| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Lasse Stach | |
| Paul S Freemont | |||
| P2860 | cites work | Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin | Q33785301 |
| An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF. | Q33920064 | ||
| Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma | Q34117172 | ||
| Normalization of nomenclature for peptide motifs as ligands of modular protein domains | Q34120337 | ||
| Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation | Q34159592 | ||
| U box proteins as a new family of ubiquitin-protein ligases | Q24291397 | ||
| The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum | Q24291942 | ||
| The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle | Q24293051 | ||
| Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins | Q24293182 | ||
| Ubiquitin is phosphorylated by PINK1 to activate parkin | Q24296532 | ||
| Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway | Q24297296 | ||
| OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis | Q24297538 | ||
| Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3 | Q24298529 | ||
| Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum | Q24298901 | ||
| RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly | Q24300428 | ||
| Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3 | Q24304415 | ||
| A ubiquitin ligase complex assembles linear polyubiquitin chains | Q24305030 | ||
| The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function | Q24305086 | ||
| An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis | Q24307381 | ||
| Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains | Q24307429 | ||
| Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover | Q24307768 | ||
| UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover | Q24310742 | ||
| The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation | Q24313311 | ||
| Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3 | Q24318431 | ||
| The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER | Q24323509 | ||
| Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha | Q24329214 | ||
| Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane | Q24336904 | ||
| Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. | Q24539071 | ||
| Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications | Q24608343 | ||
| VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo | Q24673098 | ||
| Enhanced protein degradation by branched ubiquitin chains. | Q33637926 | ||
| Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis | Q24682823 | ||
| Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin | Q26747328 | ||
| Drugging the undruggables: exploring the ubiquitin system for drug development | Q26752823 | ||
| Ubiquitin chain diversity at a glance | Q26767117 | ||
| ESCRT-III controls nuclear envelope reformation | Q27316488 | ||
| Structure of the AAA ATPase p97 | Q27629334 | ||
| Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair | Q27634006 | ||
| The crystal structure of murine p97/VCP at 3.6A | Q27642642 | ||
| Detailed structural insights into the p97-Npl4-Ufd1 interface | Q27644733 | ||
| Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation | Q27644749 | ||
| Structure and Function of the PLAA/Ufd3-p97/Cdc48 Complex | Q27658051 | ||
| WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins | Q27665843 | ||
| Hierarchical binding of cofactors to the AAA ATPase p97 | Q27668175 | ||
| Crystal structure of FAF1 UBX domain in complex with p97/VCP N domain reveals a conformational change in the conserved FcisP touch-turn motif of UBX domain | Q27670731 | ||
| The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97 | Q27673802 | ||
| Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP | Q27680404 | ||
| Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP) | Q27682050 | ||
| Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling | Q27690030 | ||
| Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97 | Q27703264 | ||
| Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions | Q27703265 | ||
| 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition | Q27703745 | ||
| Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4 | Q27718850 | ||
| Key steps in ERAD of luminal ER proteins reconstituted with purified components | Q27929992 | ||
| Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain | Q27930054 | ||
| Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. | Q27931418 | ||
| The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment | Q27932818 | ||
| A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. | Q27935265 | ||
| Role of a ribosome-associated E3 ubiquitin ligase in protein quality control | Q27936843 | ||
| RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. | Q27937465 | ||
| Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes | Q27938702 | ||
| Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome | Q27939735 | ||
| Ubx2 links the Cdc48 complex to ER-associated protein degradation | Q27939739 | ||
| Mutations in the Human AAA+ Chaperone p97 and Related Diseases | Q28080241 | ||
| Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. | Q51018275 | ||
| Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase. | Q51105472 | ||
| Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease. | Q51420255 | ||
| Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes. | Q53161512 | ||
| Mutations in p97/VCP induce unfolding activity. | Q53566724 | ||
| Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. | Q53613309 | ||
| Polyubiquitylation drives replisome disassembly at the termination of DNA replication | Q57755271 | ||
| Ubiquitous soluble Mg2+-ATPase complex | Q58438730 | ||
| The Polycomb Protein Ring1B Generates Self Atypical Mixed Ubiquitin Chains Required for Its In Vitro Histone H2A Ligase Activity | Q62125897 | ||
| A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting | Q81277350 | ||
| Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships | Q85661492 | ||
| The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. | Q34178673 | ||
| The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. | Q34226618 | ||
| The resistance mechanisms of proteasome inhibitor bortezomib | Q34256126 | ||
| p97 complexes as signal integration hubs. | Q34303052 | ||
| Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis | Q34411329 | ||
| Mechanistic insights into the recycling machine of the SNARE complex | Q35058666 | ||
| Ubiquitin acetylation inhibits polyubiquitin chain elongation | Q35084540 | ||
| Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum | Q35381401 | ||
| Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy | Q35408665 | ||
| Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly. | Q35717827 | ||
| The ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment | Q35838940 | ||
| Golgi reassembly after mitosis: the AAA family meets the ubiquitin family | Q36118875 | ||
| CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication | Q36192735 | ||
| Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions | Q36215827 | ||
| gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum | Q36337039 | ||
| Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum | Q36355930 | ||
| Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. | Q36367307 | ||
| p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα. | Q36476873 | ||
| Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain | Q36512322 | ||
| Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression | Q36549348 | ||
| Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway | Q36579840 | ||
| Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD) | Q36666150 | ||
| The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1. | Q36744845 | ||
| Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin | Q36755008 | ||
| Doa1 targets ubiquitinated substrates for mitochondria-associated degradation | Q36789938 | ||
| Role of p97/VCP (Cdc48) in genome stability | Q36804013 | ||
| Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα | Q36970233 | ||
| Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits | Q37066029 | ||
| Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle | Q37089621 | ||
| p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair | Q37413678 | ||
| Phosphorylation regulates VCIP135 function in Golgi membrane fusion during the cell cycle. | Q37418470 | ||
| Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. | Q37457799 | ||
| UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation | Q37536620 | ||
| p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions | Q37577090 | ||
| Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination | Q28115740 | ||
| Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities | Q28198216 | ||
| Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains | Q28204441 | ||
| ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity | Q28215759 | ||
| p47 is a cofactor for p97-mediated membrane fusion | Q28243107 | ||
| Altered cofactor regulation with disease-associated p97/VCP mutations | Q28258936 | ||
| The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation | Q28264480 | ||
| Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis | Q28269674 | ||
| Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083) | Q28269767 | ||
| Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells | Q28279454 | ||
| Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase | Q28283214 | ||
| Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation | Q28284708 | ||
| An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments | Q28288911 | ||
| The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97 | Q28289459 | ||
| Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death | Q28295447 | ||
| Conformational changes in the AAA ATPase p97-p47 adaptor complex | Q28306308 | ||
| Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways | Q28306744 | ||
| Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47 | Q28511891 | ||
| Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression | Q28552714 | ||
| Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation | Q28554390 | ||
| Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase | Q28577671 | ||
| Activators and target genes of Rel/NF-kappaB transcription factors | Q29547882 | ||
| A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein | Q29547884 | ||
| AAA+ proteins: have engine, will work | Q29617410 | ||
| Evolutionary relationships and structural mechanisms of AAA+ proteins | Q29617454 | ||
| Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA | Q29617951 | ||
| Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B | Q29618193 | ||
| Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein | Q29619232 | ||
| Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations | Q30179386 | ||
| VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy | Q30274624 | ||
| Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication | Q30663146 | ||
| Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study | Q30789737 | ||
| Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. | Q30826494 | ||
| p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis | Q33265274 | ||
| Withaferin A Analogs That Target the AAA+ Chaperone p97. | Q33360763 | ||
| FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. | Q33629325 | ||
| Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains | Q37637735 | ||
| E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis | Q37698652 | ||
| Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family. | Q37941379 | ||
| Ubiquitination in signaling to and activation of IKK. | Q37995681 | ||
| Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance | Q38540229 | ||
| Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine | Q38648242 | ||
| Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy | Q38682988 | ||
| VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. | Q38742057 | ||
| Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. | Q38841261 | ||
| CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination | Q38943169 | ||
| The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation | Q38979904 | ||
| The p97-FAF1 protein complex reveals a common mode of p97 adaptor binding | Q39007131 | ||
| The emerging complexity of ubiquitin architecture | Q39052139 | ||
| Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction | Q39159347 | ||
| Linear ubiquitin chains: enzymes, mechanisms and biology | Q39265294 | ||
| The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97. | Q39268583 | ||
| p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. | Q39275998 | ||
| Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia | Q39684007 | ||
| Tyrosine phosphorylation of ATPase p97 regulates its activity during ERAD. | Q39950274 | ||
| The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. | Q39965496 | ||
| Cytoplasmic localization of the ORF2 protein of hepatitis E virus is dependent on its ability to undergo retrotranslocation from the endoplasmic reticulum | Q40182274 | ||
| Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1. | Q40219075 | ||
| The influenza A virus matrix protein 2 undergoes retrograde transport from the endoplasmic reticulum into the cytoplasm and bypasses cytoplasmic proteasomal degradation | Q40413608 | ||
| Caveolin-1 is an aggresome-inducing protein | Q41789431 | ||
| The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP. | Q42558471 | ||
| Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins | Q42610544 | ||
| Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease | Q42818202 | ||
| Mitotic phosphorylation of VCIP135 blocks p97ATPase-mediated Golgi membrane fusion. | Q44689481 | ||
| Definitive evidence for Ufd2-catalyzed elongation of the ubiquitin chain through Lys48 linkage | Q44968325 | ||
| The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism | Q45061748 | ||
| VAT, the thermoplasma homolog of mammalian p97/VCP, is an N domain-regulated protein unfoldase | Q46763702 | ||
| The opposite role of two UBA-UBX containing proteins, p47 and SAKS1 in the degradation of a single ERAD substrate, α-TCR. | Q48271302 | ||
| Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly | Q48871478 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 17 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | nuclear protein | Q16860021 |
| enzyme | Q8047 | ||
| biomedical investigative technique | Q66648976 | ||
| P304 | page(s) | 2953-2976 | |
| P577 | publication date | 2017-08-17 | |
| P1433 | published in | Biochemical Journal | Q864221 |
| P1476 | title | The AAA+ ATPase p97, a cellular multitool | |
| P478 | volume | 474 |
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