SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells

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SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M701862200
P698PubMed publication ID17502376

P2093author name stringYuan Wang
Margaret M P Pearce
Richard J H Wojcikiewicz
Grant G Kelley
P2860cites workIdentification of the receptor component of the IkappaBalpha-ubiquitin ligaseQ22008569
Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ERQ24296860
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulumQ24298901
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradationQ24302539
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsQ24307429
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductaseQ24324257
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membraneQ24336904
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membraneQ24530318
The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding siteQ24535990
Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.Q24539071
Formation of membrane-bound ring complexes by prohibitins in mitochondriaQ24558660
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell typesQ41345900
Angiotensin II-induced down-regulation of inositol trisphosphate receptors in WB rat liver epithelial cells. Evidence for involvement of the proteasome pathwayQ41928419
Morphological analysis of protein transport from the ER to Golgi membranes in digitonin-permeabilized cells: role of the P58 containing compartmentQ42135792
Down-regulation of types I, II and III inositol 1,4,5-trisphosphate receptors is mediated by the ubiquitin/proteasome pathwayQ42148401
The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytesQ42818064
Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cellsQ44209245
A Functional Interaction between Chromogranin B and the Inositol 1,4,5-Trisphosphate Receptor/Ca2+ ChannelQ44594114
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniolQ44620965
Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomainsQ44626599
Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductaseQ44626799
Stable suppression of tumorigenicity by virus-mediated RNA interferenceQ45730805
Ancient origin of reggie (flotillin), reggie-like, and other lipid-raft proteins: convergent evolution of the SPFH domainQ47230997
Secretagogues cause ubiquitination and down-regulation of inositol 1, 4,5-trisphosphate receptors in rat pancreatic acinar cells.Q52534839
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.Q52931787
The Jalview Java alignment editorQ27861026
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradationQ27930372
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.Q27930706
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteinsQ27931299
The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitmentQ27932818
Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondriaQ27934696
Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradationQ27935765
Ubx2 links the Cdc48 complex to ER-associated protein degradationQ27939739
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradationQ27939982
Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+Q28187990
Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)Q28207747
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradationQ28263220
ERAD: the long road to destructionQ28264823
N-glycan processing in ER quality controlQ28271200
Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptorsQ28576636
Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44Q28594382
The versatility and universality of calcium signallingQ29547402
The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteinsQ33878571
Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosolQ33944123
IP(3) receptors: the search for structure.Q34313146
ER-associated degradation in protein quality control and cellular regulationQ34970862
Regulated ubiquitination of proteins in GPCR-initiated signaling pathwaysQ35629252
Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?Q35879605
Structural insights into the regulatory mechanism of IP3 receptor.Q35979572
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.Q36119119
Host regulation of lysogenic decision in bacteriophage lambda: transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA).Q36150293
Flotillins and the PHB domain protein family: rafts, worms and anaestheticsQ36230683
The inositol 1,4,5-trisphosphate receptorsQ36231356
The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediateQ36310746
Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.Q36358009
Reggie/flotillin proteins are organized into stable tetramers in membrane microdomainsQ40186084
Characterization of the stomatin domain involved in homo-oligomerization and lipid raft association.Q40269152
Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradationQ40537146
Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasomeQ40618418
Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpressionQ40619944
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vectorQ40773079
Lipid-mediated, reversible misfolding of a sterol-sensing domain proteinQ40919604
Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomesQ41079635
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)20104-20115
P577publication date2007-05-14
P1433published inJournal of Biological ChemistryQ867727
P1476titleSPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells
P478volume282

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