Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

scientific article

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1046919299
P356DOI10.1038/NATURE08657
P3181OpenCitations bibliographic resource ID996694
P932PMC publication ID2904806
P698PubMed publication ID20016603
P5875ResearchGate publication ID40693980

P50authorStephen P JacksonQ37392575
Sophie E PoloQ50199081
Yaron GalantyQ57410063
P2093author name stringJulia Coates
Rimma Belotserkovskaya
Kyle M Miller
P2860cites workMDC1 is a mediator of the mammalian DNA damage checkpointQ24296229
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaksQ24299852
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsQ24300411
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damageQ24309181
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsQ24309287
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repairQ24310221
Human MMS21/NSE2 is a SUMO ligase required for DNA repairQ24529887
Human CtIP promotes DNA end resectionQ24646062
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligaseQ24653776
SAP - a putative DNA-binding motif involved in chromosomal organizationQ28145637
SUMO: a history of modificationQ28243325
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotesQ28274268
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signalsQ28292900
Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3Q28509725
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cellsQ28511551
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATMQ29614843
Good timing in the cell cycle for precise DNA repair by BRCA1.Q33221793
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damageQ34179079
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.Q34619746
Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperationQ35880280
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repairQ36510700
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stabilityQ36602569
A New Method for Introducing Double-Strand Breaks into Cellular DNAQ36695831
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damageQ36696336
Chromatin dynamics and the preservation of genetic informationQ36854289
Principles of ubiquitin and SUMO modifications in DNA repair.Q37424808
An additional role for SUMO in ubiquitin-mediated proteolysisQ37498263
Cell biology: SUMO.Q43519621
P433issue7275
P407language of work or nameEnglishQ1860
P304page(s)935-9
P577publication date2009-12-17
P1433published inNatureQ180445
P1476titleMammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
P478volume462

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cites work (P2860)
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Q34537060Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking
Q42604248Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia
Q35803573Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma
Q38656328Spatiotemporal regulation of posttranslational modifications in the DNA damage response
Q38219978Sumoylation and the DNA damage response
Q35539883Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.
Q36090318Sumoylation of MDC1 is important for proper DNA damage response
Q33698685Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association
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Q38901752System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.
Q28115456Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair
Q38959150Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
Q39251706Systematic identification of functional residues in mammalian histone H2AX
Q24295574TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
Q50926267Targeting histone deacetylase 4/ubiquitin-conjugating enzyme 9 impairs DNA repair for radiosensitization of hepatocellular carcinoma cells in mice.
Q37875478The BRCA1 ubiquitin ligase and homologous recombination repair
Q27861055The DNA Damage Response: Making It Safe to Play with Knives
Q37977004The DNA damage response and cancer therapy
Q33870522The DNA damage response: the omics era and its impact
Q24302499The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
Q94951027The HSV-1 ubiquitin ligase ICP0: modifying the cellular proteome to promote infection
Q64103296The Impact of the C-Terminal Region on the Interaction of Topoisomerase II Alpha with Mitotic Chromatin
Q34127693The MRN complex in double-strand break repair and telomere maintenance
Q54582549The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.
Q37397475The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair
Q34801900The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage
Q39194387The Role of PIAS SUMO E3-Ligases in Cancer
Q47095192The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
Q36419253The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation.
Q35225049The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death
Q24307375The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA
Q92570284The SUMO Pathway in Hematomalignancies and Their Response to Therapies
Q36619481The SUMO ligase PIAS1 regulates UV-induced apoptosis by recruiting Daxx to SUMOylated foci
Q27865256The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
Q38126813The SUMO system: a master organizer of nuclear protein assemblies.
Q39560571The USP1/UAF1 complex promotes double-strand break repair through homologous recombination
Q36178244The Use of Laser Microirradiation to Investigate the Roles of Cohesins in DNA Repair
Q33804824The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
Q64077175The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms
Q39160987The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases
Q38056099The emerging role of Polycomb repressors in the response to DNA damage
Q38056496The heterochromatic barrier to DNA double strand break repair: how to get the entry visa
Q33941037The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.
Q36293421The mechanism of Jurkat cells apoptosis induced by Aggregatibacter actinomycetemcomitans cytolethal distending toxin
Q33995521The multifunctional SNM1 gene family: not just nucleases
Q34191583The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair
Q52730181The post-translational modification, SUMOylation, and cancer (Review).
Q37381571The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy
Q38738534The proteasome enters the meiotic prophase fray
Q37888122The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks
Q37807639The ubiquitous role of ubiquitin in the DNA damage response
Q37987125The use of fluorescence microscopy to study the association between herpesviruses and intrinsic resistance factors
Q41861552Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation
Q29871439Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α.
Q33602611USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism
Q89768702Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
Q63965414Ubiquitin signalling in DNA replication and repair
Q24293610Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination
Q36670706Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling
Q39031491Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks
Q34041994Uncovering global SUMOylation signaling networks in a site-specific manner
Q64387083WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks
Q26742134Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair
Q92832654hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
Q28246258mRNA expression of BRCA1, PIAS1, and PIAS4 and survival after second-line docetaxel in advanced gastric cancer

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