| scholarly article | Q13442814 |
| P50 | author | Yon Rojanasakul | Q28036799 |
| Todd A. Stueckle | Q57066727 | ||
| Hosam A Elbaz | Q59691248 | ||
| P2093 | author name string | Cerasela Zoica Dinu | |
| William Tse | |||
| P2860 | cites work | Control of apoptosis and mitotic spindle checkpoint by survivin | Q22008570 |
| Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells | Q23913664 | ||
| Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension | Q24305061 | ||
| Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex | Q24530605 | ||
| Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells | Q24562089 | ||
| FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. | Q27325401 | ||
| A cell cycle regulatory network controlling NF-kappaB subunit activity and function | Q28116296 | ||
| Control of the G2/M transition | Q28236097 | ||
| Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells | Q43756233 | ||
| Tamoxifen-induced increases in cytoplasmic free Ca2+ levels in human breast cancer cells | Q43907662 | ||
| Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases | Q43925892 | ||
| Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress | Q44392778 | ||
| Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin | Q44799506 | ||
| Sodium pump inhibition, enhanced calcium influx via sodium-calcium exchange, and positive inotropic response in cultured heart cells | Q44878367 | ||
| Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity | Q44997717 | ||
| Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells. | Q45081067 | ||
| Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis? | Q46009317 | ||
| Relationship between survivin expression and chemosensitivity of human lung cancer cells | Q46960909 | ||
| The erroneous pharmacology of a cat. | Q47352860 | ||
| Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis | Q47420652 | ||
| Proscillaridin A Immunoreactivity: Its Purification, Transport in Blood By A Specific Binding Protein And Its Correlation With Blood Pressure | Q47771968 | ||
| Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases | Q48010243 | ||
| Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes | Q52201951 | ||
| Evidence of a modifying influence of heart glucosides on the development of breast cancer. | Q52764670 | ||
| Expression of survivin and proliferating cell nuclear antigen in human non-small cell lung cancer | Q53351908 | ||
| Expression of survivin and its clinical significance in non-small cell lung cancer | Q53353475 | ||
| Signal transductions by the MAP kinase cascades | Q53431875 | ||
| Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). | Q54429273 | ||
| Survivin gene expression in early-stage non-small cell lung cancer. | Q54762265 | ||
| Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells. | Q55034250 | ||
| Role of caveolae in ouabain-induced proliferation of cultured vascular smooth muscle cells of the synthetic phenotype | Q57374677 | ||
| Cardiac glycosides and breast cancer | Q66702285 | ||
| Ouabain sensitizes tumor cells but not normal cells to radiation | Q67955104 | ||
| [Inhibition of the active Na-K-transport and Na-K-activated membrane ATP-ase of erythrocyte stroma by ouabain] | Q68372881 | ||
| Cardiac glycosides and breast cancer, revisited | Q70275959 | ||
| Effects of arrhythmia-producing concentrations of digitoxin on mechanical performance of cat myocardium | Q71730016 | ||
| Growth inhibitory effect of cardiac glycosides and aglycones on neoplastic cells: in vitro and in vivo studies | Q71879447 | ||
| Digitalis and cancer | Q72580111 | ||
| Digitoxin is a potential anticancer agent for several types of cancer | Q73477042 | ||
| Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events | Q73896625 | ||
| Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs | Q73931534 | ||
| Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells | Q74088025 | ||
| The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer | Q75403132 | ||
| Structure–cytotoxic activity relationship for the toad poison bufadienolides | Q77213593 | ||
| Is digitalis a therapy for breast carcinoma? | Q77325783 | ||
| Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells | Q77402803 | ||
| Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes | Q77927017 | ||
| Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins | Q80607767 | ||
| Assessment of prognostic significance of cytoplasmic survivin expression in advanced oesophageal cancer | Q80882431 | ||
| Prolonged digitoxin half-life in very elderly patients | Q81501970 | ||
| [Effects of ouabain at different concentrations on growth of leukemia cells] | Q83677224 | ||
| Expression and prognostic significance of cyclin B1 and cyclin A in non-small cell lung cancer | Q84248085 | ||
| [Subcellular localization of survivin in non-small cell lung cancer] | Q84512782 | ||
| Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms | Q28238946 | ||
| Role of survivin in mitosis | Q28242087 | ||
| Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function | Q28247779 | ||
| Cell death by mitotic catastrophe: a molecular definition | Q28255830 | ||
| Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells | Q28267868 | ||
| The activator protein-1 transcription factor in respiratory epithelium carcinogenesis | Q28289410 | ||
| Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics | Q28290655 | ||
| Evaluation of anticyclin B1 serum antibody as a diagnostic and prognostic biomarker for lung cancer | Q28295958 | ||
| A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis | Q28397506 | ||
| Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2 | Q28575003 | ||
| Chk1 and Chk2 kinases in checkpoint control and cancer | Q29617706 | ||
| Regulation of c-SRC activity and function by the adapter protein CAS | Q30168872 | ||
| Historical perspectives on health. Early Arabic medicine | Q33205625 | ||
| SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis | Q33241072 | ||
| Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth | Q33385608 | ||
| Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor | Q33868825 | ||
| Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility | Q33913667 | ||
| LC/MS/MS analyses of an oleander extract for cancer treatment | Q33914762 | ||
| Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization | Q33933859 | ||
| Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells | Q33950327 | ||
| Ouabain modulates epithelial cell tight junction. | Q33952894 | ||
| Digitalis toxicity: Epidemiology and clinical use of serum concentration measurements | Q33988313 | ||
| Targeting lymphatic vessel functions through tyrosine kinases | Q34078275 | ||
| Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin | Q34083686 | ||
| Treatment of congestive heart failure--current status of use of digitoxin | Q34088364 | ||
| Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators | Q34092412 | ||
| Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process | Q34143616 | ||
| Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells | Q34166582 | ||
| Selective inhibitory effect of bufalin on growth of human tumor cells in vitro: association with the induction of apoptosis in leukemia HL-60 cells | Q34332331 | ||
| Oleandrin-mediated oxidative stress in human melanoma cells | Q34501148 | ||
| Contemporary use of digoxin in the management of cardiovascular disorders | Q34532122 | ||
| Biochemistry of Na,K-ATPase | Q34667442 | ||
| Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside. | Q34720018 | ||
| Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A. | Q40259456 | ||
| Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells | Q40266680 | ||
| Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay | Q40280218 | ||
| Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients | Q40347405 | ||
| Role of calcium-induced mitochondrial hydroperoxide in induction of apoptosis of RBL2H3 cells with eicosapentaenoic acid treatment | Q40349374 | ||
| Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells. | Q40480287 | ||
| Ouabain binding to Na+,K+-ATPase relaxes cell attachment and sends a specific signal (NACos) to the nucleus. | Q40541877 | ||
| Oleandrin suppresses activation of nuclear transcription factor-κB and activator protein-1 and potentiates apoptosis induced by ceramide | Q40617978 | ||
| Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase | Q40864666 | ||
| Pleiotropic cell-division defects and apoptosis induced by interference with survivin function | Q40913411 | ||
| The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells | Q41191937 | ||
| The use of digitalis in heart failure | Q41271518 | ||
| C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity | Q42072891 | ||
| The lead structure in cardiac glycosides is 5 beta, 14 beta-androstane-3 beta 14-diol | Q42228911 | ||
| Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells | Q42277663 | ||
| Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents | Q42746400 | ||
| Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. | Q42911524 | ||
| Dual effects of ouabain, digoxin and proscillaridin A on the regulation of apoptosis in human fibroblasts | Q43169322 | ||
| Cardiac glycosides as novel cancer therapeutic agents | Q34760542 | ||
| Novel therapeutic applications of cardiac glycosides | Q34864765 | ||
| Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets | Q34996739 | ||
| Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications | Q35003431 | ||
| Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs | Q35011593 | ||
| Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell | Q35018903 | ||
| Drug discovery targeting Chk1 and Chk2 kinases | Q35573721 | ||
| Membrane cation transport and the control of proliferation of mammalian cells | Q35649484 | ||
| Targeting the checkpoint kinases: chemosensitization versus chemoprotection | Q35679781 | ||
| Pathways of apoptotic and non-apoptotic death in tumour cells | Q35852309 | ||
| p38 MAP kinase's emerging role as a tumor suppressor | Q35941622 | ||
| Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth | Q36817975 | ||
| On the importance and mechanism of amplification of digitalis signal through Na+/K+-ATPase | Q36834499 | ||
| The pathways to tumor suppression via route p38. | Q36877196 | ||
| Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved | Q36897343 | ||
| A connection between MAPK pathways and circadian clocks | Q36959485 | ||
| Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia | Q37000320 | ||
| The prince and the pauper. A tale of anticancer targeted agents | Q37042365 | ||
| Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer | Q37065279 | ||
| The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin | Q37090296 | ||
| Dual-specificity MAP kinase phosphatases (MKPs) and cancer | Q37106291 | ||
| Death through a tragedy: mitotic catastrophe | Q37135368 | ||
| Erk1/2 MAP kinases are required for epidermal G2/M progression | Q37237648 | ||
| The TGF-beta paradox in human cancer: an update | Q37261631 | ||
| Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth | Q37298570 | ||
| Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways | Q37445594 | ||
| ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence | Q37618297 | ||
| The dual kinase complex FAK-Src as a promising therapeutic target in cancer | Q37771259 | ||
| Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray. | Q38519339 | ||
| Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression | Q39134067 | ||
| Liaisons between survivin and Plk1 during cell division and cell death | Q39709805 | ||
| Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition | Q39812929 | ||
| Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells | Q39976119 | ||
| Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells. | Q40044677 | ||
| Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells. | Q40151992 | ||
| Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity | Q40194965 | ||
| P6195 | funding scheme | extramural research | Q124503498 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | manufacturing | Q187939 |
| P5008 | on focus list of Wikimedia project | Wikimedia–NIOSH collaboration | Q104416361 |
| P304 | page(s) | 4 | |
| P577 | publication date | 2012-04-05 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Experimental Hematology & Oncology | Q23979095 |
| P859 | sponsor | NIOSH Health Effects Laboratory Division | Q123344455 |
| P1476 | title | Digitoxin and its analogs as novel cancer therapeutics | |
| P478 | volume | 1 |
| Q38720703 | A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. |
| Q29248485 | Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers |
| Q53149725 | Cardiac glycosides and the risk of breast cancer in women with chronic heart failure and supraventricular arrhythmia |
| Q28392316 | Cardiac glycosides use and the risk of lung cancer: a nested case-control study |
| Q28391684 | Current management and prognostic features for gastrointestinal stromal tumor (GIST) |
| Q38658378 | Digitalis use and lung cancer risk by histological type in men. |
| Q28397351 | Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel |
| Q40398640 | Digitoxin for Airway Inflammation in Cystic Fibrosis: Preliminary Assessment of Safety, Pharmacokinetics, and Dose Finding. |
| Q28397747 | Digoxin Downregulates NDRG1 and VEGF through the Inhibition of HIF-1α under Hypoxic Conditions in Human Lung Adenocarcinoma A549 Cells |
| Q28387220 | Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia |
| Q132042347 | Emerging roles for the YAP/TAZ transcriptional regulators in brain tumour pathology and targeting options |
| Q28817274 | Exploring targeted therapy of osteosarcoma using proteomics data |
| Q58322723 | Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin |
| Q28389577 | Homozygous A polymorphism of the complement C1qA276 correlates with prolonged overall survival in patients with diffuse large B cell lymphoma treated with R-CHOP |
| Q28391063 | Inactivation of Src-to-ezrin pathway: a possible mechanism in the ouabain-mediated inhibition of A549 cell migration |
| Q38379632 | Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era. |
| Q27027499 | Intensity modulated radiotherapy for sinonasal malignancies with a focus on optic pathway preservation |
| Q58181734 | Is digoxin a breast cancer risk factor? |
| Q28384383 | Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate |
| Q92347227 | New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification |
| Q38709867 | Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. |
| Q28390112 | Novel CD20 monoclonal antibodies for lymphoma therapy |
| Q38775646 | Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death. |
| Q28396209 | Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells |
| Q26781498 | Plant derived substances with anti-cancer activity: from folklore to practice |
| Q92108627 | Potential Anticancer Agents Characterized from Selected Tropical Plants |
| Q50005505 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing |
| Q23919744 | Real-time analysis of the effects of toxic, therapeutic and sub-therapeutic concentrations of digitoxin on lung cancer cells |
| Q64086789 | Regulatory mechanisms of fluvastatin and lovastatin for the p21 induction in human cervical cancer HeLa cells |
| Q29248487 | Repositioning approved drugs for the treatment of problematic cancers using a screening approach. |
| Q58739088 | Repurposing of Drugs Targeting YAP-TEAD Functions |
| Q38790879 | Risk of cancer in patients with heart failure who use digoxin: a 10-year follow-up study and cell-based verification |
| Q28390181 | Rituximab and new regimens for indolent lymphoma: a brief update from 2012 ASCO Annual Meeting |
| Q53166906 | Simultaneous quantification of digoxin, digitoxin, and their metabolites in serum using high performance liquid chromatography-tandem mass spectrometry |
| Q28397373 | Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells |
| Q86366943 | Synthesis and structure–activity relationships study of cytotoxic bufalin 3-nitrogen-containing-ester derivatives |
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