| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1034773057 |
| P356 | DOI | 10.1038/NCB746 |
| P3181 | OpenCitations bibliographic resource ID | 1891498 |
| P698 | PubMed publication ID | 11813000 |
| P2093 | author name string | Daniel Finley | |
| Corinna Volkwein | |||
| Ernst Jarosch | |||
| Thomas Sommer | |||
| Dieter H Wolf | |||
| Javier Bordallo | |||
| Christof Taxis | |||
| P2860 | cites work | Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation | Q24291519 |
| Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction | Q24324602 | ||
| A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways | Q24594082 | ||
| Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation | Q27930550 | ||
| A regulatory link between ER-associated protein degradation and the unfolded-protein response | Q27931238 | ||
| The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation | Q27931326 | ||
| Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. | Q27931418 | ||
| ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway | Q27932376 | ||
| A proteolytic pathway that recognizes ubiquitin as a degradation signal | Q27932607 | ||
| Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation | Q27933221 | ||
| The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release | Q27933726 | ||
| Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins | Q27934337 | ||
| Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome | Q27937064 | ||
| Role of Cue1p in ubiquitination and degradation at the ER surface | Q27937138 | ||
| Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. | Q27937925 | ||
| The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing | Q27939678 | ||
| Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant | Q27939929 | ||
| Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation | Q28131669 | ||
| Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation | Q28247695 | ||
| Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p | Q28366803 | ||
| Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae | Q29546523 | ||
| Retrograde protein translocation: ERADication of secretory proteins in health and disease | Q33676998 | ||
| The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate | Q36310746 | ||
| Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome | Q38337469 | ||
| Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity | Q38477851 | ||
| ER quality control: the cytoplasmic connection | Q41351861 | ||
| The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor | Q41708900 | ||
| A yeast mutant showing diagnostic markers of early and late apoptosis | Q42065466 | ||
| Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein | Q42646222 | ||
| Cytosolic degradation of T-cell receptor alpha chains by the proteasome | Q46406320 | ||
| A Major Conformational Change in p97 AAA ATPase upon ATP Binding | Q63370009 | ||
| Ubiquitin and the control of protein fate in the secretory and endocytic pathways | Q77803382 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| VCP-NPL4-UFD1 AAA ATPase complex | Q21109268 | ||
| Polyubiquitin-binding protein UFD1 YGR048W | Q27548232 | ||
| AAA family ATPase CDC48 YDL126C | Q27548297 | ||
| Nuclear protein localization protein 4 YBR170C | Q27552645 | ||
| P304 | page(s) | 134-9 | |
| P577 | publication date | 2002-02-01 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. | |
| P478 | volume | 4 |
| Q45990611 | A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates. |
| Q27931659 | A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis |
| Q33790385 | A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase |
| Q64096816 | A Practical Review of Proteasome Pharmacology |
| Q55441114 | A comprehensive study of calcific aortic stenosis: from rabbit to human samples. |
| Q27939846 | A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway |
| Q27934931 | A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation |
| Q24297732 | A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol |
| Q24297703 | A membrane protein required for dislocation of misfolded proteins from the ER |
| Q30179453 | A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity |
| Q28596603 | A non-canonical role of the p97 complex in RIG-I antiviral signaling |
| Q36089014 | A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum |
| Q27934511 | A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates. |
| Q89969620 | A protein quality control pathway at the mitochondrial outer membrane |
| Q36887431 | A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation |
| Q36689673 | A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery |
| Q28744484 | A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation |
| Q24305231 | A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation |
| Q28279098 | AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation |
| Q28215759 | ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity |
| Q36673300 | Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions |
| Q53613309 | Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. |
| Q24682823 | Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis |
| Q27935283 | Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD. |
| Q24321768 | BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex |
| Q34103187 | BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum |
| Q38082449 | Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation. |
| Q36192735 | CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication |
| Q47068734 | Caenorhabditis elegans UBX cofactors for CDC‐48/p97 control spermatogenesis |
| Q33235326 | Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin |
| Q40727848 | Cdc48 can distinguish between native and non-native proteins in the absence of cofactors. |
| Q34641420 | Cdc48-Ufd1-Npl4: stuck in the middle with Ub. |
| Q27938488 | Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. |
| Q42917685 | Cdc48p is required for the cell cycle commitment point at Start via degradation of the G1-CDK inhibitor Far1p |
| Q42177180 | Cell biology. An ancient portal to proteolysis |
| Q35102083 | Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding. |
| Q36362409 | Cellular response to endoplasmic reticulum stress: a matter of life or death |
| Q40095134 | Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity |
| Q36812713 | Chaperones and proteases--guardians of protein integrity in eukaryotic organelles |
| Q44213642 | Characterization of AtCDC48. Evidence for multiple membrane fusion mechanisms at the plane of cell division in plants |
| Q34328026 | Characterization of coding synonymous and non-synonymous variants in ADAMTS13 using ex vivo and in silico approaches |
| Q28237362 | Cleaning up in the endoplasmic reticulum: ubiquitin in charge |
| Q38700656 | Co-translational mechanisms of quality control of newly synthesized polypeptides |
| Q44546893 | Cold-inducible expression of the cell division cycle gene CDC48 and its promotion of cell proliferation during cold acclimation in zebrafish cells |
| Q28306308 | Conformational changes in the AAA ATPase p97-p47 adaptor complex |
| Q53876964 | Conserved ERAD-like quality control of a plant polytopic membrane protein. |
| Q53360861 | Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy. |
| Q33249013 | Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. |
| Q41597296 | Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. |
| Q36832854 | Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation |
| Q83225744 | Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1 |
| Q39968686 | Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast |
| Q93016060 | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications |
| Q35215974 | Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry |
| Q42515885 | Cytoplasmic Hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane ATPase, PMA1. |
| Q36161562 | Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila |
| Q28481415 | Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p |
| Q44478790 | D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP. |
| Q37095440 | Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD) |
| Q34327353 | Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation |
| Q27937556 | Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery. |
| Q92615943 | Degradation of integral membrane proteins modified with the photosensitive degron module requires the cytosolic endoplasmic reticulum-associated degradation pathway |
| Q46747220 | Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system |
| Q40448063 | Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway. |
| Q33989072 | Delivery of ubiquitinated substrates to protein-unfolding machines |
| Q27938831 | Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane |
| Q35381401 | Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum |
| Q34256709 | Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis |
| Q51143702 | Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis. |
| Q27938609 | Differential requirements of novel A1PiZ degradation deficient (ADD)genes in ER-associated protein degradation |
| Q24539071 | Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. |
| Q92286458 | Direct visualization of degradation microcompartments at the ER membrane |
| Q35973552 | Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer |
| Q27930024 | Dissecting the ER-associated degradation of a misfolded polytopic membrane protein |
| Q28242760 | Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin |
| Q27938024 | Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein |
| Q40618418 | Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome |
| Q36789938 | Doa1 targets ubiquitinated substrates for mitochondria-associated degradation |
| Q96690036 | Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation |
| Q24554438 | E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system |
| Q34970862 | ER-associated degradation in protein quality control and cellular regulation |
| Q39617157 | ER-golgi traffic is a prerequisite for efficient ER degradation. |
| Q28264823 | ERAD: the long road to destruction |
| Q41643911 | Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger |
| Q38237803 | Emerging mechanistic insights into AAA complexes regulating proteasomal degradation |
| Q37345887 | Endoplasmic reticulum stress and the pancreatic acinar cell |
| Q37969971 | Endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins and mutant P23H rhodopsin in photoreceptor cells |
| Q45200798 | Endoplasmic reticulum-associated degradation of ricin A chain has unique and plant-specific features. |
| Q38669157 | Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome |
| Q60526595 | Endoplasmic reticulum-associated protein degradation |
| Q92333939 | Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism |
| Q41832901 | Evading the proteasome: absence of lysine residues contributes to pertussis toxin activity by evasion of proteasome degradation |
| Q24337432 | Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B |
| Q24600792 | Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum |
| Q35125892 | For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection |
| Q27015865 | From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation |
| Q24307429 | Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains |
| Q28204260 | Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells |
| Q38012690 | Gaucher disease paradigm: from ERAD to comorbidity |
| Q38606832 | Glycosylation-directed quality control of protein folding |
| Q48109062 | Golgi-mediated vacuolar sorting of the endoplasmic reticulum chaperone BiP may play an active role in quality control within the secretory pathway |
| Q24304451 | HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome |
| Q35239937 | Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells |
| Q37529532 | Heat shock proteins in antigen trafficking--implications on antigen presentation to T cells. |
| Q35213373 | Hepatic cytochrome P450 degradation: mechanistic diversity of the cellular sanitation brigade |
| Q24318770 | Herp enhances ER-associated protein degradation by recruiting ubiquilins |
| Q84565033 | High-speed atomic force microscopy techniques for observing dynamic biomolecular processes |
| Q49295322 | Hijacking of the Host Ubiquitin Network by Legionella pneumophila |
| Q89866933 | Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins |
| Q36947877 | Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase |
| Q35216145 | Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect |
| Q24298901 | Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum |
| Q34858547 | Human cytomegalovirus US3 chimeras containing US2 cytosolic residues acquire major histocompatibility class I and II protein degradation properties |
| Q37672299 | Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis |
| Q29041263 | Identification and Characterization of Endoplasmic Reticulum-Associated Degradation Proteins Differentially Affected by Endoplasmic Reticulum Stress |
| Q37200837 | In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase |
| Q53535093 | In vivo hexamerization and characterization of the Arabidopsis AAA ATPase CDC48A complex using forster resonance energy transfer-fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy. |
| Q30492940 | Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation |
| Q47758356 | Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding |
| Q42183323 | Intracellular events regulating cross-presentation |
| Q37262161 | Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system |
| Q27929992 | Key steps in ERAD of luminal ER proteins reconstituted with purified components |
| Q34537028 | Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol |
| Q24529995 | Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum |
| Q40949522 | Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions |
| Q34159592 | Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation |
| Q37143424 | MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation. |
| Q37855729 | Making new out of old: recycling and modification of an ancient protein translocation system during eukaryotic evolution. Mechanistic comparison and phylogenetic analysis of ERAD, SELMA and the peroxisomal importomer |
| Q35049120 | Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation |
| Q88544285 | Mechanistic insights into ER-associated protein degradation |
| Q37401247 | Membrane protein targeting to the MVB/lysosome |
| Q27935765 | Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation |
| Q34095072 | Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion protein |
| Q24677354 | Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control |
| Q35613397 | Misfolded proteins traffic from the endoplasmic reticulum (ER) due to ER export signals |
| Q36741530 | Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi |
| Q28083423 | Mitochondrial protein quality control: the mechanisms guarding mitochondrial health |
| Q34107647 | Molecular clearance of ataxin-3 is regulated by a mammalian E4 |
| Q21131559 | Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps |
| Q24530318 | Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane |
| Q29017135 | Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum-associated degradation pathway |
| Q45719229 | Myopathy in Marinesco-Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology |
| Q24320023 | NMR characterization of the interaction between the PUB domain of peptide:N-glycanase and ubiquitin-like domain of HR23 |
| Q38970691 | Nucleotide Excision Repair: Finely Tuned Molecular Orchestra of Early Pre-incision Events |
| Q24312778 | OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD |
| Q24658302 | One step at a time: endoplasmic reticulum-associated degradation |
| Q35867037 | OsHrd3 is necessary for maintaining the quality of endoplasmic reticulum-derived protein bodies in rice endosperm |
| Q99708814 | Oxidoreductases in Glycoprotein Glycosylation, Folding, and ERAD |
| Q33815368 | Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model |
| Q34354314 | Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders |
| Q27939680 | Physical and genetic associations of the Irc20 ubiquitin ligase with Cdc48 and SUMO. |
| Q31122631 | Plant UBX domain-containing protein 1, PUX1, regulates the oligomeric structure and activity of arabidopsis CDC48. |
| Q37148338 | Polyubiquitin chains: functions, structures, and mechanisms |
| Q44482155 | Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane |
| Q28308130 | Positive cooperativity of the p97 AAA ATPase is critical for essential functions |
| Q91889406 | Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity |
| Q34637854 | Processing and turnover of the Hedgehog protein in the endoplasmic reticulum |
| Q33552559 | Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A. |
| Q26823157 | Protein folding and quality control in the ER |
| Q90182689 | Protein quality control in the secretory pathway |
| Q36432134 | Protein quality control: the who's who, the where's and therapeutic escapes |
| Q38585206 | Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast |
| Q64971224 | Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways. |
| Q38196654 | Quality control: ER-associated degradation: protein quality control and beyond |
| Q33241705 | RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics |
| Q45185172 | RNA interference of VCP/p97 increases Mallory body formation |
| Q24323658 | RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR) |
| Q26823514 | Recent technical developments in the study of ER-associated degradation |
| Q24336904 | Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane |
| Q38237571 | Regulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin. |
| Q26853389 | Regulation of Unperturbed DNA Replication by Ubiquitylation |
| Q38086397 | Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code |
| Q34627241 | Retro-translocation of proteins from the endoplasmic reticulum into the cytosol |
| Q27938951 | Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p |
| Q36980987 | Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism |
| Q26747328 | Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin |
| Q33748594 | Role of intramembrane charged residues in the quality control of unassembled T-cell receptor alpha-chains at the endoplasmic reticulum |
| Q40414043 | Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate |
| Q40429314 | Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation |
| Q36355930 | Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum |
| Q24306367 | SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation |
| Q34628253 | SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells |
| Q24540390 | SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation |
| Q36090973 | Search and destroy: ER quality control and ER-associated protein degradation |
| Q27930621 | Sec61p is part of the endoplasmic reticulum-associated degradation machinery |
| Q45424613 | Signal peptide-regulated toxicity of a plant ribosome-inactivating protein during cell stress. |
| Q36033903 | Simulations of the p97 complex suggest novel conformational states of hydrolysis intermediates |
| Q37308987 | Single base substitution in OsCDC48 is responsible for premature senescence and death phenotype in rice |
| Q35058026 | Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing |
| Q36321616 | Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation |
| Q42111753 | Spatial control of lipid droplet proteins by the ERAD ubiquitin ligase Doa10. |
| Q48171061 | Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors |
| Q39792127 | Ssz1 restores endoplasmic reticulum-associated protein degradation in cells expressing defective cdc48-ufd1-npl4 complex by upregulating cdc48. |
| Q35049666 | Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms |
| Q34579798 | Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module |
| Q36677811 | Structural and functional deviations in disease-associated p97 mutants |
| Q51420255 | Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease. |
| Q39371142 | Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes. |
| Q36767612 | Structure and function of the AAA+ ATPase p97/Cdc48p |
| Q35915784 | Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation |
| Q27935126 | Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family |
| Q35889115 | Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. |
| Q28261886 | Targeting proteins for degradation |
| Q37069517 | Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation |
| Q42276650 | Termination of DNA replication forks: "Breaking up is hard to do". |
| Q45061748 | The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism |
| Q27931660 | The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis |
| Q61415389 | The Arabidopsis SERK1 protein interacts with the AAA-ATPase AtCDC48, the 14-3-3 protein GF14λ and the PP2C phosphatase KAPP |
| Q115234654 | The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein |
| Q49914104 | The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins |
| Q37403586 | The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation |
| Q27932818 | The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment |
| Q41877787 | The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control |
| Q24297892 | The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD |
| Q34726848 | The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly |
| Q38222629 | The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function |
| Q36301264 | The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD) |
| Q36982944 | The activities and function of molecular chaperones in the endoplasmic reticulum |
| Q27931138 | The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). |
| Q24676115 | The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system |
| Q52567071 | The degradation pathway of a model misfolded protein is determined by aggregation propensity. |
| Q27015793 | The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology |
| Q36418006 | The endoplasmic reticulum-associated degradation pathways of budding yeast |
| Q34490515 | The evolutionary origin of peroxisomes: an ER-peroxisome connection. |
| Q38979904 | The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation |
| Q33980716 | The final moments of misfolded proteins en route to the proteasome |
| Q47223785 | The involvement of endoplasmic reticulum formation and protein synthesis efficiency in VCP- and ATL1-related neurological disorders |
| Q33934283 | The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation |
| Q34341195 | The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain. |
| Q27931542 | The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane |
| Q37100233 | The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum |
| Q40274580 | The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins. |
| Q40446518 | The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells. |
| Q35138099 | The role of glucosidase II and endomannosidase in glucose trimming of asparagine-linked oligosaccharides |
| Q42558471 | The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP. |
| Q30476859 | The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus |
| Q24338770 | The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins |
| Q36268060 | The ubiquitin-proteasome system of Saccharomyces cerevisiae |
| Q40157250 | The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy |
| Q37424805 | The ubiquitylation machinery of the endoplasmic reticulum |
| Q33582810 | The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo |
| Q40323216 | The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins |
| Q38101256 | Three old and one new: protein import into red algal-derived plastids surrounded by four membranes |
| Q35040957 | Transferring substrates to the 26S proteasome. |
| Q41662080 | Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates |
| Q58378466 | Two Hrd1p homologues in the yeast Yarrowia lipolytica which act in different pathways |
| Q51485232 | UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. |
| Q24320201 | USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation |
| Q37706866 | UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein |
| Q33817822 | Ube2g2-gp78-mediated HERP polyubiquitylation is involved in ER stress recovery |
| Q24324707 | Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD |
| Q40537146 | Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation |
| Q46626985 | Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation |
| Q36384570 | Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation |
| Q35175501 | Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. |
| Q24301569 | Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6 |
| Q24683139 | Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3 |
| Q44495359 | Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum |
| Q44151437 | Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome |
| Q27939739 | Ubx2 links the Cdc48 complex to ER-associated protein degradation |
| Q27939043 | Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum |
| Q24317242 | Ubxd1 is a novel co-factor of the human p97 ATPase |
| Q34348618 | Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein |
| Q36659841 | Unfolded protein response and activated degradative pathways regulation in GNE myopathy |
| Q33515572 | Usa1 protein facilitates substrate ubiquitylation through two separate domains |
| Q44504087 | Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. |
| Q24677725 | VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments |
| Q24673098 | VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo |
| Q36708176 | VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
| Q36755008 | Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin |
| Q35578562 | Valosin-containing protein and neurofibromin interact to regulate dendritic spine density |
| Q38739273 | Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication |
| Q36242585 | Versatility of the endoplasmic reticulum protein folding factory |
| Q36266461 | Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond |
| Q44852706 | Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation |
| Q36337039 | gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum |
| Q57372274 | p97 Is in a Complex with Cholera Toxin and Influences the Transport of Cholera Toxin and Related Toxins to the Cytoplasm |
| Q38364252 | p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation |
| Q79091747 | p97, a protein coping with multiple identities |
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