| scholarly article | Q13442814 |
| P50 | author | James Olzmann | Q43129096 |
| P2093 | author name string | Ethan J Greenblatt | |
| Ron R Kopito | |||
| P2860 | cites work | A membrane protein required for dislocation of misfolded proteins from the ER | Q24297703 |
| A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol | Q24297732 | ||
| Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling | Q24298141 | ||
| Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator | Q24299501 | ||
| Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation | Q24302539 | ||
| Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane | Q24336904 | ||
| Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane | Q24530318 | ||
| The HHpred interactive server for protein homology detection and structure prediction | Q24530456 | ||
| A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised | Q24535941 | ||
| MolProbity: all-atom structure validation for macromolecular crystallography | Q24649111 | ||
| Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases | Q24672054 | ||
| The Role of L1 Loop in the Mechanism of Rhomboid Intramembrane Protease GlpG | Q27648936 | ||
| Protein structure prediction on the Web: a case study using the Phyre server | Q27860664 | ||
| Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. | Q27930706 | ||
| Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins | Q27931299 | ||
| Usa1 functions as a scaffold of the HRD-ubiquitin ligase. | Q27932065 | ||
| Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast | Q27933512 | ||
| Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins | Q27933915 | ||
| Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD. | Q27935454 | ||
| Mitochondrial membrane remodelling regulated by a conserved rhomboid protease | Q27935531 | ||
| Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis | Q27936462 | ||
| The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol | Q27936514 | ||
| Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p | Q27938951 | ||
| AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation | Q27939982 | ||
| Central pore residues mediate the p97/VCP activity required for ERAD | Q28241412 | ||
| Alpha1-antitrypsin as model to assess glycan function in endoplasmic reticulum. | Q30350461 | ||
| Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex | Q31050217 | ||
| Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity | Q33836549 | ||
| A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma | Q33932480 | ||
| A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands | Q34079257 | ||
| Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases | Q34098885 | ||
| Yeast N-glycanase distinguishes between native and non-native glycoproteins | Q34165777 | ||
| Topogenic signals in integral membrane proteins | Q34167358 | ||
| A role for N-glycanase in the cytosolic turnover of glycoproteins | Q34179944 | ||
| Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. | Q34379351 | ||
| Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry | Q34581109 | ||
| Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase | Q34600228 | ||
| Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate | Q34623352 | ||
| Rhomboid proteases and their biological functions | Q34793043 | ||
| SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins | Q36858538 | ||
| Rhomboid protease dynamics and lipid interactions | Q37186369 | ||
| Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids | Q39615340 | ||
| In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells | Q39861099 | ||
| Stable suppression of gene expression in murine embryonic stem cells by RNAi directed from DNA vector-based short hairpin RNA. | Q40605147 | ||
| Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome | Q40618418 | ||
| Structural and mechanistic basis of Parl activity and regulation. | Q41772411 | ||
| Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system. | Q41785201 | ||
| m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria | Q42976619 | ||
| Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. | Q44504087 | ||
| The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism | Q45061748 | ||
| Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane | Q45068680 | ||
| Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides. | Q53790105 | ||
| Crystal structure of a rhomboid family intramembrane protease. | Q54453416 | ||
| P433 | issue | 10 | |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| P304 | page(s) | 1147-1152 | |
| P577 | publication date | 2011-09-11 | |
| P1433 | published in | Nature Structural & Molecular Biology | Q1071739 |
| P1476 | title | Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum | |
| P478 | volume | 18 |
| Q28237387 | A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect |
| Q33790385 | A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase |
| Q27939846 | A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway |
| Q36887431 | A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation |
| Q36448861 | A ubiquitin-binding rhomboid protease aimed at ERADication. |
| Q38003982 | Aggrephagy: selective disposal of protein aggregates by macroautophagy. |
| Q89879448 | Alpha 1-Antitrypsin Deficiency: A Disorder of Proteostasis-Mediated Protein Folding and Trafficking Pathways |
| Q90577327 | Alternative splice variants of rhomboid proteins: In silico analysis of database entries for select model organisms and validation of functional potential |
| Q33858526 | Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion. |
| Q39810882 | Architectural and thermodynamic principles underlying intramembrane protease function |
| Q28078319 | Arms Race between Enveloped Viruses and the Host ERAD Machinery |
| Q46390248 | Autoadaptive ER-associated degradation defines a preemptive unfolded protein response pathway |
| Q38165139 | Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models |
| Q28237362 | Cleaning up in the endoplasmic reticulum: ubiquitin in charge |
| Q36464919 | Cleaning up: ER-associated degradation to the rescue |
| Q33797023 | Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins |
| Q47924713 | Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). |
| Q28266780 | Control of p97 function by cofactor binding |
| Q35215974 | Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry |
| Q37095440 | Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD) |
| Q24298439 | Defining human ERAD networks through an integrative mapping strategy |
| Q27938831 | Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane |
| Q35790894 | Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets |
| Q28730861 | Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice |
| Q34256709 | Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis |
| Q37132121 | Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum |
| Q90048020 | Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis |
| Q38234935 | ERAD and how viruses exploit it. |
| Q40080379 | Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses |
| Q92333939 | Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism |
| Q91754174 | Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor |
| Q34468295 | Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast. |
| Q37695233 | Identification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response. |
| Q37583253 | Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation |
| Q30524630 | Live cell imaging of protein dislocation from the endoplasmic reticulum |
| Q39594613 | Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD. |
| Q26830475 | Mechanisms for quality control of misfolded transmembrane proteins |
| Q88544285 | Mechanistic insights into ER-associated protein degradation |
| Q55114046 | Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1. |
| Q27937563 | N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates |
| Q38025278 | New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. |
| Q90349193 | OsDER1 Is an ER-Associated Protein Degradation Factor That Responds to ER Stress |
| Q26801052 | Pathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible? |
| Q57036995 | Protein Quality Control in the Endoplasmic Reticulum and Cancer |
| Q85241666 | Protein quality control in the endoplasmic reticulum |
| Q33648830 | RHBDD1 upregulates EGFR via the AP-1 pathway in colorectal cancer |
| Q24323658 | RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR) |
| Q26823514 | Recent technical developments in the study of ER-associated degradation |
| Q33694413 | Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin |
| Q28070034 | Rhomboids, signalling and cell biology |
| Q26866096 | Road to ruin: targeting proteins for degradation in the endoplasmic reticulum |
| Q26824733 | Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation |
| Q24304271 | Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u |
| Q38202500 | Signaling pathways from the endoplasmic reticulum and their roles in disease |
| Q24307768 | Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover |
| Q38092216 | Specificity and regulation of the endoplasmic reticulum-associated degradation machinery |
| Q28554390 | Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation |
| Q38083850 | Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids |
| Q51420255 | Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease. |
| Q36767612 | Structure and function of the AAA+ ATPase p97/Cdc48p |
| Q34438267 | Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures |
| Q37175122 | Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast |
| Q29871423 | TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. |
| Q41438223 | The AAA+ ATPase p97, a cellular multitool |
| Q34951600 | The C-terminal amino acid of the MHC-I heavy chain is critical for binding to Derlin-1 in human cytomegalovirus US11-induced MHC-I degradation |
| Q49914104 | The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins |
| Q40448397 | The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein |
| Q36301264 | The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD) |
| Q38979904 | The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation |
| Q37122324 | The mammalian endoplasmic reticulum-associated degradation system |
| Q64072139 | The molecular, cellular and pathophysiological roles of iRhom pseudoproteases |
| Q35214289 | Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency |
| Q64087546 | Toxins Utilize the Endoplasmic Reticulum-Associated Protein Degradation Pathway in Their Intoxication Process |
| Q34247194 | Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE |
| Q37131458 | UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum. |
| Q57065714 | Ubiquitin-dependent Protein Degradation at the Endoplasmic Reticulum and Nuclear Envelope |
| Q24293182 | Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins |
| Q35175501 | Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. |
| Q50073383 | Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity. |
| Q40941851 | Unveiling the degradative route of the V247M α-sarcoglycan mutant responsible for LGMD-2D. |
| Q36650360 | VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis. |
| Q35778045 | iRhom1 regulates proteasome activity via PAC1/2 under ER stress |
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