Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair

scientific article published on 7 January 2016

Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.6832
P932PMC publication ID4868741
P698PubMed publication ID26756216
P5875ResearchGate publication ID290378569

P2093author name stringJae-Hoon Jeong
Mi-Sook Kim
Jee-Hyun Um
Wonwoo Kim
Jie-Young Song
Mi Ae Kang
Young-Joo Shin
P2860cites workRNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesQ24306486
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsQ24309287
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligaseQ24653776
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repairQ24669691
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin markQ29465773
Development by self-digestion: molecular mechanisms and biological functions of autophagyQ29547880
Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogensQ34000894
Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cellsQ34309146
Cardiac glycosides as novel cancer therapeutic agentsQ34760542
Novel therapeutic applications of cardiac glycosidesQ34864765
Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targetsQ34996739
Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathwayQ35419466
The role of autophagy in cancer development and response to therapy.Q36251939
Chromatin modifications and the DNA damage response to ionizing radiation.Q36550882
Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involvedQ36897343
Mitochondria as targets for cancer therapyQ37362332
ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescenceQ37618297
Autophagy as a target for anticancer therapyQ37876679
Cardiotonic steroids-mediated targeting of the Na(+)/K(+)-ATPase to combat chemoresistant cancersQ37971948
Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cellsQ38891752
Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathwaysQ39322055
Huachansu, containing cardiac glycosides, enhances radiosensitivity of human lung cancer cells.Q39510928
Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells.Q40044677
Mitoptosis, a novel mitochondrial death mechanism leading predominantly to activation of autophagyQ42160305
Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sitesQ43101547
Nuclear retention of ATM at sites of DNA double strand breaksQ43675407
Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells.Q44671716
Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.Q47223810
Ouabain sensitizes tumor cells but not normal cells to radiationQ67955104
Digitoxin is a potential anticancer agent for several types of cancerQ73477042
The p53 functional circuitQ77338403
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
cell growthQ189159
P304page(s)6074-6087
P577publication date2016-01-07
P1433published inOncotargetQ1573155
P1476titleLanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair
P478volume7

Reverse relations

cites work (P2860)
Q52653145Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death.
Q92539463Cytogenotoxic effects of Adenium obesum seeds extracts on breast cancer cells
Q33902853Elimination of undifferentiated human embryonic stem cells by cardiac glycosides
Q41472320HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.

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