helicase activities of PcrA.Q35130884
Single-stranded DNA translocation of E. coli UvrD monomer is tightly coupled to ATP hydrolysisQ35851112
Lessons learned from UvrD helicase: mechanism for directional movementQ36344950
Purification and characterization of the PcrA helicase of Bacillus anthracisQ37052065
A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaeaQ37518026
Involvement of helicase II (uvrD gene product) and DNA polymerase I in excision mediated by the uvrABC protein complexQ37524603
The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repairQ38350448
Kinetic mechanism for formation of the active, dimeric UvrD helicase-DNA complexQ38353902
Biochemical characterization of the Staphylococcus aureus PcrA helicase and its role in plasmid rolling circle replicationQ38362741
Identification and characterization of Escherichia coli DNA helicase II mutants that exhibit increased unwinding efficiency.Q39564271
Plasmid replication initiator protein RepD increases the processivity of PcrA DNA helicaseQ39727465
UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli.Q40919283
5'-Single-stranded/duplex DNA junctions are loading sites for E. coli UvrD translocaseQ41694137
Single-molecule imaging of the oligomer formation of the nonhexameric Escherichia coli UvrD helicaseQ41761243
Stimulation of UvrD helicase by UvrAB.Q41960449
Contribution of hydrophobic interactions to protein stabilityQ42030075
Purification and characterization of Thermus thermophilus UvrD.Q43032396
Characterization of a thermostable UvrD helicase and its participation in helicase-dependent amplificationQ43198071
Characterization in vitro and in vivo of the DNA helicase encoded by Deinococcus radiodurans locus DR1572.Q44050364
A Dimer of Escherichia coli UvrD is the active form of the helicase in vitroQ44277846
Mechanism of ATP-dependent translocation of E.coli UvrD monomers along single-stranded DNA.Q45160725
Applications of fluorescence anisotropy to the study of protein-DNA interactionsQ46927996
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectDeinococcus radioduransQ386827
P304page(s)e77364
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleStructural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD
P478volume8

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cites work (P2860)
Q28072374A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
Q58595875Conservation and diversity of radiation and oxidative stress resistance mechanisms in Deinococcus species
Q38240728Grip it and rip it: structural mechanisms of DNA helicase substrate binding and unwinding.
Q51742882Novel Sequence Features of DNA Repair Genes/Proteins from Deinococcus Species Implicated in Protection from Oxidatively Generated Damage.
Q64100696Rep and UvrD Antagonize One Another at Stalled Replication Forks and This Is Exacerbated by SSB
Q100454924Reply to: "Does PCNA diffusion on DNA follow a rotation-coupled translation mechanism?"
Q27324828Taking a molecular motor for a spin: helicase mechanism studied by spin labeling and PELDOR.
Q41900375The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase
Q100958631UvrD helicase-RNA polymerase interactions are governed by UvrD's carboxy-terminal Tudor domain

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