scholarly article | Q13442814 |
P2093 | author name string | Robert Grant | |
Michael S Y Huen | |||
Junjie Chen | |||
Michael B Yaffe | |||
Xiaochun Yu | |||
Kay Minn | |||
Isaac Manke | |||
P2860 | cites work | Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair | Q22009084 |
N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8 | Q24291166 | ||
MDC1 is a mediator of the mammalian DNA damage checkpoint | Q24296229 | ||
The BRCT Domain Is a Phospho-Protein Binding Domain | Q24298428 | ||
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination | Q24299584 | ||
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks | Q24299852 | ||
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins | Q24300411 | ||
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage | Q24306743 | ||
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response | Q24306765 | ||
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites | Q24306789 | ||
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response | Q24306807 | ||
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains | Q24306945 | ||
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair | Q24310221 | ||
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II | Q24337471 | ||
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair | Q24669691 | ||
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms | Q27628846 | ||
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2 | Q27639080 | ||
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes | Q27860502 | ||
Likelihood-enhanced fast rotation functions | Q27860684 | ||
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. | Q27937465 | ||
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint | Q27937738 | ||
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage | Q28144576 | ||
Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX | Q28191330 | ||
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway | Q28203777 | ||
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways | Q28207549 | ||
BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting | Q28212263 | ||
MDC1 is required for the intra-S-phase DNA damage checkpoint | Q28212500 | ||
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways | Q28212514 | ||
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control | Q28213030 | ||
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 | Q28215916 | ||
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage | Q28238604 | ||
The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity | Q28246541 | ||
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks | Q28286203 | ||
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks | Q28291639 | ||
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals | Q28292900 | ||
Chfr is required for tumor suppression and Aurora A regulation | Q28510913 | ||
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Q29614216 | ||
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Q29614217 | ||
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage | Q29614528 | ||
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation | Q29619155 | ||
The FHA domain mediates phosphoprotein interactions. | Q34078695 | ||
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites | Q34479820 | ||
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. | Q34619746 | ||
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP | Q34863348 | ||
Regulation of DNA repair by ubiquitylation | Q36457732 | ||
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility | Q36533572 | ||
A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair | Q40372381 | ||
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae | Q43230977 | ||
The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation | Q46744819 | ||
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors | Q64387467 | ||
P433 | issue | 5 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | DNA damage | Q5205747 |
positive regulation of DNA repair | Q14860458 | ||
Ring finger protein 8 | Q21118319 | ||
ubiquitination | Q33059483 | ||
P304 | page(s) | 901-14 | |
P577 | publication date | 2007-11-30 | |
P1433 | published in | Cell | Q655814 |
P1476 | title | RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly | |
P478 | volume | 131 |
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Q92380165 | 53BP1: a DSB escort |
Q26828847 | 53BP1: pro choice in DNA repair |
Q36432567 | A DNA repair BRCA1 estrogen receptor and targeted therapy in breast cancer |
Q38805774 | A Generic Platform for Cellular Screening Against Ubiquitin Ligases |
Q26774980 | A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response |
Q37669871 | A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation. |
Q90162818 | A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis |
Q54216760 | A Screen for Epstein-Barr Virus Proteins that Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. |
Q33715275 | A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage |
Q24302261 | A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair |
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Q37168494 | A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks |
Q37525823 | A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci |
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Q28118543 | A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses |
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Q58804970 | ATM in breast and brain tumors: a comprehensive review |
Q34557700 | ATM mediated phosphorylation of CHD4 contributes to genome maintenance |
Q24321489 | ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks |
Q43177489 | ATR and H2AX cooperate in maintaining genome stability under replication stress |
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Q24313476 | Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage |
Q27676128 | Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination |
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Q36962466 | Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy |
Q34025378 | Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci |
Q35108163 | Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair |
Q36647310 | Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress |
Q48411490 | An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168. |
Q33843055 | An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells |
Q34487215 | An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control. |
Q37099895 | An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks |
Q91623871 | Analysis of RNA polymerase II ubiquitylation and proteasomal degradation |
Q37401963 | Analysis of chromatin remodeling during formation of a DNA double-strand break at the yeast mating type locus |
Q33557371 | And-1 is required for homologous recombination repair by regulating DNA end resection |
Q47856962 | Angiogenesis: escape from hypoxia |
Q35449028 | Assessing 'radiosensitivity' with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci |
Q38130677 | At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence |
Q37278036 | Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer |
Q42221274 | Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4. |
Q36086628 | Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression. |
Q30498797 | Autophosphorylation and ATM activation: additional sites add to the complexity |
Q33589782 | Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites |
Q24305535 | BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8 |
Q47428787 | BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer |
Q36063107 | BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis |
Q24323889 | BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response |
Q35895262 | BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair |
Q33952979 | BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response |
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Q24634217 | BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair |
Q24632998 | BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair |
Q35166086 | BRCA1 A‐complex fine tunes repair functions of BRCA1. |
Q37507563 | BRCA1 and its toolbox for the maintenance of genome integrity |
Q35861690 | BRCA1 tumor suppressor network: focusing on its tail |
Q35879933 | BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro |
Q35212757 | BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. |
Q35572248 | Bora downregulation results in radioresistance by promoting repair of double strand breaks. |
Q89638551 | CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis |
Q34188958 | CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage |
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Q36831407 | CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis. |
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Q39328632 | Cell cycle-dependent control of homologous recombination |
Q48137760 | Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution |
Q38979542 | Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. |
Q37648742 | Cellular radiosensitivity: how much better do we understand it? |
Q38891869 | Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair |
Q24657907 | Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 |
Q35854193 | Changing the ubiquitin landscape during viral manipulation of the DNA damage response |
Q37600456 | Chapter 6. Application of new methods for detection of DNA damage and repair |
Q36108201 | Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response |
Q35089499 | Chfr and RNF8 synergistically regulate ATM activation |
Q24310231 | Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair |
Q26744843 | Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture |
Q37310881 | Choreography of recombination proteins during the DNA damage response |
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Q37904144 | Chromatin and the DNA damage response: the cancer connection. |
Q38068091 | Chromatin and the genome integrity network. |
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Q36550882 | Chromatin modifications and the DNA damage response to ionizing radiation. |
Q26782637 | Chromatin perturbations during the DNA damage response in higher eukaryotes |
Q37321372 | Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. |
Q38240348 | Chromatin regulation of DNA damage repair and genome integrity in the central nervous system |
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Q37961878 | Chromatin response to DNA double-strand break damage |
Q30854865 | Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites |
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Q37976267 | Epigenetic regulation of genomic integrity |
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Q38871644 | Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage |
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Q36109836 | INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells |
Q35909521 | INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells |
Q34093782 | Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen |
Q36579431 | Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage |
Q35472154 | Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. |
Q35499704 | Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation. |
Q42530355 | Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation |
Q27337186 | Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks |
Q36272320 | Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage |
Q43146796 | Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9. |
Q37861028 | Inherited mutations in breast cancer genes--risk and response |
Q34551194 | Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks |
Q37213329 | Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage |
Q38107828 | Interplay between DNA tumor viruses and the host DNA damage response. |
Q35941469 | Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19(ARF)/p53 axis in hematopoiesis, early T-cell development and tissue differentiation |
Q36868759 | Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells |
Q36917433 | It takes two to tango: Ubiquitin and SUMO in the DNA damage response |
Q41792397 | JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks |
Q92266857 | JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity |
Q42123187 | K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites |
Q64885990 | K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair. |
Q35971438 | K63-linked ubiquitination in kinase activation and cancer |
Q87603422 | K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks |
Q24310641 | K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1 |
Q38839983 | KMT Set7/9 affects genotoxic stress response via the Mdm2 axis |
Q38329562 | Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishment |
Q37235809 | Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. |
Q34804030 | Ku80 removal from DNA through double strand break-induced ubiquitylation |
Q64389662 | L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage |
Q64387249 | LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation |
Q36905850 | Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair |
Q36693239 | Launching a ubiquitination cascade at DNA breaks |
Q42080792 | Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. |
Q47446718 | Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. |
Q38029897 | Links between genome integrity and BRCA1 tumor suppression. |
Q64376375 | Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation |
Q64388445 | Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination |
Q64071389 | MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis |
Q36648222 | MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination |
Q34825129 | MDC1 collaborates with TopBP1 in DNA replication checkpoint control |
Q34879712 | MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells |
Q36837486 | MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks |
Q28275795 | MDC1: The art of keeping things in focus |
Q48151792 | MEIOTIC F-BOX Is Essential for Male Meiotic DNA Double-Strand Break Repair in Rice. |
Q24317241 | MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks |
Q24317291 | MERIT40 facilitates BRCA1 localization and DNA damage repair |
Q59794421 | MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs |
Q28304648 | MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites |
Q42375517 | MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. |
Q33569624 | MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. |
Q24608599 | Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks |
Q34317108 | Mechanisms of double-strand break repair in somatic mammalian cells |
Q35541520 | Meiotic functions of RAD18. |
Q39260655 | Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways. |
Q24321615 | Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining |
Q31156407 | Microbial pathogens trigger host DNA double-strand breaks whose abundance is reduced by plant defense responses |
Q43070586 | Mitosis, double strand break repair, and telomeres: a view from the end: how telomeres and the DNA damage response cooperate during mitosis to maintain genome stability. |
Q28274000 | Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis |
Q37623815 | Modifying chromatin architecture during the response to DNA breakage |
Q36153880 | Modular evolution of phosphorylation-based signalling systems |
Q39355026 | Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics. |
Q39334895 | Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13. |
Q24633548 | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation |
Q36792626 | Molecular targets and mechanisms of radiosensitization using DNA damage response pathways |
Q35150282 | Monoubiquitination of H2AX protein regulates DNA damage response signaling |
Q34176919 | Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance |
Q24594847 | Multiple roles of ATM in monitoring and maintaining DNA integrity |
Q33966572 | Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families |
Q40116814 | Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity |
Q24317325 | NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control |
Q39918729 | NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway |
Q41870614 | NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8-BARD1 to promote cell survival in squamous esophageal tumorigenesis |
Q37398589 | New developments in post-translational modifications and functions of histone H2A variants |
Q37149784 | New players in the BRCA1-mediated DNA damage responsive pathway |
Q24296739 | Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 |
Q36899005 | Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly |
Q38743349 | Nucleolar Reorganization Upon Site-Specific Double-Strand Break Induction |
Q59123049 | Nucleolar exit of RNF8 and BRCA1 in response to DNA damage |
Q58699976 | Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription |
Q35113119 | Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. |
Q37122315 | Nucleosome dynamics as modular systems that integrate DNA damage and repair |
Q35006034 | Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response |
Q37401106 | OGT restrains the expansion of DNA damage signaling |
Q27677192 | OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function |
Q35150138 | Oligomerization of MDC1 protein is important for proper DNA damage response |
Q34043691 | On the road with WRAP53β: guardian of Cajal bodies and genome integrity |
Q38777487 | Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice |
Q64057055 | Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features |
Q42356676 | Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks |
Q38022938 | Overview for the histone codes for DNA repair |
Q28243398 | PALB2: the hub of a network of tumor suppressors involved in DNA damage responses |
Q55615916 | PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. |
Q24312535 | PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry |
Q47096369 | PRPF8 is important for BRCA1-mediated homologous recombination |
Q37258492 | PTIP regulates 53BP1 and SMC1 at the DNA damage sites |
Q27653149 | Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1 |
Q64073414 | Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks |
Q37308719 | Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents. |
Q52627910 | Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. |
Q64115304 | Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response |
Q28297156 | Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response |
Q24336328 | Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage |
Q36694981 | Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response |
Q53827263 | Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer. |
Q33889482 | Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins |
Q37424808 | Principles of ubiquitin and SUMO modifications in DNA repair. |
Q38801085 | Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II. |
Q39767262 | Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin |
Q26823693 | Protein degradation and the stress response |
Q37014677 | Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes |
Q38133962 | Push back to respond better: regulatory inhibition of the DNA double-strand break response |
Q43101547 | Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites |
Q28254921 | Quality control mechanisms in cellular and systemic DNA damage responses |
Q35078454 | RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure |
Q37802636 | RAD18 lives a double life: Its implication in DNA double-strand break repair |
Q39882034 | RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. |
Q37344711 | RAD18 transmits DNA damage signalling to elicit homologous recombination repair |
Q24294922 | RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage |
Q33911226 | RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger |
Q30388307 | RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. |
Q37190148 | RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites |
Q36080420 | RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo |
Q32884525 | RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks |
Q39167940 | RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549. |
Q36677932 | RNF111-dependent neddylation activates DNA damage-induced ubiquitination |
Q64388640 | RNF126 Quenches RNF168 Function in the DNA Damage Response |
Q24309287 | RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins |
Q36882870 | RNF168 forms a functional complex with RAD6 during the DNA damage response |
Q24298746 | RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling |
Q24317544 | RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX |
Q56221440 | RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair |
Q37914341 | RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response. |
Q36603136 | RNF4 is required for DNA double-strand break repair in vivo |
Q34290557 | RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair |
Q34515173 | RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment |
Q50287329 | RNF8 and RNF168 ubiquitinate H2AFX |
Q50422500 | RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes. |
Q36853491 | RNF8 deficiency results in neurodegeneration in mice |
Q93176831 | RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling |
Q44943966 | RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. |
Q89592030 | RNF8 promotes efficient DSB repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60 |
Q36969257 | RNF8 promotes epithelial-mesenchymal transition of breast cancer cells |
Q36496577 | RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. |
Q24300411 | RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins |
Q24306486 | RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites |
Q50635296 | RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. |
Q34761198 | RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage |
Q28589254 | RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis |
Q34829400 | RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis |
Q35108533 | RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage. |
Q46820597 | RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain |
Q38938428 | Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining |
Q39385329 | Rad18 is a transcriptional target of E2F3. |
Q21129305 | Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects |
Q58773614 | Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy |
Q50494189 | Reading chromatin signatures after DNA double-strand breaks. |
Q38095917 | Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair |
Q26752453 | Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks |
Q37120275 | Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network |
Q45314235 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
Q39454278 | Regulation and Modulation of Human DNA Polymerase δ Activity and Function |
Q35358319 | Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair |
Q34799443 | Regulation of Akt signaling activation by ubiquitination |
Q24315969 | Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379 |
Q38841261 | Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. |
Q35125130 | Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. |
Q37088926 | Regulation of DNA repair throughout the cell cycle |
Q24304951 | Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1 |
Q38050704 | Regulation of human DNA polymerase delta in the cellular responses to DNA damage |
Q37137813 | Regulation of the DNA damage response on male meiotic sex chromosomes |
Q39105540 | Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining |
Q27012688 | Repair of strand breaks by homologous recombination |
Q41833935 | Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding |
Q41083642 | Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage |
Q47372639 | Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation |
Q24338950 | Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage |
Q33839938 | Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer |
Q26773800 | Role of Deubiquitinating Enzymes in DNA Repair |
Q92113346 | Role of deubiquitinases in DNA damage response |
Q34243070 | Role of polycomb group protein cbx2/m33 in meiosis onset and maintenance of chromosome stability in the Mammalian germline |
Q35212226 | Role of polycomb group proteins in the DNA damage response--a reassessment |
Q92761162 | Role of some epigenetic factors in DNA damage response pathway |
Q37769457 | Role of ubiquitination in meiotic recombination repair |
Q99634411 | Roles for MDC1 in cancer development and treatment |
Q35338785 | SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. |
Q38953670 | SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1. |
Q93180057 | SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair |
Q33812604 | SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression. |
Q39858269 | SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence |
Q34581827 | SON is a spliceosome-associated factor required for mitotic progression. |
Q24329163 | SOSS complexes participate in the maintenance of genomic stability |
Q28569714 | SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage |
Q33870712 | SUMOylation and de-SUMOylation in response to DNA damage. |
Q39858162 | Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells |
Q38919423 | Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells |
Q33824877 | Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair |
Q37098468 | Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways |
Q26863739 | Shedding light on filovirus infection with high-content imaging |
Q39488102 | Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells |
Q28246908 | Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response |
Q37615165 | Single α-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites |
Q35814999 | Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication |
Q38136518 | Small RNAs: emerging key players in DNA double-strand break repair |
Q39962986 | Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis |
Q102058917 | Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break |
Q38656328 | Spatiotemporal regulation of posttranslational modifications in the DNA damage response |
Q43723696 | Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients |
Q41836192 | Speckle-type POZ protein, SPOP, is involved in the DNA damage response. |
Q41216366 | Splicing controls the ubiquitin response during DNA double-strand break repair |
Q44084623 | Structural and functional characterization of the MERIT40 to understand its role in DNA repair |
Q34988545 | Structural and functional implication of RAP80 ΔGlu81 mutation |
Q27675542 | Structural basis for role of ring finger protein RNF168 RING domain |
Q48251425 | Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168. |
Q27676675 | Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain |
Q37282157 | Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks |
Q37095471 | Structure Change from β-Strand and Turn to α-Helix in Histone H2A-H2B Induced by DNA Damage Response |
Q27671846 | Structure and Interactions of the Cytoplasmic Domain of the Yersinia Type III Secretion Protein YscD |
Q34326278 | Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. |
Q38959150 | Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity |
Q39251706 | Systematic identification of functional residues in mammalian histone H2AX |
Q37044588 | TRAIP regulates replication fork recovery and progression via PCNA |
Q24339324 | Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks |
Q55339616 | Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. |
Q34718519 | The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation |
Q41438223 | The AAA+ ATPase p97, a cellular multitool |
Q24298486 | The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks |
Q37875478 | The BRCA1 ubiquitin ligase and homologous recombination repair |
Q34787446 | The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection |
Q92111307 | The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination |
Q27861055 | The DNA Damage Response: Making It Safe to Play with Knives |
Q38746796 | The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation |
Q37034923 | The DNA damage response pathways: at the crossroad of protein modifications |
Q24302499 | The E3 ligase RNF8 regulates KU80 removal and NHEJ repair |
Q34079012 | The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection |
Q37138573 | The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response |
Q92643741 | The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer |
Q38765054 | The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair |
Q34155445 | The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments |
Q33678587 | The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage |
Q24309181 | The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage |
Q34309225 | The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination |
Q28592784 | The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination |
Q24309142 | The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks |
Q39762239 | The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. |
Q35873110 | The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex |
Q33507756 | The annealing helicase HARP protects stalled replication forks |
Q37843633 | The cellular response to DNA damage: a focus on MDC1 and its interacting proteins |
Q34110993 | The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage |
Q34915507 | The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks |
Q38860961 | The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80. |
Q39160987 | The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases |
Q38056099 | The emerging role of Polycomb repressors in the response to DNA damage |
Q64214332 | The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases |
Q36340722 | The emerging role of nuclear architecture in DNA repair and genome maintenance |
Q42474850 | The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres |
Q37445199 | The great escape: Active genes on inactive sex chromosomes and their evolutionary implications |
Q24339556 | The histone demethylase LSD1/KDM1A promotes the DNA damage response |
Q33941037 | The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. |
Q48102770 | The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. |
Q34590928 | The many faces of ubiquitinated histone H2A: insights from the DUBs |
Q30417554 | The miR-99 family regulates the DNA damage response through its target SNF2H |
Q27676681 | The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator |
Q38979892 | The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair |
Q37369189 | The multiple layers of ubiquitin-dependent cell cycle control. |
Q38848092 | The nucleosome: orchestrating DNA damage signaling and repair within chromatin. |
Q34191583 | The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair |
Q41965110 | The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities |
Q37381571 | The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy |
Q24297147 | The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response |
Q38806266 | The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1. |
Q34807044 | The role of BRCA1 in DNA damage response |
Q33707078 | The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis |
Q33736010 | The role of histone ubiquitination during spermatogenesis. |
Q38217924 | The role of ubiquitin-binding domains in human pathophysiology |
Q34697751 | The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair |
Q37214640 | The sticky business of histone H2AX in V(D)J recombination, maintenance of genomic stability, and suppression of lymphoma |
Q28303222 | The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression |
Q42065210 | The ubiquitin E3 ligase activity of BRCA1 and its biological functions. |
Q37425595 | The ubiquitin landscape at DNA double-strand breaks |
Q37224708 | The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks |
Q37888122 | The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks |
Q37807639 | The ubiquitous role of ubiquitin in the DNA damage response |
Q34236779 | The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin |
Q34089181 | Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. |
Q34350912 | Time to bloom. |
Q37693590 | Tip60: connecting chromatin to DNA damage signaling |
Q34315565 | TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint |
Q38809301 | TopBP1-mediated DNA processing during mitosis |
Q33832626 | Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison |
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