A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges

scientific article

A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CSBJ.2016.04.001
P8608Fatcat IDrelease_o3bahrveivd6tm3wx477ejqws4
P3181OpenCitations bibliographic resource ID4908933
P932PMC publication ID5128194
P698PubMed publication ID27924191
P5875ResearchGate publication ID301746756

P50authorElin MoeQ43022039
Joanna TimminsQ57089695
P2093author name stringElin Moe
Joanna Timmins
P2860cites workComparative and evolutionary analysis of the bacterial homologous recombination systemsQ21092503
Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrDQ21132480
Expression, purification and crystallization of two endonuclease III enzymes from Deinococcus radioduransQ43058500
Analysis of the recJ gene and protein from Deinococcus radioduransQ43234349
The evolution of RecD outside of the RecBCD complexQ43258499
Characterization of the Escherichia coli X-ray endonuclease, endonuclease III.Q43860794
Mismatch uracil glycosylase from Escherichia coli: a general mismatch or a specific DNA glycosylase?Q44385769
NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans.Q44438600
Small-angle X-ray scattering reveals architecture and A₂B₂ stoichiometry of the UvrA-UvrB DNA damage sensor.Q44536579
Crystal structure of RecA from Deinococcus radiodurans: insights into the structural basis of extreme radioresistanceQ45151313
Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans.Q46616256
Dps from Deinococcus radiodurans: oligomeric forms of Dps1 with distinct cellular functions and Dps2 involved in metal storage.Q46682116
The crystal structure of mismatch-specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans reveals a novel catalytic residue and broad substrate specificity.Q46751737
Identification and disruption analysis of the recN gene in the extremely radioresistant bacterium Deinococcus radioduransQ47912758
Substrate specificity of Deinococcus radiodurans Fpg protein.Q51450003
RecN and RecG are required for Escherichia coli survival of Bleomycin-induced damage.Q51608920
PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans.Q52550949
Pleiotropic effects of RecQ in Deinococcus radiodurans.Q52595130
Identification and characterization of two uvrA genes of Xanthomonas axonopodis pathovar citri.Q54450944
Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans.Q54452515
An interaction between the Escherichia coli RecF and RecR proteins dependent on ATP and double-stranded DNA.Q54598042
Dimerization of Escherichia coli UvrA and its binding to undamaged and ultraviolet light damaged DNAQ54696970
Deinococcus radiodurans: What Belongs to the Survival Kit?Q56657202
Specific Expansion of Protein Families in the Radioresistant Bacterium Deinococcus RadioduransQ57263059
Identification of the RecR Toprim Domain as the Binding Site for both RecF and RecOQ57663086
ATP hydrolysis and DNA binding by the Escherichia coli RecF proteinQ64388887
Recombinational DNA repair: the RecF and RecR proteins limit the extension of RecA filaments beyond single-strand DNA gapsQ73863469
The crystal structure of Deinococcus radiodurans Dps protein (DR2263) reveals the presence of a novel metal centre in the N terminusQ79950672
Dual role of NER in mutagenesis in Pseudomonas putidaQ80846403
Deinococcus geothermalis: the pool of extreme radiation resistance genes shrinksQ21144427
Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1Q22065550
Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactionsQ24315065
Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomicsQ24548476
Critical role of RecN in recombinational DNA repair and survival of Helicobacter pyloriQ24657854
DNA glycosylases: in DNA repair and beyondQ26830166
Biology of extreme radiation resistance: the way of Deinococcus radioduransQ27006730
DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkAQ27621390
Domain closure and action of uracil DNA glycosylase (UDG): structures of new crystal forms containing the Escherichia coli enzyme and a comparative study of the known structures involving UDGQ27639404
UvrD helicase unwinds DNA one base pair at a time by a two-part power strokeQ27640956
Structure of a trapped endonuclease III-DNA covalent intermediateQ27641607
The structure of uracil-DNA glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation featuresQ27641716
Structural conservation of RecF and Rad50: implications for DNA recognition and RecF functionQ27643663
The structure of the E. coli recA protein monomer and polymerQ27643868
Crystal structure and mutational study of RecOR provide insight into its mode of DNA bindingQ27646121
The crystal structure of the Dps2 from Deinococcus radiodurans reveals an unusual pore profile with a non-specific metal binding siteQ27646221
Crystal structure of the DNA repair enzyme ultraviolet damage endonucleaseQ27648789
Crystal Structure of Bacillus stearothermophilus UvrA Provides Insight into ATP-Modulated Dimerization, UvrB Interaction, and DNA BindingQ27649421
Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQQ27650322
DNA binding to RecD: role of the 1B domain in SF1B helicase activityQ27651386
Crystal structure of the IrrE protein, a central regulator of DNA damage repair in deinococcaceaeQ27653440
Structural and mutational analyses of Deinococcus radiodurans UvrA2 provide insight into DNA binding and damage recognition by UvrAsQ27654777
Mechanistic basis of 5'-3' translocation in SF1B helicasesQ27655717
Structure of UvrA nucleotide excision repair protein in complex with modified DNAQ27666597
Mechanism of RecO recruitment to DNA by single-stranded DNA binding proteinQ27667563
RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNAQ27673699
Structure and mechanism of the UvrA-UvrB DNA damage sensorQ27677070
An 'open' structure of the RecOR complex supports ssDNA binding within the core of the complexQ27678854
Structure and Cellular Dynamics of Deinococcus radiodurans Single-stranded DNA (ssDNA)-binding Protein (SSB)-DNA ComplexesQ27678980
Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radioduransQ27681054
Structural and functional characterization of an SMC-like protein RecN: new insights into double-strand break repairQ27682913
Structural and functional studies of MutS2 from Deinococcus radioduransQ27690172
Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radioduransQ27701550
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structureQ27729885
The structural basis of specific base-excision repair by uracil-DNA glycosylaseQ27730352
Structural basis for the excision repair of alkylation-damaged DNAQ27733235
Reassembly of shattered chromosomes in Deinococcus radioduransQ28265761
Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaksQ28292707
Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysisQ28298751
PprA: a novel protein from Deinococcus radiodurans that stimulates DNA ligationQ28485660
A major role of the RecFOR pathway in DNA double-strand-break repair through ESDSA in Deinococcus radioduransQ28485661
DdrB protein, an alternative Deinococcus radiodurans SSB induced by ionizing radiationQ28485663
DNA helicase activity of the RecD protein from Deinococcus radioduransQ28485666
Visualization of DNA double-strand break repair in live bacteria reveals dynamic recruitment of Bacillus subtilis RecF, RecO and RecN proteins to distinct sites on the nucleoidsQ28488848
Escherichia coli, Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N6-ethenoadenine when present in DNAQ28610592
Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylasesQ28610597
Repair of oxidative damage to DNA: enzymology and biologyQ29618065
Oxidative stress resistance in Deinococcus radioduransQ30499016
The IrrE protein of Deinococcus radiodurans R1 is a novel regulator of recA expressionQ30717114
Mutation in recR gene of Deinococcus radiodurans and possible involvement of its product in the repair of DNA interstrand cross-linksQ30952885
Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radioduransQ33294477
Rising from the Ashes: DNA Repair in Deinococcus radioduransQ33525019
Molecular cloning and functional analysis of the MutY homolog of Deinococcus radioduransQ33553542
Radiation resistance: the fragments that remainQ33860430
RecN is a cohesin-like protein that stimulates intermolecular DNA interactions in vitroQ33883179
The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteinsQ33889321
The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathwaysQ33959536
Crystal structure of the Deinococcus radiodurans single-stranded DNA-binding protein suggests a mechanism for coping with DNA damage.Q33978574
Deinococcus radiodurans - the consummate survivorQ33991135
An N -Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine ResiduesQ34052545
The MRN complex in double-strand break repair and telomere maintenanceQ34127693
Crystal structure of Deinococcus radiodurans RecQ helicase catalytic core domain: the interdomain flexibility.Q34177595
The MRN complex: coordinating and mediating the response to broken chromosomesQ34250399
Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenineQ34276952
RecA Protein from the extremely radioresistant bacterium Deinococcus radiodurans: expression, purification, and characterizationQ34306302
Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair.Q34572092
A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged regionQ34708982
Sit down, relax and unwind: structural insights into RecQ helicase mechanismsQ35100587
Homologous recombination-mediated double-strand break repairQ35848423
Additive effects of SbcCD and PolX deficiencies in the in vivo repair of DNA double-strand breaks in Deinococcus radioduransQ35879403
How radiation kills cells: survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stressQ36088685
At the heart of the chromosome: SMC proteins in actionQ36457726
Prokaryotic nucleotide excision repair.Q36626668
Repair of UV damage in bacteriaQ36976950
Regulation of Deinococcus radiodurans RecA protein function via modulation of active and inactive nucleoprotein filament statesQ37175208
Solution small angle X-ray scattering (SAXS) studies of RecQ from Deinococcus radiodurans and its complexes with junction DNA substrates.Q37289224
Double-strand break repair in bacteria: a view from Bacillus subtilisQ37868655
Structure and function of the UvrB proteinQ38296691
Protein interactions in genetic recombination in Escherichia coli. Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA-binding proteinQ38302209
Repair of oxidized bases in the extremely radiation-resistant bacterium Deinococcus radiodurans.Q38330164
Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans.Q38330458
Both ATPase sites of Escherichia coli UvrA have functional roles in nucleotide excision repairQ38334778
A novel structure of DNA repair protein RecO from Deinococcus radiodurans.Q38335907
Kinetics of DNA unwinding by the RecD2 helicase from Deinococcus radioduransQ38345204
Expression, purification and preliminary structural analysis of the head domain of Deinococcus radiodurans RecN.Q40247665
Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA.Q40442255
Deinococcus radiodurans RecA nucleoprotein filaments characterized at the single-molecule level with optical tweezersQ40544150
Excision repair of uracil incorporated in DNA as a result of a defect in dUTPaseQ40859816
Expression, purification and preliminary structural analysis of the coiled-coil domain of Deinococcus radiodurans RecN.Q40917486
The base excision repair pathwayQ40930021
RecR forms a ring-like tetramer that encircles dsDNA by forming a complex with RecFQ42425375
Characterization of pathways dependent on the uvsE, uvrA1, or uvrA2 gene product for UV resistance in Deinococcus radioduransQ42754939
ATP-type DNA ligase requires other proteins for its activity in vitro and its operon components for radiation resistance in Deinococcus radiodurans in vivoQ42870047
Multiple uracil-DNA glycosylase activities in Deinococcus radioduransQ43014625
P407language of work or nameEnglishQ1860
P921main subjectDeinococcus radioduransQ386827
biochemistryQ7094
P304page(s)168-176
P577publication date2016-04-07
P1433published inComputational and Structural Biotechnology JournalQ19865804
P1476titleA Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
P478volume14

Reverse relations

cites work (P2860)
Q58719693Bacterial cell wall nanoimaging by autoblinking microscopy
Q58595875Conservation and diversity of radiation and oxidative stress resistance mechanisms in Deinococcus species
Q52312057DdrI, a CRP family member, acts as a major regulator for adaptation of Deinococcus radiodurans to various stresses.
Q51742882Novel Sequence Features of DNA Repair Genes/Proteins from Deinococcus Species Implicated in Protection from Oxidatively Generated Damage.
Q94464339Too Much of a Good Thing: How Ectopic DNA Replication Affects Bacterial Replication Dynamics

Search more.