| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Keith I Block | Q94114016 |
| P2093 | author name string | Peiying Yang | |
| Robert A Newman | |||
| Alison D Pawlus | |||
| P2860 | cites work | Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases | Q40186826 |
| Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells | Q40266680 | ||
| Bufadienolides and a new lignan from the bulbs of Urginea maritima | Q43544881 | ||
| Cytotoxic cardenolides from woods of Euonymus alata | Q71708315 | ||
| Flow cytometric estimation of cytotoxic activity of rhodexin A isolated from Rhodea japonica in human leukemia K562 cells | Q73367636 | ||
| P433 | issue | 1 | |
| P304 | page(s) | 36-49 | |
| P577 | publication date | 2008-02-01 | |
| P1433 | published in | Molecular Interventions: pharmacological perspectives from biology, chemistry and genomics | Q15756221 |
| P1476 | title | Cardiac glycosides as novel cancer therapeutic agents | |
| P478 | volume | 8 |
| Q42130306 | "The Lower Threshold" phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis? |
| Q28397506 | A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis |
| Q51067287 | A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. |
| Q41005896 | A convergent total synthesis of ouabagenin |
| Q38720703 | A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. |
| Q39595777 | A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs |
| Q35581883 | A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment |
| Q94362513 | A pilot phase II Study of digoxin in patients with recurrent prostate cancer as evident by a rising PSA |
| Q34568560 | Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells |
| Q38841438 | Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro |
| Q36476123 | Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects |
| Q48341352 | Anticancer and Immunogenic Properties of Cardiac Glycosides |
| Q39439229 | Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia |
| Q38896986 | Apocynaceae species with antiproliferative and/or antiplasmodial properties: a review of ten genera |
| Q35745302 | Asymmetric synthesis of dihydroindanes by convergent alkoxide-directed metallacycle-mediated bond formation |
| Q38254442 | Autosis and autophagic cell death: the dark side of autophagy |
| Q30560419 | Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia |
| Q37479544 | BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin |
| Q37854486 | Bufadienolides and their antitumor activity |
| Q39247480 | C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity |
| Q42072891 | C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity |
| Q35184108 | Cancer as a channelopathy: ion channels and pumps in tumor development and progression |
| Q34504844 | Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest. |
| Q36226639 | Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity |
| Q52653145 | Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death. |
| Q39147059 | Cardiac glycosides correct aberrant splicing of IKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3. |
| Q39311553 | Cardiac glycosides exert anticancer effects by inducing immunogenic cell death |
| Q38113122 | Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials. |
| Q38872784 | Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase |
| Q39812929 | Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition |
| Q41092445 | Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells |
| Q35641864 | Cellular location and expression of Na+, K+ -ATPase α subunits affect the anti-proliferative activity of oleandrin |
| Q37200859 | Changes in sodium pump expression dictate the effects of ouabain on cell growth |
| Q43143252 | Comment on 'Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer. |
| Q38598719 | Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses |
| Q28541345 | Convallatoxin, a dual inducer of autophagy and apoptosis, inhibits angiogenesis in vitro and in vivo |
| Q52683791 | Coroglaucigenin induces senescence and autophagy in colorectal cancer cells. |
| Q36367538 | Critical role of the α1-Na(+), K(+)-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain |
| Q35101095 | Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria |
| Q38972948 | Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation. |
| Q37642547 | Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells |
| Q37173140 | Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. |
| Q39781732 | Digitoxin analogues with improved anticytomegalovirus activity |
| Q23913664 | Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells |
| Q21195743 | Digitoxin and its analogs as novel cancer therapeutics |
| Q33385608 | Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth |
| Q39305936 | Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes. |
| Q47146141 | Digoxin enhances radiation response in radioresistant A549 cells by reducing protein phosphatase 2A. |
| Q36041722 | Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury |
| Q48100195 | Digoxin reduces the mutagenic effects of Mitomycin C in human and rodent cell lines. |
| Q37131343 | Digoxin treatment is associated with an increased incidence of breast cancer: a population-based case-control study |
| Q33566322 | Digoxin use and risk of invasive breast cancer: evidence from the Nurses' Health Study and meta-analysis. |
| Q41508786 | Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. |
| Q35123373 | Effects of bilberry on deoxyribonucleic Acid damage and oxidant-antioxidant balance in the lens, induced by ultraviolet radiation |
| Q34605877 | Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets |
| Q28386608 | Evaluating the cancer therapeutic potential of cardiac glycosides |
| Q33796670 | Ex vivo activity of cardiac glycosides in acute leukaemia |
| Q36081864 | Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins |
| Q54345421 | First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors. |
| Q36741027 | Flavonolignans As a Novel Class of Sodium Pump Inhibitors. |
| Q58322723 | Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin |
| Q36172394 | Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene. |
| Q34087018 | Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres |
| Q90773557 | Identification and screening of cardiac glycosides in Streptocaulon griffithii using an integrated data mining strategy based on high resolution mass spectrometry |
| Q40229769 | Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virus |
| Q28270149 | Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action |
| Q27318801 | Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents |
| Q34008343 | Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening |
| Q48876895 | In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models |
| Q28391063 | Inactivation of Src-to-ezrin pathway: a possible mechanism in the ouabain-mediated inhibition of A549 cell migration |
| Q89849213 | Influence of Endogenous Cardiac Glycosides, Digoxin, and Marinobufagenin in the Physiology of Epithelial Cells |
| Q28390870 | Influence of Sugar Amine Regiochemistry on Digitoxigenin Neoglycoside Anticancer Activity |
| Q38972699 | Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma |
| Q46718054 | Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human |
| Q35170993 | Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms |
| Q37604348 | Is digoxin use for cardiovascular disease associated with risk of prostate cancer? |
| Q36905850 | Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair |
| Q37740993 | Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells |
| Q36057365 | Membrane potential-dependent inhibition of the Na+,K+-ATPase by para-nitrobenzyltriethylammonium bromide |
| Q40215178 | Microbial Transformation of 14-Anhydrodigoxigenin by Alternaria alternata |
| Q38010820 | Modulators of Na/K-ATPase: a patent review |
| Q23923209 | Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation |
| Q38162901 | Na+/K+-ATPase and cancer |
| Q39254499 | Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy |
| Q38288274 | Natriuretic hormones in brain function |
| Q96768636 | Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis |
| Q39248982 | Na⁺i,K⁺i-Dependent and -Independent Signaling Triggered by Cardiotonic Steroids: Facts and Artifacts. |
| Q34634743 | Neuroprotective effects of lutein in the retina |
| Q92347227 | New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification |
| Q28831303 | Novel stereoselective bufadienolides reveal new insights into the requirements for Na(+), K(+)-ATPase inhibition by cardiotonic steroids |
| Q34864765 | Novel therapeutic applications of cardiac glycosides |
| Q37699239 | Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation |
| Q58114487 | Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway |
| Q39280515 | On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease |
| Q36296274 | Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells |
| Q38957007 | Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway |
| Q44499577 | Ouabain targets the Na+/K+-ATPase α3 isoform to inhibit cancer cell proliferation and induce apoptosis |
| Q37582393 | Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice |
| Q35288875 | PBI-05204, a supercritical CO₂ extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway |
| Q97536359 | Phytochemical Analysis and Various Biological Activities of the Aerial Parts of Scrophularia Atropatana Growing in Iran |
| Q24634545 | Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer |
| Q92132749 | Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics |
| Q64057165 | Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery |
| Q34478346 | Pro-death and pro-survival properties of ouabain in U937 lymphoma derived cells |
| Q36374894 | Probing the regiospecificity of enzyme-catalyzed steroid glycosylation. |
| Q46710246 | Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers |
| Q23919744 | Real-time analysis of the effects of toxic, therapeutic and sub-therapeutic concentrations of digitoxin on lung cancer cells |
| Q47761720 | Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy |
| Q37521136 | Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle. |
| Q58739088 | Repurposing of Drugs Targeting YAP-TEAD Functions |
| Q39618628 | Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides |
| Q52324132 | Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. |
| Q43283461 | Signal pathways in ouabain-induced proliferation of leukemia cells |
| Q34017477 | Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins |
| Q39017201 | Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines |
| Q35018903 | Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell |
| Q35796826 | Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug |
| Q89497251 | Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers |
| Q38951744 | Structures, chemotaxonomic significance, cytotoxic and Na(+),K(+)-ATPase inhibitory activities of new cardenolides from Asclepias curassavica |
| Q38729229 | Suppression of Adenovirus Replication by Cardiotonic Steroids |
| Q42746400 | Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents |
| Q38807596 | Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer |
| Q38072110 | Targeting Ca²⁺ transport in cancer: close reality or long perspective? |
| Q37665204 | Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma |
| Q38089963 | Targeting apoptosis by the remodelling of calcium-transporting proteins in cancerogenesis. |
| Q26767351 | Targeting hypoxic response for cancer therapy |
| Q46889322 | The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice. |
| Q58108327 | The Connection Between the Cardiac Glycoside-Induced Senescent Cell Morphology and Rho/Rho Kinase Pathway |
| Q39181842 | The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals |
| Q57146238 | The cardenolide ouabain suppresses coronaviral replication via augmenting a Na/K-ATPase-dependent PI3K_PDK1 axis signaling |
| Q34150328 | The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice |
| Q37042365 | The prince and the pauper. A tale of anticancer targeted agents |
| Q39221272 | The synthesis of cardenolide and bufadienolide aglycones, and related steroids bearing a heterocyclic subunit. |
| Q48157665 | Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinase and angiogenesis induced by different growth factors. |
| Q38204742 | Toad glandular secretions and skin extractions as anti-inflammatory and anticancer agents |
| Q35886637 | Toxicarioside A inhibits SGC-7901 proliferation, migration and invasion via NF-κB/bFGF signaling |
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| Q37310890 | Transcriptome and Metabolite analysis reveal candidate genes of the cardiac glycoside biosynthetic pathway from Calotropis procera |
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