Epigenetic modifications in double-strand break DNA damage signaling and repair

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Epigenetic modifications in double-strand break DNA damage signaling and repair is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-10-0513
P3181OpenCitations bibliographic resource ID4948281
P932PMC publication ID2940951
P698PubMed publication ID20823147

P50authorAndrew W TrumanQ61104160
Jacques CotéQ42712452
Stephen J. KronQ43233339
P2093author name stringDorine Rossetto
P2860cites workNew Histone Incorporation Marks Sites of UV Repair in Human CellsQ63383593
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaksQ24299852
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsQ24300411
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repairQ24302261
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sitesQ24306789
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activityQ24309061
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repressionQ24309909
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisionsQ24313501
Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferaseQ24320001
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaksQ24321489
BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage responseQ24323889
Involvement of human MOF in ATM functionQ24529072
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2AQ24546161
A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damageQ24554315
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionQ24563397
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaksQ24608599
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replicationQ24626425
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56Q24633791
Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assemblyQ24634725
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX inductionQ38310324
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.Q39719766
Cohesion establishment factor, Eco1 represses transcription via association with histone demethylase, LSD1.Q39724160
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibitionQ39747969
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cellsQ39858162
Local action of the chromatin assembly factor CAF-1 at sites of nucleotide excision repair in vivoQ39927746
Histone acetyltransferase 1 is dispensable for replication-coupled chromatin assembly but contributes to recover DNA damages created following replication blockage in vertebrate cellsQ40273789
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repairQ40347113
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesionsQ40495236
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiationQ40570996
Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeastQ40701887
RSC functions as an early double-strand-break sensor in the cell's response to DNA damageQ41114918
Induction of CAF-1 expression in response to DNA strand breaks in quiescent human cellsQ41843208
Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damageQ41852552
Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncappingQ42091851
Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexesQ42850451
RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatinQ42924860
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repairQ43217577
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiaeQ43230977
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.Q43796805
Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiaeQ46432359
Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activationQ50731881
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligaseQ24653776
CBP/p300-mediated acetylation of histone H3 on lysine 56Q24657910
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repairQ24669691
Megabase chromatin domains involved in DNA double-strand breaks in vivoQ24680284
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamicsQ24681614
A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatinQ24801790
The role of chromatin during transcriptionQ27860995
ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complexQ27929959
A role for Saccharomyces cerevisiae histone H2A in DNA repair.Q27930827
Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variantsQ27931128
Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4.Q27931428
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sitesQ27931488
Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repairQ27933564
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recoveryQ27933727
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.Q27933934
Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.Q27934708
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaksQ27934796
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replicationQ27935707
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.Q27935926
NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.Q27936275
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domainQ27937364
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.Q27937957
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4Q27938208
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodelingQ27938440
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Q27939003
Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repairQ27940284
PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpointQ28117742
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageQ28144576
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressQ28201846
Endogenous DNA damage in humans: a review of quantitative dataQ28259993
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATMQ28270543
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaksQ28286203
Phosphorylation of histone H2B at DNA double-strand breaks.Q36402644
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage controlQ36639688
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damageQ36696336
Histone modifications in response to DNA damage.Q36738568
Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is completeQ37078952
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.Q37347174
gammaH2AX: a sensitive molecular marker of DNA damage and repairQ37687078
Chaperoning histones during DNA replication and repairQ37689255
"Contextual" synthetic lethality and/or loss of heterozygosity: tumor hypoxia and modification of DNA repair.Q37786125
Perspective on the Pipeline of Drugs Being Developed with Modulation of DNA Damage as a TargetQ37786126
The epigenomics of cancerQ28289975
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signalsQ28292900
Genomic instability in mice lacking histone H2AXQ28589826
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damageQ29614528
Cancer epigenomics: DNA methylomes and histone-modification mapsQ29615524
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaksQ29617463
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction mapQ29618911
Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repairQ29620305
Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damageQ30441323
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaksQ30480374
Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sitesQ30854865
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiaeQ33226323
gammaH2AX foci form preferentially in euchromatin after ionising-radiation.Q33303665
Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand breakQ33409251
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progressionQ33537400
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.Q33705076
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repairQ33963853
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AXQ34031720
Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic BiomarkersQ34134483
The diverse functions of histone acetyltransferase complexes.Q34205129
Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repairQ34286591
Poly (ADP-ribose) polymerase as a novel therapeutic target in cancerQ34308770
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand breakQ34354650
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.Q34422309
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.Q34433751
Activation and regulation of ATM kinase activity in response to DNA double-strand breaksQ34722727
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.Q34841266
Crosstalk between histone modifications during the DNA damage response.Q34973824
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage responseQ35006034
Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage.Q35018049
Cellular machineries for chromosomal DNA repair.Q35742332
Contribution of the serine 129 of histone H2A to chromatin structureQ35856903
New anti-cancer strategies: epigenetic therapies and biomarkersQ36071790
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammalsQ36118803
Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repairQ36159147
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)4543-4552
P577publication date2010-09-07
P1433published inClinical Cancer ResearchQ332253
P1476titleEpigenetic modifications in double-strand break DNA damage signaling and repair
P478volume16

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