| scholarly article | Q13442814 |
| P2093 | author name string | Robert Grant | |
| Michael S Y Huen | |||
| Junjie Chen | |||
| Michael B Yaffe | |||
| Xiaochun Yu | |||
| Kay Minn | |||
| Isaac Manke | |||
| P2860 | cites work | Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair | Q22009084 |
| N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8 | Q24291166 | ||
| MDC1 is a mediator of the mammalian DNA damage checkpoint | Q24296229 | ||
| The BRCT Domain Is a Phospho-Protein Binding Domain | Q24298428 | ||
| A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination | Q24299584 | ||
| MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks | Q24299852 | ||
| RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins | Q24300411 | ||
| ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage | Q24306743 | ||
| Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response | Q24306765 | ||
| RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites | Q24306789 | ||
| Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response | Q24306807 | ||
| DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains | Q24306945 | ||
| BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair | Q24310221 | ||
| Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II | Q24337471 | ||
| Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair | Q24669691 | ||
| The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms | Q27628846 | ||
| Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2 | Q27639080 | ||
| HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes | Q27860502 | ||
| Likelihood-enhanced fast rotation functions | Q27860684 | ||
| RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. | Q27937465 | ||
| Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint | Q27937738 | ||
| A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage | Q28144576 | ||
| Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX | Q28191330 | ||
| Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway | Q28203777 | ||
| Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways | Q28207549 | ||
| BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting | Q28212263 | ||
| MDC1 is required for the intra-S-phase DNA damage checkpoint | Q28212500 | ||
| MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways | Q28212514 | ||
| Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control | Q28213030 | ||
| DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 | Q28215916 | ||
| Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage | Q28238604 | ||
| The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity | Q28246541 | ||
| Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks | Q28286203 | ||
| Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks | Q28291639 | ||
| MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals | Q28292900 | ||
| Chfr is required for tumor suppression and Aurora A regulation | Q28510913 | ||
| Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Q29614216 | ||
| DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Q29614217 | ||
| Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage | Q29614528 | ||
| Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation | Q29619155 | ||
| The FHA domain mediates phosphoprotein interactions. | Q34078695 | ||
| The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites | Q34479820 | ||
| A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. | Q34619746 | ||
| BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP | Q34863348 | ||
| Regulation of DNA repair by ubiquitylation | Q36457732 | ||
| H2AX haploinsufficiency modifies genomic stability and tumor susceptibility | Q36533572 | ||
| A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair | Q40372381 | ||
| Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae | Q43230977 | ||
| The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation | Q46744819 | ||
| Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors | Q64387467 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | DNA damage | Q5205747 |
| positive regulation of DNA repair | Q14860458 | ||
| Ring finger protein 8 | Q21118319 | ||
| ubiquitination | Q33059483 | ||
| P304 | page(s) | 901-14 | |
| P577 | publication date | 2007-11-30 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly | |
| P478 | volume | 131 |
| Q42535570 | 'A mover and a shaker': 53BP1 allows DNA doublestrand breaks a chance to dance and unite |
| Q37501480 | 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response |
| Q91907550 | 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage |
| Q37713592 | 53BP1, BRCA1, and the choice between recombination and end joining at DNA double-strand breaks |
| Q92380165 | 53BP1: a DSB escort |
| Q26828847 | 53BP1: pro choice in DNA repair |
| Q36432567 | A DNA repair BRCA1 estrogen receptor and targeted therapy in breast cancer |
| Q38805774 | A Generic Platform for Cellular Screening Against Ubiquitin Ligases |
| Q26774980 | A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response |
| Q37669871 | A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation. |
| Q90162818 | A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis |
| Q54216760 | A Screen for Epstein-Barr Virus Proteins that Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. |
| Q33715275 | A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage |
| Q24302261 | A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair |
| Q38727581 | A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis |
| Q28472643 | A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint |
| Q55639040 | A new bioinformatics tool to help assess the significance of BRCA1 variants. |
| Q34270749 | A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure |
| Q86044072 | A novel ruthenium(II)-polypyridyl complex inhibits cell proliferation and induces cell apoptosis by impairing DNA damage repair |
| Q42249588 | A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase |
| Q37548532 | A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination |
| Q39378494 | A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. |
| Q37339272 | A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage. |
| Q37299259 | A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining |
| Q64259085 | A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair |
| Q37168494 | A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks |
| Q37525823 | A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci |
| Q33669971 | A strategy for interaction site prediction between phospho-binding modules and their partners identified from proteomic data |
| Q24338452 | A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network |
| Q28118543 | A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses |
| Q45068235 | ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks |
| Q36283879 | ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase |
| Q39921855 | ATM activation and signaling under hypoxic conditions. |
| Q58804970 | ATM in breast and brain tumors: a comprehensive review |
| Q34557700 | ATM mediated phosphorylation of CHD4 contributes to genome maintenance |
| Q24321489 | ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks |
| Q43177489 | ATR and H2AX cooperate in maintaining genome stability under replication stress |
| Q53255032 | Abnormalities in DNA double-strand break response beyond primary immunodeficiency. |
| Q24313476 | Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage |
| Q27676128 | Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination |
| Q47347231 | Acetylation of 53BP1 dictates the DNA double strand break repair pathway. |
| Q39701908 | Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway |
| Q27933881 | Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis |
| Q35175356 | Achieving peptide binding specificity and promiscuity by loops: case of the forkhead-associated domain |
| Q36962466 | Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy |
| Q34025378 | Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci |
| Q35108163 | Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair |
| Q36647310 | Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress |
| Q48411490 | An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168. |
| Q33843055 | An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells |
| Q34487215 | An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control. |
| Q37099895 | An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks |
| Q91623871 | Analysis of RNA polymerase II ubiquitylation and proteasomal degradation |
| Q37401963 | Analysis of chromatin remodeling during formation of a DNA double-strand break at the yeast mating type locus |
| Q33557371 | And-1 is required for homologous recombination repair by regulating DNA end resection |
| Q47856962 | Angiogenesis: escape from hypoxia |
| Q35449028 | Assessing 'radiosensitivity' with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci |
| Q38130677 | At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence |
| Q37278036 | Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer |
| Q42221274 | Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4. |
| Q36086628 | Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression. |
| Q30498797 | Autophosphorylation and ATM activation: additional sites add to the complexity |
| Q33589782 | Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites |
| Q24305535 | BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8 |
| Q47428787 | BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer |
| Q36063107 | BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis |
| Q24323889 | BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response |
| Q35895262 | BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair |
| Q33952979 | BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response |
| Q39674232 | BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery |
| Q24634217 | BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair |
| Q24632998 | BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair |
| Q35166086 | BRCA1 A‐complex fine tunes repair functions of BRCA1. |
| Q37507563 | BRCA1 and its toolbox for the maintenance of genome integrity |
| Q35861690 | BRCA1 tumor suppressor network: focusing on its tail |
| Q35879933 | BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro |
| Q35212757 | BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. |
| Q35572248 | Bora downregulation results in radioresistance by promoting repair of double strand breaks. |
| Q89638551 | CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis |
| Q34188958 | CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage |
| Q36580923 | CHFR is important for the first wave of ubiquitination at DNA damage sites |
| Q36831407 | CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis. |
| Q22001526 | CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response |
| Q34104535 | Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4 |
| Q49685857 | Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar. |
| Q24317690 | Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint |
| Q35164329 | Cell biology of mitotic recombination |
| Q39328632 | Cell cycle-dependent control of homologous recombination |
| Q48137760 | Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution |
| Q38979542 | Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. |
| Q37648742 | Cellular radiosensitivity: how much better do we understand it? |
| Q38891869 | Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair |
| Q24657907 | Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 |
| Q35854193 | Changing the ubiquitin landscape during viral manipulation of the DNA damage response |
| Q37600456 | Chapter 6. Application of new methods for detection of DNA damage and repair |
| Q36108201 | Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response |
| Q35089499 | Chfr and RNF8 synergistically regulate ATM activation |
| Q24310231 | Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair |
| Q26744843 | Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture |
| Q37310881 | Choreography of recombination proteins during the DNA damage response |
| Q55024049 | Chromatin and nucleosome dynamics in DNA damage and repair. |
| Q37904144 | Chromatin and the DNA damage response: the cancer connection. |
| Q38068091 | Chromatin and the genome integrity network. |
| Q33729186 | Chromatin at the intersection of viral infection and DNA damage |
| Q37826623 | Chromatin dynamics and the repair of DNA double strand breaks |
| Q37760043 | Chromatin dynamics during repair of chromosomal DNA double-strand breaks |
| Q36012981 | Chromatin dynamics in DNA double-strand break repair |
| Q38253643 | Chromatin modifications and DNA repair: beyond double-strand breaks |
| Q36550882 | Chromatin modifications and the DNA damage response to ionizing radiation. |
| Q26782637 | Chromatin perturbations during the DNA damage response in higher eukaryotes |
| Q37321372 | Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. |
| Q38240348 | Chromatin regulation of DNA damage repair and genome integrity in the central nervous system |
| Q38090114 | Chromatin remodeling at DNA double-strand breaks |
| Q37128128 | Chromatin remodeling finds its place in the DNA double-strand break response |
| Q37961878 | Chromatin response to DNA double-strand break damage |
| Q30854865 | Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites |
| Q41189289 | Chromatin structure and DNA damage repair |
| Q34227706 | Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma |
| Q33839896 | Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 |
| Q46816064 | Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling |
| Q36017990 | Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer. |
| Q38578748 | Comprehensive Catalog of Currently Documented Histone Modifications |
| Q21092524 | Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation |
| Q37396825 | Control of histone methylation and genome stability by PTIP |
| Q35971460 | Coordinate to guard: crosstalk of phosphorylation, sumoylation, and ubiquitylation in DNA damage response. |
| Q51713162 | Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network. |
| Q37777788 | Core histone H2A ubiquitylation and transcriptional regulation |
| Q35182983 | Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response |
| Q35063105 | Critical roles of ring finger protein RNF8 in replication stress responses |
| Q27023465 | Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair |
| Q34162380 | Cul4A is essential for spermatogenesis and male fertility |
| Q48271368 | DNA Damage-Induced Foci of E2 Ubiquitin-Conjugating Enzyme are Detectable upon Co-transfection with an Interacting E3 Ubiquitin Ligase. |
| Q37063328 | DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis |
| Q38090434 | DNA damage emergency: cellular garbage disposal to the rescue? |
| Q64386811 | DNA damage in the presence of chemical genotoxic agents induce acetylation of H3K56 and H4K16 but not H3K9 in mammalian cells |
| Q35723863 | DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway. |
| Q78177428 | DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens. |
| Q35608458 | DNA damage response and repair: insights into strategies for radiation sensitization of gliomas |
| Q35371237 | DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells |
| Q37803476 | DNA damage response. |
| Q38118223 | DNA damage response: three levels of DNA repair regulation |
| Q38134064 | DNA damage sensing by the ATM and ATR kinases. |
| Q39675593 | DNA damage signaling in response to double-strand breaks during mitosis |
| Q47209621 | DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway. |
| Q24314513 | DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger |
| Q60456069 | DNA damage: Conducting repair |
| Q60199986 | DNA damage: a histone-code mediator leaves the stage |
| Q58236930 | DNA damage: ubiquitin marks the spot |
| Q64386879 | DNA double-strand break repair pathway choice - from basic biology to clinical exploitation |
| Q37855947 | DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome |
| Q34360500 | DNA double-strand break signaling and human disorders |
| Q36588889 | DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. |
| Q28587725 | DNA-damage response and repair activities at uncapped telomeres depend on RNF8 |
| Q64108804 | De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation |
| Q42547893 | Deciphering the DNA damage histone code |
| Q37871126 | Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy. |
| Q35956564 | Deregulation of DNA damage response pathway by intercellular contact |
| Q38083939 | Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining |
| Q34155439 | Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex |
| Q24337753 | Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation |
| Q27676862 | Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1 |
| Q39262414 | Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication |
| Q39945678 | Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation |
| Q36510700 | Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair |
| Q28281514 | Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis |
| Q27938115 | Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins |
| Q30497973 | Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase |
| Q28661754 | Double strand break repair functions of histone H2AX |
| Q26830517 | Double-strand break repair on sex chromosomes: challenges during male meiotic prophase |
| Q26991670 | Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability |
| Q34391068 | Double-strand break repair: 53BP1 comes into focus |
| Q37822707 | Double-strand breaks and the concept of short- and long-term epigenetic memory. |
| Q39223233 | Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis |
| Q36246404 | Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome |
| Q39007611 | Dub3 controls DNA damage signalling by direct deubiquitination of H2AX. |
| Q24608343 | Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications |
| Q34047330 | Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity |
| Q28086796 | Dysregulation of ubiquitin ligases in cancer |
| Q35656738 | Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining |
| Q37393820 | Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications |
| Q24622802 | Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development |
| Q37232111 | Engineering a DNA damage response without DNA damage |
| Q24607287 | Epigenetic modifications in double-strand break DNA damage signaling and repair |
| Q37976267 | Epigenetic regulation of genomic integrity |
| Q38218535 | Epigenetics in radiation-induced fibrosis |
| Q45324762 | Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle |
| Q38871275 | Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage. |
| Q37956184 | Eukaryotic DNA damage checkpoint activation in response to double-strand breaks |
| Q27014044 | Expression and functionality of histone H2A variants in cancer |
| Q36986396 | FHA-RING ubiquitin ligases in cell division cycle control |
| Q38871644 | Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage |
| Q37217527 | Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function |
| Q27324256 | Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites |
| Q26781153 | Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work |
| Q36963162 | Focus on histone variant H2AX: to be or not to be. |
| Q92259153 | Focus-ING on DNA Integrity: Implication of ING Proteins in Cell Cycle Regulation and DNA Repair Modulation |
| Q37347174 | Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. |
| Q35788248 | From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry. |
| Q24293084 | Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation |
| Q47927250 | Function of RAD6B and RNF8 in spermatogenesis |
| Q38221703 | Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. |
| Q38007361 | Fusing telomeres with RNF8. |
| Q90707056 | GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival |
| Q42740797 | GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARγ. |
| Q37261069 | Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin |
| Q38813244 | Genome maintenance in the context of 4D chromatin condensation. |
| Q36144711 | Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. |
| Q33892356 | Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome |
| Q35051157 | Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling events |
| Q36751607 | H1 provides the missing link |
| Q38155902 | H2AX a promising biomarker for lung cancer: a review |
| Q34306825 | H2AX post-translational modifications in the ionizing radiation response and homologous recombination |
| Q24292928 | HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes |
| Q33731091 | HMGNs, DNA repair and cancer |
| Q38736259 | HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks |
| Q33635656 | HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation |
| Q38554935 | HSV-I and the cellular DNA damage response. |
| Q35749018 | HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation. |
| Q42123243 | Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways |
| Q42506988 | High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells |
| Q41792409 | Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. |
| Q42418108 | Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair |
| Q58609638 | Histone Modifications and the DNA Double-Strand Break Response |
| Q33627079 | Histone demethylase KDM5B is a key regulator of genome stability |
| Q37995722 | Histone marks: repairing DNA breaks within the context of chromatin |
| Q38716430 | Histone modifications in DNA damage response |
| Q37683656 | Histone modifications: crucial elements for damage response and chromatin restoration |
| Q37881417 | Histone tails: Directing the chromatin response to DNA damage |
| Q35971184 | Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer |
| Q28506770 | Histone ubiquitination associates with BRCA1-dependent DNA damage response |
| Q28081194 | Histone ubiquitylation and its roles in transcription and DNA damage response |
| Q33630867 | Histone variants: emerging players in cancer biology |
| Q28085364 | Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins |
| Q28729894 | Homologs of breast cancer genes in plants |
| Q39662092 | Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining |
| Q27325197 | Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks |
| Q24312250 | Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks |
| Q36109836 | INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells |
| Q35909521 | INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells |
| Q34093782 | Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen |
| Q36579431 | Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage |
| Q35472154 | Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. |
| Q35499704 | Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation. |
| Q42530355 | Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation |
| Q27337186 | Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks |
| Q36272320 | Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage |
| Q43146796 | Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9. |
| Q37861028 | Inherited mutations in breast cancer genes--risk and response |
| Q34551194 | Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks |
| Q37213329 | Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage |
| Q38107828 | Interplay between DNA tumor viruses and the host DNA damage response. |
| Q35941469 | Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19(ARF)/p53 axis in hematopoiesis, early T-cell development and tissue differentiation |
| Q36868759 | Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells |
| Q36917433 | It takes two to tango: Ubiquitin and SUMO in the DNA damage response |
| Q41792397 | JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks |
| Q92266857 | JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity |
| Q42123187 | K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites |
| Q64885990 | K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair. |
| Q35971438 | K63-linked ubiquitination in kinase activation and cancer |
| Q87603422 | K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks |
| Q24310641 | K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1 |
| Q38839983 | KMT Set7/9 affects genotoxic stress response via the Mdm2 axis |
| Q38329562 | Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishment |
| Q37235809 | Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. |
| Q34804030 | Ku80 removal from DNA through double strand break-induced ubiquitylation |
| Q64389662 | L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage |
| Q64387249 | LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation |
| Q36905850 | Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair |
| Q36693239 | Launching a ubiquitination cascade at DNA breaks |
| Q42080792 | Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. |
| Q47446718 | Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. |
| Q38029897 | Links between genome integrity and BRCA1 tumor suppression. |
| Q64376375 | Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation |
| Q64388445 | Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination |
| Q64071389 | MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis |
| Q36648222 | MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination |
| Q34825129 | MDC1 collaborates with TopBP1 in DNA replication checkpoint control |
| Q34879712 | MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells |
| Q36837486 | MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks |
| Q28275795 | MDC1: The art of keeping things in focus |
| Q48151792 | MEIOTIC F-BOX Is Essential for Male Meiotic DNA Double-Strand Break Repair in Rice. |
| Q24317241 | MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks |
| Q24317291 | MERIT40 facilitates BRCA1 localization and DNA damage repair |
| Q59794421 | MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs |
| Q28304648 | MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites |
| Q42375517 | MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. |
| Q33569624 | MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. |
| Q24608599 | Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks |
| Q34317108 | Mechanisms of double-strand break repair in somatic mammalian cells |
| Q35541520 | Meiotic functions of RAD18. |
| Q39260655 | Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways. |
| Q24321615 | Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining |
| Q31156407 | Microbial pathogens trigger host DNA double-strand breaks whose abundance is reduced by plant defense responses |
| Q43070586 | Mitosis, double strand break repair, and telomeres: a view from the end: how telomeres and the DNA damage response cooperate during mitosis to maintain genome stability. |
| Q28274000 | Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis |
| Q37623815 | Modifying chromatin architecture during the response to DNA breakage |
| Q36153880 | Modular evolution of phosphorylation-based signalling systems |
| Q39355026 | Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics. |
| Q39334895 | Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13. |
| Q24633548 | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation |
| Q36792626 | Molecular targets and mechanisms of radiosensitization using DNA damage response pathways |
| Q35150282 | Monoubiquitination of H2AX protein regulates DNA damage response signaling |
| Q34176919 | Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance |
| Q24594847 | Multiple roles of ATM in monitoring and maintaining DNA integrity |
| Q33966572 | Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families |
| Q40116814 | Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity |
| Q24317325 | NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control |
| Q39918729 | NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway |
| Q41870614 | NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8-BARD1 to promote cell survival in squamous esophageal tumorigenesis |
| Q37398589 | New developments in post-translational modifications and functions of histone H2A variants |
| Q37149784 | New players in the BRCA1-mediated DNA damage responsive pathway |
| Q24296739 | Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 |
| Q36899005 | Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly |
| Q38743349 | Nucleolar Reorganization Upon Site-Specific Double-Strand Break Induction |
| Q59123049 | Nucleolar exit of RNF8 and BRCA1 in response to DNA damage |
| Q58699976 | Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription |
| Q35113119 | Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. |
| Q37122315 | Nucleosome dynamics as modular systems that integrate DNA damage and repair |
| Q35006034 | Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response |
| Q37401106 | OGT restrains the expansion of DNA damage signaling |
| Q27677192 | OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function |
| Q35150138 | Oligomerization of MDC1 protein is important for proper DNA damage response |
| Q34043691 | On the road with WRAP53β: guardian of Cajal bodies and genome integrity |
| Q38777487 | Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice |
| Q64057055 | Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features |
| Q42356676 | Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks |
| Q38022938 | Overview for the histone codes for DNA repair |
| Q28243398 | PALB2: the hub of a network of tumor suppressors involved in DNA damage responses |
| Q55615916 | PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. |
| Q24312535 | PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry |
| Q47096369 | PRPF8 is important for BRCA1-mediated homologous recombination |
| Q37258492 | PTIP regulates 53BP1 and SMC1 at the DNA damage sites |
| Q27653149 | Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1 |
| Q64073414 | Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks |
| Q37308719 | Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents. |
| Q52627910 | Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. |
| Q64115304 | Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response |
| Q28297156 | Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response |
| Q24336328 | Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage |
| Q36694981 | Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response |
| Q53827263 | Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer. |
| Q33889482 | Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins |
| Q37424808 | Principles of ubiquitin and SUMO modifications in DNA repair. |
| Q38801085 | Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II. |
| Q39767262 | Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin |
| Q26823693 | Protein degradation and the stress response |
| Q37014677 | Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes |
| Q38133962 | Push back to respond better: regulatory inhibition of the DNA double-strand break response |
| Q43101547 | Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites |
| Q28254921 | Quality control mechanisms in cellular and systemic DNA damage responses |
| Q35078454 | RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure |
| Q37802636 | RAD18 lives a double life: Its implication in DNA double-strand break repair |
| Q39882034 | RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. |
| Q37344711 | RAD18 transmits DNA damage signalling to elicit homologous recombination repair |
| Q24294922 | RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage |
| Q33911226 | RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger |
| Q30388307 | RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. |
| Q37190148 | RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites |
| Q36080420 | RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo |
| Q32884525 | RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks |
| Q39167940 | RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549. |
| Q36677932 | RNF111-dependent neddylation activates DNA damage-induced ubiquitination |
| Q64388640 | RNF126 Quenches RNF168 Function in the DNA Damage Response |
| Q24309287 | RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins |
| Q36882870 | RNF168 forms a functional complex with RAD6 during the DNA damage response |
| Q24298746 | RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling |
| Q24317544 | RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX |
| Q56221440 | RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair |
| Q37914341 | RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response. |
| Q36603136 | RNF4 is required for DNA double-strand break repair in vivo |
| Q34290557 | RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair |
| Q34515173 | RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment |
| Q50287329 | RNF8 and RNF168 ubiquitinate H2AFX |
| Q50422500 | RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes. |
| Q36853491 | RNF8 deficiency results in neurodegeneration in mice |
| Q93176831 | RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling |
| Q44943966 | RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. |
| Q89592030 | RNF8 promotes efficient DSB repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60 |
| Q36969257 | RNF8 promotes epithelial-mesenchymal transition of breast cancer cells |
| Q36496577 | RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. |
| Q24300411 | RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins |
| Q24306486 | RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites |
| Q50635296 | RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. |
| Q34761198 | RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage |
| Q28589254 | RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis |
| Q34829400 | RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis |
| Q35108533 | RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage. |
| Q46820597 | RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain |
| Q38938428 | Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining |
| Q39385329 | Rad18 is a transcriptional target of E2F3. |
| Q21129305 | Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects |
| Q58773614 | Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy |
| Q50494189 | Reading chromatin signatures after DNA double-strand breaks. |
| Q38095917 | Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair |
| Q26752453 | Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks |
| Q37120275 | Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network |
| Q45314235 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| Q39454278 | Regulation and Modulation of Human DNA Polymerase δ Activity and Function |
| Q35358319 | Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair |
| Q34799443 | Regulation of Akt signaling activation by ubiquitination |
| Q24315969 | Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379 |
| Q38841261 | Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. |
| Q35125130 | Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. |
| Q37088926 | Regulation of DNA repair throughout the cell cycle |
| Q24304951 | Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1 |
| Q38050704 | Regulation of human DNA polymerase delta in the cellular responses to DNA damage |
| Q37137813 | Regulation of the DNA damage response on male meiotic sex chromosomes |
| Q39105540 | Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining |
| Q27012688 | Repair of strand breaks by homologous recombination |
| Q41833935 | Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding |
| Q41083642 | Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage |
| Q47372639 | Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation |
| Q24338950 | Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage |
| Q33839938 | Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer |
| Q26773800 | Role of Deubiquitinating Enzymes in DNA Repair |
| Q92113346 | Role of deubiquitinases in DNA damage response |
| Q34243070 | Role of polycomb group protein cbx2/m33 in meiosis onset and maintenance of chromosome stability in the Mammalian germline |
| Q35212226 | Role of polycomb group proteins in the DNA damage response--a reassessment |
| Q92761162 | Role of some epigenetic factors in DNA damage response pathway |
| Q37769457 | Role of ubiquitination in meiotic recombination repair |
| Q99634411 | Roles for MDC1 in cancer development and treatment |
| Q35338785 | SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. |
| Q38953670 | SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1. |
| Q93180057 | SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair |
| Q33812604 | SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression. |
| Q39858269 | SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence |
| Q34581827 | SON is a spliceosome-associated factor required for mitotic progression. |
| Q24329163 | SOSS complexes participate in the maintenance of genomic stability |
| Q28569714 | SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage |
| Q33870712 | SUMOylation and de-SUMOylation in response to DNA damage. |
| Q39858162 | Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells |
| Q38919423 | Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells |
| Q33824877 | Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair |
| Q37098468 | Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways |
| Q26863739 | Shedding light on filovirus infection with high-content imaging |
| Q39488102 | Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells |
| Q28246908 | Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response |
| Q37615165 | Single α-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites |
| Q35814999 | Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication |
| Q38136518 | Small RNAs: emerging key players in DNA double-strand break repair |
| Q39962986 | Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis |
| Q102058917 | Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break |
| Q38656328 | Spatiotemporal regulation of posttranslational modifications in the DNA damage response |
| Q43723696 | Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients |
| Q41836192 | Speckle-type POZ protein, SPOP, is involved in the DNA damage response. |
| Q41216366 | Splicing controls the ubiquitin response during DNA double-strand break repair |
| Q44084623 | Structural and functional characterization of the MERIT40 to understand its role in DNA repair |
| Q34988545 | Structural and functional implication of RAP80 ΔGlu81 mutation |
| Q27675542 | Structural basis for role of ring finger protein RNF168 RING domain |
| Q48251425 | Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168. |
| Q27676675 | Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain |
| Q37282157 | Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks |
| Q37095471 | Structure Change from β-Strand and Turn to α-Helix in Histone H2A-H2B Induced by DNA Damage Response |
| Q27671846 | Structure and Interactions of the Cytoplasmic Domain of the Yersinia Type III Secretion Protein YscD |
| Q34326278 | Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. |
| Q38959150 | Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity |
| Q39251706 | Systematic identification of functional residues in mammalian histone H2AX |
| Q37044588 | TRAIP regulates replication fork recovery and progression via PCNA |
| Q24339324 | Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks |
| Q55339616 | Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. |
| Q34718519 | The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation |
| Q41438223 | The AAA+ ATPase p97, a cellular multitool |
| Q24298486 | The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks |
| Q37875478 | The BRCA1 ubiquitin ligase and homologous recombination repair |
| Q34787446 | The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection |
| Q92111307 | The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination |
| Q27861055 | The DNA Damage Response: Making It Safe to Play with Knives |
| Q38746796 | The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation |
| Q37034923 | The DNA damage response pathways: at the crossroad of protein modifications |
| Q24302499 | The E3 ligase RNF8 regulates KU80 removal and NHEJ repair |
| Q34079012 | The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection |
| Q37138573 | The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response |
| Q92643741 | The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer |
| Q38765054 | The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair |
| Q34155445 | The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments |
| Q33678587 | The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage |
| Q24309181 | The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage |
| Q34309225 | The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination |
| Q28592784 | The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination |
| Q24309142 | The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks |
| Q39762239 | The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. |
| Q35873110 | The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex |
| Q33507756 | The annealing helicase HARP protects stalled replication forks |
| Q37843633 | The cellular response to DNA damage: a focus on MDC1 and its interacting proteins |
| Q34110993 | The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage |
| Q34915507 | The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks |
| Q38860961 | The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80. |
| Q39160987 | The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases |
| Q38056099 | The emerging role of Polycomb repressors in the response to DNA damage |
| Q64214332 | The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases |
| Q36340722 | The emerging role of nuclear architecture in DNA repair and genome maintenance |
| Q42474850 | The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres |
| Q37445199 | The great escape: Active genes on inactive sex chromosomes and their evolutionary implications |
| Q24339556 | The histone demethylase LSD1/KDM1A promotes the DNA damage response |
| Q33941037 | The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. |
| Q48102770 | The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. |
| Q34590928 | The many faces of ubiquitinated histone H2A: insights from the DUBs |
| Q30417554 | The miR-99 family regulates the DNA damage response through its target SNF2H |
| Q27676681 | The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator |
| Q38979892 | The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair |
| Q37369189 | The multiple layers of ubiquitin-dependent cell cycle control. |
| Q38848092 | The nucleosome: orchestrating DNA damage signaling and repair within chromatin. |
| Q34191583 | The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair |
| Q41965110 | The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities |
| Q37381571 | The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy |
| Q24297147 | The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response |
| Q38806266 | The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1. |
| Q34807044 | The role of BRCA1 in DNA damage response |
| Q33707078 | The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis |
| Q33736010 | The role of histone ubiquitination during spermatogenesis. |
| Q38217924 | The role of ubiquitin-binding domains in human pathophysiology |
| Q34697751 | The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair |
| Q37214640 | The sticky business of histone H2AX in V(D)J recombination, maintenance of genomic stability, and suppression of lymphoma |
| Q28303222 | The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression |
| Q42065210 | The ubiquitin E3 ligase activity of BRCA1 and its biological functions. |
| Q37425595 | The ubiquitin landscape at DNA double-strand breaks |
| Q37224708 | The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks |
| Q37888122 | The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks |
| Q37807639 | The ubiquitous role of ubiquitin in the DNA damage response |
| Q34236779 | The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin |
| Q34089181 | Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. |
| Q34350912 | Time to bloom. |
| Q37693590 | Tip60: connecting chromatin to DNA damage signaling |
| Q34315565 | TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint |
| Q38809301 | TopBP1-mediated DNA processing during mitosis |
| Q33832626 | Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison |
| Q42351267 | Two-faced activity of RNF8: What "twists" it from a genome guardian to a cancer facilitator? |
| Q38201972 | Two-way communications between ubiquitin-like modifiers and DNA. |
| Q91866761 | UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks |
| Q34278026 | UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells |
| Q90501700 | UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity |
| Q55416803 | UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. |
| Q64081710 | UFL1 promotes histone H4 ufmylation and ATM activation |
| Q50287335 | UIMC1 and FAM175A bind DNA DSBs |
| Q24305173 | UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway |
| Q38824349 | USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168. |
| Q90029400 | USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair |
| Q33770883 | USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response |
| Q64389276 | USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination |
| Q37587018 | USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15. |
| Q28596573 | USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response |
| Q36184372 | USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168. |
| Q26739716 | Ubc13: the Lys63 ubiquitin chain building machine |
| Q89768702 | Ubiquitin and ubiquitin-like molecules in DNA double strand break repair |
| Q59123044 | Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis |
| Q63965414 | Ubiquitin signalling in DNA replication and repair |
| Q36189465 | Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168 |
| Q64389021 | Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis |
| Q59351757 | Ubiquitination at the interface of tumor viruses and DNA damage responses |
| Q38198020 | Ubiquitination events that regulate recombination of immunoglobulin Loci gene segments |
| Q39147444 | Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair |
| Q28087342 | Ubiquitylation, neddylation and the DNA damage response |
| Q91990357 | Ultra-soft X-ray system for imaging the early cellular responses to X-ray induced DNA damage |
| Q64389511 | Understanding the Histone DNA Repair Code: H4K20me2 Makes Its Mark |
| Q36828487 | Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain |
| Q35164644 | Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage |
| Q26742134 | Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair |
| Q96171717 | m5C modification of mRNA serves a DNA damage code to promote homologous recombination |
| Q36189350 | miR-214-mediated downregulation of RNF8 induces chromosomal instability in ovarian cancer cells |
| Q53181384 | p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response. |
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